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Preprint ARTICLE | doi:10.20944/preprints202408.1231.v1

Antioxidant and Antibacterial Activities of Selected Medicinal Plants from Addis Ababa against MDR-Uropathogenic Bacteria

Mebrahtu Eyasu, Juana Benedí, José Antonio Romero, Sagrario Martín-Aragón

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Thymus schimperi; Rhamnus prinoides; Justicia shimperiana; multidrug resistance; Escherichia coli; Klebsiella pneumoniae ESBL

Online: 16 August 2024 (10:11:07 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202408.0937.v1

Eosinophilic granulomatosis with polyangiitis; a Distinctive Presentation with Myocarditis and Autoimmune Haemolytic Anaemia: Case Report

Doaa Abdulwahab Mohammed Ayish, Fatma Ayish, Asayel Alhasan Khamjan, Amal. H. Mohamed, Nagla Abdalgani, Osama Albasheer

Subject: Medicine And Pharmacology, Hematology Keywords: Eosinophilia; myocarditis; vasculitis; autoimmune haemolytic anaemia; heart failure

Online: 13 August 2024 (13:04:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0735.v1

Relationship Between Marriage and Prediabetes Among Health Care Workers: Mediating Effect of Triglycerides

Yong-Hsin Chen, Jia June Lin, Hsiu-Mei Tang, Ching-wen Yang, Gwo-Ping Jong, Yi Sun Yang

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Diabetes; Prediabetes; Impaired fasting glucose; Triglycerides; Marriage; Obesity

Online: 12 August 2024 (04:24:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0719.v1

Exploring the Rise in Precocious Puberty: Interplay of Genetic and Environmental Factors

Jhancy Malay, Biji Thomas George, Rajani Dube, Subhranshu Sekhar Kar, Imran Rashid Rangraze

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: precocious puberty; genetic factors; endocrinal factors; environmental factors

Online: 12 August 2024 (03:55:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0489.v1

A Machine Learning Approach for Predicting Pedaling Force Profile in Cycling

Reza Ahmadi, Shahram Rasoulian, Samira Fazeli Veisari, Atousa Parsaei, Hamidreza Heidary, Walter Herzog, Amin Komeili

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural Networks; Pedal Reaction Force; Radial and Mediolateral Forces; Cycling

Online: 7 August 2024 (18:00:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2603.v1

Sesame an Underutilized Oil Seed Crop: Breeding Achievements and Future Challenges

Saeed Rauf, Taiyyibah Basharat, Adane Gebeyehu, Mohammed Elsafy, Mahbubjon Rahmatov, Rodomiro Ortiz, Yalcin Kaya

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Abiotic stress; Capsules; CRISPR/Cas9; Genomics, SNPs; Yield

Online: 31 July 2024 (15:14:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2005.v1

Heart Rate Variability in Acute Myocardial Infarction: Results of the HeaRt-V-AMI Single-Center Cohort Study

Crischentian Brinza, Mariana Floria, Dragos-Viorel Scripcariu, Alexandra Maria Covic, Adrian Covic, Alexandru Burlacu

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart rate variability; myocardial infarction; percutaneous coronary intervention; wearable technology; risk stratification

Online: 25 July 2024 (09:26:59 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202407.1673.v1

Address Social Injustices in Taxonomy: Implement Extended Revisions of Names with Ethical Issues and Persistent Identifiers for Tracing Name Changes

Desalegn Chala, Dag Endresen, Sebsebe Demissew, Laura A. Slaughter, Einar Broch Johnsen, Nils Chr. Stenseth

Subject: Biology And Life Sciences, Other Keywords: Catalogue of Life (COL); ethical issues in taxonomic names; nomenclature; Persistent ID; social injustices in taxonomic names; social equity in science; Taxonomy

Online: 22 July 2024 (07:41:48 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202407.0355.v1

A Novel de Novo Missense Mutation in KIF1A Associated with Young-Onset Upper-Limb Amyotrophic Lateral Sclerosis

Emilien Bernard, Florent Cluse, Adrien Bohic, Marc Hermier, Cédric Raoul, Pascal Leblanc, Claire Guissart

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Amyotrophic Lateral Sclerosis; Genome sequencing; KIF1A; de novo mutation

Online: 3 July 2024 (15:27:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0217.v1

Bacterial and Genetic Features of Raw Retail Pork Meat: Integrative Analysis of Antibiotic Susceptibility, Whole Genome Sequencing and Metagenomics

Michelle Lowe, Wilhelmina Strasheim, Wai Yin Chan, Olga Perovic

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: whole genome sequencing; metagenomics; antibiotic residue testing; retail pork meat; South Africa

Online: 2 July 2024 (14:50:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0052.v1

Growth Hormone Upregulates Melanoma Drug Resistance and Migration via Melanoma Derived Exosomes

Prateek Kulkarni, Reetobrata Basu, Taylor Bonn, Beckham Low, Nathaniel Mazurek, John Kopchick

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: growth hormone; exosomes; melanoma; chemotherapy resistance; ABC transporters; N-cadherin; MMP2; pegvisomant

Online: 1 July 2024 (10:12:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.2024.v1

Strategies to Delay Ethylene-Mediated Ripening in Climacteric Fruits: Implications for Shelf-Life Extension and Postharvest Quality

Alonso-Salinas Ramiro, López-Miranda Santiago, López-Pérez Antonio José, Acosta-Motos José Ramón

Subject: Biology And Life Sciences, Food Science And Technology Keywords: delayed ripening; climacteric fruit; fruit preservation; phytohormone

Online: 29 June 2024 (05:31:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1784.v1

Understanding Galectin-3's Role in Diastolic Dysfunction: A Contemporary Perspective

Wen-Rui Hao, Chun-Han Cheng, Ju-Chi Liu, Huan-Yuan Chen, Jin-Jer Chen, Tzu-Hurng Cheng

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diastolic dysfunction; galectin-3; fibrosis; biomarker; heart failure; cardiac remodeling

Online: 27 June 2024 (12:07:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1729.v1

Left Ventricular Function and Myocardial Longitudinal Strain Analysis in Patients with Chagas Disease: Case Series and Systematic Literature Review

José Victor da Nóbrega Borges, Samira Abdel Correia Leila, Kiran Sooraj Thirukonda Jegadeesh Babu, Karma Jashvantbhai Patel, Kavya Hiteshkumar Shah, Muhammad Ahmed Shaikh, Abdul Majid Shaik, Mahitha Reddy Takkasila, Sahithi Burra

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Chagas Disease; Echocardiography; Global Longitudinal Strain

Online: 25 June 2024 (09:33:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1645.v1

Preparation and Characterization of Oxide Nanotubes on Titanium Surface for Use in Controlled Drug Release Systems

Patrycja Osak, Sandra Skwarek, Dariusz Łukowiec, Grzegorz Przeliorz, Bożena Łosiewicz

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: anodizing; corrosion resistance; drug delivery system; oxide nanotubes; titanium

Online: 24 June 2024 (12:25:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1641.v1

Is Left Ventricle Global Longitudinal Strain by Two-Dimensional Speckle Tracking Echocardiography Useful at Detection of Subclinical Myocardial Dysfunction in Patients After Coronavirus-2019 infection?

