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Preprint ARTICLE | doi:10.20944/preprints202311.1778.v1

Research on Multi-Objective Optimization of High-Speed Solenoid Valve Drive Strategies under the Synergistic Effect of Dynamic Response and Energy Loss

Zhiqing Yu, Li Yang, Jianhui Zhao, Leonid Grekhov

Subject: Engineering, Energy And Fuel Technology Keywords: High Speed solenoid valve; Dynamic response; Energy loss; BPNN; NSGA-II; multi-objective optimization

Online: 29 November 2023 (07:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1797.v1

Variability of Wood Basic Density and Other Parameters of Trees on a 45-Year-Old Plantation of Scots Pine (Pinus sylvestris L.)

Evgenii Sharapov, Yury Demakov, Aleksandr Korolev

Subject: Biology And Life Sciences, Forestry Keywords: core sample; drilling resistance; moisture content; nondestructive testing; initial plantation density; ultrasound velocity

Online: 28 November 2023 (10:08:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1606.v1

Associations between Gender Expression, Protective Coping Strategies, Alcohol Saliency, and High-Risk Alcohol Use in Post-Secondary Students at Two Canadian Universities

Anees Bahji, Paul Boonmak, Michelle Koller, Christina Milani, Cate Sutherland, Salinda Horgan, Shu-Ping Chen, Scott Patten, Heather Stuart

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Gender expression; High-risk alcohol use; Protective coping strategies; Canadian universities

Online: 27 November 2023 (07:16:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1516.v1

Richard Kerner’s Path Integral Approach Aims to Understand the Self-Organized Matter Agglomeration and Its Translation into the Energy Landscape Kinetics Paradigm

Gerardo G. Naumis

Subject: Chemistry And Materials Science, Other Keywords: Self-assemble; Matter agglomeration; Glasses; Quasicrystals; Carbon Fullerenes; Graphene; Virus Structures; Nanotechnology; Energy landscape; Path Integrals.

Online: 23 November 2023 (11:07:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1505.v1

Our Mental Health is Determined by an Intrinsic Interplay Between the Central Nervous System, Enteric Nerves, and Signals Generated by Gut Microbiota

Leon M. T. Dicks

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Gut microbiota; enteric nervous system; mental health

Online: 23 November 2023 (10:33:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1489.v1

In-Vitro Activity of N, N-diethyldithiocarbamate against Ureaplasma urealyticum and Ureaplasma parvum Isolated from Women with Infections of the Urogenital Tract

Małgorzata Biernat-Sudolska, Danuta Rojek-Zakrzewska, Kamil Drożdż, Anna Bilska-Wilkosz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Ureaplasma urealyticum; Ureaplasma parvum; N,N-diethyldithiocarbamate; disulfiram; urease

Online: 23 November 2023 (07:38:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1422.v1

Sensor-Based Assessment of Time-of-Day Dependent Physiological Responses and Physical Performance during a Walking Football Match in Higher Weight Men

Sami Hidouri, Tarak Driss, Semah Tagougui, Noureddine Kammoun, Hamdi Chtourou, Omar Hammouda

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Recreational soccer; Circadian rhythms; HRV; metabolic health

Online: 23 November 2023 (01:21:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1203.v1

PCR Array Profiles the Expression of miRNAs Involved in Differentiation of Amniotic Fluid Stem Cells towards Endothelial and Smooth Muscle Progenitor Cells

Florin Iordache, Adriana Ionescu Petcu, Aurelia Magdalena Pisoschi, Loredana Stanca, Ovidiu Ionut Geicu, Liviu Bilteanu, Carmen Curutiu, Bogdan Amuzescu, Andreea Iren Serban

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: microRNA; stem cells; differentiation; endothelial progenitor cells; smooth muscle progenitor cells

Online: 22 November 2023 (15:08:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1418.v1

Vibration-Based SHM in the Synthetic Mooring Lines of the Semi-Submersible OO-Star Wind Floater Under Varying Environmental and Operational Conditions

