Search | Preprints.org

Preprint REVIEW | doi:10.20944/preprints202405.2067.v1

Maternal Vaccination for the Prevention of Infantile RSV Disease: An Overview of the Authorized, In-Progress, and Unsuccessful Vaccine Candidates.

Georgios Papazisis, Xanthippi Topalidou

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: infant immunity; maternal antibody transfer; respiratory syncytial virus; maternal immunization; RSV vaccine; clinical trial; safety; immunogenicity

Online: 30 May 2024 (14:23:14 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.2016.v1

Tolerance Mechanisms of Olive Tree (Olea europaea) Under Saline Conditions

Mohamed El Yamani, María del Pilar Cordovilla

Subject: Biology And Life Sciences, Plant Sciences Keywords: ; salt stress; tolerance; morphological adaptation; photosynthesis; antioxidant defense; osmotic adjustment; proteins; molecular mechanisms

Online: 30 May 2024 (08:33:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1907.v1

Skin Health Benefits and Microbial Consortium of Stevia Fermented with Barley Nuruk

Hyun-Ju Han, Min Nyeong Ko, Chan Seong Shin, Chang-Gu Hyun

Subject: Biology And Life Sciences, Food Science And Technology Keywords: antioxidant; barley nuruk; α -glucosidase; microbiome; skin irritation; stevia; UPLC-Q-TOF-MS

Online: 29 May 2024 (08:33:51 CEST)

Show abstract| Download PDF| Share

In this study, the microbial community during the barley yeast fermentation of stevia leaves and its correlation with antioxidant, antiobesity, and anti-inflammatory properties, as well as metabolites, were investigated using UPLC-Q-TOF-MS. Stevia was fermented using commercial TSB media (TSB 1, TSB 2, and TSB 3) and sucrose (Sucrose 1, Sucrose 3, and Sucrose 3) for 1, 3, and 5 days, respectively. Stevia ferments showed higher DPPH and ABTS radical scavenging capacity compared to samples incubated with sucrose for 5 days, and all six ferments inhibited nitric oxide production in a concentration-dependent manner in LPS-induced mouse macrophages. Furthermore, UPLC-QTOF-MS analysis identified 23 related substances, including 10 terpenoids, including rubusoside, steviolbioside, and rebadioside derivatives; dulcoside A; and phlomisoside II, which are indicators of stevia, as well as five flavonoids, four phenolic acids, and four fatty acids. We also identified the microbial community during fermentation via the next-generation sequencing of the 16S rRNA gene for bacteria and the internal transcribed spacer (ITS) gene for fungi. The results showed that TSB 1 and Sucrose 1 ferments were dominated by the pathogens Enterococcus hirae (58.93%) and Cronobacter sakazakii (80.92%), while samples fermented for more than 3 days were pathogen-free and dominated by lactic acid bacteria such as Pediococcus stilesii (73.37%). Microbial community analysis using the ITS region showed that Saccharomycopsis fibuligera, classified as a yeast rather than a mold, dominated the stevia fermentation regardless of the fermentation duration. In particular, the microbial community of the fermentation with a sugar solution was dominated by S. fibuligera by more than 99% throughout the fermentation periods of 1, 3, and 5 days. Finally, to apply the stevia ferments topically to human skin, skin irritation tests were performed on 30 volunteers. The results showed that the highly concentrated extracts (1 mg/mL) of all six stevia ferments were hypoallergenic. Taken together, these findings suggest that brewer's yeast fermented from stevia leaves with a sugar solution offers promise as a natural ingredient for use in functional foods and cosmetics.

Preprint ARTICLE | doi:10.20944/preprints202405.1793.v1

A Secure Rubber Supply Chain Management System Based on Hyperledger Fabric Blockchain: A Use Case in Cambodia

Ratanak Keo, Muhammad Firdaus, Kyung-hyune Rhee

Subject: Computer Science And Mathematics, Information Systems Keywords: blockchain; rubber supply chain management; traceability; sustainability; security; privacy-preserving

Online: 28 May 2024 (08:10:44 CEST)

Show abstract| Download PDF| Share

Conventional traceability systems in Cambodian agriculture, such as Rubber Supply Chain Management (RSCM), often struggle to provide timely data and fair market prices, leading to mistrust among stakeholders, exploitation by intermediaries, and hindering progress towards ethical sourcing and sustainable practices. This research aims to showcase the potential of integrating blockchain technology, the Internet of Things (IoT), the InterPlanetary File System (IPFS), and Differential Privacy (DP) methods to empower Cambodian rubber farmers. By enhancing transparency, facilitating fair pricing, and promoting sustainable methods in the rubber industry, this integrated approach leverages Hyperledger Fabric (HLF) to create a decentralized and secure system for tracking rubber from its source to the end consumer. Integration with IPFS ensures secure and easily accessible data storage, further enhancing the system’s reliability. Additionally, the implementation of differential privacy techniques safeguards confidential data during information sharing among farmers and supply chain stakeholders, minimizing potential privacy concerns. This comprehensive system encourages consumers to make ethical and sustainable alternative options by providing accessible information on harvesting methods, processing procedures, labor conditions, and environmental impacts. The potential benefits extend beyond Cambodia, serving as a model for other developing countries aiming to modernize and enhance the agricultural distribution networks. Our results show that transaction send rates (TPS) and throughput in systems with and without differential privacy grow with increased transaction volumes. However, the system without differential privacy achieves greater scalability and efficiency above a certain threshold. However, it offers a slightly reduced latency, reflecting a trade-off between privacy and performance efficiency in blockchain-based agricultural traceability systems.

Preprint ARTICLE | doi:10.20944/preprints202403.0927.v2

Modeling Dynamics of Permafrost Degradation and their Impact on Ecosystems Across Entire Alaska: Arctic and Subarctic Engineering Design Tool (Part-1)

Sergey Marchenko, Kevin Bjella, Dmitry Nicolsky, Vladimir Romanovsky

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Permafrost; Active Layer; Permafrost Dynamics; Climate Change; Ecosystem; Numerical Modeling; Soil Thermal Properties.

Online: 1 May 2024 (10:08:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.2018.v1

Multiple Attack Detection Using SHAP and Heterogeneous Ensemble Model in the UAV’s Controller Area Network

Young-Woo Hong, Dong-Young Yoo

Subject: Computer Science And Mathematics, Security Systems Keywords: controller area network (CAN); shapley additive explanations (SHAP); machine learning(ML); deep learning(DL); unmanned aerial vehicles (UAVs)

Online: 30 April 2024 (15:36:13 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0971.v1

The New Horizon of Antipsychotics beyond the Classic Dopaminergic Hypothesis—The Case of the Xanomeline-Trospium Combination: A Systematic Review

Octavian Vasiliu, Beatrice Budeanu, Mihai Stefan Catanescu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: xanomeline; trospium; schizophrenia; Alzheimer’s disorder; psychoses; acetylcholine; muscarinic receptors; antipsychotics; dopaminergic hypothesis

Online: 15 April 2024 (14:36:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0850.v1

Green Synthesis of Cobalt-Doped CeFe2O5 Nanocomposites Using Waste Gossypium arboreum L. Stalk and Its Application in the Removal of Toxic Water Pollutants

Saloni Koul, Mamata Singhvi, Beom Soo Kim

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: green synthesis; co-precipitation; adsorption; dye removal; pollutant removal; cotton stalk; wastewater treatment; adsorption capacity

Online: 12 April 2024 (12:22:49 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Currently, there is a tenacious need to find new ways to purify water by eliminating bacterial biofilms, textile dyes, and toxic water pollutants. These contaminants pose significant risks to both human health and the environment. To address this issue, in this study, we have developed an eco-friendly approach that involves synthesizing Cobalt-doped Cerium Iron Oxide (CCIO) nanocomposite (NC) using an aqueous extract of Gossypium arboreum L. stalks. The resulting nanoparticles can be used to effectively purify water and tackle the challenges associated with these harmful pollutants. Nanoparticles excel in water pollutant removal by providing high surface area for efficient adsorption, versatile design for simultaneous removal of multiple contaminants, catalytic properties for organic pollutant degradation, and magnetic features for easy separation, offering cost-effective and sustainable water treatment solutions. CCIO nanocomposite has been synthesized by green co-precipitation method due to biomolecules and co-enzymes present in the aqueous extract of Gossypium arboreum L. stalk; a single-step procedure completed in 5 h reaction time. Further, the synthesis of nanocomposites was confirmed by various characterization techniques such as Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Thermogravimetric analysis (TGA), Dynamic light scattering (DLS), and Energy Dispersive X-Ray (EDX). CCIO NCs were discovered to have a spherical shape and an average size of 40 nm. Based on DLS zeta potential analysis, CCIO NCs were found to be anionic. Also, CCIO NCs showed significant antimicrobial and antioxidant activity. Overall, considering the physical and chemical properties, the application of CCIO NCs in the adsorption of various dyes (~91 %) and water pollutants (chromium = ~ 60 %) has been considered since they exhibit great adsorption capacity owing to their microporous structure which can be a step forward in water purification.

