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Preprint ARTICLE | doi:10.20944/preprints202406.1352.v1

Strategies for Carbon Neutrality: Innovations in Construction Material Production and Usage

Adrian Ioana, Diana Cristina Labes (Craciun), Nicolae Constantin, Augustin Semenescu, Roxana Marina Solea (Iordachescu), Dumitru Viorel Deonise, Alexandra Istrate

Subject: Engineering, Civil Engineering Keywords: construction; materials; carbon; emission; strategy.

Online: 19 June 2024 (12:51:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0001.v1

High-throughput Analysis of Department-Specific Dynamic Patterns of Bacterial Communities and Antibiotic Resistance in the Hospital Indoor Environments

Qing Yang, Miao Zhang, Yuhong Sun, Bixi Zhao, Zhanwen Cheng, Liming Chen, Zhenfeng Zhong, Yuhui Ye, Yu Xia

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: antibiotic resistance; antibiotic resistance genes; hospital indoor environment; microbial communities; high-throughput qPCR; department-specific; tap water; p-trap water; air dust; mobile gene elements

Online: 1 March 2024 (00:21:18 CET)

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The hospital indoor environment plays a significant role in shaping the microbial exposures that humans encounter. Resistance to antibiotics is one of the mechanisms employed by bacteria to develop resilience against stress in indoor environments. The extensive usage of antibiotics has been a key factor in driving changes in the ecological function of antibiotic resistance genes (ARGs) and their acquisition by pathogenic bacteria. By integrating the 16S rRNA Illumina sequencing and high throughput-qPCR approaches with water and air dust samples across seven departments at Peking University Shenzhen Hospital, China, this study yielded intriguing findings regarding the department-specific variation, transmission, and correlation of bacteria, ARGs and MGEs within the hospital indoor environment. One notable observation was that the seasonal variation played a vital role in shaping the bacterial composition in the overall hospital indoor environment across seven studied departments. Nevertheless, a similar significant seasonal impact was only observed in the blood test room and emergency departments, rather than in the other five departments. Another intriguing finding was the correlation between ARGs and MGEs abundance. This correlation was evident in the overall hospital indoor environment, which was conversely not found in the emergency, pneumology and gynecology departments. Additionally, while there was no significant relationship that occurred between bacterial communities and ARGs/MGEs within the hospital, the gynecology department demonstrated a close link between bacterial communities and the presence of ARGs/MGEs. Notably, the gynecology department also stood out as an important source of bacteria and ARGs/MGEs for other departments. This study underscores the need for careful surveillance and monitoring of antibiotic resistance, particularly in Legionella spp. in man-made water systems. The findings also show the importance of monitoring and understanding the genetic elements such as Tp614 involved in gene transfer and recombination, as well as their impact on antimicrobial treatment efficacy.

Preprint REVIEW | doi:10.20944/preprints202408.0585.v1

Grover Disease Association with Cutaneous Keratinocyte Cancers: More than a Coincidence?

Roxana Nedelcu, Alexandra Dobre, Gabriela Turcu, Razvan Andrei, Elena Balasescu, Florentina Pantelimon, Mihaela David-Niculescu, Adina Dobritoiu, Raluca Radu, Georgiana Zaharia, Ionela Hulea, Alice Brinzea, Lorena Manea, Mihaela Gherghiceanu, Daniela Ion

Subject: Medicine And Pharmacology, Dermatology Keywords: cutaneous keratinocyte cancers; non-melanoma; basal cell carcinomas; cutaneous squamous cell carcinomas; Grover disease; transient acantholytic dermatosis

Online: 8 August 2024 (12:07:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0364.v1

Papillary Thyroid Cancer Remodels the Genomic Fabrics of DNA Replication, Repair and Transcription

Dumitru A Iacobas, Sanda Iacobas

Subject: Biology And Life Sciences, Life Sciences Keywords: 8505C cells; BCPAP cells; ERCC#; evading apoptosis; PCNA; POLD4; POLR2L; TAF7; UBXN1

Online: 4 April 2024 (09:50:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0284.v1

Continuous Time Simulation and System Level Control Model of a Modern MVDC Distribution Grid including SST and MMC Based AFE

Daniel Siemaszko, Mauro Carpita

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC distribution systems; Power systems simulation; Power distribution control; Power system planning,; Pulse Width Modulation; Modular Multilevel Converter (MMC); Solid State Transformer

Online: 3 April 2024 (10:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1462.v1

Efficiency Improvement on Indium Tin Oxide Films for Dye-sensitized Solar Cell using Oxygen Plasma by Bias-magnetron RF Sputtering Process

Wittawat Poonthong, Narong Mungkung, Tanes Tanitteerapan, Threerapong Maneepen, Apidat Songruk, Khanchai Tunlasakun, Anumut Siricharoenpanich, Somchai Arunrungrusmi, Nat Kasayapanand

Subject: Chemistry And Materials Science, Nanotechnology Keywords: ITO-nanorod; oxygen plasma; RF sputtering; DC-self bias; DSSCs

Online: 20 August 2024 (11:59:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0303.v1

A Methodology Based on Lidar, Time-Of-Flight Camera and Odometry for a Real-Time 3D Model Generation

Carlos M Mesa-Cantillo, Itziar Alonso-González, David Sánchez-Rodríguez, Miguel A Quintana-Suárez, Kilian D García-Mederos

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: time-of-flight; LiDAR; indoor mapping; ROS; SLAM

Online: 5 June 2023 (10:17:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0453.v1

Detection of Novel Biomarkers in Saliva of Rheumatoid Arthritis Model Mice by Proteomics and Pathological Analysis

Wakako Sakaguchi, Juri Saruta, Shinya Fuchida, Yuko Yamamoto, Masahiro To, Tomoko Shimizu, Mayumi Yakeishi, Keiichi Tsukinoki

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: anti-citrullinated protein antibody (ACPA); alpha-1-antitrypsin (A1AT); DBA/1JJmsSlc mice Proteome analysis; rheumatoid arthritis (RA)

Online: 28 December 2021 (14:44:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0798.v1

A General Framework for Visualizing Machine Learning Models

Ziqian Bi, Raymond Gao, Shiaofen Fang

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine learning; multi-dimensional data visualization; classification; morphing; scattered data interpolation

Online: 14 February 2024 (10:56:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2035.v1

The Effect of an Interval Training Program on Aerobic and Anaerobic Indices of Adolescent Soccer Players

Angelos E. Kyranoudis, Athanasios Beglis, Yiannis Michailidis, Efstratios Kyranoudis, Lazaros Vardakis, Thomas Metaxas

Subject: Biology And Life Sciences, Life Sciences Keywords: High-Intensity Interval Training; Vo2max; Repeated Sprint Ability; Youth Soccer

Online: 26 September 2024 (09:34:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0004.v1

Removal of organic pollutants by subcritical water under moderate conditions

Jaroslava Svarc Gajic, Tanja Brezo-Borjan, Sandra Jaksic, Vesna Despotovic, Nina Fincur, Szabolcs Bognár, Dusica Jovanovic, Daniela Sojic Merkulov

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: water pollutants; remediation; subcritical water decomposition; pesticides; pharmaceuticals; mycotoxins

