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Preprint ARTICLE | doi:10.20944/preprints202405.0734.v1

Electronic Logistic Management Information System in Public Health Facilities and its Implications for the Medicine Supply Chain in Singida District Council, Tanzania

Anwar Milulu, Stanley Mwita, Namanya Basinda

Subject: Public Health And Healthcare, Health Policy And Services Keywords: Electronic Logistics Management Information System; Health Facilities; Medicine Supply Chain; Tanzania

Online: 12 May 2024 (07:44:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0323.v1

Molecular Composition of Exogenous Dissolved Organic Matter Regulates Dissimilatory Iron Reduction and Carbon Emissions in Paddy Soil

Haibo Wang, XiPeng Liu, Yuchen Shu, Gang Li, ChengLiang Sun, Davey Jones, YongGuan Zhu, Xianyong Lin

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Greenhouse gas emissions; Biochar; Dissimilatory iron reduction; C sequestration; Organic amendments; Soil microbiome

Online: 4 September 2024 (12:04:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1735.v1

Co-management Effects on Forest Restoration in Protected Areas of Bangladesh: A Remote Sensing and GIS-based Analysis

Md Rezaul Karim, Md Abdul Halim, Imrul Kayes, Wenxi Liao, Sharif A. Mukul, Tuihedur Rahman, Sean Thomas

Subject: Biology And Life Sciences, Forestry Keywords: Co-management; protected area; vegetation cover; vegetation indices; tropical forest; Bangladesh

Online: 23 August 2024 (13:31:33 CEST)

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Co-management is increasingly recognized as an effective approach of forest governance while recognizing local people's forest dependency and traditional rights. Moreover, co-management is expected to positively impact forest cover and ecosystem health. Bangladesh, facing a rapid decline in forest cover, has one of the lowest per capita forest areas worldwide. For quite a while, co-management practices have been used to improve forest cover and the livelihoods of forest-dependent people in Bangladesh. Several studies have assessed the efficacy of co-management in different protected areas in Bangladesh from livelihood, social, and cultural aspects. However, the overall changes in forest cover due to co-management from the very beginning of co-management initiatives in the country have been overlooked. We used remotely sensed Landsat images to assess the changes in forest cover and overall land use in five forest protected areas where co-management was piloted. Three major vegetation indices (NDVI, EVI, and MSAVI) were examined to ensure the study's robustness. This study aims to assess the scope and weaknesses of the current policy that incorporates co-management in the country's first five protected areas (SNP, LNP, RKWS, TWS, and CWS), which were brought under co-management in 2003, and compare the efficacy of the co-management relative to non-comanaged protected areas (RRF). The land cover analysis based on NDVI, MSAVI, and EVI values indicated dominant dense forest coverage (41–71%) across five protected areas. During the co-management period (2004–2015), there was a significant decrease in the dense forest proportion, with slopes ranging from -3.7 to -0.96. Similarly, the RRF showed a decreasing pattern, with the slope of the decreasing trendline ranging from -0.48 to -0.62 across the three indices. Agriculture and forest-agriculture mosaics showed a significant increase, with varying slopes among protected areas in both co-managed and non-comanaged sites. Pixel-to-pixel changes revealed dynamic shifts in vegetation indices, and Global Forest Watch data highlighted forest cover losses, notably in CWS (158.77 ha) and SNP (0.49 ha).

Preprint ARTICLE | doi:10.20944/preprints202406.1260.v1

Role of Pre-harvest Sorbitol-Calcium Treatments in Controlling Berry Drop in Bagged Table Grapes of the "Doña María" Variety

Alberto Guirao, Juan Miguel Valverde, Huertas María Díaz-Mula, Daniel Valero, María Serrano, Domingo Martínez-Romero

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Vitis vinífera, polyol, postharvest, shattering, ABA, MDA, organic acids, polyphenols; sugars

Online: 18 June 2024 (12:28:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1993.v1

Banana Lectin: A Novel Immunomodulatory Strategy for Mitigating Inflammatory Bowel Disease

Radmila Miljkovic, Emilija Marinkovic, Ivana Lukic, Ana Kovacevic, Mina Popovic, Zorana Lopandić, Marija Gavrovic-Jankulovic, Irma Schabussova, Aleksandra Inic-Kanada, Marijana Stojanovic

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: banana lectin; inflammatory bowel diseases; anti-inflammatory activity; vaccination; prevention

Online: 30 April 2024 (11:38:48 CEST)

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Compared to the general population, patients with inflammatory bowel disease (IBD) are less likely to be vaccinated, putting them at an increased risk of vaccine-preventable illnesses. This risk is further compounded by the immunosuppressive therapies commonly used in IBD management. Therefore, developing new treatments for IBD that maintain immune function is crucial, as successful management can lead to better vaccination outcomes and overall health for these patients. Here, we investigate the potential of recombinant banana lectin (rBanLec) as a supporting therapeutic measure to improve IBD control and possibly increase vaccination rates among IBD patients. By examining the therapeutic efficacy of rBanLec in a murine model of experimental colitis, we aim to lay the foundation for its application in improving vaccination outcomes. After inducing experimental colitis in C57BL/6 and BALB/c mice with 2,4,6-trinitrobenzene sulfonic acid, we treated animals orally with varying doses of rBanLec 0.1-10 µg/ml (0.01 – 1 µg/dose) during the course of the disease. We assessed the severity of colitis and rBanLec’s modulation of the immune response compared to control groups. rBanLec administration resulted in a dose-dependent reduction in colitis severity (less pronounced weight loss, less shortening of the colon) and an improved recovery profile, highlighting its therapeutic potential. Notably, rBanLec-treated mice exhibited significant modulation of the immune response, favoring anti-inflammatory pathways (primarily reduction in a local [TNFα]/[IL-10]) crucial for effective vaccination. Our findings suggest that rBanLec could mitigate the adverse effects of immunosuppressive therapy on vaccine responsiveness in IBD patients. By improving the underlying immune response, rBanLec may increase the efficacy of vaccinations, offering a dual benefit of disease management and prevention of vaccine-preventable illnesses. Further studies are required to translate these findings into clinical practice.

Preprint ARTICLE | doi:10.20944/preprints202403.1359.v1

Efficient Pipeline Conflict Resolution for Layered QC-LDPC Decoders in OFDM-PON

Zhijie Wang, Zhengjun Xu, Kun Chen, Yuanzhe Qu, Xiaoqun Liu, Yingchun Li, Junjie Zhang

Subject: Engineering, Electrical And Electronic Engineering Keywords: QC-LDPC; pipeline conflicts; patch method; variable-to-check message; OFDM-PON

Online: 22 March 2024 (09:21:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0551.v1

Depressive Symptoms and Gut Microbiota after Bowel Preparation and Colonoscopy: A Pre-post Intervention Study

Amelia McGuinness, Martin O'Hely, Douglas Stupart, David Watters, Samantha Dawson, Christopher Hair, Michael Berk, Mohammadreza Mohebbi, Amy Loughman, Glenn Guest, Felice Jacka

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Gut microbiota; colonoscopy; bowel preparation; depression; microbiota-gut-brain axis; mental health; psychiatry; gastroenterology. ;

Online: 11 March 2024 (09:45:31 CET)

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Objective: Mechanical bowel preparation is essential for the visualisation of the colon during colonoscopy, and previous studies have identified changes in gut microbiota composition after bowel preparation and colonoscopy. Considering the gut microbiota is increasingly implicated in mood, we aimed to explore the potential impact of this intervention on mood and the microbiota-gut-brain axis. Methods: We conducted a pre-post intervention study, with timepoints of one week before and one month after bowel preparation and colonoscopy, in community-dwelling adults referred for colonoscopy. Our primary outcome was change in average Hospital Anxiety and Depression Scale depression sub-scores using generalised estimating equations. We also examined changes in average anxiety, stress, and quality of life scores, and faecal microbiota composition and potential function using 16S rRNA sequencing. We further explored associations between changes in depressive symptoms and the gut microbiota and conducted post-hoc analyses to explore potential effect modifiers. Key Results: 59 participants were included in the analyses. Depressive symptoms decreased one-month post-procedure compared to baseline (adjusted β=−0.64; 95%CI: −1.18, −0.11). Irritable bowel syndrome (IBS) appeared to moderate this relationship (1.78; 0.292, 3.26); depressive symptoms increased in those with, and decreased in those without, IBS. Changes in gut microbiome composition included reduced alpha diversity, modest effects on beta-diversity, and increases in genera associated with potential health benefits, one-month post-procedure compared to baseline. Increases in the CLR-transformed abundance of Ruminococcaceae UCG-009 were associated with improvements in depressive symptoms. Conclusions: There is preliminary evidence of a potential mental health effect of bowel preparation and colonoscopy, which may be associated with changes to the gut microbiota. There may also be a differential mental health impact of this procedure for those with and without IBS. Considering the limitations of our study, further research is required to confirm these findings and their clinical relevance.