Preprint ARTICLE | doi:10.20944/preprints202403.1855.v1

Social Media Users' Visual and Emotional Preferences of internet-famous sites in Urban Riverfront Public Spaces: A Case Study on Changsha, China

Yuanyuan HUANG, Bohong Zheng, You Peng

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: riverfront public space; riverfront internet-famous sites (RIFS); visual elements; emotional preferences; social media; internet-celebrity city; Changsha; China

Online: 29 March 2024 (16:00:26 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1833.v1

ResECA-Unet: Enhancement of GI Tract Segmentation Using an Improved U-Net Framework

SM Nuruzzaman Nobel, Omar Faruque Sifat, MD Rajibul Islam, MD Shohel Sayeed, Md Amiruzzaman

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: U-Net; Deep learning; Transfer learning; ECA-Net; Computer vision; GI tract; Segmentation; Radiation therapy

Online: 29 March 2024 (13:51:41 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1403.v1

Botulinum Toxin in Chronic Lateral Epicondylitis, from Tendon to Muscle Approach

Daniela Poenaru, Miruna Ioana Sandulescu, Claudia-Gabriela Potcovaru, Delia Cinteza

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: botulinum toxin; lateral epicondylitis; intramuscular injection; intratendinous injection

Online: 25 March 2024 (07:57:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1099.v1

A Transient Voltage-based Approach for Mid-voltage Fault Detection through Low-voltage Sensors

Mingze ZHANG, Xinyu GUAN, Xin AI

Subject: Engineering, Electrical And Electronic Engineering Keywords: LV sensor measurement; non-effectively grounded system; single-phase-to-ground fault; transient aerial mode voltage

Online: 22 March 2024 (07:36:32 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1300.v1

Synthesis and Electrochemical Characterization of Nitrate-Doped Polypyrrole/Ag Nanowire Nanorods as Supercapacitors

Hyo-Kyung Kang, Ki-Hyun Pyo, Yoon Hee Jang, Yun-soo Kim, and Jin-Yeol Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Supercapacitor; Silver nanowire-polypyrrole composite; Nanorods; Core-shell structure

Online: 21 March 2024 (11:21:33 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202403.1086.v1

Intention Recognition in Digital Forensics: Systematic Review

Yidnekachew Worku Kassa, Joshua Isaac James, Elefelious Getachew Belay

Subject: Computer Science And Mathematics, Security Systems Keywords: Digital Forensics; Intention Recognition; Goal Recognition; plan recognition; cyberattack; cybercrime; model

Online: 19 March 2024 (10:21:02 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1057.v1

Disruptive Factors in Product Portfolio Management: A Qualitative Exploratory Study in B2B Manufacturing

Till Gramberg, Thomas Bauernhansl, Andreas Eggert

Subject: Business, Economics And Management, Business And Management Keywords: product portfolio management; disruption; digitalization; sustainability; servitization; generative artificial intelligence; decision-making; value-oriented; business model; b2b; manufacturing

Online: 18 March 2024 (14:31:51 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0843.v1

Brain-inspired agents for Quantum Reinforcement Learning

E. Andrés, Manuel Pegalajar Cuellar, Gabriel Navarro

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Quantum Reinforcement Learning; Quantum Neural Networks; Quantum Spiking Neural Network; Quantum Long Short-Term Memory; Brain-inspired models.

Online: 18 March 2024 (10:24:38 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0768.v1

Towards Cognition-Aligned Visual Language Models via Zero-Shot Instance Retrieval

Teng Ma, Daniel Organisciak, Wenbao Ma, Yang Long

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Large Visual Language Models; Zero-Shot Instance Retrieval; Cognition-Alignment

Online: 13 March 2024 (07:29:35 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0498.v1

Investigation of Deposition Parameters for Near-Beta Alloy Ti-55511 Fabricated by Directed Energy Deposition

Addison Rayner, Greg Sweet, Owen Craig, Mahdi Habibnejad-Korayem, Paul Bishop

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Directed energy deposition; Near-beta titanium alloys; Ti-55511; Plasma Atomized Powder

Online: 8 March 2024 (09:24:55 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.1596.v1

Advances in Target Therapy Research in Osteosarcoma

Caterina Chiappetta, Carlo Della Rocca, Claudio Di Cristofano

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Osteosarcoma; Next Generation Sequencing; Tumor targeted therapy; Immunotherapy

Online: 28 February 2024 (08:01:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1581.v1

Identification and Characterization of the Gene responsible for 2 the O3 Mating Type Substance in Paramecium caudatum

Yuta Chiba, Yasuhiro Takenaka, Nobuyuki Haga

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: mating-type substance; kinase-C domain; EF hand motif; Phylogenic tree; RNAi; silent mutations; microinjection; Paramecium caudatum

Online: 28 February 2024 (00:09:21 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202402.1252.v1

Regulatory and Sensing Iron-Sulfur Clusters: New Insights and Unanswered Questions

Anna M. SantaMaria, Tracey A. Rouault

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Iron-sulfur clusters; iron metabolism; iron sensing; IRE; PAIR; Aft1/2; IRP1/2; RirA; Yap5; ACO1; IREB2; HSCB

Online: 22 February 2024 (09:23:28 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1082.v1

Development of a Landslide Hazard Index to Land Use by Using Logistic Regression and Geographic Information System: A Case Study in Pingtung County in Southern Taiwan

Chih-Ming Tseng, Yie-Ruey Chen, Ching-Ya Tsai, Shun-Chieh Hsieh

Subject: Environmental And Earth Sciences, Environmental Science Keywords: land use; mountainous area; rainfall; landslide hazard; random tree classifier; logistic regression; geographic information system; Taiwan

Online: 20 February 2024 (11:27:32 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0916.v1

Floating Zone Growth of Pure and Pb-Doped Bi-2201 Crystals

Maria Roslova, Bernd Büchner, Andrey Maljuk

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Bi-2201; floating zone crystal growth; crystal structure; cuprates; superconductivity

Online: 17 February 2024 (09:10:37 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0768.v1

Validation of the Gaming Skills Questionnaire: Gaming Skills Effects on Cognitive and Affective Functioning in Adolescence

Triantafyllia Zioga, Chrysanthi Nega, Petros Roussos, Panagiotis Kourtesis

Subject: Social Sciences, Psychology Keywords: Videogames; Adolescence; Cognition; Memory; Executive Functions; Attention; Language; Verbal Fluency; Emotion Recognition; Empathy

Online: 14 February 2024 (09:34:09 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201702.0067.v1

Influences of Multiscale Land Cover Characteristics and Specific Conductivity on Fish Assemblages in the Nolichucky River Watershed, Tennessee

Hayley S. Gotwald, J. Brian Alford

Subject: Environmental And Earth Sciences, Environmental Science Keywords: spatial scale; CCA; indicator species analysis; land use; SWAT; bioassessment

Online: 17 February 2017 (07:33:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201611.0058.v1

Effects of Domain Boundaries on the Diffraction Patterns of One Dimensional Structures

Frederic Timmer, Joachim Wollschläger

Subject: Physical Sciences, Condensed Matter Physics Keywords: spot-profile analysis; one dimensional physics; low energy electron diffraction; binary surface technique; supercell model; domain boundary

Online: 10 November 2016 (15:50:29 CET)

Show abstract| Download PDF| Share

Motivated by diffraction experiments on the

(2 \sqrt{3} \times \sqrt{3}) R 30^{\circ}

reconstructed Si(111) due to deposition of rare earth elements (Dy, Tb) and silicide formation we analyse the splitting and non-splitting of superstructure spots. For this purpose, we model diffraction patterns for one dimensional structures generated by the binary surface technique and use supercell models to keep the analysis simple. Diffraction pattern are calculated in the framework of the kinematical diffraction theory and they are analyzed as a function of the domains and domain boundaries. Basic properties of the diffraction pattern are analyzed for model systems of a two-fold and a three-fold periodicity. The rules derived from these calculations are applied to the "real-world" system of Si(111)-(

(2 \sqrt{3} \times \sqrt{3}) R 30^{\circ}

)-RESi

2

(RE = Dy or Tb). Depending on the combination of domains and domain boundaries of different types a plethora of different features are observed in the diffraction patterns. These are analyzed to determine the sizes of both domain boundaries and domains from experimentally observed splitting of specific superstructure spots.

Preprint ARTICLE | doi:10.20944/preprints201610.0102.v1

Isolation and Characterisation of Probiotics for Antagonising Cariogenic Bacterium Streptococcus mutans and Preventing Biofilm Formation

Pei-Pei Lin, You-Miin Hsieh, Cheng-Chih Tsai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: dental caries; Streptococcus mutans; lactic acid bacteria; biofilm; glucosyltransferases

Online: 24 October 2016 (09:37:48 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201609.0114.v1

Marginal Generation Technology in the Chinese Power Market towards 2030 Based on Consequential Life Cycle Assessment

Guangling Zhao, Josep M. Guerrero, Yingying Pei

Subject: Environmental And Earth Sciences, Environmental Science Keywords: marginal technology; power grid; consequential LCA; China

Online: 28 September 2016 (11:49:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201608.0235.v1

American’s Energy Future: An Analysis of the Proposed Energy Policy Plans in Presidential Election

Ming-Hsun Cheng, Minliang Yang, Yu Wang

Subject: Social Sciences, Political Science Keywords: president election; renewable energy; energy future; public opinion; polarization

Online: 31 August 2016 (08:34:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0184.v1

Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (Euterpe oleracea, Mart.)