Online: 3 June 2024 (11:48:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0051.v1

Environmental Aspects and Recycling of Solid-State Batteries: A Comprehensive Review

Abniel Machín, María Cotto, Francisco Díaz, José Ducongé, Carmen Morant, Francisco Márquez

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Solid-state batteries; Sustainability; Recycling; Waste management; Green technology

Online: 4 June 2024 (02:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1293.v1

Microbiological Diagnosis – an Important Tool for Prevention and Management of Peri-Implant Infective Diseases

Adrian Țandără, Cristian Funieru, Oana Slușanschi, Cristina Preoteasa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: peri-implant infective diseases; microbiota; antibiogram

Online: 18 September 2024 (04:51:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2487.v1

Mechanical Behaviour of Breast Tissue: An In-Depth Systematic Review

Letlhogonolo Semakane, Turup Pandurangan Mohan, Harry Ngwangwa, Thanyani Pandelani, Fulufhelo Nemavhola

Subject: Engineering, Bioengineering Keywords: Mechanical properties; Mechanical characterisation; breast tissues; soft tissue

Online: 31 July 2024 (07:04:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1957.v2

BRAF Mutations: Oncogenic Drivers in Solid Tumors

Paola Roa, Nicole Virginia Bremer, Valentina Foglizzo, Emiliano Cocco

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: BRAF; solid tumors; NGS; targeted therapy; therapy resistance

Online: 12 February 2024 (11:02:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0986.v1

Experimental and Numerical Analysis of the Assembling Stresses in Parabolic Leaf Springs for Railway Freight Wagons

Vítor M. G. Gomes, Miguel A.V. de Figueiredo, José A. F. O. Correia, Abílio M. P. de Jesus

Subject: Engineering, Mechanical Engineering Keywords: railway; freight wagon; parabolic leaf springs; assembling stresses; finite element analysis.

Online: 18 March 2024 (10:16:23 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0011.v1

The Short and Long-term Effects of Pregnancy on Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Pamela McCombe

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; pregnancy; epigenetics; experimental autoimmune encephalomyelitis

Online: 1 October 2018 (14:00:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1629.v1

Research on Stator Sections Switching Process of High thrust Linear Motors

Xing Liu, Jie Li, Lianchun Wang, Minghe Qu, Danfeng Zhou, Qiang Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: High thrust linear motor; Sectionalized stator; Section switch; Anti-parallel thyristor; Current zero-crossing switching

Online: 20 September 2024 (16:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1171.v1

The Regenerate Study: A Non-randomised Feasibility Study of an Intervention to Reduce Anticholinergic Burden in Older Patients

Athagran Nakham, Christine Bond, Moira Cruickshank, Rumana Newlands, Phyo Kyaw Myint

Subject: Public Health And Healthcare, Other Keywords: Anticholinergic burden; Deprescribing; Feasibility study

Online: 17 September 2024 (05:05:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0705.v2

CrackScopeNet: A Lightweight Neural Network for Rapid Cracks Detection on Resource-Constrained Drone Platforms

Tao Zhang, Liwei Qin, Quan Zou, Liwen Zhang, Rongyi Wang, Heng Zhang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Computer vision; Crack detection; Drone platforms; Semantic segmentation; Lightweight neural network

Online: 10 July 2024 (10:52:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0405.v2

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+-Influx

Johannes Brockhaus, Iris Kahl, Mohiuddin Ahmad, Daniele Repetto, Carsten Reissner, Markus Missler

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Neurexin; Calcium Channel Subtypes; Presynapse; Endocannabinoid System; Genetically Encoded Calcium Indicator

Online: 27 May 2024 (10:06:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0587.v1

Efficacy of Commercial Biocontrol Products for Management of Verticillium and Fusarium Wilt in Greenhouse Tomatoes: Impact on Disease Severity, Fruit Yield, and Quality

Maria-Dimitra Tsolakidou, Georgia Demetriou, Sotiria Panagiotou, Loukia Vassiliou, Vlasios Goulas, Iakovos Pantelides

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Tomato; Verticillium dahliae, Fusarium oxysporum f. sp. lycopersici; Trichoderma sp.; Clonostachys sp.; Streptomyces sp.; Pseudomonas sp.

Online: 9 May 2024 (12:02:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0568.v1

Gender-Difference in Response to Treatment with Liraglutide 3.0 mg

Ilaria Milani, Gloria Guarisco, Marianna Chinucci, Chiara Gaita, Frida Leonetti, Danila Capoccia

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: ; Obesity; gender; GLP1-RAs; Liraglutide; weight loss ;

Online: 9 May 2024 (07:24:37 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1153.v1

Pancreaticoduodenectomy with Anatomical Vascular Variant in Groove Pancreatitis – a Case Report

Gelu Mihai Breaza, Radu Gheorghe Dan, Florin Emil Hut, Flavia Baderca, Octavian Marius Cretu, Laurentiu Vasile Sima

Subject: Medicine And Pharmacology, Surgery Keywords: Smoking, severe fibrosis; arterial abnormality; groove pancreatitits; pancreatoduodenectomy

Online: 19 March 2024 (12:36:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1006.v1

PlasmaBlade versus Electrocautery for DIEP Flap Harvesting in Autologous Breast Reconstruction: A Comparative Clinical Outcome Study.

Angela Augustin, Ines Schoberleitner, Sophie-Marie Unterhumer, Johanna Krapf, Thomas Bauer, Dolores Wolfram

Subject: Medicine And Pharmacology, Surgery Keywords: autologous breast reconstruction; clinical outcome; electrosurgery; flap harvesting; PEAK PlasmaBlade

Online: 18 March 2024 (10:24:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1753.v1

Si-Wu-Tang Promotes Cell Proliferation and Osteogenic Gene Expression during Osteoblastogenesis Yet Dampens the Formation of Osteoclast

Shuenn-Yun Wu, Yu-Hsu Chen, Ming‑Te Cheng, Yu-Pao Hsu, Ying-Chou Hsieh, Ching‑Hsiao Yu

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Si-Wu-Tang; bone formation; bone resorption; osteoblastogenesis; osteoclastogenesis

Online: 29 February 2024 (14:09:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0073.v1

Shape Evolution of Hierarchical W₁₈O₄₉ Nanostructures: A Systematic Investigation of the Growth Mechanism, Properties and Morphology-Dependent Photocatalytic Activities

Guojuan Hai, Jianfeng Huang, Liyun Cao, Yanni Jie, Jiayin Li, Xing Wang

Subject: Chemistry And Materials Science, Nanotechnology Keywords: W18O49; microstructure; phase transformation; photocatalytic activity

Online: 14 December 2016 (08:33:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0404.v1

Darknet Traffic Big-Data Analysis and Network Management to Real-Time Automating the Malicious Intent Detection Process by a Weight Agnostic Neural Networks Framework

Konstantinos Demertzis, Konstantinos Tsiknas, Dimitrios Takezis, Charalabos Skianis, Lazaros Iliadis

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Darknet; Traffic Analysis; Network Management; Malicious Intent Detection; Weight Agnostic Neural Networks; Real-Time Forensics; Shapley Value; Power Predicting Score

Online: 18 February 2021 (09:56:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0143.v1