Preprint ARTICLE | doi:10.20944/preprints202408.1829.v1

A New NDSA (Normalized Differential Spectral Attenuation) Measurement Campaign for Estimating Water Vapor along a Radio Link

Luca Facheris, Fabrizio Cuccoli, Ugo Cortesi, Samuele del Bianco, Marco Gai, Giovanni Macelloni, Francesco Montomoli

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: microwaves; water vapor; troposphere; differential attenuation

Online: 27 August 2024 (02:50:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1063.v1

Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4+ T-Cells to Infiltrate the Colonic Mucosa

Javier Campos, Francisco Osorio-Barrios, Felipe Villanelo, Sebastian E. Gutierrez-Maldonado, Pablo Vargas, Tomas Perez-Acle, Rodrigo Pacheco

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Dopamine; chemokines; T cell migration

Online: 14 August 2024 (16:40:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0463.v1

Development and Validation of a Combined RT-LAMP Assay for the Rapid and Sensitive Detection of Dengue Virus in Clinical Samples from Colombia

Katherine Escorcia-Lindo, Leidy Hurtado-Gómez, Juan Sebastian Rosero, Nataly Solano Llanos, Camilo Barrios Sánchez, Anderson Diaz Pérez, Yirys Díaz-Olmos, Jennifer García, Yesit Bello-Lemus, Leonardo C Pacheco-Londoño, Antonio J. Acosta-Hoyos, Lisandro A Pacheco-Lugo

Subject: Biology And Life Sciences, Life Sciences Keywords: RT-LAMP; Dengue virus (DENV); Sensitivity; Point-of-Care

Online: 5 September 2024 (12:37:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1291.v1

Emotional Impact of COVID-19 and Emotional Eating and the Risk of Alcohol Use Disorder in Healthcare Students

Jhon Alex Zeladita-Huaman, Juan Pablo Aparco, Eduardo Franco-Chalco, Luz Nateros-Porras, Sonia Tejada-Muñoz, Denices Abarca-Fernandez, Iris Jara-Huayta, Roberto Zegarra-Chapoñan

Subject: Public Health And Healthcare, Other Keywords: depression; mental health; COVID-19; alcohol drinking; health occupations students

Online: 16 July 2024 (13:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0758.v1

Exogenous Melatonin Improves Oocyte Competence and Blastocyst Development in Indigenous Donor Cattle During Summer

Anupama Solanki, Hitesh Jangra, Pradeep Saini, Sandeep Kumar, Ramakant Kaushik, Meenakshi Virmani, Vinay Ganeshrao Joshi, Rajesh Kumar, Rahul Verma, Kushal Grakh, Satish Kognole, Yogesh Bangar, Anand Kumar Pandey

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: blastocyst development; donor cow; melatonin; oocyte competence; Sahiwal cattle; summer

Online: 12 August 2024 (05:27:45 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.2099.v1

Acylcarnitine Profiling in Meningiomas with Different NF2 Mutation Status

Joanna Bogusiewicz, Jacek Furtak, Marcin Birski, Krystyna Soszyńska, Anna Majdańska, Agata Ryfa, Marek Harat, Barbara Bojko

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: acylcarnitine; solid-phase microextraction; meningioma; merlin; NF2

Online: 31 May 2024 (08:51:40 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202402.1691.v1

Central Line-Associated Bloodstream Infection Due to Elizabethkingia anophelis: Case Report and Literature Review on Pediatric Infections

Sophia Maraki, Nikolaos Katzilakis, Ioannis Neonakis, Dimitra Stafylaki, Viktoria Eirini Mavromanolaki, Ioannis Kyriakidis, Iordanis Pelagiadis, Eftychia Stiakaki

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Elizabethkingia anophelis; pediatric infections; neonate; identification; antimicrobial susceptibility

Online: 29 February 2024 (10:38:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0725.v1

Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review

Małgorzata Kulesa-Mrowiecka, Anna Lipowicz, Bożena Anna Marszałek-Kruk, Damian Kania, Wojciech Wolański, Andrzej Myśliwiec, Krzysztof Dowgierd

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: cleft lip and palate; aethiology; rehabilitation; risk factors

Online: 13 February 2024 (08:25:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0529.v1

Hydrocarbon Reservoir Characterization in the Challenging Structural Setting of Southern Gulf of Suez: Synergistic Approach of Well Log Analyses and 2D Seismic Data Interpretation

Mohamed Reda, Taher Mostafa, Abdelmoneam Raef, Mohamed Fathy, Fahad Alshehri, Mohamed Ahmed

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: seismic interpretation; well-log analysis; 3D structural model; Miocene reservoir modeling; Ras Ghara oil field; prospect evaluation

Online: 8 January 2024 (11:16:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1846.v1

Time Series Analysis of Water Quality Factors Enhancing Harmful Algal Blooms (HABs): A Study Integrating In-Situ and Satellite Data, Vaal Dam, South Africa

Altayeb A. Obaid, Elhadi Adam, K. Adem Ali, Tamiru A. Abiye

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Vaal Dam; Time Series; Chlorophyll-a; Harmful Algal Blooms

Online: 26 December 2023 (02:52:18 CET)

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The Vaal Dam catchment, which is the source of potable water for Gauteng province, holds various human activities including mining, urbanization, agricultural and industrial activities coupled with high fluxes of nutrients from different areas within the catchment. This situation led to an enhancement of Harmful Algal Blooms (HABs) in the dam reservoir. Phosphorus and Nitrogen are the limiting nutrients for HABs in many eutrophic aquatic systems when their concentrations are raised in such waters. In this study, multi-time-series plot types and scutter plots were analysed to reveal the relationship between HABs proxy chlorophyll-a (Chl-a) and the potential nutrients. Also (Chl-a) data extracted from landsat-8 satellite images were visualised to show the spatial distribution of HABs in the reservoir. The results showed that the Vaal Dam HABs productivity is a function of the total phosphorus (TP) and the organic nitrogen (KJEL_N) levels, which were positively correlated with chlorophyll-a (Chl-a) concentration. The long-term analysis of Chl-a in-situ data (1986 – 2022) measured at one point within the reservoir showed an average of 11.25μg/l but at some stochastic dates, the Chl-a concentration jumped to very high values reaching the maximum value of 452.8μg/l. Such high values are associated with high records of TP and KJEL_N concentrations at the same dates which clearly reveals their effect on the productivity levels. The decadal time series and its trend analysis showed that the average productivity level of Chl-a increased during the studded period from 4.75μg/l in the first decade (1990 – 2000) to 10.51μg/l in the second decade (2000 – 2010) reaching 16.7 during the last decade (2010 – 2020). The increasing averages of the decadal values are associated with the increasing decadal average of its driving factors, TP from 0.1043 to 0.1096 to 0.1119mg/l for the three decades, respectively and KJEL_N from 0.80mg/l in the first decade to 1.14mg/l in the last decade. The decadal average of temperature showed no significant increase, 17.9 °C in the first decade and 18 °C in the last decade which suggests that temperature is not the only enhancing factor of the HABs productivity in the Vaal Dam. The satellite data analysis during the last decade revealed that the HABs spatial dynamics is a function of the dam geometry and the levels of the discharges from its two feeding rivers. Higher concentrations were observed where the reservoir is meandering and within the areas of restricted water circulation.

Preprint ARTICLE | doi:10.20944/preprints202311.0661.v1

Survival and Recurrence of Endocarditis Following Mechanical vs. Biological Aortic Valve Replacement in Patients Aged 40 to 65 Years: Data from the INFECT-REGISTRY

Antonio Salsano, Michele Di Mauro, Laura Labate, Alessandro Della Corte, Federica Lo Presti, Michele De Bonis, Cinzia Trumello, Mauro Rinaldi, Erik Cura Stura, Guglielmo Actis Dato, Giuseppe Punta, Francesco Nicolini, Davide Carino, Carlo De Vincentiis, Andrea Garatti, Giangiuseppe Cappabianca, Andrea M Musazzi, Diego Cugola, Maurizio Merlo, Davide Pacini, Gianluca Folesani, Sandro Sponga, Igor Vendramin, Alberto Pilozzi Casado, Francesco Rosato, Elisa Mikus, Carlo Savini, Francesco Onorati, Giovanni Battista Luciani, Roberto Scrofani, Francesco Epifani, Francesco Musumeci, Antonio Lio, Andrea Colli, Giosuè Falcetta, Salvatore Nicolardi, Salvatore Zaccaria, Enrico Vizzardi, Antonio Pantaleo, Giuseppe Minniti, Emmanuel Villa, Margherita Dalla Tomba, Francesco Pollari, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Francesco Santini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: endocarditis; aortic valve replacement; prosthetic heart valve.