Iago Castro da Silva, Pamela Suelen da Silva Seabra, Kely Campos Navegantes Lima, Ricardo Barbosa Bezerra Filho, Alanna Lorena P. dos Santos, Amanda Caroline dos Santos Monteiro, Giovanna Quintero Pamplona, Alexandre Guilherme da Silva Dias, Rayane Caroline dos Santos Pereira, Leticia Araujo Costa, Thays Jhessica Mota Pinheiro, Lauro Henrique Hamoy Guerreiro, Nélio Teixeira Machado, Marta Chagas Monteiro

Subject: Medicine And Pharmacology, Pharmacy Keywords: Açaí; Bio-oil; Pyrolysis

Online: 2 August 2024 (16:44:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202410.1821.v1

Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients

Marton Papp, Can Ince, Jan Bakker, Zsolt Molnar

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sepsis; septic shock; hemoadsorption; cytokines; endothelium; capillary leakage

Online: 24 October 2024 (08:28:08 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202410.1732.v1

A Qualitative Study on Understanding Family Experiences: Mental Health Literacy in Adolescent Eating Disorder Diagnoses

Eva García Carpintero-Blas, Esperanza Vélez-Vélez, Esther Martínez-Miguel, Alberto Tovar-Reinoso, Pablo DelPozo-Herce, Carlos González-Navajas, Cristina Gómez-Moreno

Subject: Public Health And Healthcare, Nursing Keywords: Family Therapy; Nursing; Eating Disorders; Qualitative Research; Mental Health Literacy

Online: 22 October 2024 (16:37:24 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202410.0764.v1

Drowsiness Detection of Construction Workers: A Proactive Approach to Accident Prevention Leveraging Yolov8 Deep Learning And Computer Vision Techniques

Adetayo Olugbenga Onososen, Innocent Musonda, Damilola Onatayo, Abdullahi Babatunde Saka, Samuel Adeniyi Adekunle, Eniola Onatayo

Subject: Engineering, Architecture, Building And Construction Keywords: Construction; Deep Learning; Drowsiness; Construction safety; Computer vision; Accident; Yolo

Online: 10 October 2024 (06:22:56 CEST)

Show abstract| Download PDF| Share

Construction projects' unsatisfactory performance has been linked to factors influencing individuals' well-being and mental alertness on projects. Drowsiness is a significant indicator of sleep deprivation and fatigue, being able to identify the cognitive and physical preparedness of workers on site to engage in construction tasks. As a consequence of the strenuous nature of the work involved in construction, long work hours, and environmental conditions, drowsiness is commonplace and has received less attention despite being a leading cause of accidents occurring on-site. Detecting drowsiness is essential for determining the safety and well-being of site workers. This study presents a vision-based approach using an improved version of the You Only Look Once (YOLOv8) algorithm for real-time drowsiness exposure among construction workers. The proposed method leverages computer vision techniques to analyse facial and eye features, enabling early detection of drowsiness signs, effectively preventing accidents, and enhancing on-site safety. The model showed significant precision and efficiency in detecting drowsiness from the given dataset, accomplishing a drowsiness class with a mean average precision (mAP) of 92%. However, it also exhibited difficulties handling imbalanced classes, particularly the underrepresented 'Awake with PPE' class, which was detected with high precision but comparatively lower recall and mAP. This highlighted the necessity of balanced datasets for optimal deep learning performance. The YOLOv8 model's average mAP of 78% in drowsiness detection compared favourably with other studies employing different methodologies. The vision-based drowsiness detection system has broad applications in the construction industry. It can be integrated into existing safety protocols, enabling real-time alerts to supervisors or workers when drowsiness is detected. The system improves productivity and reduces costs by preventing accidents and enhancing worker safety. However, limitations, such as sensitivity to lighting conditions and occlusions, must be addressed in future iterations.

Preprint ARTICLE | doi:10.20944/preprints202410.0229.v1

Efficient Access to New Structures with Incorporated 1,2,3-Triazolium Salts as Preferred Dual Cholinesterase Inhibitors

Milena Mlakić, Maja Ratajec, Ana Ratković, Anamarija Raspudić, Danijela Baric, Ivana Šagud, Zlata Lasić, Ilijana Odak, Irena Škorić

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: cholinesterase inhibition; docking; genotoxicity; 1,2,3-triazolium salts

Online: 3 October 2024 (10:55:40 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1980.v1

Enhanced Outer Membrane Vesicle Production in Escherichia coli: from Metabolic Network Model to Designed Strain Lipidomic Profile

Héctor Alejandro Ruiz-Moreno, Juan Daniel Valderrama-Rincon, Monica Patricia Cala, Miguel Fernández-Niño, Andrés Fernando Gonzalez Barrios

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Outer Membrane Vesicles; Lipidomics; CRISPR; Metabolic Network Models; E. coli JC8031

Online: 25 September 2024 (12:15:52 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1918.v1

Stable Microclimates and Autonomic Modulation in Horses Sin-Gle-Stall Housed in Different Stable Architectures During Mon-Soon in a Tropical Savannah Environment

Chanoknun Poochipakorn, Kanokpan Sanigavatee, Kansuda Leelehapongsathon, Thita Wonghanchao, Metha Chanda

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Air velocity; Humidity; Interior environment; Monsoon; Noxious gases; Single-stall housing; Stress responses; Temperature; Tropical savannah climate; Welfare

Online: 24 September 2024 (14:06:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1224.v1

Translation, Cultural Adaptation of the Portuguese Provider Attitudes toward Cardiac Rehabilitation and Referral (PACRR-P) Scale and Assessment of its’ Measurement Properties

Mayara Moura Alves da Cruz, Luiz Carlos Marques Vanderlei, Carolina Takarashi, Maria Julia Lopez Laurino, Murilo Reis Alves da Cruz, Sherry L Grace, Gabriela L M Ghisi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Attitudes; Cardiac rehabilitation; Health knowledge; Physician’ s practice patterns; Practice; Questionnaires

Online: 16 September 2024 (12:29:57 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.0349.v1

Evaluation of a Point of Care Gem Premier ChemSTAT Analyzer in Emergency Department: Prevention of Contrast-Induced Nephropathy and Optimization of Patient Flow

Marina Brailova, Marie Audin, Julien Raconnat, Jean-Baptiste Bouillon-Minois, Jeannot Schmidt, Bruno Pereira, Damien Bouvier, Vincent Sapin

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: contrast media; creatinine; contrast-induced nephropathy; point-of-care; ChemSTAT; emergency

Online: 4 September 2024 (11:24:04 CEST)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints202409.0141.v1

Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report

Serena Xodo, Bassma Benchick, Ginevra Battello, Giovanni Baccarini, Marta Angelini, Maria Orsaria, Lorenza Driul

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cervical insufficiency; triple antibiotic therapy; cerclage; intra-amniotic infection; case report

Online: 3 September 2024 (11:21:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1609.v1

Expression Profiling of Coding and Noncoding RNAs in the Endometrium of Patients with Endometriosis

Mi Ran Choi, Hye Jin Chang, Jeong-Hyeon Heo, Sun Hyung Yum, Eunae Jo, Miran Kim, Sang-Rae Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endometriosis; endometrium; menstrual cycle; long noncoding RNA; neighboring gene

Online: 23 August 2024 (10:12:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1305.v1

Comorbidity Burden among Adults with Symptomatic COVID-19 Illness: A Cross-Sectional Study

Mini M. Jose, Juan Feng, Bushra Manakkat, Hoang Nguyen, Josie Tombrella, Patricia Savard, Hanaa S. Sallam, Hani Serag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 positive adults; Charlson Comorbidity Index; Comorbidity burden and COVID-19; Depression and COVID-19; Comorbidities and COVID-19; Social determinants of COVID-19

Online: 19 August 2024 (10:05:29 CEST)

Show abstract| Download PDF| Share

Preprint ESSAY | doi:10.20944/preprints202408.1079.v1

Overexpression of EuSIP5 Gene to Improve Drought Resistance in Tobacco

Yue-Ling Lin, Xi Chen, De-Gang Zhao, Chao Li

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: E. ulmoides; EuSIP5; transgenic; tobacco; drought resistance

Online: 15 August 2024 (12:19:08 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Soluble inorganic pyrophosphatase (sPPase), a pyrophosphate hydrolase, has been shown to play an important role in several physiological processes such as plant growth and development, metabolic activities, and response to abiotic stresses, but sPPase has been less studied in woody plants. In order to preliminarily verify whether the soluble inorganic pyrophosphatase in Eucommia ulmoides Oliver (E. ulmoides) has a role in resistance to drought stress, we amplified the EuSIP5 (E. ulmoides soluble inorganic pyrophosphatase 5) cDNA sequence from E. ulmoides by RT-PCR. In order to study the drought resistance of the Eucommia ulmoides soluble inorganic pyrophosphatase 5 (EuSIP5) gene, the cDNA sequence of the EuSIP5 gene was amplified from Eucommia ulmoides Oliver by RT-PCR. Bioinformatic analysis indicated that EuSIP5 might be an unstable amphipathic protein, mainly located in the cytoplasm. E. ulmoides, the highest expression of the EuSIP5 gene was found in male leaves and pericarp from April to October, and in leaves of E. ulmoides in July and September. During drought, the expression of EuSIP5 in seedling E. ulmoides leaves was significantly higher than that of the control. An overexpression vector harboring the EuSIP5 was constructed and introduced into the tobacco (Nicotiana tabacum cv. Xanthi). We found that during drought stress, the appearance of wilting was delayed by 4 days in transgenic tobacco plants (OE) compared with wild type plants (WT), and the expression of drought-related genes DET2, CYP85A1, P5CS, ERF1 and F-box was found to be increased in transgenic tobacco leaves, as well as the enzyme activities of the protective enzymes: peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) were significantly higher than those of the WT, and the malondialdehyde (MDA) content was lower than the WT. These results indicated that the introduction of EuSIP5 gene into tobacco increased the expression of drought-related genes, enhanced the anti-membrane oxidation ability of tobacco, and reduced the oxidative stress damage, thus improving the drought resistance of tobacco.