José Victor da Nóbrega Borges, Samira Abdel Correia Leila, Kiran Babu, Sahithi Burra, Muhammad Ahmed Shaikh, Abdul Majid Shaik, Mahitha Reddy Takkasila, Kavya Hiteshkumar Shah, Karma Jashvantbhai Patel

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Global Longitudinal Strain; COVID-19; Echocardiography

Online: 24 June 2024 (06:56:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1325.v1

Performance Analysis of a 50 MW Solar PV Installation at BUI Power Authority: A Comparative Study Between Sunny and Overcast Days

Rahimat Oyiza Yakubu, Muzan Williams Ijeoma, Hammed Yusuf, Abdulazeez Alhaji Abdulazeez, Peter Acheampong, Michael Carbajales-Dale

Subject: Engineering, Energy And Fuel Technology Keywords: Solar PV System; Solar Radiation; AC Energy Output; Performance Ratio; System Yield; Capacity Factor; Solar PV Performance Analysis

Online: 19 June 2024 (08:09:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0920.v1

The Diagnostic Challenge of Cystic Echinococcosis in Humans: First Assessment of Underreporting Rates in Mongolia

Bolor Bold, Christian Schindler, Uranshagai Narankhuu, Agiimaa Shagj, Erdenebileg Bavuujav, Sonin Sodov, Tsogbadrakh Nyamdorj, Jakob Zinsstag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cystic echinococcosis 1; Mongolia 2; clinical guideline 5; burden of disease 6; Echinococcus granulosus 6

Online: 13 June 2024 (14:54:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0435.v2

CRISPR/Cas Mediated Genome Engineering in Plants: Application and Future Prospective

Swetaleena Mishra, Subhendu Nayak, Narendra Tuteja, Sowmya Poosapati, Durga Madhab Swain, Rajan Kumar Sahoo

Subject: Biology And Life Sciences, Plant Sciences Keywords: CRISPR-Cas system; crop improvement; genome engineering; prime editing

Online: 7 June 2024 (15:06:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1487.v2

Plug-and-Play: An Efficient Post-training Pruning Method for Large Language Models

Yingtao Zhang, Haoli Bai, Haokun Lin, Jialin Zhao, Lu Hou, Carlo Vittorio Cannistraci

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: post-training pruning; combinatorial optimization; large language models; inference acceleration

Online: 27 May 2024 (08:34:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1622.v1

Assessment of the Thermomechanical Behavior and Microstructure of AA 7075-T6 Aluminum Alloy Lap Joints at Optimal Predicted FSW Process Parameters

Oumayma Toumi, Romdhane Ben Khalifa, Alessia Teresa Silvestri, Ridha Ennetta, Fabio Scherillo, Umberto Prisco

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: FSW; AA 7075-T6 Aluminum alloy; lap joint; microstructure; thermomechanical proprieties

Online: 24 May 2024 (13:21:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1500.v1

Identification of Anastatica hierochuntica L. Methanolic Leaves Extract-Derived Metabolites Exhibiting Xanthine Oxidase Inhibitory Activities: In Vitro and in Silico Approaches

Saranya Rameshbabu, Zeyad Alehaideb, Sahar S Alghamdi, Rasha S Suliman, Feras Almourfi, Syed Ali Mohamed Yacoob, Anuradha Venkataraman, Safia Messaoudi, Sabine Matou-Nasri

Subject: Biology And Life Sciences, Life Sciences Keywords: Anastatica hierochuntica; chemical composition; metabolites; metabolic enzyme inhibitor; xanthine oxidase

Online: 23 May 2024 (10:53:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1334.v1

Study on the Deformation Behavior of Two Phases during Low Cycle Fatigue of S32750 Duplex Stainless Steel

Shun Bao, Han Feng, Zhigang Song, Jianguo He, Xiaohan Wu, Yang Gu

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: S32750 duplex stainless steel; ow cycle fatigue; plastic deformatio; dislocation evolution

Online: 21 May 2024 (17:22:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1380.v1

A Comparative Analysis of Librarians’ Views on AI Support for Learning Experiences, Lifelong Learning, and Digital Literacy in Malaysia and Indonesia

Fitri Mutia, Mohamad Noorman Masrek, Mohammad Fazli Baharuddin, Shamila Mohamed Shuhidan, Tri Soesantari, Helmy Prasetyo Yuwinanto, Ragil Tri Atmi

Subject: Social Sciences, Library And Information Sciences Keywords: artificial intelligence; librarians; learning experience; lifelong learning; digital literacy

Online: 21 May 2024 (12:50:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1333.v1

Effects of a Bank Plant on the Control of Rice Planthoppers: A Field Study

Xin Guo, Qiao-yu Zhou, Meng-meng Ru, Bei Cao, Xin Huang, Xu-song Zheng, Ping-yang Zhu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Leersia sayanuka; bank plant; sesame; rice; ecological engineering for pest control

Online: 21 May 2024 (04:48:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0964.v1

Activated Carbon Prepared from Waste Coffee Grounds: Characterization and Adsorption Properties of Dyes

Ferielle Aouay, Attia Afef, Lasaad Damak, Raja Ben Amar, Andre Deratani

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: dye removal; AO7; activated carbon; spent coffee grounds; adsorption process; experimental design methodology; optimization

Online: 14 May 2024 (14:59:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0603.v1

Smartphone Digital Image Colorimetry: An Affordable Easy-To-Use Approach for Hands-On Training in Resource-Limited Settings

Victor Markus, Abraham Abbey Paul, Robert S. Marks, Jude Caleb

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Improvisation in science education, quantitative analysis, colorimetry, smartphone digital image colorimetric.

Online: 9 May 2024 (13:46:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0574.v1

Biallelic Variants in LIPT2 as a Cause of Infantile-Onset Dystonia: Expanding the Clinical and Molecular Spectrum

Kuntal Sen, Alonso Zea Vera, Anna Puronurmi, Andrea Gropman, Parith Wongkittichote, Rebecca Ganetzky, Kaija Autio, Alexander Kastaniotis

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: LIPT2; mitochondrial disorder; dystonia; lipoic acid biosynthesis disorder

Online: 9 May 2024 (07:31:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0867.v1

Stratification of Homologous Recombination Deficiency-Negative High-Grade Ovarian Cancer by the Type of Peritoneal Spread into Two Groups with Distinct Survival Outcome

Simon Schnaiter, Esther Schamschula, Juliane Laschtowiczka, Heidelinde Fiegl, Johannes Zschocke, Alain Zeimet, Katharina Wimmer, Daniel Reimer

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Personalized medicine; genomic instability; Miliary disease; epithelial ovarian cancer; PARP inhibitor; staging

Online: 12 April 2024 (21:20:09 CEST)

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Preprint ESSAY | doi:10.20944/preprints202404.0814.v1

Nest Characteristics and Nest Site Selection of Giant Babax in Lhasa

Shengling Zhou, Zhaoxiang Wang, Shiyang Weng, Rui Wang, Huaiming Jin, Hui Han, Le Yang

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Giant Babax; nest; nest site selection; Reproductive success rate

Online: 12 April 2024 (04:50:53 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0786.v1

Conceptualizing Ethical AI-Enabled Marketing: Current State and Agenda for Future Research

Mohammad Al Haj Eid, Mohammad Abu Hashesh, Abdel-Aziz Ahmad Sharabati, Ahmad Khraiwish, Shafig Al-Haddad, Hesham Abusaimeh

Subject: Business, Economics And Management, Marketing Keywords: Artificial Intelligence (AI); AI Ethics; Marketing; Privacy; Data Security; Bias; Transparency; Accountability; Trust; Regulatory Frameworks for AI