Nikolas P. Anastasiadis, Christos S. Sakaris, Rune Schlanbusch, John S. Sakelariou

Subject: Engineering, Marine Engineering Keywords: structural health monitoring; synthetic fiber ropes; varying environmental and operating conditions; transmittance function; autoregressive models; Floating Offshore Wind Turbine; mooring lines; damage detection; functional models

Online: 22 November 2023 (12:15:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1247.v1

Assessment of Future Water Demand for Resilient Water Allocation under Socioeconomic and Climate Change Scenarios, a Case of Ghba Subbasin, Northern Ethiopia

Mehari Gebreyohannes Hiben, Admasu Gebeyehu Awoke, Abraha Adugna Ashenafi

Subject: Engineering, Civil Engineering Keywords: Climate change; SDSM; WEAP; IPCC; water demand

Online: 20 November 2023 (13:57:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1080.v1

Modified Hydrothermal Microwave-Assisted Synthesis of Monoclinic LaPO4:Pr3+ Colloidal Nanorods and their X-ray Excited UV-C Luminescence for Cancer Theranostics

Artem Timurovich Shaidulin, Elena Olegovna Orlovskaya, Alexandr Vladimirovich Popov, Sergey Khachaturovich Batygov, Umama Quddusi, Sanu Bifal Maji, Liudmila Dmitrievna Iskhakova, Oleg Venediktovich Uvarov, Gleb Olegovich Silaev, Yurii Vladimirovich Orlovskii, Yuri Grigorievich Vainer, Vladimir Nikolaevich Makhov

Subject: Chemistry And Materials Science, Nanotechnology Keywords: UV-C cathodoluminescence; X-ray excited luminescence; LaPO4; Pr3+; hydrothermal conditions; microwave heating; colloidal solution; ultramicroscopy

Online: 16 November 2023 (11:14:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1013.v1

Influence of Low-Pressure Plasma Treatments on the Lap-Shear Strength of Laser Joined AISI 304 Hybrids with Polypropylene and Polyamide 6.6

Wolfgang Tillmann, Lukas Wojarski, Christian Hopmann, Patricia Fatherazi, Christian Timmer

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Plastic-metal hybrid; laser joining; Surface free energy; Low-pressure plasma; OWRK-method; Polyamide 6.6; Polypropylene; AISI 304; Joining process; Dissimilar joining

Online: 16 November 2023 (03:15:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0957.v1

Exploring the Potential Relationship Between Oxidative Stress in Fertile Individuals and Secondary Infertility: A Comparative Analysis of Proteomic Profiles in Seminal Plasma

Raneen Sawaid Kaiyal, Sromona D Mukherjee, Manesh Kumar Panner Selvam, Miller AW, Sarah C Vij, Scott D Lundy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: sperm proteome; oxidative stress; secondary male infertility; bioinformatics

Online: 15 November 2023 (10:05:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0845.v1

Multi-Material Additive Manufacturing of PLLA-HA/GO Scaffold Fabricated via DLP for Bone Loss: Experimental Investigation, Numerical Analysis, and Cell Study

Iman Ghaderi, Amir Hossein Behravesh, Seyyed Kaveh Hedayati, Seyed Alireza Alavinasab Ardebili, Omid Kordi, Ghaus Rizvi, Khodayar Gholivand

Subject: Engineering, Mechanical Engineering Keywords: Multi-Material; Additive Manufacturing; Bone Tissue Engineering; Digital Light Processing; Biomedical Application; Triply Periodic Minimal Surfaces (TPMS)

Online: 14 November 2023 (16:39:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0742.v1

Psychosocial Work Conditions as Determinants of Well-Being in Jamaican Police Officers: The Mediating Role of Perceived Job Stress and Job Satisfaction

Kenisha Nelson, Andrew P Smith

Subject: Social Sciences, Psychology Keywords: Police; Jamaica; Stress; Work Support; Job Demands; Job Satisfaction; Well-being; Physical Health; Mediation