Development of Potential Slip Surface Identification Model for Active Deep-seated Landslide Sites: A Case Study in Taiwan

Shih-Meng Hsu, Chun-Chia Hsiung, Yu-Jia Chiu, Yi-Fan Liao, Jie-Ru Lin

Subject: Engineering, Civil Engineering Keywords: disturbed rock formation; landslide slip surface; hydraulic conductivity; principle component analysis; geological indicators

Online: 3 September 2024 (11:35:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0554.v1

Analysis of Human Papillomavirus 51 (HPV51) Genetic Variations Detected in Women with Cervical Dysplasia

Chiara Giubbi, Chiara Villa, Maria Letizia Di Meo, Illari Sechi, Ruth Chinyere Njoku, Narcisa Muresu, Federica Perdoni, Andrea Fausto Piana, Roberto Pietri, Robert Fruscio, Fabio Landoni, Clementina Elvezia Cocuzza, Marianna Martinelli

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Human Papillomavirus; HPV51; HPV lineage; HPV variants; cervical dysplasia

Online: 5 July 2024 (20:39:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2283.v1

State of the Art Synthesis of Ag-ZnO-Based Nanomaterials by Novel Atmospheric Pressure Microplasma Techniques

Ayesha Khalid, M. Naeem, Omar Atrooz, M. R. Mozafari, Fatemeh Anari, Elham Taghavi, Umair Rashid, Bushra Aziz

Subject: Medicine And Pharmacology, Other Keywords: Atmospheric microplasma technique; core shall nanoparticles; antibacterial activity; antifungal activity; silver nanoparticles

Online: 29 July 2024 (09:59:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2269.v1

Long Short-Term Memory (LSTM) Networks for Automated Identification the Stationary Phase in Tribological Experiments

Yuxiao Zhao, Leyu Lin, Alois K. Schlarb

Subject: Mechanical Engineering, Engineering Keywords: Artificial Neural Network (ANN); Long-Short Term Memory (LSTM); Tribology; Polymer-based composites

Online: 29 September 2024 (11:04:07 CEST)

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Working Paper ARTICLE

Long-Term Follow-up for Patients with Early Esophageal Cancer Treated with Photodynamic Therapy (PDT)

Yu-Han Huang, Ke-Cheng Cheng, Pei-Wen Yang, Mong-Wei Lin, Pei-Ming Huang, Sunn-We Kuo, Jang-Ming Lee

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: photodynamic therapy for esophageal cancer

Online: 5 January 2020 (15:16:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1029.v1

Research on Multimodal Transport Electronic Documents Based on Blockchain

Xueqi Qian, Lixin Shen, Dong Yang, Zhiwen Zhang, Zhihong Jin

Subject: Business, Economics And Management, Other Keywords: multimodal transport; electronic documents; "one-bill coverage system" blockchain; smart contract

Online: 16 April 2024 (10:52:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1711.v1

APAR: A Structural Design and Guidance Framework for Gamification in Education

J. Carlos López-Ardao, Raúl F. Rodríguez-Rubio, Sergio Herrería-Alonso, Miguel Rodríguez Pérez, María-Estrella Sousa-Vieira

Subject: Social Sciences, Education Keywords: Gamification; Education; Motivation

Online: 28 March 2024 (08:40:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2092.v1

Utilization of Post-Process Osmotic Solution Based on Tomato Juice Through Spray Drying

Aleksandra Zimmer, Klaudia Masztalerz, Małgorzata Serowik, Mariusz Nejman, Krzysztof Lech

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Spray Drying; food by-products; Osmotic Solution; Maltodextrin; Inulin; Physical properties of powders

Online: 26 September 2024 (16:52:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2039.v1

Germline Variants in Proto-Oncogenes and Tumor Suppressor Genes in Women with Cervical Cancer

Ksenia Lenkova, Rita Khusainova, Raushaniya Minyazeva, Aliya Zaripova, Irina Gilyazova, Natalia Mokrysheva, Ildar Minniakhmetov

Subject: Biology And Life Sciences, Life Sciences Keywords: cancer; oncogenes; tumor suppressor genes; molecular genetic landscape

Online: 25 September 2024 (15:33:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1849.v1

Development and Enhancement of Autonomous Mobile Robots Using Reinforcement Learning: Improving Navigation and Obstacle Avoidance in Small-Scale Industrial Settings

Tharaga Sharmilan, Nadeesha Abeysekara

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: ; Automation; Dynamic Object Collision Avoidance; Reinforcement Learning; Robotics; 23 Small-Scale Manufacturing ;

Online: 26 August 2024 (17:06:03 CEST)

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The rapid development and integration of Autonomous Mobile Robots (AMRs) have 1 revolutionized industries by enhancing automation capabilities. A critical challenge in this evolution 2 is achieving effective navigation and obstacle avoidance, which are essential for deploying AMRs 3 seamlessly in varied environments. This paper presents a detailed exploration of AMR navigation 4 and obstacle avoidance advancements through the application of reinforcement learning, specifically 5 focusing on small-scale Sri Lankan manufacturing facilities. The study demonstrates the effectiveness 6 of Q-learning in managing dynamic obstacles within a factory environment. The AMR successfully 7 avoided obstacles in 36 out of 50 test runs, achieving a 72% success rate, and maintained an average 8 distance of 12 cm from each obstacle, underscoring the algorithm’s precision in maintaining safe nav- 9 igation paths while dynamically adapting to environmental changes. The continuous monitoring by 10 ultrasonic sensors, combined with iterative learning, enabled the robot to refine its decision-making 11 process and efficiently navigate through the environment. This paper also provides a comprehensive 12 examination of conventional methods, tracing their historical development and assessing their role in 13 addressing real-world challenges. The results highlight the significant improvements brought by rein- 14 forcement learning, particularly when integrated with sensor fusion and motor control technologies, 15 to enhance navigation and dynamic object collision avoidance. The study involves developing an 16 AMR prototype, refining algorithms, and assessing system performance in controlled environments. 17 By automating material transportation and addressing operational constraints in manufacturing 18 settings that predominantly rely on manual labor, this paper advances the practical deployment of 19 AMRs. Additionally, it discusses ethical considerations, potential limitations, and the importance 20 of real-world validation, offering valuable insights for the future development and integration of 21 autonomous mobile robotics in dynamic industrial environments.