Online: 11 April 2024 (09:35:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1129.v1

A Novel Differentiated Control Strategy for Energy Storage System That Minimizes Battery Aging Cost Based on Multiple Health Features

Wei Xiao, Jun Jia, Weidong Zhong, Wenxue Liu, Zhuoyan Wu, Cheng Jiang, Binke Li

Subject: Engineering, Energy And Fuel Technology Keywords: energy storage station; lithium-ion battery; differentiated control; health feature; aging cost

Online: 22 March 2024 (07:44:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0656.v1

Assessment of Sustainable Mobility Patterns of University Students and Staff: Case of a LMIC

Stephen Kome Fondzenyuy, Isaac Ndumbe Jackai II, Steffel Ludivin Feudjio Tezong, Davide Shingo Usami, Brayan Gonzalez-Hernandez, Jean François WOUNBA, George NKENG ELAMBO, Luca Persia

Subject: Engineering, Transportation Science And Technology Keywords: mobility; travel choices; active modes; public transport; low- and middle-income countries

Online: 11 March 2024 (17:56:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0030.v1

The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease

Giuseppe Guido Maria Scarlata, Carmen Colaci, Marialaura Scarcella, Marcello Dallio, Alessandro Federico, Luigi Boccuto, Ludovico Abenavoli

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: alcohol; oxidative stress; inflammation; gut dysbiosis; biological drugs; probiotics

Online: 4 March 2024 (06:18:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1642.v1

Measuring Device Detecting Impact Forces on Impact Rollers

Leopold Hrabovský, Daniel Kurač, Štěpán Pravda, Eliška Nováková, Tomáš Machálek

Subject: Engineering, Mechanical Engineering Keywords: impact roller; fixed conveyor idler; steel trestle; rubber bracket; vibration; impact force; laboratory equipment.

Online: 28 February 2024 (16:02:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1139.v1

Phenolic profiles and antitumor activity against colorectal cancer cells of seeds from selected Ribes taxa

Svetlana Lyashenko, Rosalía López-Ruiz, Ana Minerva García-Cervantes, Ignacio Rodríguez-García, Svetlana Yunusova, José Luis Guil-Guerrero

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Ribes; blackcurrant cultivars; phenolic compounds; LC-MS; HT-29; MTT assay

Online: 20 February 2024 (14:28:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1091.v1

The Soluble Human Leukocyte Antigen-G Levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies

Márió Vincze, János Sikovanyecz Jr., Andrea Suranyi, Imre Foldesi, Szabolcs Várbíró, Gábor Németh, Zoltan Kozinszky, János Sikovanyecz

Subject: Public Health And Healthcare, Other Keywords: soluble Human Leukocyte Antigen-G; serum; amniotic fluid; fetus; placenta; sonography

Online: 20 February 2024 (05:55:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0801.v1

Chiral Jahn-Teller Distortion in Quasi-Planar Boron Clusters

Dongbo Zhao, Xin He, Yilin Zhao, Tianlv Xu, Shankai Hu, Paul W. Ayers, Shubin Liu

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: Jahn-Teller effect; Helical spin density; Helical molecular orbital; Boron clusters

Online: 14 February 2024 (11:26:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0676.v1

Microbiome Dysbiosis Associates to Castration Resistance and Cancer Stemness in Metastatic Prostate Cancer

Matthew Uzelac, Ruomin Xin, Weg M. Ongkeko

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostate cancer; castration-resistant prostate cancer; microbiome; cancer stem cells

Online: 12 February 2024 (10:44:58 CET)

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Preprint REVIEW | doi:10.20944/preprints201701.0039.v1

Curcumin a Multifaceted Compound with Hormetic Behaviour that Mediates an Intricate Crosstalk between Mitochondrial Biogenesis, Mitophagy, Mitophagic Death and Apoptosis

Nathan Earl Rainey, Aoula Moustapha, Raphaelle Parker, Patrice Xavier Petit

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: apoptosis; autophagy; cancer; crosstalk; curcumin; endoplasmic reticulum; hormatic behavior; lysosomes; mitochondria

Online: 10 January 2017 (03:46:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0512.v1

Evidence On Viral Suppression Supports Scaling-Up Transition To Dolutegravir-Based Regimens In Pediatric Populations In Cameroon: A Multicentre Baseline Assessment For The Cipher-Adola Study

Joseph FOKAM, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Yakouba Liman, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Augustin Komego Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Atsama Amougou, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Bille Eyoum, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo Federico Perno, Anne-Cécile Zoung-Kanyi Bissek

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Virological suppression; low level viremia; children, adolescents, and young-adults; DTG-based regimen; elimination of paediatric AIDS; Cameroon.

Online: 5 July 2024 (12:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1844.v1

Evaluation of Electrical Characteristics of Weft-Knitted Strain Sensors for Joint Motion Monitoring: Focus on Plating Stitch Structure

Youkyung Oh, Youn-Hee Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: knitted strain sensors; plain stitch; plating stitch structure; stitch pattern; yarn thickness; NP number; joint motion monitoring

Online: 23 October 2024 (16:29:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1982.v1

A Method for the Solution of Certain Non-Linear Problems of Combined Seagoing Main Engines Performance and Fixed Pitch Propeller Hydrodynamics

E.C. Andritsakis

Subject: Engineering, Marine Engineering Keywords: seagoing; main engines performance; fixed pitch propeller hydrodynamics; combined solution

Online: 25 September 2024 (12:45:29 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202409.1348.v1

Optimized Nanocellulose-Based Magnetic Metal-Organic Frameworks for Antibiotic Adsorption: A Cutting-Edge Strategy in Environmental Remediation

Pham Vu Nhat Uyen, Dang Anh Tuan

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Nanocellulose; Metal-Organic Frameworks; Water Remediation; Antibiotic Adsorption; Environmental Sustainability

Online: 18 September 2024 (12:00:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2192.v1

The Impact of Restrictive Macroprudential Policies through Borrower-Targeted Instruments on Income Inequality: Evidence from a Bayesian Approach

Lindokuhle Talent Zungu, Lorraine Greyling

Subject: Business, Economics And Management, Economics Keywords: Bayesian; DTI; Emerging markets; Financial restrictions; GMM; Income Inequality; LTV; Macroprudential policies; PVAR

Online: 12 September 2024 (15:27:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0384.v1

AI, Cultural Heritage and Bias: Some Key Queries that Arise from the Use of GenAI

Anna Foka, Gabriele Griffin

Subject: Arts And Humanities, Other Keywords: Cultural Heritage; genAI; Artificial Intelligence; Human-in-the-loop; Bias

Online: 5 September 2024 (12:34:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1183.v1

Community Engagement and Collaboration between Researchers and Community Stakeholders for Schistosomiasis and Malaria Projects in Ingwavuma, uMkhanyakude District, KwaZulu‐Natal

Zinhle Mthembu, Moses John Chimbari

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: community engagement; collaboration; KEP researchers; headmen; community advisory boards

Online: 20 August 2024 (03:52:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1145.v1

Manufacturing Strategies for a Family of Integrated Photovoltaic-Fuel Cell Systems

Chukwuma Ogbonnaya, Grace Hegarthy

Subject: Engineering, Energy And Fuel Technology Keywords: Renewable energy technologies; Supply chain management; Lean and agile manufacturing; Modularisation; IPVFC systems; Decarbonisation; Hydrogen; Distributed generation; Manufacturing management; Domain-based thinking; Model-based systems engineering