Online: 13 November 2023 (14:18:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0816.v1

Smallholder Farmers’ Knowledge, Perception and Management of Spodoptera frugiperda (Lepidoptera: Noctuidae) on Zea mays at Irrigation Schemes in Limpopo Province, South Africa

Phophi Nethononda, Brett Philip Hurley, Bernard Slippers, Moraka Nakedi Makhura

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fall armyworm; focus group discussion; insect pest management

Online: 13 November 2023 (11:29:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0682.v1

Testing and Modeling Performance Growth of PV Water Pumping System Using Multi-Parallel Pumps Switching for An Optimal Hydraulic Power Point Tracking

Assia Harkani, H. Fihri Fassi, Abdellah El-Aissaoui

Subject: Engineering, Energy And Fuel Technology Keywords: HPPT; Performance; Standalone; Management Method; DC PVWPS

Online: 10 November 2023 (07:51:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0584.v1

Nurturing the Positive Mental Health of Autistic Children, Adolescents and Adults alongside That of Their Familycare-Givers: A Scoping Review of Reviews

Roy McConkey

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Autism; Autistic; Mental health; emotional wellbeing; family caregivers; Low and middle in-come countries; review; international

Online: 9 November 2023 (07:29:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0564.v1

Assessment Method Research of Structural Risk Reliability on Continuous Beam Bridge in Cantilever and Horizontal Rotation Constructing Based on Interval Reliability Theory

Linyu Yuan, Huan Yang, Zhaoyong Zou, Fenghui Dong

Subject: Engineering, Control And Systems Engineering Keywords: carbon fiber reinforced polymers; CRFP aera; safety factor; continuous beam bridge; cantilever and horizontal rotation construction; overall overturning stability; symmetrical reliability theory; uncertainty; target reliability index

Online: 8 November 2023 (14:38:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0496.v1

Marina Khodanovich, Mikhail Svetlik, Anna Naumova, Daria Kamaeva, Anna Usova, Marina Kudabaeva, Tatyana Anan’ina, Irina Wasserlauf, Valentina Pashkevich, Marina Moshkina, Victoria Obukhovskaya, Nadezhda Kataeva, Anastasia Levina, Yana Tumentceva, Vasily Yarnykh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: normal aging; myelin; quantitative MRI; neuroimaging; macromolecular fraction mapping; magnetization transfer; MPF; white matter; FLAIR hyperintensities; demyelination; myelin-specific autoantibodies; myelin basic protein, proteolipid protein

Online: 8 November 2023 (07:41:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0418.v1

Experimental Research on Avoidance Obstacle Control for Mobile Robots Using Q-Learning (QL) and Deep Q-Learning (DQL) Algorithms in Dynamic Environments

Than Thi Thuong, Vo Thanh Ha

Subject: Engineering, Control And Systems Engineering Keywords: Autonomous Mobile Robot; ROS; DQL; QL

Online: 7 November 2023 (10:44:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0363.v1

Phylogeography of Two Enigmatic Sulphur Butterflies, Colias mongola Alphéraky, 1897 and Colias tamerlana Staudinger, 1897 (Lepidoptera, Pieridae), with Relations to Wolbachia Infection

Nazar A. Shapoval, Alexander V. Kir’yanov, Anatoly V. Krupitsky, Roman V. Yakovlev, Anna E. Romanovich, Jing Zhang, Qian Cong, Nick V. Grishin, Margarita G. Kovalenko, Galina N. Shapoval

Subject: Biology And Life Sciences, Insect Science Keywords: Colias; DNA barcoding; Lepidoptera; molecular taxonomy; PCR screening; Wolbachia

Online: 6 November 2023 (14:54:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0302.v1

Optimizing Intrusion Detection Systems: Exploring the Impact of Feature Selection, Normalization and Three-Phase Precision on the Cse-Cic-Ids-2018 Dataset