Online: 9 November 2023 (15:01:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1051.v1

The Influence of Mineral NPK Fertilizer Rates and Their Ratio on Potassium Dynamics in Soil: Data from a Long-Term Agricultural Plant Fertilization Experiment

Jonas Arbačauskas, Zigmas Jonas Vaišvila, Gediminas Staugaitis, Lina Žičkienė, Aistė Masevičienė, Donatas Šumskis

Subject: Environmental And Earth Sciences, Soil Science Keywords: potassium fertilizers; nutrient interaction; metabolizable energy; balance; soil

Online: 15 September 2023 (09:36:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1573.v1

AI Will Change EA Practice – but Are We Ready for It? A Call for Discussion Based on Developments in Collecting and Processing Biodiversity Data

Robin Sandfort, Birthe Uhlhorn, Gesa Geissler, Ivar Lyhne, Alexandra Jiricka-Pürrer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Artificial intelligence; environmental impact assessment; strategic environmental assessment; biodiversity; digitalisation

Online: 24 July 2023 (08:46:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0024.v1

Association between Serum High-Density Lipoprotein Cholesterol and Hypertension: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (Kitchen-9)

Kei Nakajima, Manami Igata, Kotone Tanaka, Ryoko Higuchi, Kaori Mizusawa, Teiji Nakamura

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: high-density lipoprotein cholesterol; hypertension; blood pressure; low high-density lipoprotein cholesterol; extremely high high-density lipoprotein cholesterol; body mass index; big data

Online: 1 July 2021 (11:53:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0595.v1

Estimating the Total Number of Residential Fire-Related Incidents and Underreported Residential-Fire Incidents in New South Wales, Australia by Using Linked Administrative Data

Nargess Ghassempour, W. Kathy Tannous, Gulay Avsar, Kingsley E. Agho, Lara A. Harvey

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Residential Fire; Linked Data; Health Economics; Epidemiology

Online: 24 June 2021 (08:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0019.v1

Simulation of Organic Liquid Products Deoxygenation by Multistage Countercurrent Absorber/Stripping Using CO2 as Solvent with Aspen-Hysys: Thermodynamic Data Basis and EOS Modeling

Elinéia Castro Costa, Welisson de Araújo Silva, Eduardo Gama Ortiz Menezes, Marcilene Paiva Silva, Vânia Maria Borges Cunha, Andréia de Andrade Mâncio, Marcelo Costa Santos, Sílvio Alex Pereira da Mota, Marilena Emmi Araújo, Nélio Teixeira Machado

Subject: Engineering, Automotive Engineering Keywords: OLP; Thermodynamic Data Basis; EOS Modeling; Process Simulation; Aspen-Hysys

Online: 4 May 2021 (13:49:18 CEST)

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In this work, the thermodynamic data basis and EOS modeling necessary to simulate the fractionation of organic liquid products (OLP), a liquid reaction product obtained by thermal catalytic cracking of palm oil at 450ºC, 1.0 atmosphere, with 10% (wt.) Na2CO3 as catalyst, in multistage countercurrent absorber/stripping columns using SC-CO2 as solvent, with Aspen-Hysys was systematically investigated. The chemical composition of OLP was used to predict the physical (), thermo-physical properties (Tb, Tc, Pc, Vc), and acentric factor () of all the compounds present in OLP by applying the group contribution methods of Marrero-Gani, Han-Peng, Marrero-Pardillo, Constantinou-Gani, Joback and Reid, and Vetere. The RK-Aspen (EOS) used as thermodynamic fluid package, applied to correlate the experimental phase equilibrium data of binary systems organic liquid products compounds (OLP)-i/CO2 available in the literature. The group contribution methods selected based on the lowest relative average deviation by computing Tb, Tc, Pc, Vc, and . For n-alkanes, the method of Marrero-Gani selected for the prediction of Tc, Pc and Vc, and that of Han-Peng for . For alkenes, the method of Marrero-Gani selected for the prediction of Tb and Tc, Marrero-Pardillo for Pc and Vc, and Han-Peng for . For unsubstituted cyclic hydrocarbons, the method of Constantinou-Gani selected for the prediction of Tb, Marrero-Gani for Tc, Joback for Pc and Vc, and the undirected method of Vetere for . For substituted cyclic hydrocarbons, the method of Constantinou-Gani selected for the prediction of Tb and Pc, Marrero-Gani for Tc and Vc, and the undirected method of Vetere for . For aromatic hydrocarbon, the method of Joback selected for the prediction of Tb, Constantinou-Gani for Tc and Vc, Marrero-Gani for Pc, and the undirected method of Vetere for . The regressions show that RK-Aspen EOS was able to describe the experimental phase equilibrium data for all the binary pairs undecane-CO2, tetradecane-CO2, pentadecane-CO2, hexadecane-CO2, octadecane-CO2, palmitic acid-CO2, and oleic acid-CO2, showing average absolute deviation (AADx) between 0.8% and 1.25% for the liquid phase and (AADy) between 0.01% to 0.66% for gaseous phase.

Preprint ARTICLE | doi:10.20944/preprints202102.0404.v1

Darknet Traffic Big-Data Analysis and Network Management to Real-Time Automating the Malicious Intent Detection Process by a Weight Agnostic Neural Networks Framework

Konstantinos Demertzis, Konstantinos Tsiknas, Dimitrios Takezis, Charalabos Skianis, Lazaros Iliadis

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Darknet; Traffic Analysis; Network Management; Malicious Intent Detection; Weight Agnostic Neural Networks; Real-Time Forensics; Shapley Value; Power Predicting Score

Online: 18 February 2021 (09:56:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0347.v1

Increased Autoimmune Responses to Oxidative Specific Epitopes in Bipolar Disorder Type 1 and Major Depression: Towards A Data-Driven, Mechanistic Model of Mood Disorders

Drozdstoy Stoyanov, Jean–Claude Leunis, Marianna Murdjeva, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mood disorders; depression; nitrosative and oxidative stress; IgM autoimmunity; neuro-immune; inflammation

Online: 16 September 2020 (04:17:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0393.v1

Introducing a New Activity-Based Balance Index Using Accelerometer Data and Evaluating it as a Predictor of Skill Level among Elite Junior Soccer Players

Shahram Lenjannejadian, Jalil Reisi, Mehdi Salimi

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: activity-based balance index; soccer; accelerometer; performance; skill assessment

Online: 24 May 2020 (18:09:18 CEST)

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Working Paper DATA DESCRIPTOR

Data on Dietary Composition and Foraging Habitats of The Indian Pangolin (Manis crassicaudata) in A Tropical Lowland Forest-Associated Landscape in Southwest Sri Lanka

Hasitha Karawita, Priyan Perera

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Indian pangolin; dietary; habitats; foraging intensity; faecal

Online: 10 December 2019 (03:06:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0004.v1

Modeling Temperature Dependency of Oil-Water Relative Permeability in Thermal Enhanced Oil Recovery Processes Using Group Method of Data Handling and Gene Expression Programming

Nait Amar Menad, Zeraibi Noureddine, Abdolhossein Hemmati-Sarapardeh, Shahab Shamshirband, Amir Mosavi, Kwok-wing Chau

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Thermal enhanced oil recovery (TEOR); temperature effect on oil/water relative; group method of data handling (GMDH) and gene expression programming (GEP), machine learning, deep learning

Online: 1 July 2019 (11:12:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0207.v1

Smart Home Anti-Theft System: A Novel Approach for Near Real-Time Monitoring, Smart Home Security and Large Video Data Handling for Wellness Protocol

Sharnil Pandya, Hemant Ghayvat, Ketan Kotecha, Moi Hoon Yap, Prosanta Gope

Subject: Computer Science And Mathematics, Security Systems Keywords: smart anti-theft system; intruder detection; unsupervised activity monitoring; smart home; partially/fully covered faces

Online: 11 July 2018 (16:47:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0062.v1

An Adaptive Self-powered Piezoelectric Energy Harvesting Circuit and Its Application on Bridge Condition Monitoring

Teng Li, Yunxin Zhang, Xinlai Geng

Subject: Engineering, Electrical And Electronic Engineering Keywords: piezoelectric cantilever energy harvester 1; autonomous 2; adaptive 3; self-powered 4; voltage doubler interface circuit 5; closed loop control 6; feed-forward 7; multi-shot technology 8

Online: 12 January 2017 (10:45:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0459.v1

New Geological and Ecological Insights on the Lake Faro Global Geosite Within the Messina Strait Framework (Italy)

Roberta Somma, Ezio Giuffrè, Sakho Amonullozoda, Sebastiano Ettore Spoto, Arturo Giacobbe, Salvatore Giacobbe

Subject: Environmental And Earth Sciences, Ecology Keywords: Coastal lakes; Morpho-structures; Geodiversity; Biodiversity