Online: 15 August 2024 (14:32:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1784.v1

Emergency Mapping for Flood Events Using Satellite Imagery (Optical and/or Synthetic Aperture Radar) and Benchmarking between Open Source and Commercial Geospatial Analysis Tools

Nancy Alvan Romero, Wilson A. Suarez Alayza

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: weather; cyclone; emergency map; flood; satellite image; Peru

Online: 23 July 2024 (13:39:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1159.v1

Progressive Keratoconus Treatment with Transepithelial 2-Step Phototherapeutic Keratectomy Combined with Corneal Cross-Linking (CXL): Clinical Outcomes and Postoperative Management including Potential Complications, of the Modified Athens Protocol De

Anastasios John Kanellopoulos, Alexander J. Kanellopoulos

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Ectasia; keratoconus; cornea crosslinking; excimer ablation; PRK; Athens Protocol

Online: 15 July 2024 (11:34:58 CEST)

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Purpose: To report a novel application of excimer ablation for normalization of central corneal refractive irregularity, combined with higher fluence CXL in the effective management and visual rehabilitation of progressive keratoconus. Methods: 17 cases with progressive keratoconus were treated with a corneal surface excimer laser ablation normalization using the topographyguided (Contura) myopic ablation for customized corneal re-shaping using a 6mm optical zone. The epithelial removal was accounted for by adding a -2.75 diopters correction in the topographyguided normalizing surface ablation followed by, a second, wavefront-optimized hyperopic excimer treatment of + 2.75 diopters at 6mm optical zone. The 2 sequential excimer ablations were followed by the corneal crosslinking (CXL). Visual acuity, refraction, and keratoconus documentation via keratometry, topography, and pachymetry, as well as endothelial cell density were evaluated over 36 months. Results: Keratoconus stabilized in all cases. The severity of keratoconus stage by Amsler-Krumeich criteria improved for the OD from an average 2.2 to 1. Mean UDVA showed marked improvement at one-year follow-up all values in decimal: from 0.21±0.18 pre-operative to 0.51±0.25 at 12 months, with small additional improvement through the 3 years to 0.51±0.16. CDVA respectively increased from 0.55±0.11 to 0.77±0.14 at 1 year, and to 0.79±0.16 at 3 years. Mean minimal corneal thickness decreased significantly from 466.74±34.25 µm to 396.17±45.17 µm (P<.01) as recorded the first year postoperatively and then slightly increased to 405.17±32.21 µm at the 3-year follow-up. Conclusions: We introduce herein initial clinical data with the use of novel, off-label therapeutic excimer laser surface ablation application: Designed to perform both epithelial removal and anterior corneal stroma reshaping, to be combined with CXL, in order to apply the Athens Protocol CXL with US excimer laser approved specifications.

Preprint REVIEW | doi:10.20944/preprints202406.0329.v1

Are Viruses Taxonomic Units? – A Protein Domain and Loop-Centric Phylogenomic Assessment

Gustavo Caetano-Anollés

Subject: Biology And Life Sciences, Virology Keywords: holobionts; hologenomes; LUCA; origin of viruses; phylogenomic reconstruction; process; protein structure; reductive evolution; superkingdom; syncytins

Online: 6 June 2024 (07:52:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1624.v1

Analysis of User Experience data and Methodology of application to improve the development of User Interface

Ellada Ismailova, Andrei Ermakov

Subject: Computer Science And Mathematics, Other Keywords: user experience, user interface, data analysis

Online: 24 May 2024 (09:56:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1017.v2

Review of Nature-Based Echo-Hydraulic Aqua-Forest Technology for Coastal Resilience and Sea Level Rise Climate-Induced Adaptation

Olanrewaju Oladokun, Unberto Lazzaro

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Nature-based solution; seaweed; seagrass; platform; coastal protection

Online: 16 April 2024 (10:46:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1457.v1

Systemic Financial Risk Forecasting: A Novel Approach with IGSA-RBFNN

Yishuai Tian, Yifan Wu

Subject: Business, Economics And Management, Business And Management Keywords: Financial stress index; Risk prediction; AHM; CRITIC; IGSA-RBFNN

Online: 25 March 2024 (13:10:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1177.v1

A New Approach to Achieving Implant Stability with Flexible Synthetic Polymer Bone Graft: An In Vitro Study

Zeynep Dilan Orhan, Levent Ciğerim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: bone model; dental implant; implant stability; bone graft; flexible bone graft

Online: 20 March 2024 (13:01:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1043.v1

Neural Information Organizing and Processing – Neural Machines

Iosif Iulian Petrila

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: neural information; neural machines; neural networks; sensors and actuators; nervous systems; artificial intelligence

Online: 18 March 2024 (16:14:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0743.v1

PointNet++ Network with Contextual Feature and Mutual Learning for Point Sets

Xi Hu, Xiaolan Xie

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: point cloud; part segmentation; deep learning; self-attention; object classification

Online: 13 March 2024 (10:18:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0650.v1

Developmental, Physiologic and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles

Joseph Foon Yoong Hoh

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Craniofacial muscles; myosin heavy chain; gene expression; myogenesis; neural regulation; thyroid hormone; muscle plasticity; phylogeny

Online: 11 March 2024 (17:36:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0742.v2

On How to Measure the Subdivision Potential in Nanothermodynamics

Dick Bedeaux, Signe Kjelstrup

Subject: Physical Sciences, Thermodynamics Keywords: Nanothermodynamics; Subdivision potential; Porous media; Shape dependence; Scaling laws

Online: 6 March 2024 (04:15:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0788.v2

Creating An Array Of Parallel Vortical Optical Needles

Paulius Šlevas, Sergej Orlov

Subject: Physical Sciences, Optics And Photonics Keywords: diffraction; optical engineering; spatial light modulator; Bessel beam; optical vorte; optical needle; focal line; translation of Bessel beams

Online: 15 February 2024 (09:43:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2097.v1

Engineering a Computable Epiblast for in silico Modeling of Developmental Toxicity

Kaitlyn Barham, Richard Spencer, Nancy C. Baker, And Thomas B. B. Knudsen

Subject: Biology And Life Sciences, Toxicology Keywords: cellular dynamics; multicellular agent-based model; computer simulation; developmental toxicity.