Preprint ARTICLE | doi:10.20944/preprints202408.1040.v1

Creation of an Experimental Animal Model for the Study of Postmortal Dark Scleral Spots

Matteo Nioi, Pietro Emanuele Napoli, Domenico Nieddu, Alberto Chighine, Maurizio Fossarello, Ernesto D'Aloja

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: postmortal scleral spots; postmortem tache noire; forensic ophthalmology; eye postmortem; ocular surface; sclera; animal models; postmortem interval; postmortem optical coherence tomography

Online: 14 August 2024 (18:04:17 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0580.v1

Optical Properties of Yttrium Orthoferrite Films Prepared by Plasma Laser Deposition

Dinara Sobola, Saleh H. Fawaeer, Pavla Kočková, Richard Schubert, Rashid Dallaev, Tomáš Trčka

Subject: Engineering, Electrical And Electronic Engineering Keywords: yttrium orthoferrite; plasma laser deposition; optical properties; thin films; bandgap; optoelectronics

Online: 8 August 2024 (12:03:41 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0303.v1

Characterisation of the Mitochondrial Genome of Capulus danieli: Insights into Evolutionary History and Ecological Adaptations

Yaoyu Xie, Yida Han, Junxia Mao, Xubo Wang, Zhenlin Hao, Ying Tian

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Capulus danieli; mitochondrial genome; protein-coding genes; divergence time estimation

Online: 6 August 2024 (03:19:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0237.v1

Emotional Intelligence Increases Nurses’ Work Performance: Evidence from Greece

Petros Galanis, Aglaia Katsiroumpa, Ioannis Moisoglou, Konstantina Derizioti, Parisis Gallos, Maria Kalogeropoulou, Vasiliki Papanikolaou

Subject: Public Health And Healthcare, Nursing Keywords: emotional intelligence; work performance; job performance; nurses; emotions

Online: 5 August 2024 (08:18:24 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.2276.v1

Understanding the Mellowing Effect of Bottle Aging on the Sensory and Aesthetic Perceptions of Varietal Dry White Wines

Giovanni Marasà, Joana Ferreira, Mariana Mota, Manuel Malfeito-Ferreira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fine wines; aging bouquet; vertical tasting; maturation; quality; complexity; sensory space; aroma; mouthfeel

Online: 29 July 2024 (10:07:48 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1835.v1

Population-Based Incidence and Mortality Rates of Hematologic Malignancies regarding the Adult Population of Crete, Greece, and Analyses of Their Time Trends and Their Geographical Dis-Tribution: A First Approach from the Cancer Registry of Crete (CRC) for a 22-Year Time Period (1992–2013)

Stelios Lionakis, Dimitra Sifaki-Pistolla, Helen A. Papadaki, Dimitrios Mavroudis, Christos Lionis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hematologic neoplasms; incidence; mortality; cancer epidemiology; kaplan meier estimate; registries; spatio-temporal analysis

Online: 24 July 2024 (07:10:57 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.1521.v1

Forecasting Temperature Trends Using SARIMAX: A Case Study in Ahmedabad City, India

Vyom Shah, Nishil Patel, Dhruvin Apurva Shah, Debabrata Swain, Manorama Mohanty, Biswaranjan Acharya, Vassilis C. Gerogiannis, Andreas Kanavos

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: temperature forecasting; weather forecasting; time series; augmented Dickey-Fuller test; seasonal autoregressive integrated moving average with eXogenous factors (SARIMAX); root mean squared error; seasonality; climate change

Online: 18 July 2024 (14:27:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0867.v1

PlanteSaine: An Artificial Intelligent empowered mobile application for pests and disease management for maize, tomato, and onion farmers in Burkina Faso

Obed Appiah, Kwame Oppong Hackman, Belko Abdoul Aziz Diallo, Kehinde O. Ogunjobi, Son Diakalia, Ouedraogo Valentin, Damoue Abdoul-Karim, Gaston Dabire

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial Intelligence in Agriculture; Pest and Disease Detection; Mobile Application for Farmers; Burkina Faso Agriculture; Real-time Plant Diagnosis; Sustainable Farming Practices

Online: 13 June 2024 (11:52:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202406.0826.v1

Sequential Behavior of Broiler Chickens in Enriched Environments Under Varying Thermal Conditions Using the Generalized Sequential Pattern Algorithm: A Proof of Concept

Juliana M. Massari, Daniella J. Moura, Irenilza A. Nääs, Danilo F. Pereira, Stanley R. M. Oliveira, Tatiane Branco, Juliana de S. G. Barros

Subject: Engineering, Bioengineering Keywords: animal behavior; animal welfare; data mining; environment; machine learning; precision livestock farming

Online: 12 June 2024 (11:25:20 CEST)

Show abstract| Download PDF| Share

Behavior analysis is a widely used non-invasive tool in the practical production routine, as the animal acts as a biosensor capable of reflecting its degree of adaptation and discomfort to some environmental challenge. Predominantly, conventional statistics use occurrence data for behavioral evaluation and well-being estimation, disregarding the temporal sequence of events. The Generalized Sequential Pattern (GSP) algorithm is a data mining method that identifies recurrent sequences that exceed a user-specified support threshold, whose potential has not yet been investigated for broiler chickens in enriched environments. Enrichment aims to increase environmental complexity with promising effects on animal welfare, stimulating priority behaviors and potentially reducing the deleterious effects of heat stress. The objective was to validate the application of the GSP algorithm to identify temporal correlations between heat stress and the behavior of broiler chickens in enriched environments through proof of concept. Video image collection was carried out automatically for 48 continuous hours, analyzing a continuous period of seven hours, from 12:00 PM to 6:00 PM, during two consecutive days of tests for chickens housed in enriched and non-enriched environments under comfort and stress temperatures. Chickens at comfort temperature showed high motivation to perform the behaviors of Preening (P), Foraging (F), Lying down (Ld), Eating (E), and Walking (W) whose sequences <{Ld,P}>; <{Ld,F}>; <{P,F,P}>; <{Ld,P,F}> and <{E,W,F}> were the only ones observed in both treatments. All other sequential patterns (comfort and stress) were distinct, suggesting that environmental enrichment alters the behavioral pattern of broiler chickens. Heat stress drastically reduced the sequential patterns found at the 20% threshold level in the tested environments. The behavior of lying laterally "Ll" is a strong indicator of heat stress in broilers and was only frequent in the non-enriched environment, which may suggest that environmental enrichment provides the animal with better opportunities to adapt to stress-inducing challenges, such as heat.

Preprint ARTICLE | doi:10.20944/preprints202406.0391.v1

Laser-Assisted versus Open Cordectomy for Early Glottic Cancer

Christine Langer, Florian Glatt, Steffen Wagner, Michael Knitschke, Shachi Jenny Sharma, Claus Wittekindt

Subject: Medicine And Pharmacology, Otolaryngology Keywords: cordectomy; open approach; functional outcome; early glottic cancer; head and neck cancer

Online: 6 June 2024 (12:40:32 CEST)

Show abstract| Download PDF| Share

Purpose: Early glottic cancer is a highly curable malignancy. Disease control is achieved by resec-tion or external beam radiation with similar long-term results according survival. Surgery is predominantly performed by transoral endoscopic approach, due to reduced complication rates when compared to open cordectomy. Open cordectomy might still be warranted in cases of inad-equate surgical accessibility. Aim of the present study was to compare endoscopic versus open approach in relation to complications and outcome in an up-to-date patient group. Methods: 219 patients underwent primary tumor resection in early glottic cancer (UICC stages I-II). 168 opera-tions were performed endoscopically, 51 operations were open transcervical cordectomies. We compared survival data with non-parametric methods and functional outcome according to need of tracheostomy, feeding tube and voice functional outcome following ELS protocol. Results: There were no significant differences in overall survival (OS). 2 years OS after endoscopic surgery was 90.5% vs 95.3% after transcervical resection. As expected, OS in T1b and T2 tumors was worse than in T1a tumors. We found a statistically significant difference in disease free survival (DFS) within the T1a and T1b/T2 group (Log rank test: p=0.006) but no relevant difference be-tween the two surgical modalities, even when the data was stratified by T-categories performing a Cox regression (hazard ratio 1.21, p=0.712). Patients who underwent open surgery had a sig-nificantly worse peri- and postoperative course with longer hospital stay, higher frequency of tracheotomies and longer need for nasogastric tubes. Functional results were comparable within the two patient groups while higher tumor size / stage was an unfavorable predictor for voice re-habilitation. Conclusion: Open cordectomy leads to more complications but offers comparable oncological and functional outcome when compared to transoral endoscopic approach in early glottic cancer. Open surgery therefore continues to be a valid treatment option when endoscopic resection is not possible.