Surasit Songma, Theera Sathuphan, Thanakorn Pamutha

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: intrusion detection system; machine learning techniques; Exploratory Data Analysis; Performance Evaluation; feature selection; CSE-CIC-IDS-2018 dataset; Three phase models

Online: 6 November 2023 (07:46:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0225.v1

Effect of Frequency and Ratio of Wet/Dry Stages in Cyclic Corrosion Test on Localized Corrosion of Complex Phase High-Strength Steel

Jin-Seok Yoo, Geon-il Kim, Jung-Gu Kim

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: advanced high-strength steel; complex-phase; atmospheric corrosion; cyclic corrosion test; iron oxide

Online: 3 November 2023 (09:14:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1935.v1

Effect of Electrodeposited Gold Coatings on Micro-Gaps, Surface Profile and Bacterial Leakage of UCLA Abutments Attached to External Hexagon Dental Implants

Terry R Walton

Subject: Engineering, Bioengineering Keywords: External-hexagon implants; implant-abutment connections; electrolytic deposition; micro-gap; SEM; bacterial leakage

Online: 31 October 2023 (02:39:02 CET)

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Purpose: The objective of the study was to qualitatively assess micro-gap dimensions, connecting fitting surface profile and bacterial leakage of machined and cast high gold alloy UCLA abutments, with or without electrodeposited gold coatings attached to external hexagon implants. Materials and methods: 16 plastic UCLA (PUCLA) and 5 machined cast-to UCLA (GUCLA) abutments were cast with a high gold content alloy. 10 were electrolytically gold plated (8 - PUCLA, 2 - GUCLA). All abutments were attached to implants giving 21 implant-abutment combinations (IACs). External perimeter micro-gaps measured with SEM under different illumination and magnification conditions were averaged over three regions. The IACs were examined for E.coli leakage following an initial sterility test. Disassembled combinations were examined with SEM and surface profiles qualitatively assessed. Results: External micro-gap measurements did not reflect the variable connecting surface profiles but average values < 3.5 μm were observed for all IACs. Bacterial transfer was observed in 3 of 5 PUCLA plated and 2 of 5 PUCLA non-plated IACs. No transfer occurred in the 3 GUCLA non-plated or 2 GUCLA plated IACs. Abutment connecting surfaces, both Au plated and not Au plated, showed plastic deformation (smearing) in variable mosaic patterns across the micro-gap. External micro-gap dimensions although not truly reflective of surface connecting profiles averaged < 3.5 μm measured under shadow eliminating silhouette illumination for both cast and pre-machined external hexagon abutments with and without Au plating. Conclusions: Micro-gap dimensions < 5 μm were obtained with both high noble metal cast and pre-machined external hexagon abutments with and without Au electrodeposited on the abutment connecting surface. Regions of intimate contact due to plastic deformation (smearing) of these surfaces was observed. A continuous smeared region around the circumference of the surfaces can provide an effective barrier to egress of E.coli bacteria from the internal regions of the implant under static loading.

Preprint ARTICLE | doi:10.20944/preprints202310.1559.v1

Investigation and Improvement Strategies for Mold Fracture: A Study on the Application of a Double-Pulse Electrodeposition Method for Enhancing Mold Lifespan

Xionghua Jiang, Fengyu Kong

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: mold; fracture; double-pulse electrodeposition; Nico coating

Online: 24 October 2023 (14:44:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1420.v1

Prognostic Effectiveness of Blood Gas Lactate Values and Peripheral Perfusion Indices in Patients Diagnosed with Acute Coronary Syndrome in The Emergency Department

Hüseyin ŞAHİN, Mehmet Efe Can KIRCA

Subject: Public Health And Healthcare, Other Keywords: acute coronary syndrome; peripheral perfusion index; arterial blood gas; lactate; diagnostic metrics; noninvasive techniques

Online: 23 October 2023 (10:30:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1219.v1