Online: 29 September 2023 (12:02:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1178.v1

Land use change scenarios building combining agricultural development policies, landscape planning approaches and ecosystem services assessment. The Campania Region (Italy) case-study

Elena Cervelli, Pier Francesco Recchi, Ester Scotto di Perta, And Stefania Pindozzi

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Land-use change; Land-use planning; Ecosystem services; Erosion; Climate change; Agricultural policies; Soil tillage

Online: 18 July 2023 (07:40:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0395.v1

SynPred: Prediction of Drug Combination Effects in Cancer using Full-Agreement Synergy Metrics and Deep Learning

António J. Preto, Pedro Matos-Filipe, Joana Mourão, and Irina S. Moreira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Deep-Learning; Interpretability; Omics; Biophysics; Drug Synergy; Cancer

Online: 14 April 2021 (17:44:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0415.v1

Optical Sensing Approach to Recognition of Different Types of Particulate Matters for Sustainable Indoor Environment Management

Hosang Ahn, Jae Sik Kang, Gyeong-Seok Choi, and Hyun Jung Choi

Subject: Engineering, Architecture, Building And Construction Keywords: optical sensing; particulate matter; sustainable indoor environment; contaminant control

Online: 20 October 2020 (15:05:25 CEST)

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As climate changes, our daily life has been much influenced by abnormal meteorological phenomena such as heavy rainfall, heat wave, heavy snowfall, and fine dust. Atmospheric air quality is worsening day by day and indoor air quality is also affected by interconnected daily activities throughout the inside and outside of buildings and houses. Nowadays, pollutants from various sources are emitted, transformed by sunlight, vapor, and ozone and transported into the city from country to country. Due to these reasons, there have been high demands to monitor the transportation of particulate matters and improve air quality. Monitoring of pollutants and identification of type and its concentration enables us to track and control its generation and consequently find out the solution. However, monitoring of pollutants, especially, particulate matter generation and its transportation is still not fully operated in atmospheric air due to its open nature and meteorological factors. Even though indoor air is relatively easy to monitor and control than outdoor in the aspect of specific volume and contaminant source, but it still needs to consider the meteorological parameters because indoor air is not fully separated from the outdoor air flow and contaminants transportation. In this study, optical approach using spectral sensor was attempted to reveal the feasibility of wavelength and chromaticity values of reflected light from specific particles. From the analysis of reflected light of various particulate matters according to different liquid additives, parameter studies were performed to investigate which experimental conditions can contribute to the enhanced selective sensing of particulate matters. Five different particulate matters such as household dust, soil, talc powder, gypsum powder and yellow pine tree pollen were utilized and observed to elucidate the relationship between property of particulate matter and detected light spectrum. Applicable approaches to assist current particle matter sensors and improve the selective sensing were suggested.

Preprint ARTICLE | doi:10.20944/preprints202008.0271.v1

Soil Loss and Sediment Export from Land Use of the George Town Conurbation Catchment

Zullyadini A. Rahaman, Mohamad Adam Omar, Narimah Samat, and Mohd Amirul Mahamud

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: geographic information system; land demand; land use; universal soil loss erosion

Online: 12 August 2020 (05:09:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0008.v1

Spectral and Polarization Signatures of Relativistic Shocks in Blazars

Markus Boettcher

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: active galaxies; blazars; jets; polarization; shock acceleration

Online: 8 July 2016 (03:03:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.2590.v1

Oceanic Breakthroughs: Marine-Derived Innovations in Vaccination, Therapy and Immune Health

Chiara Gamberi, Chad Leverette, Alexis C Davis, Moayad Ismail, Ilaria Piccialli, Nicola Borbone, Giorgia Oliviero, Caterina Vicidomini, Rosanna Palumbo, Giovanni N Roviello

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: marine microalgae; recombinant vaccines; Nannochloropsis spp.; Dunaliella salina; immunomodulatory agents; vaccine adjuvants

Online: 1 November 2024 (03:43:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.2044.v1

Vitamin D Levels on Glycemic Control, Lipid Profile, and Apolipoprotein in Children and Adolescents with Type 1 Diabetes Mellitus

Luis Felipe Pimenta, Eduardo Federighi Baisi Chagas, Jesselina Francisco dos Santos Haber, Thais Menegucci, Karina Quesada, Pedro Zutin, Tereza Lais Menegucci Zutin, Adriano Cressoni Araújo, Cláudia Rucco Penteado Detregiachi, Elizandra Lopes, Lucas Fornari Laurindo, Sandra M. Barbalho, Elen Landgraf Guiguer

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 1 Diabetes Mellitus; Vitamin D; Lipid Profile; Apolipoprotein; Children; Adolescents

Online: 25 October 2024 (13:31:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1834.v1

Salivary Nitrate Level and Lipid Profile in Patients with Hypertension: A Cross-Sectional Study in Saudi Sub-Population

Khalil Ibrahim Assiri, Ali Mosfer A. Alqahtani, Abdullah Alqarni, Hassan Ahmed Assiri, Saeed Alassiri, Samiunnisa Begum Shaik, Ali Azhar Dawasaz, Mohammad Shahul Hameed

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Hypertension; triglycerides; nitric oxide; saliva; HDL Lipoproteins; LDL Lipoproteins

Online: 23 October 2024 (13:32:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1337.v1

Higher Blood Neuropeptide Y Concentration Is Associated with Better Prognosis After Surgery for Colorectal Cancer

Jacek Budzyński, Damian Czarnecki, Marcin Ziółkowski, Beata Szukay, Natalia Mysiak, Agata Staniewska, Małgorzata Michalska, Ewa Żekanowska, Krzysztof Tojek

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: neuropeptide Y; colorectal cancer; surgery; nutritional status; nutritional risk; prognosis

Online: 17 October 2024 (03:28:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1097.v1

Exploring the Link between Vitamin B Levels and Metabolic Syndrome Risk: Insights from a Case-Control Study in Kazakhstan

Alma Nurtazina, Ivan Voitsekhovskiy, Maxat Toishimanov, Daulet Dautov, Kairat Karibayev, Yerbol Smail, Saule Rakhyzhanova, Saltanat Adilgozhina, Bakyt Kanapiyanov, Nurgul Myrzabayeva, Magripa Bapayeva, Altay Dyussupov

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolic syndrome; serum levels of vitamins B; Kazakh population

Online: 14 October 2024 (15:38:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0824.v1

Bioactivity, Efficacy, and Safety of a Wound Healing Ointment with Medicinal Plant Bioactives: In Vitro and In Vivo Preclinical Evaluations

Juliana Floriano, Daniel Rodrigues, Rie Ohara, Nara Almeida, Vanessa Soares, Patricia Sartorelli, Carlos Graeff, Simone Grecco, Alejandra González, Paulo D'Alpino

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: chronic wounds; wound care; natural compounds; biocompatibility; pre-clinical tests

Online: 10 October 2024 (12:59:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1545.v1

Comprehensive Geophysical Exploration Technology for Sedimentary Exhalative Deposits: An Example from the Huaniushan Lead-Zinc-Silver Polymetallic Deposit in Gansu, China

Shunji Wang, Guanwen GU, Ye Wu, Xingguo Niu, Lin Zhu, Zhihe Xu, Haoyuan He, Yingjie Wang, Xinglong Lin, Lai Cao

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Sedimentary exhalative deposit; Huaniushan lead-zinc-silver polymetallic deposit; Gravity, magnetic and electric exploration; Three-dimensional inversion; Three-dimensional geological-geophysical model

Online: 19 September 2024 (14:53:35 CEST)

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The Huaniushan lead-zinc-silver deposit is a hydrothermal sedimentary exhalative deposit (SEDEX). The mining area has complex geological conditions. The main tectonic structure in the area is the Huaheitan-Shuangfengshan Fault (F3), which controls the distribution of strata and magmatic rocks. Since the discovery of the Huaniushan Lead-zinc-silver polymetallic deposit, there are diverse understandings of the deposit's genesis and mineralization law, making it challenging to meet the geological interpretation requirements of the Huaniushan Lead-zinc-silver polymetallic deposit. Moreover, a single geophysical exploration method utilizes limited rock physical parameters, making it difficult to effectively characterize underground structures. The integrated exploration of multiple geophysical methods can effectively integrate the geophysical characteristics of different rock physical parameters, reducing the multiplicity and uncertainty of geophysical data inverse interpretation. The comprehensive interpretation of three-dimensional inversion based on various geophysical data, the construction of geological-geophysical models based on geological grounds, the establishment of hidden ore exploration and positioning, and the rapid evaluation of geophysical technology systems are the current development trends in mineral exploration. In light of this, this paper conducts research on the three-dimensional inversion interpretation of the heavy magnetoelectric exploration data of the Huaniushan sedimentary exhalative deposit lead-zinc-silver polymetallic deposit in the mining area and constructs a three-dimensional geological-geophysical model of the study area based on the obtained three-dimensional physical structure of the underground three-dimensional density, magnetization intensity, resistivity, and polarizability structure of the study area, in combination with the information of related geology and drilling holes. It comprehensively interprets the favorable mineralization parts in the study area.