Preprint ARTICLE | doi:10.20944/preprints202005.0001.v1

Using High-Content Screening Technology as a Tool to Generate Single-Cell Patient-Derived Gene-Corrected Isogenic iPS Clones for Parkinson’s Disease Research

Peter A. Barbuti, Paul M. Antony, Bruno F.R. Santos, François Massart, Gérald Cruciani, Claire M. Dording, Jonathan Arias, Jens C. Schwamborn, Rejko Krüger

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: CRISPR-Cas9; high-content screening (HCS); fluorescent-activated cell sorting (FACS); Parkinson's disease (PD); patient-derived iPS; single-cell clones; isogenic cell lines; SNCA; alpha-synuclein; A30P

Online: 2 May 2020 (11:20:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0356.v1

IL-6 Polymorphism as a Predisposing Genetic Factor for Gestational Diabetes or Preeclampsia Development in Pregnancy with Obesity: VEGF and VEGFF Receptor Related Gene Expression Modalities

Panagiotis Halvatsiotis, Theodora Tsokaki, Vassileios Tsitsis, Lina Palaiodimou, Georgios Tsivgoulis, Iraklis Tsangaris, Ourania Panagiotou, Dimitra Houhoula

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: pregnancy; obesity; gestational diabetes; preeclampsia; interleukin 6; VEGF; VEGF receptor; type 2 diabetes mellitus ;

Online: 7 May 2024 (10:19:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0012.v1

Flexible Techniques to Detect Typical Hidden Errors in Large Longitudinal Datasets

Renato Bruni, Cinzia Daraio, Simone Di Leo

Subject: Computer Science And Mathematics, Computer Science Keywords: big data; information processing; information reconstruction; data quality: longitudinal data sequences

Online: 1 March 2024 (10:33:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1712.v1

Using the Theoretical-experiential Binomial for Educating AI-Literate Students

Horia Alexandru Modran, Doru Ursuțiu, Cornel Samoilă

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial Intelligence (AI); AI Literacy; PSoC 6; Experiential learning; Sustainability.

Online: 29 February 2024 (09:37:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.1515.v1

Muscle Fatigue in Health and Disease

Payam Dibaj, Uwe Windhorst

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Muscle Fatigue; Peripheral and Central Fatigue; Neurological Diseases; Group III/IV Muscle Afferents

Online: 20 September 2024 (11:01:17 CEST)

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An untrained couch potato involuntarily forced to undergo a long strenuous exercise towards exhaustion will feel it at the end as a discomforting fatigue. A well-trained athlete will feel the same but after a longer time. Patients of various neurological diseases will do so much earlier. All may also finally experience muscle pain and soreness the next day.Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force. Muscle fatigability varies with muscle use, age and sex. It is commonly divided into two broad categories: peripheral and central fatigue. The first refers to the many processes in the fatiguing muscle(s), the second to subsequent processes in the central nervous system (CNS). Peripheral muscle fatigue can be caused by numerous different mechanisms, ranging from the accumulation of metabolites within muscle fibers to their damage. Central fatigue involves the inadequacy of the CNS to generate and maintain sufficiently strong motor command. There must of course be a mediator relating the two fatigue types, and this is the collection of small-diameter group III (Aδ) and IV (C) nerve fibers emanating from the muscle and distributing their activation effects throughout the CNS.Muscle fatigue develops during eventually exhausting exercise that goes along with activations of the cardio-vascular and respiratory system to supply oxygen and energy resources. While these functions are supported by a number of sensory afferents, fatigue-activated group III/IV muscle afferents have been proposed to contribute their share to cardio-vascular and ventilatory reflex responses that are mediated in the brainstem. Neural feedback from working skeletal muscle is a vital component in providing a high capacity for endurance exercise because muscle perfusion and O₂ delivery determine the fatigability of skeletal muscle (Amann 2012).The development of chronic muscle fatigue is related to muscle wasting mediated by aging, myopathies, muscle dystrophies, immobilization, insulin resistance, diseases associated with systemic inflammation (arthritis, sepsis, infections), trauma, cardio-vascular (heart failure) and respiratory disorders (chronic obstructive pulmonary disease (COPD)), chronic kidney failure, multiple sclerosis (MS), and, more recently, coronavirus disease 2019 (COVID-19).

Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0997.v1

Chemical Markers in Italian Propolis: Chrysin, Galangin and Cape as Indicators of Geographic Origin

Elisabetta Miraldi, Giorgio Cappellucci, Giulia Baini, Elia Silvia Pistone, Marika Allodi, Gabriele Costantino, Chiara Spaggiari, Marco Biagi

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Italian propolis; flavonoids; pinocembrin; chrysin; CAPE; geographical diversity

Online: 12 September 2024 (15:41:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1727.v3

On Bisphosphonates and COVID-19: In Silico Model Suggests Inhibition of SARS-CoV-2 RdRp as Potential Explanation

Muzaffar-Ur-Rehman Mohammed, Kishore Suryakant Chougule, Chandu Ala, Pranali Vijaykumar Kuthe, Mohit Garg, Murugesan Sankaranarayanan, Seshadri S Vasan

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Alendronate; COVID-19; Minodronate; MM-GBSA; Molecular docking; Molecular dynamics; RdRp; SARS-CoV-2; Virtual screening; Zoledronate

Online: 26 February 2024 (13:51:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1501.v1

A Full Calibration Approach on a Drone-Borne Platform for HF Antenna Measurements in Smart Grid Energy Facilities

Marius Pastorcici, Andreea Constantin, Adelaida Heiman, Razvan D. Tamas

Subject: Engineering, Electrical And Electronic Engineering Keywords: drone-borne; HF antennas; Internet of Things (IoT); folded dipole; Open Area Test Site (OATS); antenna measurements; near-field antenna measurements

Online: 24 June 2024 (05:16:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2070.v1

Finite Element Analysis of the Alternate Cyclic Forging Process for 6061-Т4 Aluminum Alloy Billets

Maxat Abishkenov, Zhassulan Ashkeyev, Kayrosh Nogaev, Ilgar Tavshanov, Nazira Aykenbayeva, Saltanat Kydyrbayeva

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: finite element analysis (FEA); alternate cyclic forging (ACF); metal flow; effective strain; effective stress; forging load

Online: 26 July 2024 (04:46:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1332.v1

Fault-Tolerant Optimal Consensus Control for Heterogeneous Multi-agent System

Yandong Li, Yongan Liu, Ling Zhu, Zehua Zhang

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: uncrewed aerial vehicle; uncrewed ground vehicle; heterogeneous multi-agent system; actuator failures; consensus; Lyapunov stability theory; optimal method

Online: 16 July 2024 (12:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1744.v1

Identification and Differential Expression Analysis of miRNAs in Lirianthe delavayi Reveals Lacks of miRNA Expression in Plant-Pathogen Interaction Pathway in the Cultivated Population

Tongxing Zhao, Jing Yang, Lang Yuan, Yuan Luo, Pinzheng Zhang, Tao Xu

Subject: Biology And Life Sciences, Horticulture Keywords: Lirianthe delavayi; microRNA; plant-pathogen interaction pathway; miRNA-loss

Online: 25 June 2024 (10:09:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0002.v1

The Microalgae Chlamydomonas for Bioremediation and Bioproduct Production

Carmen M Bellido-Pedraza, Maria J Torres, Angel Llamas

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Microalga; Chlamydomonas; bioremediation; wastewater; high-value-added products

Online: 3 June 2024 (08:35:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1983.v1

Polycyclic Aromatic Hydrocarbons (PAHs) in Freshwater Systems: A Comprehensive Review of Sources, Distribution, and Impacts

Pedro J. Berríos-Rolón, María Cotto, Francisco Márquez

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Polycyclic Aromatic Hydrocarbons; Water Pollution; Ecotoxicology; Environmental Distribution; Analytical Methods; Regulatory Frameworks.

Online: 30 April 2024 (11:22:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0968.v1

Peritoneum Adhesion Genetic Determinism

Mirela Lungu, Iuliana-Laura Candussi, Claudiu N Lungu, Mihaela C Mehedinti

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: peritoneum, adhesion , adhesion genes, peritonitis, reintervention.