Preprint REVIEW | doi:10.20944/preprints202405.1689.v1

Bibliometric Analysis of Patient Safety in Nursing

Nükhet BAYER, Güney GÜRSEL, Ömer TURUNÇ, İbrahim Sani MERT, Müzeyyen Çiğdem AKBAŞ, Melih ALTAY, Cem ŞEN, Tamer KILIÇ

Subject: Public Health And Healthcare, Nursing Keywords: Bibliometric analysis; patient safety; nursing care

Online: 27 May 2024 (08:36:39 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.0697.v1

Reduced Pharmacological Intervention of Prehospital Services for Acute Alcohol Intoxication during the COVID-19 Pandemic in a Large District of Southern Italy

Arcangela Giustino, Annamaria Natola, Giovanni Savoia, Maria Antonietta De Salvia, Carmine Finelli

Subject: Medicine And Pharmacology, Internal Medicine Keywords: emergency service; acute alcohol intoxication; triage; pharmacological treatment; public health

Online: 10 May 2024 (18:32:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1752.v1

DATIV – Remote Enhancement of Smart Aerosol Measurement System Using Raspberry Pi Based Distributed Sensors

Gazi Hasanuzzaman, Tom Buchwald, Christoph Schunk, Christoph Egbers, Andreas Schröder, Uwe Hampel

Subject: Engineering, Control And Systems Engineering Keywords: particulate matter; COVID-19; distributed sensors; Raspberry Pi; WiFi; open source; low cost measurement system; indoor ventilation

Online: 26 April 2024 (12:36:27 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1363.v1

Status and Challenges of Medical History-Taking in Developing Countries and an Affordable Digital Solution to Tackle Them

Forhad Hossain, Mohamed Mehfoud Bouh, Md Moshiur Rahman, Faiz Shah, Tsunenori Mine, Rafiqul Islam, Naoki Nakashima, Ashir Ahmed

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Health Informatics; Digital Health; Physicians’ Workload; History Taking Challenges; Electronic Health Records (EHR); Modern Healthcare System; Artificial Intelligence; Life-long Medical History; Healthcare Data Management; Healthcare Innovation

Online: 21 April 2024 (05:28:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1265.v1

The Influence of Gender on the Psychiatric Comorbidity of Treated Danish Patients With and Without Alcoholism

Elizabeth C Penick, Waheeda A. Hossain, Wendy Madarasz, Ann M Manzardo, Joachim Knop, Erik L Mortensen, William F Gabrielli

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Alcohol use disorder; Gender; Psychiatric comorbidity

Online: 19 April 2024 (09:56:42 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202404.0991.v1

Rethinking the Esterquats: Synthesis, Stability, Ecotoxicity and Applications of Esterquats Incorporating Analogs of Betaine or Choline as the Cation in Their Structure

Marcin Wysocki, Witold Stachowiak, Mikołaj Smolibowski, Adriana Olejniczak, Michał Niemczak, Julia L. Shamshina

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Quaternary Ammonium Salts; Cleavable Compounds; Esters; Environmental Safety; Cationic Surfactants; Biological Activity

Online: 15 April 2024 (14:53:26 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0967.v1

Exploring the Immune-Related Senescence biomarkers in Predicting Gestational Diabetes Mellitus

Yanqiong Gan, Jing Mao, Yuhan He, Zhaoxia Chen, Bo Fan, Qi Shi, Hongbo Qi

Subject: Biology And Life Sciences, Aging Keywords: Gestational Diabetes Mellitus; immune infiltration; senescence; WGCNA, machine learning; CECR1; TACC2

Online: 15 April 2024 (13:23:16 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0032.v1

Transcranial Direct Current Stimulation: Effects on Motor and Non-Motor Symptoms of Parkinson's Disease

Fayda Protásio, Carlos Tomaz, Joaquim Brasil-Neto, Pedro Brandão, Nasser Allam, Maria Clotilde Henriques Tavares

Subject: Biology And Life Sciences, Behavioral Sciences Keywords: Parkinson’ s disease; neuromodulation; transcranial direct current stimulation – tDCS; movement disorders; mood; sleep; cognition

Online: 1 April 2024 (09:56:57 CEST)

Show abstract| Download PDF| Share

Abstract Introduction: In the last thirty years, brain neuromodulation techniques have been used as an alternative to pharmacological treatment of neurological disorders. Parkinson's disease (PD) is a neurodegenerative disorder leading to bradykinesia, rest tremor, postural changes, and non-motor symptoms such as depression, anxiety, sleep disorders, pain, and cognitive decline that compromises executive functions (EFs), responsible for the orderly execution of behaviors and tasks of daily life and intentional and directed actions. To this date, a few studies with transcranial direct current stimulation (tDCS) have shown beneficial effects in PD patients concerning specific motor and non-motor symptoms, targeting the motor cortex and/or prefrontal regions. Objective: The main objective of this study was to evaluate the effects of left prefrontal tDCS across a broad spectrum of motor and non-motor symptoms of PD using established validated scales. Method: Single-blind randomized clinical trial with 18 volunteers with PD, aged between 45 and 80 years (66.1 ± 9.65), who met inclusion and exclusion criteria. Participants were submitted to assessments of motor and non-motor functions employing psychometric scales and tests to evaluate EFs and were randomly divided into two groups: control (sham stimulation) and experimental (active stimulation). All participants were involved in three separate tDCS sessions. The anode was positioned over the left dorsolateral prefrontal cortex and the cathode over the right supraorbital region, with a direct current intensity of 2mA, lasting 20 minutes. At the end of the three sessions, all participants were reassessed. Results: Significant effects of tDCS on non-motor functions were observed for cognition (verbal fluency of actions, clock copy test, appointment by visual confrontation, and verbal memory with immediate free recall) and subjective assessment of sleep quality (overall restlessness and discomfort in the arms and legs at night, leg and arm cramps at night and distressing dreams). There was also an improvement in the rate of errors and successes for congruent and incongruent stimuli of the Stroop Test. The beneficial effects on motor function were decreased rigidity, improved gait, and greater agility in the finger-tapping test. Conclusion: Three tDCS sessions showed positive results for participants with PD, producing significant improvements in various motor and non-motor functions, including sleep quality, cognition, and EFs. Additionally, the present results indicate that tDCS neuromodulation of the left dorsolateral prefrontal cortex region is feasible, safe, and provides significant objective benefits for PD patients.

Preprint ARTICLE | doi:10.20944/preprints202403.1849.v1

Long-Term Organic Cultivation in Greenhouses Enhances Vegetable Yield and Soil Carbon Accumulation through the Promotion of Soil Aggregation

Lihong Tong, Yingjun Liu, Tian Lan, Xiayan Liu, Lechuan Zhang, Adu Ergu, Yajie Wen, Xiang Liu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: organic cultivation; soil aggregates; organic carbon fraction; microbial community; enzyme activity

Online: 29 March 2024 (13:20:51 CET)

Show abstract| Download PDF| Share

The long-term use of fertilizers and pesticides in conventional cultivation has resulted in a decrease in soil productivity and vegetable yields in greenhouses. However, only a limited number of studies have explored the impacts of organic cultivation on greenhouse soil. Specifically, there is a scarcity of research examining the alterations in soil aggregate mediated organic carbon and microbial communities, which are known to enhance soil productivity. This study investigated the properties of soil aggregates, including the levels of organic carbon fractions, microbial community, and enzyme activity with the three aggregate classes microaggregates (<0.25 mm), small macroaggregates (2-0.25 mm) and large macroaggregates (>2 mm). These investigations were conducted under three different cultivation methods in a greenhouse: conventional cultivation (CC), integrated cultivation (IC), and organic cultivation (OC) in greenhouse. The results showed that (1) OC and IC promoted the formation of small macro-aggregates and enhanced aggregate stability compared to CC, (2) SOC in the three size fractions of OC increased by 98.99%-92.06% compared to CC; EOC increased by 98.47%-117.59%; POC increased by 138.59%-208.70%; MBC increased by 104.71%-230.61%; DOC increased by 21.93%-40.90%, respectively; (3) Organic cultivation significantly increased enzyme activity in all three particle size aggregates and increased the relative abundance of bacteria in micro-aggregates as well as the relative abundance of fungi in small macro-aggregates. Structural equation model (SEM) analysis revealed that organic farming practices fostered the development of smaller macro-aggregates, elevated microbial and enzyme activities within soil aggregates, and facilitated the conversion of soil nutrients and carbon sequestration. consequently, this led to an increase in soil organic carbon content and improved vegetable yield in greenhouse environments. In conclusion, the soil carbon content and vegetable yield are enhanced through long-term organic cultivation in greenhouses, primarily by increasing the proportion of small macro-aggregates.