Online: 7 October 2024 (11:52:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1860.v1

Impact of Mutations in Soybean Oleate and Linoleate Desaturase Genes on the Germinability of Seed from heat-Stressed Plants at the Anthesis Stage

Johnson O Toyinbo, Gautam Saripalli, Hrishikesh P Ingole, Zachary Jones, Salman Naveed, Enoch Noh, Sruthi Narayanan, Sachin Rustgi

Subject: Biology And Life Sciences, Plant Sciences Keywords: Soybean; heat stress; fatty acid desaturase mutants; expression analysis; germination

Online: 25 September 2024 (11:38:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1704.v1

Assessing the Multiplier Effect of National Parks: A Case Study of Buiratau State National Nature Park in Kazakhstan

Akmaral Sapiyeva, Meirzhan Yessenov, Aliya Aktymbayeva, Yeldar Nuruly, Mereke Sakypbek, Olesya Razdobudko, Zhanna Assipova

Subject: Business, Economics And Management, Other Keywords: Multiplier Effect; National Parks; Economic Impact; Tourism Economics; Buiratau State National Nature Park; Tourism Kazakhstan

Online: 23 September 2024 (12:19:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1253.v1

Distribution Characteristics of Trichiurus japonicus and Its Relationship with Environmental Factors in Central and Southern East China Sea and Yellow Sea

Xinyu Shi, Zhanhu Lu, Zhongming Wang, Jianxiong Li, Xin Gao, Zhuang Kong, Wenbin Zhu

Subject: Physical Sciences, Other Keywords: East China Sea; south central Yellow Sea; Trichiurus japonicus; Species distribution model; Spatial distribution; Environmental factor

Online: 17 September 2024 (02:55:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0432.v1

The Metallogenic Chronology and Prospecting Indication of Tiechanghe Granite and Molybdenum Polymetal in Jiulong Area, West Sichuan, China

Shuang Yang, Hongqi Tan, Zhongquan Li, Junliang Hu, Xinyan Wang, Daming Liu

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Songpan-Ganzi; western Sichuan; molybdenite Re-Os; U-Pb Zircon; granite

Online: 7 August 2024 (08:33:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0650.v1

Water Injection for Cloud Cavitation Suppression: Analysis on the Effects of Injection Parameters

Wei Wang, Zhijian Li, Xiang Ji, Yun Wang, Xiaofang Wang

Subject: Engineering, Marine Engineering Keywords: Cavitation suppression; Water injection; Flow control; Injection parameters; Energy performance

Online: 9 July 2024 (10:19:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1319.v1

Dysnatremia as a Mortality Marker in Intensive Care Patients with SARS-CoV-2 Infection

Guler Eraslan Doganay, Melek Doganci, Gulsah Yurtseven, Azra Ozanbarci, Abdullah Kahraman, Ozgur Cirik, Fatma Ozturk Yalcin, Seray Hazer, Kerem Ensarioglu

Subject: Medicine And Pharmacology, Other Keywords: COVID-19; Dysnatremia; Hypernatremia; Hyponatremia; Mortality; SARS-CoV-2.

Online: 20 May 2024 (20:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1012.v2

A New Quinazolinone Alkaloid along with Known Compounds with Seed-Germination-Promoting Activity from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6

Dongliang Xiao, Yan Wang, Congcong Gao, Xuemei Zhang, Weixing Feng, Xuan Lu, Baomin Feng

Subject: Chemistry And Materials Science, Other Keywords: Rhodiola tibetica; Penicillium sp. HJT-A-6; quinazolinone; seed-germination-promoting activity

Online: 29 April 2024 (04:39:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0958.v1

Unlocking the Potential of Mannosylerythritol Lipids: Properties and Industrial Applications

Joana Dias de Almeida, Miguel Figueiredo Nascimento, Petar Kekovic, Frederico Castelo Ferreira, Nuno Torres Faria

Subject: Engineering, Bioengineering Keywords: Mannosylerythritol lipids; Glycolipids; Biosurfactants; Cosmetics; Biomedical; Food; Bioremediation

Online: 15 April 2024 (13:55:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1137.v1

The Impact of Candida albicans in the Development, Kinetics, Structure, and Cell Viability of Biofilms on Implant Surfaces. An In Vitro Study with a Validated Multispecies Biofilm Model

Enrique Bravo, Marion Arce, Honorato Ribeiro-Vidal, David Herrera, Mariano Sanz

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: peri-implantitis; oral biofilm; Candida albicans; scanning electron microscopy; confocal laser scanning microscopy; quantitative polymerase chain reaction

Online: 20 February 2024 (14:39:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0083.v3

A Semi-empirical Model of Air Waves Induced by Falling Rock in a Closed Goaf

Fengyu Ren, Yang Liu, Jianli Cao, Rongxing He, Yuan Xu, Xi You, Yanjun Zhou

Subject: Engineering, Mining And Mineral Processing Keywords: air waves; falling rock; semi-empirical model; uniform motion phase; acceleration movement phase

Online: 25 January 2017 (03:46:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0427.v1

EU Energy Law: Insufficient for the 1.5-Degree Celsius Limit

Felix Ekardt, Theresa Rath, Cäcilia Gätsch, Pierre Constantin Klotz, Katharine Heyl

Subject: Social Sciences, Law Keywords: energy; climate; EU emissions trading; Paris Agreement; EU law; hydrogen

Online: 7 October 2024 (07:51:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0189.v1

Investigating the Misguided Path of the Superior Epigastric Artery: An Explorative Anatomical Study of 40 Specimens

Edin Ahmic, Paul Swatek, Iurii Mykoliuk, Anton Busau, Jörg Lindenmann

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: superior epigastric artery; sternocostal triangle; diaphragm; Larrey`s fissure

Online: 2 October 2024 (15:01:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0533.v1

Test Results of Crystalline Silicon Melting Process from BriqueĴed Mono-Charge Obtained from Microsilica

Alibek Baisanov, Nina Vorobkalo, Yerbol Shabanov, Azat Mussin, Symbat Sharieva, Amir Makishev

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: crystalline silicon; metallurgical silicon; microsilica; silica fume; briqueĴed mono-charge; waste recycling ; ;

Online: 8 August 2024 (12:21:45 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202406.2022.v1

Extremely Rare Case of Successful Treatment of Foot Ulcer Associated with Evans’ Syndrome and Buerger's Disease

Ha Jong Nam, Se Young Kim, Je Yeon Byeon, and Hwan Jun Choi

Subject: Medicine And Pharmacology, Surgery Keywords: Evans' syndrome; Thromboangiitis Obliterans; Thrombosis; Autoimmune Disease; Case Reports

Online: 28 June 2024 (07:03:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0255.v1

Updated Risk Factors of Early Endothelial Deregulation in Type-1 Diabetes: A Meta-Analysis

Ranmali Ranasinghe, Michael Mathai, Mohammed Abdullah Alshawsh, Anthony Zulli

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: ; diabetes mellitus; type-1 diabetes; risk factors; biomarkers; therapeutic targets; meta-analysis ;

Online: 6 May 2024 (07:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1584.v1

Panmacular Micropulse Laser Treatment of Central Serous Chorioretinopathy: Two-Year Follow-Up of Morphological and Functional Parameters

Małgorzata Latalska, Sławomir Dresler, Robert Rejdak

Subject: Medicine And Pharmacology, Ophthalmology Keywords: panmacular micropulse laser treatment; central serous chorioretinopathy; choroidal thickness; pachyvessel; microperimetry; vessel density

Online: 26 March 2024 (14:17:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0745.v1

The Talent Management Digitalization and the Company Size as a Catalyst

Pedro César Martínez-Morán, Fernando Díez, Josu Solabarrieta, José María Fernández-Rico Urgoiti, Elene Igoa-Iraola

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: talent management process; digitalization; company size; levels of digitalization; talent management stages

Online: 13 March 2024 (16:56:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0698.v2

Resistance Feedback for miniaturization of Shape Memory Alloys actuators

Francesco Durante, Terenziano Raparelli, Pierluigi Beomonte Zobel

Subject: Engineering, Mechanical Engineering Keywords: shape memory alloys; control; electrical resistance feedback; soft actuator.

Online: 13 February 2024 (11:46:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0787.v1

Evaluation of Anti-CAR Linker mAbs for CAR T Monitoring After BiTEs/bsAbs and CAR T-cell Pretreatment.