Online: 15 April 2024 (13:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0169.v1

Visualising Daily PM10 Pollution in an Open-Cut Mining Valley of New South Wales, Australia - Part II: Classification of Synoptic Circulation Types and Local Meteorological Patterns and Their Relation to Elevated Air Pollution in Spring and Summer

Ningbo Jiang, Matthew Riley, Merched Azzi, Giovanni Di Virgilio, Hiep Nguyen Duc, Praveen Puppala

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: PM10 pollution; local meteorological pattern; synoptic circulation type; self-organising map (SOM); air pollution conduciveness; data clustering; data visualisation; open-cut mining valley

Online: 2 April 2024 (07:42:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1445.v1

A Review on Watershed Environment Study with Lake Sediment Records in China

Minqiao Li, Guoping Tang, Huasheng Huang

Subject: Environmental And Earth Sciences, Paleontology Keywords: literature review; lake sediments; lake ecosystems; paleoenvironment; paleoclimate; paleovegetation

Online: 25 March 2024 (08:14:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0232.v1

Characterization of Qu-aroma of Medium-High Temperature Daqu from Different Production Areas Using Sensory Evaluation, E-nose, and GC-MS/O Analysis

Jie Deng, Jia Zheng, Xing Li, Zhiguo Huang, Dan Huang, Guangbin Ye, Huibo Luo

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Medium-High Temperature Daqu; Qu-aroma; Volatile compounds

Online: 4 September 2024 (03:08:27 CEST)

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BACKGROUND: Qu-aroma is a critical quality indicator for medium-high temperature Daqu (MT-Daqu), significantly influencing the aroma profile of strong-aroma Baijiu (SAB). SAB is produced across various regions in China, each with unique environmental conditions and production techniques. These regional differences are likely to cause variations in the Qu-aroma of MT-Daqu. Despite this, comprehensive research on the variations in Qu-aroma across different regions has been lacking. This study aims to address this gap by utilizing Gas Chromatography-Olfactometry-Mass Spectrometry (GC-O-MS) and electronic nose (E-nose) technology, combined with sensory evaluation, to analyze the differences in Qu-aroma characteristics and volatile compound profiles of MT-Daqu from seven distinct production areas.RESULTS: Sensory analysis identified seven broad aroma categories and 25 specific aromas characterizing the Qu-aroma of MT-Daqu samples. Chen aroma and roasted aroma were notably more prevalent in MT-Daqu samples from Sichuan compared to those from other regions (P < 0.05), while the fermentation aroma was less prominent in Sichuan samples. In total, 123 volatile compounds were detected in MT-Daqu, with 46 classified as aroma-active compounds. Among these, 21 aroma-active compounds were identified as markers distinguishing Sichuan MT-Daqu from those produced in non-Sichuan regions, showing significant differences in their concentrations (P < 0.05). Additionally, six major aroma-active compounds-ethyl isovalerate, ethyl heptanoate, hexanal, 1-nonanal, (E)-2,4-decadienal, and 2,3-dimethyl-5-ethylpyrazine-were found to significantly contribute to the aroma differences between Sichuan and non-Sichuan MT-Daqu.CONCLUSION: This study delineates the distinct Qu-aroma characteristics of MT-Daqu from various SAB production areas and identifies the aroma-active compounds responsible for these differences. The insights gained from this research offer valuable guidance for optimizing flavor profiles in MT-Daqu production, potentially enhancing the overall quality and regional distinctiveness of the product.

Preprint ARTICLE | doi:10.20944/preprints202405.0257.v1

Effects of Fermented Navel Orange Pulp on Growth Perfor-mance, Carcass Characteristics, Meat Quality, Meat Nutrition, and Serum Biochemical Indicators of Finishing Tibetan Pigs

Chuanhui Xu, Pingwen Xiong, Wenjing Song, Qiongli Song, Yan Hu, Tongxing Song, Huayuan Ji, Xiaolian Chen, Zhiheng Zou

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fermented navel orange pulp; growth performance; carcass characteristics; meat quality; meat nutrition; serum biochemical indicators; finishing Tibetan pigs

Online: 6 May 2024 (08:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1467.v1

The Impact of Malnutrition on COPD Outcomes: Role of Mini-Nutritional Assessment (Mna) in Predicting Acute Exacerbations in Patients with Highly Complex COPD and Its Clinical and Prognostic Implications

Domenico Di Raimondo, Edoardo Pirera, Chiara Pintus, Riccardo De Rosa, Martina Profita, Gaia Musiari, Gherardo Siscaro, Antonino Tuttolomondo

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Malnutrition; Mini Nutritional Assessment (MNA); Chronic Obstructive Pulmonary Disease (COPD); acute exacerbation of COPD (AECOPD); Quality of Life; Frailty; Multimorbidity

Online: 21 June 2024 (02:48:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1699.v1

Risk–Return Anomalies: Evidence Based on the Co-Moment Augmented Fama–French Three-Factor Model in the Nigerian Stock Market

Abiodun Samue Ajayi, Ajibola Arewa, Joy Ejighomegba Omorojor, Adebanjo Joseph Falaye

Subject: Business, Economics And Management, Finance Keywords: long position; factor zoo; risk premium; test portfolios; patterns; hedged portfolios

Online: 24 September 2024 (04:05:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0418.v1

LCK Function and Modulation: Immune Cytotoxic Response and Tumor Treatment. More than a Simple Event.

Juan Bautista De Sanctis, Jenny Valentina GARMENDIA, Hana Duchová, Viktor Valentini, Alex Puskasu, Agata Kubíčková, Marián Hajdúch

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Src kinases, Lck, hematologic tumors, solid tumors, T-cell cytotoxicity, NK cytotoxicity, CAR-T cell, cell proliferation, cell adhesion.

Online: 4 July 2024 (13:31:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0110.v1

High-Speed Visual Analysis of Fluid Flow and Heat Transfer in Oscillating Heat Pipes with Different Diameters

Xiangdong Liu, Qing Sun, Chengbin Zhang, Liangyu Wu

Subject: Engineering, Energy And Fuel Technology Keywords: oscillating heat pipe; fluid flow motion; flow pattern; thermal performance; inner diameter

Online: 26 October 2016 (09:30:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0095.v1

Monkeypox: Significance of Various Clinical Samples, Clinical Manifestation, and Molecular Genetic Analysis – Experience of Bulgaria

Stefka Krumova, Radostina Stefanova, Petia Genova-Kalou, Daniel Ivanov, Maria Pishmisheva, Stanislav Kotsev, Iva Christova

Subject: Biology And Life Sciences, Virology Keywords: monkeypox virus; orthopoxviruses; real-time PCR

Online: 2 August 2024 (12:28:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1772.v1

Aloe Vera as a Printed Coating to Demote the Wear of Textiles

Michail Karypidis, Amalia Stalika, Maria Zarkogianni, Apostolos Korlos, Eleftherios G. Andriotis

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: aloe vera printing; aloe vera coating; fabric wear; green fashion

Online: 23 July 2024 (10:04:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0802.v1

Micro-Nanoparticle Characterization: Establishing Underpinnings for Proper Identification and Nanotechnology-Enabled Remediation