Recycling of Industrial Waste as Soil Binding Additives—Effects on Soil Mechanical and Hydraulic Properties during Its Stabilisation Prior to Road Construction

Ksawery Kuligowski, Witold Waciński, Marek Zając, Włodzimierz Urbaniak, Małgorzata Olejarczyk, Waldemar Cyske, Paweł Kazimierski, Robert Tylingo, Szymon Mania, Adam Cenian

Subject: Environmental And Earth Sciences, Soil Science Keywords: road construction; soil stabilization; soil binders; soil compressive strength; soil capillary forces; frost resistance; waste additives; industrial waste; pyrolytic wax; emulsions; soil water absorption

Online: 20 October 2023 (11:01:31 CEST)

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In road construction, before applying an asphalt or concrete surface, the ground must be compacted and stabilized. There are two basic methods of soil stabilization: in situ and in a stationary node (ex-situ). The method of performing stabilization in place (in-situ) is the most frequently used method due to its convenience and lower price. The most popular type of binder for stabilization is a hydraulic binder (most often cement and various ashes). Such stabilization is performed at a depth of 10-50 cm, achieving the desired load-bearing parameters. In order to improve them, various chemical additives for stabilization are often used, such as ion exchange compounds, additives based on sulfuric acid, additives based on vinyl polymers or even organic additives using lignosulfonates. However, the use of such additives is associated with much greater costs and environmental burden, resulting in seeking for cheaper and equally effective alternatives. The win-win situation would be for instance recycling the problematic waste-based materials that on one hand are landfilled or impossible to recycle and on the other hand cause problems for the waste producers. Therefore, an interesting issue is the production of stabilization additives from various types of waste materials. As a result of the extensive testing of various waste-based materials blends with soil, the mechanical (compressive strength after 7 and 28 days) and hydraulic (capillary rise, water absorption, frost resistance) soil properties were measured. The optimization process led to obtaining additives compositions ensuring the best strengthening and sealing properties. These were for sandy soil: Pure foil (wax emulsion), Pure foil (wax emulsion) + waste sulphuric acid, RDF from waste tires (wax emulsion), Pure foil (wax emulsion) + “by-pass” waste ash + NaOHx2 and for clayey soil: Pure foil (wax emulsion) + NaOH, Pure foil (wax emulsion) + waste sulphuric acid, Tequant, Pure foil (wax emulsion).

Preprint ARTICLE | doi:10.20944/preprints202310.1270.v1

A Novel Digital Fingerprinting Tool for Histopathology assessment Leveraging AI on Fresh Biopsy and Resection Tissues: A Feasibility Study using Gastrointestinal Tissues

Sunil Gaddam, Poulami Samaddar, Keerthy Gopalakrishnan, Mansunderbir Singh, Priyanka Anvekar, Suganti Shivaram, Shuvashis Dey, Sayan Roy, Dipankar Mitra, Shivaram P Arunachalam

Subject: Engineering, Electrical And Electronic Engineering Keywords: dielectric fingerprint; dielectric spectroscopy; microwaves; gastrointestinal; microwave imaging

Online: 19 October 2023 (11:31:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1205.v1

The Release of Grape Pomace Phenolics from Alginate-Based Microbeads During Simulated Digestion In Vitro: The Influence of Coatings and Drying Method

Josipa Martinović, Jasmina Lukinac, Marko Jukić, Rita Ambrus, Mirela Planinić, Gordana Šelo, Gabriela Perković, Ana Bucić-Kojić

Subject: Biology And Life Sciences, Food Science And Technology Keywords: grape pomace extract; phenolic compounds; encapsulation; drying; microbeads characterization; release in vitro

Online: 19 October 2023 (03:56:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1137.v1

The Advantages of Non-Adhesive Gel-like Embolic Materials in the Endovascular Treatment of Benign Hypervascularised Lesions of the Head and Neck

Andrey Petrov, Arkady Ivanov, Egor Kolomin, Nikita Tukanov, Anna Petrova, Larisa Rozhchenko, Ulia Suvorova