Preprint ARTICLE | doi:10.20944/preprints202409.0533.v1

Exploring the Dual Benefits of Fermented and Non-fermented Garlic on Growth, Antioxidative Capacity, Immune Responses, and Histology in Grey Mullet (Liza ramada)

Mohammed F. El Basuini, Mahasen M. E. A. Shaban, Abdelaziz M. El-Hais, Ali A. Soliman, Nermeen M. Abu-Elala, Islam I. Teiba, Mayada Alhoshy, Ghada R. Sallam, Ronick S. Shadrack, Kumbukani Mzengereza, Akram Ismael Shehata

Subject: Biology And Life Sciences, Aquatic Science Keywords: Allium sativum; Antioxidant status; Digestive enzymes; Feed additives; Fermented garlic; Growth performance; Liza ramada

Online: 6 September 2024 (11:11:47 CEST)

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This study investigated the effects of dietary garlic powder and fermented garlic powder supplementation at 1% and 2% levels on growth performance, digestive tract efficacy, blood biochemistry, immunity, and antioxidant status of Liza ramada (n=225 fish; 86.00±0.42 g) over a 60-day period. Fish fed diets supplemented with both forms of garlic at both levels exhibited significantly improved final body weight, weight gain, specific growth rate, and feed conversion ratio compared to the control group. Digestive enzyme activities (amylase, lipase, and protease) were significantly enhanced in all supplemented groups. Blood biochemical analysis revealed reduced glucose levels and increased total protein in garlic-supplemented groups, with no adverse effects on liver or kidney function markers. Immune parameters, including lysozyme activity, bactericidal activity against Streptococcus agalactiae, alternative complement pathway (ACP), and, respiratory burst (NBT) were significantly enhanced in garlic-supplemented groups, with fermented garlic showing more pronounced effects. Antioxidant enzyme activities (SOD, CAT, and GPx) were also significantly increased in all supplemented groups, particularly in those fed fermented garlic. No significant differences in survival rates were observed among treatments. The results suggest that both garlic powder and fermented garlic powder supplementation, especially at the 2% level, can effectively improve growth, feed utilization, immune function, and antioxidant status in L. ramada. Fermented garlic generally demonstrated superior effects, indicating its potential as a beneficial feed additive in aquaculture. Based on these findings, it is recommended to incorporate fermented garlic powder at a 2% level in L. ramada diets to optimize growth performance and health status. Further research is warranted to investigate the long-term effects and cost-effectiveness of this supplementation strategy in commercial aquaculture settings.

Preprint ARTICLE | doi:10.20944/preprints202408.1485.v1

Powders Synthesized from Calcium Carbonate and Water Solutions of Potassium Hydrosulfate of Various Concentrations

Tatiana V. Safronova, Peter D. Laptin, Alexandra I. Zybina, Xiaoling Liao, Tatiana B. Shatalova, Olga V. Boytsova, Dinara R. Khayrutdinova, Marat M. Akhmedov, Zichen Xu, Muslim R. Akhmedov

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: potassium hydrosulfate; calcium carbonate; heterophase synthesis; syngenite; gypsum; arcanite

Online: 22 August 2024 (03:10:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2582.v1

Investigation of Mutations in the crt-o and mdr1 Genes of Plasmodium vivax for the Molecular Surveillance of Chloroquine Resistance in Parasites from Gold Mining Areas in Roraima, Brazil

Jacqueline de Aguiar-Barros, Fabiana Granja, Rebecca de Abreu-Fernandes, Lucas Tavares de Queiroz, Daniel da Silva e Silva, Arthur Camurça Citó, Natália Ketrin Almeida-de-Oliveira Mocelin, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Amazon; malaria; chloroquine; pvcrt-o; pvmdr1; mining

Online: 2 August 2024 (11:45:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1524.v1

Global Dynamics of Environmental Kuznets Curve: A Cross-Correlation Analysis of Income and CO2 Emissions

Dora Almeida, Luísa Carvalho, Paulo Ferreira, Andreia Dionísio, Inzamam Ul Haq

Subject: Business, Economics And Management, Economics Keywords: Environmental Kuznets curve; CO2 emissions; Economic growth; Cross-correlation analysis; Income levels; Sustainable development

Online: 19 July 2024 (06:35:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1472.v1

Association between the intake/type of cheese and cognitive function in community-dwelling older women in Japan: A cross-sectional study

Takao Suzuki, Yosuke Osuka, Narumi Kojima, Hiroyuki Sasai, Kentaro Nakamura, Chisato Oba, Mayuki Sasaki, and Hunkyung Kim

Subject: Biology And Life Sciences, Aging Keywords: Cheese intake; Camembert cheese; MMSE score; Mild cognitive decline; Community-dwelling older women

Online: 18 July 2024 (08:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0432.v1

Interleukin-4 (IL-4), Plasminogen Activator Inhibitor-1 (PAI-1) or Receptor for Advanced Glycation End-Products (RAGE) in Bronchial Secretions Cannot Predict Pediatric Ventilator-Associated Pneumonia (VAP)

Argyro Ftergioti, Maria Simitsopoulou, Maria Sdougka, Styliani-Antonia Kallou, Anna-Bettina Haidich, Christina Virgiliou, Georgios Theodoridis, Emmanuel Roilides, Elias Iosifidis

Subject: Medicine And Pharmacology, Internal Medicine Keywords: ventilator-associated pneumonia; biomarkers; pediatric intensive care unit; critically-ill children; ventilator-associated pneumonia; biomarkers; pediatric intensive care unit; critically-ill children

Online: 4 July 2024 (11:00:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0230.v1

Definition of a Multi-omics Signature for Esophageal Adenocarcinoma Prognosis Prediction

Luca Lambroia, Carola Conca Dioguardi, Simone Puccio, Andrea Pansa, Giorgia Alvisi, Gianluca Basso, Javier Cibella, Federico S. Colombo, Salvatore Marano, Silvia Basato, Rita Alfieri, Simone Giudici, Carlo Castoro, Clelia Peano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Esophageal-Adenocarcinoma; Cancer; immunotherapy; treatment; single-cell RNA; single-cell sequencing; RNA sequencing; transcriptional signature; response to therapy; immune infiltrate.