Anja Grahnert, Sabine Seiffert, Kerstin Wenk, Dominik Schmiedel, Andreas Boldt, Vladan Vucinic, Maximilian Merz, Uwe Platzbecker, Christian Klemann, Koehl Ulrike, Maik Friedrich

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Anti-CAR-linker mAbs; CAR T-cell monitoring; bispecific antibody; BiTE; combination treat-ments; diagnostic; CAR; detection

Online: 10 July 2024 (04:13:17 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202407.2448.v1

Cutaneous Anthrax: A Case Report from Al-Muthanna Governorate, Iraq

Al-Salihi Karima Akool, Abdulkarim Jafar Karim, Ali Hafedh Abbas, Fatimatul-Zahraa Abdulkarim Jafar, Mahmoud Abdulkarim Jafar

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Anaerobic; Anthrax; Bacillus anthracis; bacilli; cutaneous

Online: 30 July 2024 (10:28:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0078.v1

Metabolism of Fluorinated Topolin Cytokinins in Micro Propagated Phalaenopsis amabilis

Nino Murvanidze, Karel Doležal, Lenka Plačková, Stefaan Werbrouck

Subject: Biology And Life Sciences, Plant Sciences Keywords: Phalaenopsis; orchid; cytokinin metabolism ;

Online: 6 June 2024 (03:21:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0113.v1

Regulation of Plant Metabolism by Melatonin Signaling

Dawei Shi, Lejia Zhao, Ruijia Zhang, Qiaofeng Song

Subject: Biology And Life Sciences, Plant Sciences Keywords: melatonin; novel plant hormone; signaling pathways; metabolism; plant resistance

Online: 3 June 2024 (14:48:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0112.v1

Cu₆Sn₅ Whiskers Precipitated in Sn3.0Ag0.5Cu/Cu Interconnection in Concentrator Silicon Solar Cells Solder Layer

Liang Zhang, Zhi-quan Liu, Fan Yang, Su-juan Zhong

Subject: Engineering, Electrical And Electronic Engineering Keywords: Cu6Sn5 whiskers; Ag3Sn fibers; mechanical property; screw dislocation

Online: 16 March 2017 (08:50:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1239.v1

Stakeholders' Perceptions Regarding the Impact of the Working Environment on the Occupational Safety, Health, and Well-Being of Street-Based Sex Workers in Brussels

Sophie Gateault, Carita Håkansson, Anna Oudin

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: street-based sex workers; sex workers; sex work; occupational health; occupational safety and health; Belgium; Brussels; decriminalization law

Online: 16 September 2024 (14:12:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1079.v1

The Microbiome in COPD Exacerbations: A Systematic Review

Domokos Bianca, Lea Vanessa Rohr, Doina Todea

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COPD; the lung microbiome; sequencing of the bacterial 16S ribosomal RNA gene

Online: 13 September 2024 (10:39:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2129.v1

Immortalization of Human Primary CD8⁺ T cells by Inserting a Single Copy of Human Telomerase Reverse Transcriptase via CRISPR/Cas9

He Zhiyong, Kenneth Cole, Hua-Jun He

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Human CD8⁺ T cells; Immortalization; Telomerase reverse transcriptase (TERT); CRISPR/Cas9; CDKN2A; p16; Large DNA fragment insertion; Homologous recombination

Online: 29 August 2024 (09:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1427.v1

Study of Femtosecond Laser Ablation and Polishing Process on 4H-SiC Substrate

Ziqiang Zhao, Lin Zhao, Yun Peng

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: femtosecond laser; simulation; surface polish

Online: 22 May 2024 (11:07:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0965.v1

Physical and chemical characterization of Ugandan honey and its comparison to Manuka honey

Astrid D'Souza, Adam Mehall, Arnold Alguno, Arnold Lubguban, Roberto Malaluan, Gerard Dumancas

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Honey; Uganda; physiochemical analysis; atomic absorption; metal analysis

Online: 14 June 2024 (10:46:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0862.v1

Evaluation of the Moisturizing Power of Coconut Water (Cocos nucifera L.) on Physical Persons

Koffi Maïzan Jean-Paul Bouatenin, Ekoua Regina Krabi, Yabo Majoie Géroxie Tohoyessou, Lydia Karell kokola, semassa Josiane Adjobignon, Wahauwouélé Hermann Coulibaly, Fatoumata Camara, Sébastien Niamké

Subject: Biology And Life Sciences, Food Science And Technology Keywords: coconut water; nutritional properties; functional properties; urine

Online: 14 October 2024 (03:30:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1845.v1

Production of Oncolytic Measles Virus in Vero Cells: Impact of Culture Medium and Multiplicity of Infection

Dustin Eckhardt, Jana Mueller, Jonas Friedrich, Jan-Philip Klee, Irakli Sardlishvili, Lars Erik Walter, Stefanie Fey, Peter Czermak, Denise Salzig

Subject: Biology And Life Sciences, Virology Keywords: multiplicity of infection (MOI); media adaption; chemically-defined medium (CDM); serum-free medium (SFM); viral vaccines; vectors; virus-like particles (VLPs); cell culture research; process development

Online: 24 September 2024 (04:49:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2052.v1

Distribution of Natural Trace Elements in Drinking Water Sources of Hungary

Bálint Izsák, Katalin Hegedűs-Csondor, Petra Baják, Anita Erőss, Norbert Erdélyi, Márta Vargha

Subject: Environmental And Earth Sciences, Environmental Science Keywords: drinking water source; natural elements; uranium; water quality

Online: 2 July 2024 (09:29:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1632.v1

Comparative Performance of Stool Gluten Immunogenic Peptide Platforms for Monitoring Adherence to the Gluten-Free Diet

Juan Pablo Stefanolo, Roberto Puebla, Martin Talamo, Samantha Dodds, María de la Paz Temprano, María Eugenia Oregui, María Lujan Espinet, Edgardo Smecuol, Sonia Isabel Niveloni, Julio Cesar Bai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Celiac disease; follow-up; stool gluten immunogenic peptides; gluten exposure; gluten-free diet

Online: 24 May 2024 (13:53:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1749.v1

Kidney Measurement and Glomerular Filtration Rate Evolution in Children With Polycystic Kidney Disease

Ramona Stroescu, Mihai Gafencu, Ruxandra Steflea, Flavia Chisavu

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ADPKD; children; hyperfiltration; Schwartz; quadratic formula

Online: 28 April 2024 (08:21:18 CEST)

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Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder characterized by renal tubular cystic dilatations. The cysts can develop anywhere along the nephron and over time the cystic dilatation lead to kidney enlargement. On the other hand, the cysts begin to reduce the number of functional nephrons as a consequence of cystic expansion that further contributes to the decline in renal function over the years. The pressure exerted by the dilated cysts lead to compensatory mechanisms that further contribute to the decline in renal function. These structural changes are responsible of glomerular hyperfiltration states, albuminuria, proteinuria, and haematuria. However, the presentation of ADPKD varies in children from a completely asymptomatic child with incidental ultrasound detection of cysts to a rapidly progressive disease. There have been reports of early onset of ADPKD in children younger than 2 years that showed a more rapid decline in renal function. ADPKD is caused by mutation in PKD1 and PKD2 genes. Today, the PKD1 gene mutation seems to account for up to 85% of the cases worldwide, and it is associated with worse renal outcomes. Individuals with PKD2 gene mutation seem to present a milder form of the disease, with a more delayed onset of end stage kidney disease. The cardinal sign of ADPKD is the presence of renal cysts during renal ultrasound. The current guidelines provide the clinicians the recommendations for genetic testing in children with a positive family history. Given that the vast majority of children with ADPKD present with normal or supra normal kidney function we explored the glomerular filtration rates dynamics and the renal ultrasound adjusted percentiles. 14 out of 16 patients had kidney percentile over 90%. The gene mutations were equally distributed among our cohort. In addition, we compared the modified Schwartz formula to the quadratic equation after adjusting the serum creatinine measurements. It seems that even though children with ADPKD have enlarged kidneys, the renal function is more likely normal or near normal when the quadratic estimation of glomerular filtration rate is used (qGFR tended to be lower, 111.95 ± 12.43 ml/min/1.73m2 compared to Schwartz eGFR 126.28 ± 33.07ml/min/1.73m2, p=0.14). Also, when the quadratic equation was employed, not even a patient reached the glomerular hyperfiltration thresholds. The quadratic formula showed that glomerular filtration rates are linear or slightly decreasing after 1-year of follow-up (Quadratic ΔeGFR=0.32±5.78ml/min/1.73m2) as opposed to Schwartz formula that can falsely classify children in a hyperfiltration state ΔeGFR=7.51±19.46ml/min/1.73m2), p=0.019.