Wesley Allen Williams, Shyam Aravamudhan

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: Plastics; MPL; NPL; Characterization; Pretreatment; Spectroscopy; Microscopy; MPL Remediation; LBL

Online: 13 August 2024 (03:14:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0282.v1

Chalcogen-Bond-Assisted Formation of the N→C Dative Bonds in the Complexes between Chalcogenadiazoles/Chalcogenatriazoles and Fullerene C₆₀

Yu Zhang, Weizhou Wang

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: N→ C dative bond; chalcogen bond; chalcogenadiazole; fullerene C₆₀

Online: 6 May 2024 (09:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0069.v1

Vesicle Morphogenesis in Amphiphilic Triblock Copolymer Solutions

Senyuan Liu, Mohammad Sadegh Samie, Radhakrishna Sureshkumar

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: Triblock Copolymer; Micelle; Vesicle; Polymersome; Molecular Dynamics; Information Entropy; Nanomedicine; Biomimetic

Online: 2 April 2024 (02:33:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0598.v1

Cohen-Macaulayness of Vertex Splittable Monomial Ideals

Marilena Crupi, Antonino Ficarra

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Cohen-Macaulay ideals; vertex splittable ideals

Online: 9 February 2024 (14:56:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1168.v1

Exploring Polygonal Number Sieves through Computational Triangulation

Sergei Abramovich

Subject: Computer Science And Mathematics, Mathematics Keywords: computation; number theory; triangulation; polygonal numbers; spreadsheet; Wolfram Alpha; Maple

Online: 20 November 2023 (07:51:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0085.v3

Vertex Domination in Fuzzy Graphs

Mohammadesmail Nikfar

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: fuzzy graph; fuzzy bridge; fuzzy tree; $\alpha$-strong arc; vertex domination

Online: 5 May 2019 (12:20:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1237.v1

Functional and Sensory Properties of Infant Complementary Foods Formulated From Millets, Orange-Flesh Sweet Potatoes, Carrots, Periwinkle and Oyster.

Ngozi M Nnam, Catherine A Orisa, Ijioma Okorie

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Infant Complementary food; Functional properties; Sensory properties

Online: 16 July 2024 (03:49:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1393.v1

Tubal Cancer Clinical Management: Two Exceptional Scenarios and a Review of the Literature

Irene Colombi, Marco D’Indinosante, Lucia Lazzeri, Errico Zupi, Silvia Pisaneschi, Marco Giusti, Alberto Mattei, Elisa Valentina Debonis, Angelo Cassisa, Anna Franca Cavaliere, Federica Perelli

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: tubal cancer; ovarian cancer; tubal carcinoma; primary debulking surgery; serous tubal intraepithelial carcinoma; STIC; high-grade serous carcinoma

Online: 17 July 2024 (13:55:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1740.v1

Predicting Clinical Response to Monoclonal TNF Inhibitors in Rheumatoid Arthritis: A Transcriptomic Approach Based on Transmembrane TNF Reverse Signaling and NRF2 Activation

Katy Diallo, Yannick Degboé, Michel Baron, Anais Bellin-Robert, Jean Frédéric Boyer, Arnaud Constantin, Adeline Ruyssen-Witrand, Benjamin Rauwel, Alain Cantagrel, Jean-Luc DAVIGNON

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Rheumatoid Arthritis, Anti-TNF, NRF2, Reverse Signaling, Biotherapy, Monoclonal Antibodies, Monocytes, Prediction.

Online: 29 February 2024 (14:46:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0394.v1

Identification of Key Determinants Influencing the Spatiotemporal Heterogeneity of Urban Resilience

Jingwei Hou, Bo Hou, Gongpeng He

Subject: Environmental And Earth Sciences, Geography Keywords: key determinant; spatiotemporal heterogeneity; urban resilience; Theil index; Geodetector

Online: 5 September 2024 (08:20:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2263.v1

Comparative Study of Temperature and Pressure Variation Patterns in Hydrogen and Natural Gas Storage in Salt Cavern

Zhongzhong Liu, Yuxuan Liu, Zonghao Wang

Subject: Engineering, Energy And Fuel Technology Keywords: Underground hydrogen storage; Salt cavern; Flow and heat transfer model; Hydrogen and natural gas; Diversity

Online: 2 September 2024 (10:54:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1528.v1

Farm Monitoring System with Drones and Optical Camera Communication

Shinnosuke Kondo, Naoto Yoshimoto, Yu Nakayama

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Sensor network; Optical Camera Communication; Drone; LED; Point-to-Multipoint communication

Online: 21 August 2024 (08:43:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0048.v1

Retrospective Study of Maxillary Sinus Augmentation Using Demineralized Tooth Block Bone for Dental Implant

Hyunsuk Choi, Dong-Seok Sohn

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: sinus augmentation; tooth bone graft; dental implant

Online: 4 June 2024 (02:53:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1798.v1

Conventional Machining of Metal Matrix Composites towards Sustainable Manufacturing – Present Scenario and Future Prospects

Endalkachew Mosisa Gutema, Hirpa Gelgele Lemu

Subject: Engineering, Mechanical Engineering Keywords: Metal Matrix Composites; Conventional Machining; Sustainable manufacturing

Online: 28 May 2024 (09:41:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1464.v1

Design of a Novel Intraoperative Sensor for Load Balancing and Tracking during Total Knee Replacements

Samira Al-Nasser, Siamak Noroozi, Adrian Harvey

Subject: Engineering, Mechanical Engineering Keywords: joint force measuring; soft tissue balancing; intraoperative sensors; artificial intelligence; total knee replacement

Online: 23 April 2024 (13:14:11 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.0683.v1

Transnasal Brain Sampling for Human Rabies Confirmation

Moses Barima Djimatey, Abdul-Rahim Abubakar, Augustina Annan Sylverken, Theophlius Odoom, Braimah Baba Abubakari, John Akwasi Ohemeng, Gowri Yale, Frederic Lohr, Luke Gamble, Anita Mahadevan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: rabies; brain tissue; diagnosis; autopsy; transnasal

Online: 11 June 2024 (10:37:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0389.v1

Brain Ultrasonography in Critically Ill Septic Patients: A Scoping Review

Giada Cucciolini, Irene Corda, Francesco Forfori, Francesco Corradi

Subject: Medicine And Pharmacology, Other Keywords: Brain ultrasound; TCCS; transcranial doppler; sepsis; multimodal monitoring; POCUS

Online: 5 September 2024 (12:39:56 CEST)