Preprint ARTICLE | doi:10.20944/preprints202403.1519.v1

Clinical Significance of the Immunohistochemical Expression of Histone Deacetylases (HDACs)-2, -4 and -5 in Ovarian Adenocarcinomas

Georgia Levidou, Dimitrios Arsenakis, Dimitrios I Bolovis, Roxanne Meyer, Cosima VM Brucker, Thomas Papadopoulos, Stamatios Theocharis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: HDAC; ovarial adenocarcinoma; immunohistochemistry; prognosis

Online: 26 March 2024 (06:47:57 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1410.v1

The Outcome of the Psychological and Therapeutical Care of Hospitalized COVID-19 Patients: National African Pilot Study

Yassine BENHADDOUCH, Nour ELhouda Fares, Soumaya BENMAAMAR, Youssef OUAZZANI HOUSNI TOUHAMI, Amine BOUT, Chadya AARAB, Said BOUJRAF, Rachid AALOUANE

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Anxiety; depression; post-traumatic stress; hydroxychloroquine; family support; intensive care

Online: 25 March 2024 (08:08:12 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1264.v1

Prevalence of Condom Use and Associated Factors among Undergraduate Students of Gulu University.

Brian Otim, Jerom Okot, Ritah Nantale, Winnie Kibone, Grace Madraa, Christopher Okot, Felix Bongomin

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Undergraduates; condom use; associated factors; Uganda

Online: 21 March 2024 (08:55:54 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0331.v1

Application of Optimal Scheduling for SAR Satellite Constellation: Multi-Imaging Mission in High-Density Regional Area

Kimoon Lee, Dongjin Kim, Daewon Chung, Seonho Lee

Subject: Engineering, Aerospace Engineering Keywords: Optimal scheduling; Synthetic Aperture Radar (SAR); Satellite constellation; Multi-imaging mission; High-density regional area; Modified Dynamic Programming (MDP)

Online: 6 March 2024 (07:13:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.0070.v1

Aggressiveness in Italian Children with ADHD: Maoa Gene Polymorphisms Involvement

Ludovico Neri, Beatrice Marziani, Pierluigi Sebastiani, Tiziana Del Beato, Alessia Colanardi, Maria Pia Legge, Anna Aureli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Aggressive behavior; MAOA; 5-HTT.

Online: 4 March 2024 (01:25:49 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202402.1559.v1

Enhancing Thermal Conductivity of CNT/AlN/Silicone Rubber Composites through Directly Grown CNTs on AlN for Reduced Filler Filling Ratio

Naoyuki Matsumoto, Don N. Futaba, Takeo Yamada, Ken Kokubo

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Carbon Nanotubes; Thermal conductivity; Aluminum Nitride; Chemical vapor deposition; Anti-hydrolysis; Mechanical property

Online: 27 February 2024 (14:42:29 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202402.0825.v1

Current Knowledge on the Use of Neuromonitoring in Thyroid Surgery

Beata Wojtczak, Karolina Sutkowska-Stępień, Mateusz Głód, Krzysztof Kaliszewski, Krzysztof Sutkowski, Marcin Barczyński

Subject: Medicine And Pharmacology, Surgery Keywords: recurrent laryngeal nerves; thyroid surgery; intraoperative nerve monitoring; vocal fold paresis

Online: 15 February 2024 (11:35:59 CET)

Show abstract| Download PDF| Share

Preprint CASE REPORT | doi:10.20944/preprints201701.0136.v1

Eco-Safety Assessment of Glyoxal-Containing Cellulose Ether on Freeze-Dried Microbial Strain, Cyanobacteria, Daphnia, and Zebrafish

Chang-Beom Park, Min Ju Song, Nak Woon Choi, Sunghoon Kim, Hyun Pyo Jeon, Sanghun Kim, Youngjun Kim

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Aquatic-toxic effects; EU chemical regulation; Glyoxal-containing cellulose ether

Online: 31 January 2017 (12:10:39 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201610.0044.v1

Using MODIS Data to Predict Regional Corn Yields

Ho-Young Ban, Kwang Soo Kim, No-Wook Park, Byun-Woo Lee

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: MODIS; yield; phenology; LAD; logistic function

Online: 13 October 2016 (04:40:10 CEST)

Show abstract| Download PDF| Share

A simple approach was developed to predict corn yields using the MoDerate Resolution Imaging Spectroradiometer (MODIS) data product from two geographically separate major corn crop production regions: Illinois, USA and Heilongjiang, China. The MOD09A1 data product, which are 8-day interval surface reflectance data, were obtained from day of the year (DOY) 89 to 337 to calculate the leaf area index (LAI). The sum of the LAI from early in the season to a given date in the season [end of DOY (EOD)] was well fitted to a logistic function and represented seasonal changes in leaf area duration (LAD). A simple phenology model was derived to estimate the dates of emergence and maturity using the logistic function parameters b1 and b2, which represented the rate of increase in LAI and the date of maximum LAI, respectively. The phenology model predicted emergence and maturity dates fairly well, with root mean square error (RMSE) values of 6.3 and 4.9 days for the validation dataset, respectively. Two simple linear regression models (YP and YF) were established using LAD as the variable to predict corn yield; the yield model (YP) used LAD from predicted emergence to maturity, and the yield model (YF) used LAD for a predetermined period from DOY 89 to a particular EOD. When state/province corn yields for the validation dataset were predicted at DOY 321, near completion of the corn harvest, the YP model performed much better than the YF model, with RMSE values of 0.68 t/ha and 0.66 t/ha for Illinois and Heilongjiang, respectively. The YP model showed a similar or better performance, even for the much earlier yield prediction at DOY 257, compared to that of the YF model. In conclusion, the phenology and yield models were developed based only on logistic changes in remote sensing-derived LAD, and predicted phenological dates and corn yields with considerable accuracy and precision for the two regions selected for this study. However, these models must be examined for spatial portability in more diverse agro-climatic regions.

Preprint ARTICLE | doi:10.20944/preprints201608.0189.v1

Promoting Effect of Inorganic Alkali on Carbon Dioxide Adsorption in Amine-Modified MCM-41

Yang Teng, Lijiao Li, Gang Xu, Kai Zhang, Kaixi Li

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: amine-modified MCM-41; CO2 adsorption; inorganic alkali; alkali amounts

Online: 22 August 2016 (05:47:02 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202410.1877.v1

Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook

Muneer Ahmed Khoso, Heng Liu, Tong Zhao, Wenjie Zhao, Qiang Huang, Zeqi Sun, Khuzin Dinislam, Mohammad Omar, Yong Zhang, Xin Liu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: cardiac aging; cardiac alterations; antioxidants; mechanism; reactive oxygen species

Online: 24 October 2024 (09:50:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202410.2399.v1

Aberrances of the Wound Healing Process: A Review

Montserrat Fernandez-Guarino, Jorge Naharro-Rodriguez, and Stefano Bacci

Subject: Life Sciences, Biology And Life Sciences Keywords: wound healing; acute wounds; chronic wounds; keloids; hyperthrofic scars

Online: 30 October 2024 (07:34:36 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202410.2107.v1

New Advances on the Dispersive and Polar Surface Properties of Poly(styrene-co-butadiene) using Inverse Gas Chromatography

Tayssir Hamieh

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Retention volume; adsorption; organic solvents; Hamieh thermal model; London dispersive interaction energy; deformation polarizability; Dispersive and polar surface energy; Lewis’ s acid– base constants; molecular separation distance

Online: 28 October 2024 (12:21:29 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202410.1069.v1

Simplified Gravity Load Collapse Dynamic Analysis of Old-Type Reinforced Concrete Frames

Konstantinos G. Megalooikonomou

Subject: Engineering, Civil Engineering Keywords: nonlinear dynamic analysis; collapse; axial and shear failures; reinforced concrete columns; one-component beam model

Online: 14 October 2024 (15:25:45 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202410.0840.v1

Differential Quadrature Free Vibration Analysis of Sandwich Plates with Curvilinear Fiber Variable Stiffness Composite Face Sheets

Zhenyu Zhou, Yi Liu

Subject: Engineering, Mechanical Engineering Keywords: Free vibration; sandwich plate; variable stiffness composite laminates; curvilinear fibers; differential quadrature method

Online: 11 October 2024 (09:42:07 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202409.1952.v1

Biomolecular Condensates of Interferon-Inducible Human and Murine Antiviral Mx Proteins

Pravin B. Sehgal

Subject: Biology And Life Sciences, Virology Keywords: interferon; myxovirus resistance proteins; MxA and Mx1; biomolecular condensates; metasability; rapidly reversible osmosensing; saliva-like hypotonicity; regulatory volume decrease (RVD); WNK-SPAK/OSR1 kinase pathway; oral antiviral defense

Online: 26 September 2024 (03:23:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0546.v3

Trans-eQTLs Can Be Used to Identify Tissue-Specific Gene Regulatory Networks

Majid Nikpay

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: trans-eQTLs; tissue specificity; gene regulatory network; scale-free network; Mendelian randomization

Online: 25 September 2024 (12:40:43 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202409.1337.v1