Online: 3 July 2024 (00:25:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0190.v1

Senescence in Adipose-Derived Stem Cells: Biological Mechanisms and Therapeutic Challenges

Riccardo Foti, Gabriele Storti, Marco Palmesano, Maria Giovanna Scioli, Elena Fiorelli, Sonia Terriaca, Giulio Cervelli, Bong Sung Kim, Augusto Orlandi, Valerio Cervelli

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: adipose-derived stem cells; mesenchymal stem cells; ageing; senescence; stem cell therapy; senescence; diabetes; senolytic drugs

Online: 2 July 2024 (10:24:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1553.v1

CO2-Breathing Prior to Simulated Diving Increases Decompression Sickness Risk in a Mouse Model: The Microbiota Trail Is Not Forgotten

Lucille Daubresse, Aurélie Portas, Alexandrine Bertaud, Marion Marlinge, Sandrine Gaillard, Jean-Jacques Risso, Céline Ramdani, Jean-Claude Rostain, Nabil Adjiriou, Anne-Virginie Desruelle, Jean-Eric Blatteau, Régis Guieu, Nicolas Vallée

Subject: Biology And Life Sciences, Other Keywords: Bubble formation; Dysbiosis; Auto-immune; Auto-inflammation; Akkermansia; Rhizobium; Gut-Brain axis; Hypercapnia

Online: 21 June 2024 (16:40:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0185.v1

Structural Outcomes of Corneal Cross-Linking for Keratoconus

Yauhen Statsenko, Darya Smetanina, Roman Voitetskii, Gillian Lylian Simiyu, Mikalai Pazniak, Elena Likhorad, Aleh Pazniak, Pavel Beliakouski, Dmitriy Abelskyi, Klaus N.-V. Gorkom, Milos Ljubisavljevic

Subject: Medicine And Pharmacology, Ophthalmology Keywords: keratoconus; corneal collagen cross-linking; CXL outcomes; machine learning models; predictive models; keratometry readings; corneal thickness; corneal thinning; individualized approach; precision medicine

Online: 5 June 2024 (05:54:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1776.v1

Oceanographic Research in Thermaikos Gulf: A Review over Five Decades

Yannis Androulidakis, Christos Makris, Katerina Kombiadou, Yannis N. Krestenitis, Natassa Stefanidou, Chryssanthi Antoniadou, Evangelia Krasakopoulou, Maria-Ignatia Kalatzi, Vasilis Baltikas, Maria Moustaka-Gouni, Chariton Charles Chintiroglou

Subject: Environmental And Earth Sciences, Oceanography Keywords: Aegean Sea; Mediterranean; physical processes; marine pollution; sediment transport; biological processes; monitoring

Online: 28 March 2024 (14:28:03 CET)

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Thermaikos Gulf (TG) is a semi-enclosed, river-influenced, marine system situated in the eastern Mediterranean Sea, sustaining both urban coastal regions and ecologically preserved natural areas. Facing a plethora of environmental and anthropogenic pressures, the TG serves as a critical nexus where human activities intersect with marine ecosystems. The second largest city of Greece, Thessaloniki, is located in the northern part of the gulf, while a large environmentally protected zone with multiple river deltas is lying along its western coasts. The quality and health of the TG’s marine environment are tightly linked to the socioeconomic activities of the coastal communities comprising approximately 1.5 million inhabitants. The main features of TG’s environmental dynamics and ecological status have been scrutinized by dedicated research endeavours during the last 50 years. This review synthesizes the seminal findings of these investigations, offering an evaluation of their contribution to research, their present collective impact, and their trajectory toward the future. A severe deterioration of the TG’s environmental quality was detected in the 1970s and 1980s when treatment of urban wastewater was completely absent. A steady trend of recovery was observed after the 1990s, however without achieving, so far, the goal of a “good environmental state”, mandated by national legislation and European directives. The most important research gaps and uncertainties are also discussed and specific recommendations for the improvement of monitoring and understanding about the physical, biochemical, and ecological state of the gulf are provided. The most significant discrepancy is related to the fragmentary monitoring of the TG in both space (partial coverage) and time (temporal gaps), which has been intensified after 2010 due to the reduced funding for environmental research and protection under the severe Greek economic recession. This review aspires to highlight the importance of bolstering monitoring initiatives that can provide continuous observations and further understanding on the TG's ecological and physicochemical conditions. Targeted recommendations, aimed at ameliorating the fragmented monitoring processes, are also provided, advocating for a holistic approach that can safeguard the ecological integrity of the Thermaikos Gulf and uphold its role as a crucial link to marine biodiversity and sustainability in the Mediterranean basin.

Preprint ARTICLE | doi:10.20944/preprints202403.0958.v1

Comparison of the HBSC Results of the Visegrad Countries with the Health Behavior of Young People with Disabilities Living in Hungary: A Cross-Sectional Study

Agota Barabas, Attila Csaba Nagy, Viktoria Pazmany, Anita Katalin Grestyak Molnarne, Nemeth Agnes, György Jona, Agnes Santha, Peter Takacs, Emil Toldy, Renata Javorne Erdei

Subject: Public Health And Healthcare, Other Keywords: health; health behavior; disability; Visegrad Group

Online: 18 March 2024 (09:10:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0669.v1

Assessment of Postbiotic, Mundticin-like Substance EM 41/3 Application in Broiler Rabbits

Andrea Lauková, Ľubica Chrastinová, Valentína Focková, Iveta Plachá, Eva Bino, Ľubomira Grešáková, Zuzana Formelová, Rudolf Žitňan, Grzegorz Belzecki, Renata Miltko, Monika Pogány Simonová

Subject: Biology And Life Sciences, Life Sciences Keywords: bacteriocin; broiler rabbits; postbiotic effect; health status

Online: 12 March 2024 (13:44:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0477.v1

Body Awareness as a Protective Factor against Suicidal Orientations in College Students

Olga Lucía Montoya-Hurtado, Renato Sobral Monteiro-Junior, Cyndi Yacira Meneses-Castaño, Consuelo Sancho Sanchez, Antonio Martínez-Sabater, Maria Pilar Andrés-Olivera, Pilar Sánchez-Conde, Jesús Pérez, José Maria Criado-Gutierrez, Laura Criado-Pérez, Juan Luis Sanchez-González, Raúl Juárez-Vela

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: body awareness; interoception; suicide prevention; attempted suicide

Online: 8 March 2024 (11:18:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1253.v1

Antiviral Effect of Antimicrobial Peptoids and a Murine Model of Respiratory Coronavirus Infection

Maxim Lebedev, Aaron Benjamin, Sathish Kumar, Natalia Molchanova, Jennifer S. Lin, Kent J. Koster, Julian L. Leibowitz, Annelise E. Barron, Jeffrey D. Cirillo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Peptoid; MHV; SARS-CoV-2; Antimicrobials

Online: 22 February 2024 (09:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0056.v1

The Impacts of Different Green Manure on Soil Microbial Communities and Crop Health

Hongwu Yang, Jiaojiao Niu, Jiemeng Tao, Yabing Gu, Chao Zhang, Siyuan She, Wu Chen, Hongqi Yang, Huaqun Yin

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: green manure; soil microbial communities; crop health; Illumina sequencing

Online: 18 September 2016 (08:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0040.v1

Prevalence, Characterization and Mycotoxin Production Ability of Fusarium species on Korean Adlay (Coix lacrymal-jobi L.) Seeds

Tae Jin An, Kyu Seop Shin, Narayan Chandra Paul, Young Guk Kim, Seon Woo Cha, Yu Seok Moon, Seung Hun Yu, Sang-Keun Oh

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: seeds; ELISA; Fusarium; morphological data analysis; mycotoxins; phylogenetic analysis S

Online: 4 August 2016 (10:12:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0068.v1

Multilayer Nanocarrier for Codelivery of Interferons: A Promising Strategy for Biocompatible and Long-Acting Antiviral Treatment