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Introduction Sepsis-associated encephalopathy (SAE) is common in sepsis and is linked to high mortality and impaired neurologic outcome. Brain ultrasonography (US), including transcranial Doppler (TCD) and transcranial color-coded duplex sonography (TCCS), is a non-invasive tool for cerebral monitoring and might be useful in sepsis. The aims of this review are: 1) to explore whether brain perfusion is altered in sepsis, 2) to determine the role of brain US in guiding resuscitation, and 3) its ability to predict neurological outcomes in septic patients. Materials and methods This scoping review adhered to the PRISMA-ScR protocol and JBI methodology. A comprehensive literature search was conducted across MEDLINE, Scopus, and Web of Science. The review included studies on adults with sepsis or septic shock in the ICU. Randomised controlled trials, clinical trials, observational studies and systematic reviews were included. All the data related to the review's key questions were extracted and charted independently by two authors. Results 625 articles were screened, and 34 were ultimately included after application of exclusion criteria. 85% of the studies were observational 15% were systematic reviews with or without meta-analysis. The studies primarily focused on cerebral blood flow (CBF) alterations in sepsis, reporting variable results. Findings showed variable cerebral autoregulation (CAR) impairment, with higher incidence in the early stages of sepsis and associations with poor neurological outcomes. However, while alterations in CAR and CBF are common in septic patients, their impact on neurological outcomes and mortality is not clear. Regarding resuscitation, only a paucity of studies were found and no conclusions can be drawn. Conclusions The current body of evidence has a poor grade, but it is possible to say that brain US can identify cerebral perfusions alterations. Its usage during resuscitation is feasible and warrants further investigations. Use of brain US during resuscitation and for prediction of outcome is not currently supported by evidence. Further studies on brain perfusion, acquisition of 2D images of parenchyma (TCCS) and application of a multimodal brain monitoring might be useful in these contexts.

Preprint ARTICLE | doi:10.20944/preprints202406.0694.v1

Spatial Distribution Characteristics of Urban Air Quality and the Spatial Heterogeneity of Driving Factors: A Case Study of Beijing

Zhixiong Tan, Haili Wu, Qingyang Chen, Jiejun Huang

Subject: Environmental And Earth Sciences, Pollution Keywords: air quality index; multi-scale geographically weighted regression; multi-source geographic data; spatial autocorrelation analysis; spatial heterogeneity

Online: 11 June 2024 (09:39:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0404.v1

Extracts from Artemisia annua Linne’ Regulate the Translocation of p53 to Mitochondria and Induce Apoptotic Effects on LS174T Colon Cancer Cells In Vitro and In Vivo

Gaewon Nam, Bo-Min Kim, Young-Min Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: LS174T; mitochondrial apoptosis; Artemisia annua; p53 translocation

Online: 7 May 2024 (15:35:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0250.v1

Assessment of Accuracy of MODIS Sea Surface Temperature at High Latitudes Using Saildrone Data

Chong Jia, Peter J Minnett, Malgorzata D Szczodrak

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: MODIS; sea surface skin temperature; Saildrone; validation; Arctic

Online: 6 May 2024 (08:50:58 CEST)

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The infrared (IR) satellite remote sensing of sea surface skin temperature (SSTskin) is challenging in the northern high latitude region, especially in the Arctic because of its extreme environmental conditions, and thus the accuracy of SSTskin retrievals is questionable. Several Saildrone uncrewed surface vehicles were deployed at the Pacific side of the Arctic in 2019, and two of them, SD-1036 and SD-1037, were equipped with a pair of IR pyrometers on the deck whose measurements have been shown to be useful in the derivation of SSTskin with sufficient accuracy for scientific applications, providing an opportunity to validate satellite SSTskin retrievals. This study aims to assess the accuracy of MODIS-retrieved SSTskin from both Aqua and Terra satellites by comparisons with collocated Saildrone-derived SSTskin data. The mean differences in SSTskin from the SD-1036 and SD-1037 measurements are different by ~0.4 K, largely resulting from differences in the atmospheric conditions experienced by the two Saildrones. The performance of MODIS on Aqua and Terra in retrieving SSTskin is comparable. Negative brightness temperature (BT) differences between 11 μm and 12 μm channels are identified as being physically based, but are removed from the analyses as they present anomalous conditions for which the atmospheric correction algorithm is not suited. Overall, the MODIS SSTskin retrievals show negative mean biases, -0.234 K for Aqua and -0.295 K for Terra. The variations in the retrieval inaccuracies show an association with diurnal warming events in the upper ocean from long periods of sunlight in the Arctic. Also contributing to inaccuracies in the retrieval is the surface emissivity effect in BT differences characterized by the Emissivity-introduced BT difference (EΔBT) index. This study demonstrates the characteristics of MODIS-retrieved SSTskin in the Arctic, at least at the Pacific side, and underscores that more in situ SSTskin data at high latitudes are needed for further error identification and algorithm development of IR SSTskin.

Preprint ARTICLE | doi:10.20944/preprints202403.1608.v1

Fetal Splenic Artery Pulsatility Index May Predict the Need for Neonatal Intensive Care in Gestational Diabetes Class A1 Cases

Mehmet Albayrak, Humeyra Akbas, Emine Seda Guvendag Guven, Suleyman Guven

Subject: Biology And Life Sciences, Life Sciences Keywords: Gestational diabetes; neonatal intensive care unit; prenatal sonography; splenic artery doppler

Online: 27 March 2024 (16:12:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0005.v1

Active Power Dispatch Optimization for a Grid-Connected Microgrid with Uncertain Multi-Type Loads

Kai Lv, Hao Tang, Yijin Li, Xin Li

Subject: Engineering, Electrical And Electronic Engineering Keywords: multi-type loads; active power dispatch optimization; simulated-annealing Q-learning

Online: 2 September 2016 (11:23:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1576.v1

The Dynamic Role of Curcumin in Mitigating Human Illnesses: Recent Advances in Therapeutic Applications

Shamshir Alam, Md Jamir Anwar, Manish Kumar Maity, Faizul Azam, Mariusz Jaremko, Abdul-Hamid Emwas

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Curcumin; turmeric; anti-inflammatory; anticancer; antibacterial; antifungal; antioxidant

Online: 20 September 2024 (11:49:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0004.v1

Capacity to Consent in Healthcare: A Systematic Review and Meta-Analysis Comparing Patients with Bipolar Disorder and Schizophrenia Spectrum Disorder

Donato Morena, Matteo Lippi, Nicola Di Fazio, Giuseppe Delogu, Raffaella Rinaldi, Paola Frati, Vittorio Fineschi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Capacity to consent; Mental Competency; Informed Consent; Schizophrenia Spectrum and Other Psychotic Disorders; Bipolar and Related Disorders; Systematic Review; Meta-Analysis

Online: 1 April 2024 (11:19:42 CEST)