Preprint ARTICLE | doi:10.20944/preprints202403.0693.v1

miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

Carlos García-Padilla, Estefanía Lozano-Velasco, Virginio García-López, Amelia Aránega, Diego Franco, Virginio García-Martínez, Carmen López-Sánchez

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: miR-1; epigenetic regulator; cardiac sinoatrial region; molecular mechanisms; HDAC4; Calmodulin; pErk2/MAPK1; Mef2c activity; retinoic acid signaling; cardiac development

Online: 12 March 2024 (10:22:13 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.1609.v1

Epidemiological and Genetic Characterization of Coxsackievirus A6–associated Hand, Foot, and Mouth Disease in Gwangju, South Korea, in 2022

Ji-eun Lee, Minji Kim, Mihyeon Lim, Sueji Han, Jinyeong Kim, Soohoo Kim, Yiduen Ha, Gyungli Gang, Yoon-Seok Chung, Jungmi Seo

Subject: Biology And Life Sciences, Virology Keywords: HFMD; coxsackievirus A6; molecular epidemiology; phylogenetic tree

Online: 28 February 2024 (08:10:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1071.v1

The Use of Clear Aligners in Multi-segmental Maxillary Surgery: A Case Control Study in Cleft Lip and Palate and Skeletal Class III Patients

Maria Costanza Meazzini, Leonardo Paolo Demonte, Noah Cohen, Valeria Marinella Augusta Battista, Dimitri Rabbiosi, Luca Autelitano

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Invisalign; orthognathic surgery; cleft; skeletal class III; craniofacial; segmental Le Fort I osteotomy; occlusogram

Online: 19 February 2024 (15:37:34 CET)

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Introduction: maxillary hypoplasia and mandibular asymmetry may be corrected with orthognathic surgery at the completion of growth. Many patients require segmental Le Fort I osteotomies to obtain the most stable results. Unfortunately, if Invisalign is chosen for pre-surgical preparation, ClinCheck © software does not allow for prediction when these complex surgeries are planned. The objective of this paper was to show the potential of aligners beyond its software in most complex cases like multiple-piece maxillary osteotomies in cleft and non-cleft patients. Method: Thirteen patients who underwent pre-surgical treatment with clear aligners-Invisalign (study group) were matched in terms of diagnosis, surgical procedure, and orthodontic complexity with thirteen patients treated using fixed appliances (control group). A technique based on simple superimposition was devised to enhance the software for creating a suitable occlusion for segmental pre-surgical treatments. Virtual curves following the lower arch were employed to guide the correct pre-surgical positions of the upper teeth. The amount of impressions required in both groups to achieve satisfactory pre-surgical alignment of the segmented arches was compared. Results: one or no refinement phase were needed in the Invisalign group to reach an acceptable pre-surgical occlusion while the amount of pre-surgical impressions taken in order to reach adequate coordination with fixed appliance treatment was slightly higher. The average overall treatment duration did not show a statistically significant variation between the groups. Conclusions: it appears that clear aligner could serve as an effective treatment for individuals with skeletal discrepancies, including cleft and craniofacial anomalies, necessitating segmental Le Fort I osteotomies when aided by the suggested superimposition approach during digital pre-surgical movement simulations. More sophisticated softwares will certainly be implemented in the future.

Preprint ARTICLE | doi:10.20944/preprints202402.0694.v1

Caregivers’ burden experience: a comparison between Parkinson's Disease, Multiple System Atrophy and Amyotrophic Lateral Sclerosis

Luna Carpinelli, Giulia Savarese, Claudio Russo, Giovanna Stornaiuolo, Ettore Luisi, Francesca Pellegrino, Monica Mollo, Antonella Toriello, Paolo Barone, Maria Teresa Pellecchia

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Caregivers’ burden; Quality of Life; Neurological diseases; Parkinson’ s Disease; Multiple System Atrophy; Amyotrophic Lateral Sclerosis

Online: 12 February 2024 (13:28:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0899.v1

Document-Level Event Extraction with Definition-Driven ICL

Zhuoyuan Liu, Yilin Luo

Subject: Social Sciences, Language And Linguistics Keywords: Event Extraction; aLarge Language Models; Prompt Engineering; Heuristic Clarity; Data Balancing; Document-level

Online: 13 August 2024 (09:33:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1877.v1

Exhibition of Corallopyronin A an Antibiotic from Different Soil Environments in Egypt

Mohammed Kassab

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Corallopyronin A; infection; antibiotic; resistance; myxobacteria

Online: 29 April 2024 (04:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0307.v1

The Consistency of the Distribution Function Conditional Estimate and Application on the Consistency and Asymptotic Normality of the Conditional Hazard Function Estimate for High Dimensional Quasi-Associated Data

Hamza Daoudi, Zouaoui Chikr Elmezouar, Fatimah Alshahrani

Subject: Computer Science And Mathematics, Mathematics Keywords: conditional distribution function; asymptotic normality, conditionalhazard function; quasi-associated; functional data

Online: 3 August 2023 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0773.v2

Use of Ecologically-and Evolutionary Relevant Transcriptomic Data to Infer Functions of Fungal Pathogen Gene Orthologs Essential for Limiting Fungal Stresses Caused by Interacting Host Plants and Bacteria

Stefan Olsson, Osakina Aron, Hongchen Li, Qinfang Li, Bjoern Oest Hansen, Wei Tang, Zonghua Wang, Guodong Lu, Wenhui Zheng

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: secondary data analysis; PARP/PARG; transcriptomics; biotrophy-necrotrophy transition

Online: 3 March 2021 (10:15:08 CET)

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Key genes needed for maintenance and growth for the two pathogens, Fusarium graminearum and Magnaporthe oryzae, were identified. These are genes that are induced in response to maintenance requirements (stress) and growth requirements. The processes involved are synthesizing arginine, synthesis of DNA-bases, nitric oxide synthesis needing arginine, autophagy, DNA synthesis, and DNA repair. A simplified regulatory network for these key genes for both organisms was constructed as a hypothesis for the work, and procedures previously developed to use sets of downloaded transcriptomic data were used to test hypotheses concerning what time under the course of infection of plants the key genes are expressed. The analysis shows that the transcription efforts (costs) to maintain the fungal cells (maintenance) are high before infection and during early infection. During the following biotrophic stage, maintenance activities drop, followed by a dramatic increase in the necrotrophic stage transition. Finally, in the necrotrophic stage, maintenance is again lower despite the high growth rate that can also cause stress. All identified genes' expressions behaved almost similar with an increased expression in the biotrophy-necrotrophy transition for both fungi except the DNA repair genes PARP/PARG that was not responding or absent (PARG) in the mainly clonal M. oryzae. This PARG expression pattern might indicate that M. oryzae is more subject to evolution by point mutations than F. graminearum, where sexual reproduction is frequent. The potential consequences of this in the development and the accelerated breakage of host species resistance in a Red Queen dynamics scenario are discussed. The analysis demonstrates the possibility of using large transcriptome datasets and co-regulations between key genes to test hypotheses. This technique's advantages complement molecular techniques that employ knockouts and over-expression of target genes to suggest that genes' roles are discussed.

Preprint ARTICLE | doi:10.20944/preprints202405.1745.v1

Early Mediterranean-Based Nutritional Intervention Reduces the Rate of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Post-Hoc Analysis of the San Carlos Gestational Prevention Study

Rocio Martin-O´Connor, Ana M. Ramos-Leví, Verónica Melero, María Arnoriaga-Rodríguez, Ana Barabash, Johanna Valerio, Laura Del Valle, María Paz De Miguel Novoa, Angel Díiaz, Cristina Familiar, Inmaculada Moraga, Alejandra Durán, Martín Cuesta, Maria Jose Torrejón, Mercedes Martinez-Novillo, Clara Marcuello, Mario Pazos, Miguel Ángel Rubio-Herrera, Pilar Matía-Martín, Alfonso Luis Calle-Pascual

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity; overweight; metabolic syndrome; fasting blood glucose; mediterranean diet

Online: 27 May 2024 (13:30:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.0202.v1

Basic Guide for Approaching Drug Delivery with Extracellular Vesicles

Sergey Brezgin, Oleg Danilik, Alexandra Yudaeva, Artyom Kachanov, Anastasiya Kostyusheva, Ivan Karandashov, Natalia Ponomareva, Andrey A Zamyatnin Jr., Alessandro Parodi, Vladimir Chulanov, Dmitry Kostyushev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: targeted drug delivery; nanotherapeutics; surface display

Online: 3 September 2024 (09:49:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1451.v1

Monitoring and Diagnosing Faults in Three-Phase Induction Motors Using Artificial Intelligence Techniques

Valbério Gonzaga De Araujo, Aziz Oloroun-Shola Bissiriou, Juan Moises Mauricio Villanueva, Elmer Rolando Llanos Villarreal, Andrés Ortiz Salazar, Rodrigo de Andrade Texeira, Diego Antonio de Moura Fonsêca

Subject: Engineering, Electrical And Electronic Engineering Keywords: artificial intelligence; failure classification; induction Motor; artificial neural network

Online: 20 June 2024 (15:19:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0283.v1

Ultra-broadband Plasmon Resonance in Gold Nanoparticles Precipitated in ZnO-Al2O3-SiO2 Glass