Exploring the Application of Advanced Chromatographic Methods to Characterize the Surface Physicochemical Properties and Transition Phenomena of Polystyrene-b-Poly(4-vinylpyridine)

Tayssir Hamieh

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Adsorption; London dispersion interaction; dispersive and polar free surface energy; enthalpy and entropy of adsorption; Hamieh thermal model; glass transition; Lewis’s acid-base surface energies

Online: 17 September 2024 (14:05:51 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0399.v4

Shale Compaction Kinetics: Parameter Sensitivity to a Range of Assumed Deposition Rates

James Edward Smith, Edward Millard Smith-Rowland

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: depositional model; shale compaction; kinetics; activation energy; pore interfaces; grain interfaces; fractals; experiment suggestions; model suggestions

Online: 16 September 2024 (10:24:15 CEST)

Show abstract| Download PDF| Share

Weathering and erosion transport minerals and organics toward the sea or lake bottoms over geologic time. The finest solids are deposited in lower, less turbulent areas, such as lake bottoms and continental shelves. They sometimes stack up to thicknesses of kilometers, and begin compacting. These sediment sections are called shales, and as initially deposited in water, shales can have porosities up to 50-80{\%} water, As they are buried, many alteration products from oil to slate are produced due to overburden and temperature increasess, making them important to study. A preceeding paper \cite{1} showed that pressure solution is the primary mechanism for porosity reduction, with possible mechanical compaction at shallow depths. Without naming the mineral(s) involved, it postulated that the greater the product of the water and pore interfaces, the faster the reaction would proceed. This term is $ \varphi^{4m/3}(1-\varphi)^{4n/3}$ , where $\varphi$ is porosity and m and n are numbers close to unity. The large exponents, {\em 4/3}, recognize that the reaction occurs at the molecular scale at which the surfaces are rough. A second term, $\exp^{(-E/RT)}$ , indicates that the reaction is impeded by a quantum energy barrier, E, with diminished impeding power as increased available thermal energy, represented by the absolute temperature, T, becomes available at greater depths in the Earth. These two factors combine to allow porosity $\varphi$ to reduce with time, or equivalently for the fraction of solids, $(1-\varphi)$, to increase with time,$\left. \frac{\partial(ln(1-\varphi) ) }{\partial t } \right |_{\sigma} = (\varphi )^{4m/3}( 1-\varphi )^{4n/3}Ae^{-E/(RT)}$. { \em Here it is shown that this equation can cover quantitatively any actual deposition rates which may have been experienced by the six sections studied, the actual deposition rates being unknown for these cases. Hence a time-depth depositional history for any new shale section, known in detail, would allow determination of the parameters m, n, E and a lumped proportionality constant A. This was accomplished by showing that, for a wide range of depositional rates, r, the range of E for any of the studied sections is small compared to laboratory measurements of quartz solution\cite{2}, 24+-15kJ/mol. Results were obtained over this range of r's using the previously determined m and n, and porosity and temperature profiles. The presently existing porosity profiles necessarily incorporate any overpressure or underpressure conditions that may have existed in the past or currently, as the net difference between overburden and pore pressure is a primary driving force for pressure solution. $SiO_2$ usually comprises 20-50{\%} of shales. In conclusion, pressure solution of quartz can account for vertical compaction of shales quantitatively in the studied examples. Separately, a quasi-eqivalent method for discussing reduced porosities in Macron 2 versus Macron 1 as increased vertical stress, rather than additional horizontal stress, is illustrated. Experiments are suggested to clarify the pressure solution mechanism. The role of horizontal forces is discussed. From a global point of view, shale compaction by pressure solution is a quantified step in the cycling of continental rocks, beginning with rifting.

Preprint ARTICLE | doi:10.20944/preprints202409.0125.v1

Evaluation of the Use of Cell Lines in Studies of Selenium‐Dependent Glutathione Peroxidase 2 (GPX2) Involvement in Colorectal Cancer

R Steven Esworthy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: selenium‐dependent glutathione peroxidase; peroxiredoxins; NADPH oxidase 1; colorectal cancer; cell lines; public databases

Online: 2 September 2024 (16:41:50 CEST)

Show abstract| Download PDF| Share

Hydroperoxides (ROOH) are known as damaging agents capable of mediating mutation, while a role as signaling agents through oxidation of protein sulfhydryls that can alter cancer-related pathways has gained traction. Glutathione peroxidase 2 (GPX2) is an antioxidant enzyme that reduces ROOH at the expense of glutathione (GSH). GPX2 is noted for a tendency of large in-creases or decreases in expression levels during tumorigenesis that leads to investigators focusing on its role in cancer. However, GPX2 is only one component of multiple enzyme families that metabolize ROOH and GPX2 levels are often very low in the context of these other ROOH reducing activities. Colorectal cancer (CRC) was selected as a case study for examining GPX2 function as colorectal tissues and cancers are sites where GPX2 is highly expressed. A case can be made for a significant impact of changes in expression levels. There is also a link between GPX2 and NADPH oxidase 1 (NOX1) from earlier studies that is seldom addressed and is discussed, presenting data on a unique association in colon and CRC. Tumor-derived cell lines are quite commonly used for pre-clinical studies involving the role of GPX2 in CRC. Generally, selection for this type of work is limited to identifying cell lines based on high and low GPX2 expression with the standard re-search scheme of overexpression in low expressing lines and suppression in high expressing lines to identify impacted pathways. This overlooks CRC subtypes among cell lines involving a wide range of gene expression profiles and a variety of driver mutation differences along with a large difference in GPX2 expression levels. A trend for low and high GPX2 expressing cell lines to segregate into different CRC subclasses, indicated in this report, suggests that choices based solely on GPX2 levels may provide misleading and conflicting results by disregarding other properties of cell lines and failing to factor in differences in potential protein targets of ROOH. CRC and cell line classification schemes are presented here that were intended to assist workers in performing pre-clinical studies but are largely unnoted in work on GPX2 and CRC. Studies are often initiated on the premise that the transition from normal to CRC is associated with up-regulation of GPX2. This is probably correct. However, the source normal cells for CRC could be almost any colon cell type, some with very high GPX2 levels. These factors are addressed in this study.

Preprint REVIEW | doi:10.20944/preprints202408.1584.v1

Telomere Length and Telomerase in Post-Traumatic Stress Disorder: An Update and a Reappraisal of the Evidence

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: post-traumatic stress disorder; trauma; stress; telomere length; telomerase; aging

Online: 22 August 2024 (12:21:44 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.1328.v1

Degree of Hydration, Microstructure, and Mechanical Properties of Cement-Modified TiO2 Nanoparticles

Young-Cheol Choi

Subject: Engineering, Civil Engineering Keywords: compressive strength; hydration degree; nucleation site; setting time; TiO₂ powder

Online: 19 August 2024 (11:11:13 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202408.0785.v1

Spectral Reflectance Estimation from Camera Response Using Local Optimal Dataset and Neural Networks

Shoji Tominaga, Hideaki Sakai

Subject: Computer Science And Mathematics, Computer Science Keywords: surface-spectral reflectance; reflectance estimation; multispectral imaging; local optimal dataset; neural network; training-based approach; model-based approach

Online: 12 August 2024 (10:19:13 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0835.v3

Combination Therapy in Hypertension: Renin-Angiotensin-Aldosterone System Inhibitor with a Diuretic or Calcium Channel Blocker

Md. Arafat Hossain

Subject: Biology And Life Sciences, Life Sciences Keywords: Hypertension; calcium channel blocker; combination therapy; thiazide diuretics; Renin-angiotensin-aldosterone system inhibitor

Online: 25 July 2024 (00:11:59 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0663.v1

Combining KAN with CNN: KonvNeXt's Performance in Remote Sensing and Patent Insights

Minjong Cheon, Changbae Mun

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: ConvNeXt; Kolmogorov-Arnold Network (KAN); KonvNeXt; Occlusion Sensitivity; Remote Sensing, Satellite Technology

Online: 9 July 2024 (13:05:07 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202407.0350.v1

Experience Teaching Mathematics at the University of Defence in the Study Field of Cybersecurity

Radovan Potůček

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: University of Defence; Faculty of Military Technology; Cybersecurity study program; teaching mathematics; teaching graph theory; semester exam; classified credit test, thematic units; exam evaluation.