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Background: Mental capacity is a fundamental aspect that enables patients to fully par-ticipate in various healthcare procedures. To assist healthcare professionals (HCPs) in assessing patients' capacity, especially in the mental health field, several standardized tools have been developed. These tools include the MacArthur Competence Assessment Tool for Treatment (MacCAT-T), the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR), and the Competence Assessment Tool for Psychiatric Advance Directives (CAT-PAD). The core dimensions explored by these tools include Understanding, Appreciation, Reasoning, and Expression of a choice. Objective: This meta-analysis aimed to investigate potential differences in deci-sion-making capacity within the healthcare context among groups of patients with bi-polar disorder (BD) and schizophrenia spectrum disorder (SSD). Methods: A systematic search was conducted on Medline/Pubmed, and Scopus. Addi-tionally, Google Scholar was manually inspected, and a manual search of emerging re-views and reference lists of the retrieved papers was performed. Eligible studies were specifically cross-sectional, utilizing standardized assessment tools, and involving pa-tients diagnosed with BD and SSD. Data from the studies were independently extracted and pooled using random-effect models. Hedges g was used as a measure for outcomes. Results: Six studies were identified, with three studies using the MacCAT-CR, two studies the MacCAT-T, and one the CAT-PAD. The participants included 189 individuals with BD and 324 individuals with SSD. The meta-analysis revealed that patients with BD performed slightly better, and the difference was statistically significant, compared to patients with SSD, particularly in the domain of Appreciation (ES=0.23, 95% CI: 0.01 to 0.04, p=0.037). There was no statistically significant difference between the two groups for Understanding (ES=0.09, 95% CI: - 0.10 to 0.27, p=0.352), Reasoning (ES=0.18, 95% CI: - 0.12 to 0.47, p=0.074), and Expression of a choice (ES = 0.23, 95% CI: - 0.01 to 0.48, p=0.60). In the sensitivity analysis, furthermore, when considering only studies involving patients in symptomatic remission, the difference for Appreciation also resulted in non-significant (ES=0.21, 95% CI: -0.04 to 0.46, p=0.102). (ES=0.21, 95% CI: -0.04 to 0.46, p=0.102). Conclusions: These findings indicate that there are no significant differences between patients with BD and SSD during remission phases, while differences are minimal during acute phases. The usefulness of standardized assessment of capacity at any stage of the illness should be considered, both for diagnostic-therapeutic phases and for research and advance directives. Further studies are necessary to understand the reasons for the overlap in capacity between the two diagnostic categories compared in this study.

Preprint ARTICLE | doi:10.20944/preprints202403.1593.v1

Comparative Simulation of Plasmonic Nanostructures: Optical Response of Periodic Metal Nanostrip and Nanodisk Arrays on Mirror

Niloofar Ebrahimzadeh Esfahani, Jaroslav Kováč, Jr., Giuseppe Maruccio, Silvia Rizzato, Soňa Kováčová

Subject: Engineering, Electrical And Electronic Engineering Keywords: Nanodisk; nanostrip; plasmonic; field enhancement; absorption; scattering cross section; extinction cross section

Online: 26 March 2024 (11:54:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0266.v1

In Underweight Women, Insufficient Gestational Weight Gain is Associated with Adverse Obstetric Outcomes

Alizee Montvignier Monnet, Delphine Savoy, Lise Preaubert, Pascale Hoffmann, Cécile Bétry

Subject: Biology And Life Sciences, Food Science And Technology Keywords: pregnancy; newborn; obstetric outcome; birth weight; foetal growth restriction; thinness

Online: 15 November 2022 (01:39:35 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202406.0396.v1

Copper Supplementation in Young Wistar Rats

Klaudia Kitala–Tańska, Anetta Hanć, Jerzy Juśkiewicz, Michał Majewski

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: aortic rings; copper; vascular studies

Online: 7 June 2024 (02:51:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201611.0040.v1

Some Topological Invariants of the Möbius Ladder

Shin Min Kang, Mobeen Munir, Abdul Rauf Nizami, Zakia Shahzadi, Waqas Nazeer

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Möbius ladder; topological indices

Online: 7 November 2016 (07:31:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0394.v1

Fuzzy PID Control Design of Mining Electric Locomotive Based on Permanent Magnet Synchronous Motor

Chi Ma, Baosheng Huang, Md Khairul Basher, Md Abdur Rob, Yuqiang Jiang

Subject: Engineering, Control And Systems Engineering Keywords: Fuzzy Proportional-Integral-Derivative (F-PID) controller; Mining electric locomotive; SVPWM; Vector Control; Accurate stopping

Online: 8 March 2024 (01:55:53 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.0822.v1

Positive aspects and potential drawbacks of Implementing Digital Teaching/Learning Scenarios in Health Professions Using Nursing Education as an Example: A Research Report from Germany

Lydia Pfeifer, Sophia Fries, Alexander Stirner, Lisa Nagel, Christian Cohnen, Leona Aschentrup, Marleen Schönbeck, Annette Nauerth, Patrizia Raschper, Tim Herzig, Kamil J. Wrona

Subject: Public Health And Healthcare, Nursing Keywords: virtual reality; 360 degree video; digital tools; nursing education; VR-driven scenarios; pedagogical strategies; digital methodologies; immersion; collaboration

Online: 11 January 2024 (02:47:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1284.v1

Resistance and Co-resistance of Metallo-Beta-Lactamase Genes in Diarrheal and Urinary Tract Pathogens in Bangladesh

Ayasha Siddique Shanta, Nahidul Islam, Mamun Al Asad, Kakoli Akter, Marnusa Binte Habib, Md. Jubayer Hossain, Shamsun Nahar, Brian Godman, Salequl Islam

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Bangladesh; Metallo-beta-lactamase; bla-NDM-1; bla-VIM; antimicrobial resistance; co-resistance; diarrhea, urinary tract infections; antimicrobial stewardship programs

Online: 22 February 2024 (08:48:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1611.v1

Predictive Analysis of Causal Factors Influencing Occupational Accidents in Construction Workplaces Using a Machine Learning Unified Data Model

Hajar Ait Lamkademe, Ahmed Naddami, Karim Choukri

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: machine learning; predictive analytics; data mining; safety; occupational accidents; construction; workplace; artificial intelligence; big data; incidents

Online: 20 September 2024 (11:16:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0454.v1

Evaluating the Educational Effectiveness of Radar Systems Laboratory Sessions in the Undergraduate Curriculum

Bengisu Yalcinkaya, Mohamed Benzaghta, Remziye Busra Coruk, Ali Kara

Subject: Engineering, Electrical And Electronic Engineering Keywords: educational technology; engineering education; frequency modulated continuous wave; radar systems

Online: 5 September 2024 (12:41:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1375.v1

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease: Insights into Pathophysiology and Treatment

AMER ALKHALIFA, Oula Alkhalifa, Iva Durdanovic, Dalia R. Ibrahim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; Oxidative stress; Mitochondrial dysfunction; Antioxidant; Reactive oxygen species.

Online: 19 August 2024 (16:45:14 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.1496.v1

A Wideband Circularly Polarized Dipole Antenna with Compact Size and Low-Pass Filtering Response

Xianjing Lin, Zhang Run Weng, Yi Bin Hong, Yao Zhang

Subject: Physical Sciences, Radiation And Radiography Keywords: Wideband antenna; cross dipole antenna; circularly polarized antenna; filtering antenna

Online: 23 May 2024 (10:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.2005.v1

Artificial Vision System on Digital Devices for Real-Time Head Tilt Control

Miguel Ángel Tomé de la Torre, Antonio Álvarez Fernández-Balbuena, Ricardo Bernardez Vilaboa, Daniel Vázquez Molini

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Accommodative anomalies; Binocular anomalies; Visio-postural control; Eyetracking; Image processing software; Algorithm; Artificial vision.

Online: 30 April 2024 (17:05:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0714.v1

Blockchain-Based Zero Trust Supply Chain Security Integrated with Deep Reinforcement Learning

Shereen Ismail, Hajar Moudoud, Diana Dawoud, Hassan Reza

Subject: Computer Science And Mathematics, Security Systems Keywords: Security; Zero Trust; Blockchain; Smart Contract; Supply Chain; Deep Reinforcement Learning; Cyberattacks

Online: 12 March 2024 (14:00:37 CET)

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