Georgiy Shakhgildyan, Leon Avakyan, Grigoriy Atroshchenko, Maxim Vetchinnikov, Alexandra Zolikova, Elena Ingat’eva, Mariam Ziyatdinova, Elena Subcheva, Lusegen Bugaev, Vladimir Sigaev

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: gold nanoparticles; glass; surface plasmon resonance; LSPR, plasmonics; phase separation; microstructure

Online: 3 April 2024 (10:30:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1540.v1

Simple Histogram Equalization Technique Improves Performance of VGG models on Facial Emotion Recognition Datasets

Jaher Hassan Chowdhury, Qian Liu, Sheela Ramanna

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Facial emotion recognition; Convolutional Neural Network; Histogram Equalization; Transfer Learning; VGG architecture

Online: 23 April 2024 (14:50:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1402.v1

A Preliminary Study to Understand the Microbial Composition of Fresh Panchagavya Preparation

Snehal S Funde, Hanpanthrao S Palep, Yogesh S Shouche

Subject: Biology And Life Sciences, Life Sciences Keywords: gut-microbiota; panchagavya; genome; probiotics; 16S rRNA; gut

Online: 25 March 2024 (10:09:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202408.0600.v1

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas, Ben Andagalu, Romona Ndanyi, Nancy Otieno, Vincent Obanda, Carolyne Nasimiyu, Obadiah Njagi, Juliana DaSilva, Yunho Jang, John R Barnes, Gideon Emukule, Clayton Onyango, Charles Davis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Africa; surveillance; poultry diseases; avian influenza; low pathogenic

Online: 8 August 2024 (08:53:37 CEST)

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Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7,464 specimens (oropharyngeal and cloacal swabs) from poultry and 6,531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n=292) of specimens collected from poultry and 0.2% (n=10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as low pathogenicity avian influenza H5N2 virus of the Eurasian lineage and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP/NS swabs from poultry workers with ARI (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Preprint ARTICLE | doi:10.20944/preprints202408.1995.v1

Bacterial and Viral Co-Infections in COVID-19 Patients: Etiology and Clinical Impact

Iveta Rumenova Madzharova, Ivelina Trifonova, Neli Stoyanova Korsun, Viktoria Levterova, Petar Velikov, Silvya Voleva, Ivan Ivanov, Daniel Ivanov, Ralitsa Yordanova, Tatiana Tcherveniakova, Svetla Angelova, Iva Christova

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; co-infection; respiratory viruses; Haemophilus influenzae; RSV

Online: 28 August 2024 (05:13:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1054.v1

Genetics and Molecular Mechanisms of Idiopathic Dilated Cardiomyopathy, a Possible Guide to Individualized Management

Diana-Aurora Arnautu, Octavian-Marius Cretu, Daniel Florin Lighezan, Minodora Andor, Ioana Citu, Dragoș Cozma, Brenda-Cristiana Bernad, Adrian-Pavel Trifa, Diana Lighezan, Elena-Silvia Bernad, Dragos Catalin Jianu, Cristian Oancea, Ioan-Radu Lala, Sergiu-Florin Arnautu, Mirela-Cleopatra Tomescu

Subject: Biology And Life Sciences, Life Sciences Keywords: dilated cardiomyopathy; genetics; heart failure; genotype - specific therapy

Online: 16 April 2024 (15:53:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1879.v1

A Review of Crowd Abnormal Behavior Recognition Technology Based on Computer Vision

Rongyong Zhao, Feng Hua, Bingyu Wei, Cuiling Li, Yulong Ma, Eric S. W. Wong, Fengnian Liu

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Computer Vision; Abnormal Behavior Recognition; Crowd Abnormal Behavior; Deep Learning; Neural Network; Self-Attention Mechanism

Online: 24 September 2024 (10:42:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.2030.v1

Cerebrospinal Fluid Total, Phosphorylated and Oligomeric A-synuclein in Parkinson’s Disease. A Systematic Review, Meta-Analysis and Meta-Regression Study

Ioanna Kapsali, Maria-Evgenia Brinia, Vasilios C. Constantinides

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: synuclein; Parkinson’s disease; cerebrospinal fluid; biomarkers; review; meta-analysis

Online: 28 August 2024 (13:41:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0419.v1

Mechanisms of Resistance to Rituximab Used for the Treatment of Autoimmune Blistering Diseases

Liliana Gabriela Popa, Ioana Dumitras, Calin Giurcaneanu, Ovidiu Berghi, Diana Sabina Radaschin, Iolanda Vivisenco, Marius Nicolae Popescu, Cristina Beiu

Subject: Medicine And Pharmacology, Dermatology Keywords: autoimmune blistering diseases; pemphigus; rituximab; mechanism of action; resistance

Online: 8 August 2024 (16:17:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0232.v1

Assessment of the Drought Regime in SA, Based on Drought and Vegetation Indices

Fernando Maliti Chivangulula, Malik Amraoui, Mário Gonzalez Pereira

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Drought index; vegetation index; SA; drought regime; drought descriptors SPI; SPEI

Online: 5 August 2024 (11:04:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2596.v1

Variable Concentration of Ferritin in Meconium in Relation to the Iron Regulatory Proteins and Newborn Body Size

Ewa Skarżyńska, Artur Jakimiuk, Tadeusz Issat, Barbara Lisowska-Myjak

Subject: Public Health And Healthcare, Other Keywords: calprotectin; ceruloplasmin; ferritin; fetus; haptoglobin; iron; lactoferrin; meconium; NGAL; transferrin

Online: 2 August 2024 (11:40:58 CEST)

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Ferritin is an indirect marker for total body iron stores. Comparison of the ferritin concentrations in the meconium with the concentrations of proteins regulating iron metabolism could aid better understanding of principles behind the adjustment between the fetal iron pool and newborn body size. Ferritin, transferrin, haptoglobin, ceruloplasmin, lactoferrin, myeloperoxidase, neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin concentrations were measured by ELISA in meconium samples from 122 neonates. The neonates were classified according to the meconium ferritin tertiles and the values were collated with the meconium concentrations of other proteins and newborn body weight and length measurements. Increasing ferritin concentrations in meconium in consecutive tertiles (p < 0.05) were parallel to increased NGAL concentrations (p < 0.05). The interrelationships between the meconium concentrations of transferrin, haptoglobin and NGAL as well as between myeloperoxidase, calprotectin and lactoferrin are maintained in all subsequent tertiles of ferritin concentrations, (p < 0.05). In contrast to ferritin, increasing meconium NGAL concentrations in consecutive tertiles were linked to increased concentrations of transferrin, haptoglobin, lactoferrin and myeloperoxidase (p < 0.05) and of calprotectin, ferritin and ceruloplasmin (p < 0.1). Meconium ceruloplasmin concentrations correlate exclusively with neutrophil granule proteins, i.e. myeloperoxidase, NGAL, lactoferrin and calprotectin (p < 0.05). Meconium ferritin concentrations negatively correlates with birth weight (r= -0.20) and length (r= -0.31) of neonates, whereas NGAL concentrations just with birth length (r= -0.26). The remaining proteins did not show such relationships with the size of the newborn. High meconium concentrations of both ferritin and NGAL may specifically characterize neonates of smaller size. High meconium concentrations of both ferritin and NGAL may specifically characterize neonates with lower body measurements. Correlations between meconium transferrin, haptoglobin and NGAL may confirm the interrelationships of these proteins for proper iron control and transport in the intrauterine environment. Meconium ceruloplasmin concentrations may reflect the control of neutrophil activity in utero.

Preprint ARTICLE | doi:10.20944/preprints202407.2277.v1

Investigating School Principals' Burnout: A Cross-Cultural Perspective on Stress, Sustainability, and Organizational Climate

Remus Sibisanu, Stanislav Cseminschi, Andreea Ionica, Monica Leba, Anca Draghici, Yunis Nassar

Subject: Engineering, Other Keywords: stress; burnout; heartrate; organizational climate; fuzzy; high school principals’ wellbeing

Online: 29 July 2024 (09:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2198.v1

Topic Modeling for Faster Literature Screening Using Transformer-Based Embeddings

Carlo Galli, Claudio Cusano, Marco Meleti, Nikolaos Donos, Nikolaos Donos

Subject: Medicine And Pharmacology, Other Keywords: embedding; systematic reviews; topic modeling

Online: 26 July 2024 (14:26:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0357.v1

A Novel Geothermal Wellbore Model Based on the Drift-Flux Approach

Yin Yuan, Weiqing Li, Jiawen Zhang, Junkai Lei, Xianghong Xu, Lihan Bian

Subject: Engineering, Mining And Mineral Processing Keywords: geothermal energy; geothermal wellbore modeling; drift-flux model; finite difference method; bottom hole pressure

Online: 4 July 2024 (07:02:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1975.v1

Innovative Wood Fire Retardant Coating Based on Biocompatible Nanocellulose Surfactant and Expandable Graphite

Tereza Jurczyková, Elena Kmeťová, František Kačík, Martin Lexa, Jakub Ťoupal

Subject: Chemistry And Materials Science, Biomaterials Keywords: Nanomaterials, fire protection, thermal degradation, timber, relative mass loss, burning rate.