Online: 4 July 2024 (07:01:11 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202406.0537.v1

CRISPR RNA-Guided Gene Editing and its Clinical Research Applications in Hematology with Focus on Inherited Germline Predisposition to Hematologic Malignancies

Rina Kansal

Subject: Medicine And Pharmacology, Hematology Keywords: CRISPR-Cas; gene editing; gene therapy; hematology; inherited germline predisposition to cancer; bone marrow failure; acute myeloid leukemia; myelodysplastic syndromes; myeloid neoplasms; DNA repair

Online: 10 June 2024 (08:39:04 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1631.v1

Thermal Surface Properties, London Dispersive and Polar Sur-face Energy of Graphene and Carbon Materials by Inverse Gas Chromatography at Infinite Dilution

Tayssir Hamieh

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: London dispersion equation; Hamieh thermal model; Thermal conductivity; London dispersive and polar surface energy; Lewis’ s acid– base constants; coupling amphoteric constant; average separation distance between particles; acid and base surface energy

Online: 24 May 2024 (11:56:52 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1582.v1

An Overview of the Arguments in Literature, For and Against the Use of Green Hydrogen for the Production of Direct Reduced Iron

Göran Roos

Subject: Business, Economics And Management, Business And Management Keywords: Green hydrogen; Direct Reduced Iron (DRI); Decarbonisation; Steel industry; Carbon Capture and Storage (CCS); Renewable energy; Electrolysis; Energy efficiency; Geopolitical implications; Social acceptance

Online: 23 May 2024 (16:45:11 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202405.1180.v1

Fractional Operators and Fractionally Integrated Random Fields on Z

Donatas Surgailis, Vytautė Pilipauskaitė

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: fractional differentiation/integration operators; tempered fractional operators; fractional random field; random walk; limit theorems; long-range dependence; negative dependence; conditional autoregression

Online: 21 May 2024 (10:34:48 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0722.v1

Borrajo Ana

Subject: Biology And Life Sciences, Life Sciences Keywords: Microglia; Neurodegenetrative diseases; Aging; inflammation; Oxidative stress

Online: 13 May 2024 (11:43:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1862.v1

A Systemic Model for Resilience and Time Management in Healthcare Academia

Maria Antoniadou, Rallis Antoniadis

Subject: Business, Economics And Management, Business And Management Keywords: Systemic approach; systems management; academia; academicians; time management; procrastination; prioritization; perfectionism; timewasters; systemic tools

Online: 29 April 2024 (10:25:02 CEST)

Show abstract| Download PDF| Share

Academics in healthcare grapple with the challenge of efficiently managing time while addressing diverse roles and responsibilities, leading to heightened levels of anxiety and stress within the academic community. The primary objective of this study is to offer a sustainable and systemic solution to the prevalent time-management challenges in healthcare academia, through the development of a predictive model. Employing systemic analysis software and adopting a systemic management approach, we crafted a model to address academic time-management concerns. The dynamics of time allocation for academicians are governed by three fundamental pillars: teaching, research, and administrative tasks. Significantly prioritizing administrative tasks depletes valuable academic time, making time management within academia excessively costly. This occurs as highly skilled individuals find themselves diverted towards administrative duties at the expense of their academic roles diminishing resilience levels. The proposed Timebooster Academic Systemic Model (TASM) advocates for the cultivation of soft skills in academia, en-compassing prioritization, seeking assistance, and addressing tendencies of perfectionism and procrastination. Additionally, TASM recommends the implementation of full automation, delegation of administrative responsibilities, and the mitigation of both overt and covert time-consuming elements. Furthermore, TASM reports on the pivotal role of the academic resilient manager-leaders, who actively contribute to their own satisfaction and academic growth by enhancing collaboration and teamwork. Time-management challenges emerge as a critical determinant of academic well-being and resilience. Systemic models, exemplified by TASM, offer a valuable framework for investigating prioritization concerns, identifying administrative impediments in academic processes, and managing low-value time-consuming elements. The TASM model, along with the systemic philosophy underpinning its design, presents an avenue for advancing the exploration of time-management phenomena within the context of healthcare academia.

Preprint ARTICLE | doi:10.20944/preprints202404.1469.v1

The Effect of Temperature on the London Dispersive and Lewis Acid-base Surface Energies of Poly Methyl Methacrylate Adsorbed on Silica by Inverse Gas Chromatography

Tayssir Hamieh

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Hamieh thermal effect; London dispersive surface energy; polar surface energy; recovery fraction; transition temperatures

Online: 23 April 2024 (11:24:45 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0941.v1

A Method for Identifying Proper Noun Derivative Semantic Relationships for Geographic Entities

Liu Hanyou, Wang Jizhou

Subject: Environmental And Earth Sciences, Geography Keywords: derivation relationship of proper nouns between toponyms; proper nouns derive toponym; extraction of derivatives of proper nouns; the morphological characteristics of toponym; spatial and temporal distribution characteristics of toponym

Online: 15 April 2024 (10:45:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.0863.v1

Effect of Tacticity on London Dispersive Surface Energy, Polar Free Energy, and Lewis Acid-Base Surface Energies of Poly Methyl Methacrylate by Inverse Gas Chromatography

Tayssir Hamieh

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: PMMA tacticity; London dispersive surface energy; Lewis’ s acid-base parameters, transition temperatures; intermolecular separation distance; acid-base surface energy

Online: 14 April 2024 (17:11:14 CEST)

Show abstract| Download PDF| Supplementary Files| Share

This research was devoted to study the effect of the tacticity of PMMA on the surface physicochemical properties such as the London dispersive component of the surface energy of the polymer, the polar and dispersive free energies, the Lewis’s acid-base surface parameters, and the Lewis acid and base surface energies of atactic, isotactic and syndiotactic PMMAs as a function of the temperature. Inverse gas chromatography (IGC) at infinite dilution was used to determine the surface thermodynamic properties of PMMA at different tacticities. The experimental values of the net retention time and volume of model organic molecules adsorbed on the atactic, isotactic and syndiotactic PMMAs, were obtained by IGC technique at infinite dilution. The London dispersion interaction energy was used for the separation of the polar and dispersive energy of the different n-alkanes and polar solvents adsorbed on the different PMMA surfaces. The London dispersive surface energy γ_s^d (T) of PMMAs was determined by applying the Hamieh thermal model that took into account the effect of the temperature on the surface area of adsorbed molecules. The obtained results showed non-linear variations of γ_s^d (T) of atactic, isotactic, and syndiotactic PMMAs with three maxima characterizing the three transition temperatures of PMMAs, T_g, T_g and T_(liq-liq) with a shift of these temperatures with the isotactic and syndiotactic PMMAs. It was showed that the polar interaction free energy ∆G_a^p (T) also showed the presence of the three above transition temperatures of the polymers. The study showed an important non-linearity variation of the different acid-base parameters in the various polymer surfaces proving the highest effect of the temperature and the tacticity on these parameters. The determination of the enthalpic and entropic Lewis’s acid-base parameters showed an amphoteric character for the different PMMAs. The basicity of the atactic PMMA was about four times larger than its acidity outside the neighborhood of the transition temperatures of the polymer. Whereas, the isotactic PMMA was about 2 to 2.5 times more basic than acid, while the syndiotactic PMMA exhibited the highest basicity by showing a surface 5 to 8 times more basic than acid. However, the Lewis acid-base parameters strongly depended on the temperature and sudden variations of these surface parameters were observed around the transition temperatures largely depending on the PMMA tacticity. The determination of the polar acid and base surface energies of the three PMMAs led to the same previous transition temperatures with an important effect of the tacticity of PMMA on the values of these acid-base surface energies.

Preprint ARTICLE | doi:10.20944/preprints202404.0430.v1

Landauer Bound in the Context of Minimal Physical Principles: Meaning, Experimental Verification, Controversies and Perspectives

Edward Bormashenko

Subject: Physical Sciences, Theoretical Physics Keywords: Landauer Principle; entropy; Abbe Limit; Margolus-Levitin limit; Bekenstein limit; Planck-Boltzmann time; Szcilard Engine

Online: 5 April 2024 (10:48:04 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1454.v1

Assessing the Degree of Social Responsibility Integration in Socially Responsible Public Procurement in Korea

Manki Kim, Sona Shin

Subject: Business, Economics And Management, Other Keywords: sustainable public procurement(SPP); Environment Social and Governance(ESG); south Korea; KONEPS platform

Online: 25 March 2024 (08:41:02 CET)

Show abstract| Download PDF| Share

This study delves into the critical domain of public procurement, specifically focusing on Sustainable Public Procurement (SPP) and Environmental, Social, and Governance (ESG) considerations within the context of South Korea. The aim of this research is to empirically scrutinize the factors influencing the impact index of SPP, with a particular emphasis on services related to labor standards. The investigation spans three years, from January 1, 2019, to July 31, 2021, encompassing state agency orders and post-implementation legal changes. Leveraging the comprehensive Korea On-line E-Procurement Sys-tem(KONEPS) platform, we meticulously collected data, ultimately culminating in 21,573 services meeting our criteria, from which 250 cases underwent an in-depth analysis. The study sheds light on the influence of social responsibility evaluation cri-teria on overall procurement scores, while also uncovering the moderating effects of various factors. The outcomes of this study offer valuable insights into the impact index of social responsibility evaluation criteria within South Korea's public procurement landscape. Factors including procurement year, classification, service period, and estimated price were identified as significant influencers. Moreover, the number and location of evalu-ation criteria items, inclusion of sincerity elements, and the evaluating agency were deemed pivotal determinants of the influence index. These findings hold profound implications for policymakers, procurement practitioners, and researchers and provide a roadmap for optimizing the utilization of social responsibility evaluation criteria to advance responsible and sustainable procurement practices. Future research avenues include conducting further study of additional moderat-ing variables, expanding datasets to encompass a broader spectrum of procurement contexts, and evaluating the long-term repercussions of social responsibility evaluation on procurement outcomes. These endeavors promise to further refine and advance public procurement practices in South Korea and beyond.

Search Results

40631 articles found