Thelvia I. Ramos, Carlos A. Villacis-Aguirre, Felipe Sandoval Sandoval, Sarah Martin-Solano, Viana Manrique-Suárez, Hortensia Rodríguez, Leandro Santiago-Padilla, Alexis Debut, Carolina Gómez-Gaete, Marbel Torres Arias, Raquel Montesino, Emilio Lamazares, Ignacio Cabezas, Florence Hugues, Natalie C. Parra, Claudia Altamirano, Oliberto Sánchez Ramos, Nelson Santiago-Vispo, Jorge R. Toledo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Nanoencapsulation; Interferons; Antiviral; Antiproliferative; Immunoregulation; Drug delivery system; Core-shell; Toxicity

Online: 1 October 2024 (15:35:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1326.v1

Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study

Natalya Starodubtseva, Vitaliy Chagovets, Alisa Tokareva, Madina Dumanovskaya, Evgenii N. Kukaev, Anastasia Novoselova, Vladimir Frankevich, Stanislav V. Pavlovich, Gennady Tikhonovich Sukhikh

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: lipid; endometriosis; dried blood spot; mass-spectrometry; diagnostic

Online: 21 May 2024 (17:22:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1172.v1

Chemical Composition, Antioxidant, and Cytotoxic Effects of Senna rugosa Leaf and Root Extracts on Human Leukemia Cell Lines

Cintia Miranda dos Santos, Debora da Silva Baldivia, David Tsuyoshi Hiramatsu de Castro, José Tarciso de Giffoni Carvalho, Alex Santos Oliveira, Paola dos Santos da Rocha, Jaqueline Ferreira Campos, Sikiru Olaitan Balogun, Caio Fernando Ramalho De Oliveira, Denise Brentan da Silva, Carlos Alexandre Carollo, Kely De Picoli Souza, Edson Lucas dos Santos

Subject: Biology And Life Sciences, Life Sciences Keywords: Natural Products; Anticancer Properties; Cancer; medicinal plants; Chemical profile

Online: 17 May 2024 (15:34:58 CEST)

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Senna rugosa is a species found in the Cerrado and used in folk medicine as a vermifuge and in the treatment of poisonous snakebites accidents. In this work, we identified the main secondary metabolites present in ethanolic extracts of the leaves (ELSR) and roots (ERSR) of S. rugosa and evaluated the potential cytoprotective effect against cellular macromolecular damage, as well as the cytotoxic properties of the extracts on the K562 and Jurkat leukemic cell lines. The identification of metabolites was done by liquid chromatography coupled with mass spectrometry. The antioxidant activities were investigated by direct ABTS•+ and DPPH• radical scavenging methods, protection against oxidative damage in proteins and DNA. The cytotoxic properties were investigated against healthy cells, isolated from human peripheral blood (PBMC) and leukemic cell lines. The leaf extract contains catechin, rutin, epigallocatechin derivatives, kaempferol glycosides, luteolin, and dimeric and trimeric procyanidins, while the root extract profile shows obtusichromoneside derivatives, 2-methoxystypandrone, stilbene derivatives, naphthopyranones, and flavanone derivatives. The extracts showed antioxidant activity, with IC50 of 4.86 ± 0.51 µg/mL and 8.33 ± 0.90 µg/mL in the ABTS assay for ELSR and ERSR, respectively. And in the DPPH• assay, the IC50 was 19.98 ± 1.96 µg/mL for ELSR and 13.37 ± 1.05 µg/mL for ERSR. The extracts protected macromolecules against oxidative damage at concentrations of 5 µg/mL. The cytotoxicity test against leukemic strains was observed after 24 and 48 hours of treatment. After 48 h, results against the K562 cell line demonstrate IC50 of 242.54 ± 2.38 µg/mL and 223.00 ± 2.34 µg/mL for ELSR and ERSR , respectively. While against the Jurkat cell line, these extracts showed IC50 of 171.45 ± 2.25 µg/mL and 189.30 ± 2.27 µg/mL, respectively Results on PBMC viability, demonstrate that the extracts showed selectivity for the leukemic cell lines. Together, our results reveal that the leaves and roots of S. rugosa have completely distinct and complex chemical compositions. This study expands the repertoire of identified chemical compounds and underscores their significant pharmacological potential in conditions related to oxidative stress and leukemia.

Preprint ARTICLE | doi:10.20944/preprints201608.0205.v1

Nitrogen Removal in a Horizontal Subsurface Flow Constructed Wetland Estimated Using the First-Order Kinetic Model

Lijuan Cui, Wei Li, Yaqiong Zhang, Jiaming Wei, Yinru Lei, Manyin Zhang, Xu Pan, Xinsheng Zhao, Kai Li, Wu Ma

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: horizontal subsurface flow wetland; N removal; first-order kinetics; model

Online: 25 August 2016 (08:48:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.2577.v1

Smart City Ontology Framework for Urban Data Integration and Governance Applications

Xi Kuai, Xiaolong He, Biao He, Yu Liu, Zhigang Zhao, Renzhong Guo

Subject: Engineering, Civil Engineering Keywords: Smart city ontology framework; Urban Informatics Entities; urban governance; data integration

Online: 31 October 2024 (16:47:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.2316.v1

Numerical Analysis of Knudsen Number of Helium Flow Through Gas-Focused Liquid Sheet Micro-Nozzle

Krištof Kovačič, Saša Bajt, Božidar Šarler

Subject: Engineering, Mechanical Engineering Keywords: Knudsen number; compressible hypersonic flow; vacuum; liquid sheet nozzle; sample delivery system; CFD

Online: 29 October 2024 (13:07:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.2072.v1

Curcumin and Piperine Nanoparticles inhibit CYP17A1 activity to Regulate Steroid Biosynthesis in Prostate Cancer

Jibira Yakubu, evangelos natsaridis, Therina du Toit, Isabel Sousa Barata, Oya Tagit, Amit Pandey

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Steroidogenesis; CYP17A1; Prostate Cancer; Curcumin Nanoparticles; Androgen Synthesis; Nanoparticle Formulations

Online: 28 October 2024 (13:27:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.2082.v1

Monkeypox Virus and Vaccinia Vaccines: Genomic and Antigenic Differences Relevant to Outbreaks and Vaccinology

Jane Shen-Gunther, Hong Cai, Yufeng Wang

Subject: Biology And Life Sciences, Virology Keywords: bioinformatics; disease outbreaks; monkeypox; monkeypox virus; phylogeny; poxvirus; taxonomic classification; vaccinia virus; virus database

Online: 28 October 2024 (11:09:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1762.v1

Thermal Analysis of Radiation Heat Transfer of an Improved Fractal Solar Collectors

Adylkhan Talgatovich Kibishov, Gülenay Alevay Kılıç, Nassim Tulegenovich Rustamov, Naci Genc

Subject: Engineering, Mechanical Engineering Keywords: solar energy; fractal solar collector; thermal analysis; heat transfer; renewable energy

Online: 24 October 2024 (14:16:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.1567.v1

Environmental Stress and Small Heat Shock Proteins in Selected Animals: A Comprehensive Review of Literature

Jamada Bwambale, Justus Aisu, Muziri Mugwanya

Subject: Biology And Life Sciences, Life Sciences Keywords: Abiotic stress; Biotic stress; Cell damage; Apoptosis; Oxidative stress; Resistance; Insects; Nematodes; Aquatic animals

Online: 21 October 2024 (12:01:56 CEST)

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