Online: 27 June 2024 (15:32:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0819.v1

Non-linear Relationship between MiRNA Regulatory Activity and Binding Site Counts on Target mRNAs

Shuangmei Tian, Ziyu Zhao, Beibei Ren, Degeng Wang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: miRNA (microRNA); miRNA binding site; cooperative binding; synergism; linear regression; non-linear regression; polynomial regression

Online: 12 June 2024 (12:26:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0493.v1

Low Iron Diet Improves Clinical Arthritis in the Mouse Model of Collagen-Induced Arthritis

Godehard Albert Scholz, Sisi Xie, Tasneem Arsiwala, Monique Vogel, Martin Bachmann, Burkhard Möller

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: inflammation; iron; ferroptosis; collagen-induced arthritis; clinical arthritis score

Online: 7 June 2024 (12:10:36 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202404.1375.v1

Immediate Implants Placement with Immediate Restorations after Dental Avulsions Due to Endotracheal Intubation in a Patient with Severe Chronic Periodontal Disease

Alexandre Perez, Adriana Fernandez Bargiela, Tommaso Lombardi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental implant; Immediate implant; Immediate restoration; Periodontitis; Trauma; Endotracheal intubation

Online: 22 April 2024 (16:35:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1143.v1

3D Prospectivity Modeling of the Nibao Carlin-Type Gold Deposit, China: Insights into Mineralization Localization and Gold Exploration

Hui Guo, Xiancheng Mao, Juexuan Huang

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Spatial Analysis; Mineral Prospectivity Modeling; Carlin-type Gold Deposit; Nibao Gold Deposit

Online: 17 April 2024 (12:36:10 CEST)

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Existing research indicates that mineralization of Carlin-type gold deposit is related to geological structures, but current studies mostly focus on the qualitative association, and lack quantitative analysis of the relationship between mineralization and structural features, which limits the potential for predictive mineral exploration. In this study, the Nibao Carlin-type gold deposit was selected as the research area to conduct three-dimensional geological modeling, spatial analysis, and three-dimensional prospectivity modeling. Spatial analysis revealed that the majority of gold ore bodies are situated near the main fault, with gold mineralization primarily occurring within a spatial range of approximately -80 meters to 20 meters from the main fault plane. This spatial distribution predominantly aligns in a SW-NE direction. Spatial characteristic extraction of fault slope indicators suggests that the slope angles are conducive to the migration and accumulation of ore-forming hydrothermal fluids, with ore body metal content rapidly increasing within an angle range of approximately 20° to 60°. The shape analysis of the mainfault indicates that the principal spaces of mineralization enrichment are within -10m to 20m of the fault plane undulations, where gold resources are concentrated in a relatively flat area. However, the degree of mineralization is more pronounced in the protruding sections than in the depressed areas. The areas with significant dip changes in faults display higher variations in orebody attitudes, with mineralization noticeably weaker in areas where the fault steepness changes markedly. Ore-bearing units exhibit significantly higher grades within the -17° to 3° interval of fault steepness transition. This interval also sees a rapid accumulation of gold resources. The Nibao gold mine's mineralization is derived from deep, ore-bearing hydrothermal fluids ascending along major fractures, precipitating, and accumulating in favorable ore-hosting spaces (faults, anticline cores) and lithological combinations (sedimentary tuffs, tuffs). Three deep potential gold targets were identified, highlighting the deep western edge of the F1 fault and the deep southeast-trending lower plate as prospective areas for future exploration. This study underscores the effectiveness of 3D prospective modeling as an indispensable tool for elucidating the spatial distribution of fault-controlled Carlin-type gold deposits and their tectonic determinants.

Preprint ARTICLE | doi:10.20944/preprints202404.0333.v1

The Relationship between Job Strain and Ischemic Heart Disease, Mediated by Endothelial Dysfunction Markers and Imaging

PALOMA MOISII, IRINA JARI, ANDRA MARA URSU, ALEXANDRU GRATIAN NAUM

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary artery disease; cardiovascular risk; job strain; high sensitivity C reactive protein; microalbuminuria

Online: 4 April 2024 (09:16:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1505.v1

360o Fusion of the Lumbar Spine Using Flarehawk 9 : A Retrospective Study of 58 Patients Demonstrating Imagistic and Clinical Outcomes with One Year Follow-up

Konstantinos Zygogiannis, Ioannis Chatzikomninos, Savvas Moschos, Ioannis Palavos, Dimitrios Koulalis, Anastasios Kalampokis

Subject: Medicine And Pharmacology, Surgery Keywords: clinical outcomes; posterior lumbar fusion; posture alignment

Online: 26 March 2024 (08:26:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0673.v1

Production and Characterization of biochar produced from Slow Pyrolysis of Teff-Husk

Marcin Landrat, Mamo Abawalo, Krzysztof Pikoń, Paulos Fufa

Subject: Engineering, Bioengineering Keywords: biomass; teff husk; slow pyrolysis; biofuel; biochar; TGA; FTIR; SEM; EDX

Online: 12 March 2024 (08:08:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1651.v1

Neuropsychiatric Adverse Events with Monoclonal Antibodies Approved for Multiple Myeloma: An Analysis from the FDA Adverse Event Reporting System

Giuseppe Cicala, Giulia Russo, Vincenza Santoro, Tindara Franchina, Nicola Silvestris, Mariacarmela Santarpia, Edoardo Spina, Maria Antonietta Barbieri

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Neuropsychiatric Adverse Events; Multiple Myeloma; FAERS; Monoclonal Antibody; Pharmacovigilance

Online: 20 September 2024 (14:58:48 CEST)

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Background/Objectives: Monoclonal antibodies (mAbs) have revolutionized multiple myeloma (MM) treatment. However, post-marketing data on their neuropsychiatric safety is limited. This study aimed to evaluate neuropsychiatric adverse events (AEs) related to mAbs used for MM through a retrospective pharmacovigilance analysis using the Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS) database. Methods: Individual case safety reports (ICSRs) from 2015 to 2023 with at least one neuropsy-chiatric AE and one of the MM-approved mAbs as the suspect drug (i.e., daratumumab, elo-tuzumab, isatuximab, belantamab mafodotin, teclistamab, elranatamab, and talquentamab) were analyzed using descriptive and disproportionality approaches. Results: Unknown signals of disproportionate reporting (SDR) included cerebral infarction for daratumumab (n = 45; reporting odds ratio (ROR) = 2.39, 95% confidence interval (CI) = 1.79-3.21; information component (IC) = 1.54, IC025-IC075 = 1.05-1.9), elotuzumab (25; 7.61, 5.13-11.28; 3.03, 2.37-3.51), and isatuximab (10; 2.56, 1.38-4.76; 1.67, 0.59-2.4); mental status changes for daratumumab (40; 2.66, 1.95-3.63; 1.67, 1.14-2.04) and belantamab mafodotin (10; 4.23, 2.28-7.88; 2.3, 1.22-3.03); altered state of consciousness for daratumumab (32; 1.97, 1.39-2.78; 1.32, 0.73-1.74) and belantamab mafodotin (6; 2.35, 1.05-5.23; 1.6, 0.19-2.52); Guil-lain-Barre syndrome (GBS) for daratumumab (23; 6.42, 4.26-9.69; 2.81, 2.11-3.3), isatuximab (8; 10.72, 5.35-21.48; 3.57, 2.35-4.37), and elotuzumab (3; 4.74, 1.53-14.7; 2.59, 0.52-3.8); and orthos-tatic intolerance for daratumumab (10; 12.54, 6.71-23.43; 3.75, 2.67-4.48) and elontuzumab (4; 28.31, 10.58-75.73; 5 , 3.24-6.08). Conclusions: Our analysis highlighted several previously unacknowledged SDRs for MM-approved mAbs. Given the complex and not entirely understood etiology of some neuropsy-chiatric AEs, including GBS, further investigations are necessary.

Preprint REVIEW | doi:10.20944/preprints202409.1113.v1

Public Health Safeguarding: A Review into Bioactive Molecules and Advanced Technologies for Microorganism Management

Adil Farooq Wali, Sirajunisa Talath, Sathvik B. Sridhar, Javedh Shareef, Manjunatha Goud, Imran Rangraze, Nawar Nezar Mohamed Saeed Saleh Alaani, Omnia Ibrahim Mohamed Hassanein

Subject: Public Health And Healthcare, Other Keywords: drug discovery; microorganism; natural products; structure-activity; antimicrobial resistance ;

Online: 14 September 2024 (10:03:16 CEST)

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