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: embolic agent; ONYX; SQUID; PHIL; vascular malformations; paragangliomas

Online: 18 October 2023 (07:14:26 CEST)

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Objectives: Non-adhesive gel-like embolic materials (NAGLEMs) are becoming increasingly dominant in the endovascular treatment of hypervascularised formations in the head and neck due to a combination of their key properties. The main advantages include their lack of adhesion, effective distribution and penetration through pathological vessels, and crucially, their controlla-bility during the process. Our assigned duty was to scrutinise the literature and assess the efficacy and outcomes of administering NAGLEMs, in comparison to other embolizing substances (name-ly, coils, glue, and particles), among patients treated at our clinic. The procedures involved ana-lyzing the technical aspects, efficiency, and safety of endovascular therapy applied to two catego-ries of hypervascular pathological anomalies, surgically managed from 2015 to 2023. Arteriove-nous malformations (AVMs) located in the head, neck, and paragangliomas with jugular/carotid body localization are combined by intense shunting blood flow and shared requirements for em-bolizates used in endovascular treatment (such as penetration, distribution, delayed polymeriza-tion and controllability). An analysis of the literature was also conducted. Results showed 18 pa-tients diagnosed with neck paragangliomas of the carotid body and jugular type. Five patients with arteriovenous malformation (AVM) of the face and neck were included, consisting of 16 fe-males and 7 males with an average age of 55 ± 13 years. Endovascular procedures were conduct-ed using NAGLEMs (ONYX (Medtronic), SQUID (Balt), and PHIL (Microvention)) and dimethyl sulfoxide (DMSO)-compatible balloon catheters. All patients achieved complete or partial embo-lization of hypervascularized formations using one or more stages of endovascular treatment. Additionally, three AVMs of the face and two paragangliomas of the neck were surgically ex-cised following embolization. In other instances, formations were not deemed necessary to be re-moved. The patients' condition upon discharge was assessed by the modified Rankin Scale (mRs) and rated between 0 and 2. Conclusion: Currently, NAGLEMs are predominantly used to treat hypervascularized formations in the neck and head due to their fundamental properties. These properties include a lack of adhesion and a delay in predictable polymerization (after 30-40 minutes). NAGLEMs also exhibit excellent distribution and penetration throughout the vascular bed of the formation. Adequate controllability of the process is largely achieved through the pres-ence of embolism forms of different viscosity, as well as excellent X-ray visualization.

Preprint ARTICLE | doi:10.20944/preprints202310.1103.v1

Growth Light Quality Influences the Temperature of the Leaf Surface via Regulation of the Rate of NPQ Thermal Dissipation and Stomatal Conductance

Magdalena Trojak, Ernest Skowron

Subject: Biology And Life Sciences, Plant Sciences Keywords: leaf surface temperature; thermal imaging; chlorophyll fluorescence quenching; indoor farming; light quality; LED; non-photochemical quenching; FLIR

Online: 18 October 2023 (02:19:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0793.v1

Molecular Evaluation of FLC Homologs and Coordinating Regulators on the Flowering Responses to Chilling Temperature in Cabbage (Brassica oleraceae var. capitata) Genotypes

Ju-Young Ahn, Saminathan Subburaj, Fanzhuang Yan, Yao Jian, Chandrasekaran Ajithan, Kyoung-Gu Ahn, Geung-Joo Lee

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: BoFLC homologs; cabbage flowering; flowering regulator; structural variation; vernalization

Online: 12 October 2023 (09:40:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0766.v1

Mathematical Modeling of Non-small Cell Lung Cancer Biology Through the Experimental Data on Cell Composition and Growth of Patient-Derived Organoids

Rushan A. Sulimanov, Konstantin B. Koshelev, Vladimir A. Makarov, Alexander V. Mezentsev, Mikhail O. Durymanov, Komal Zahid, Lilian Ismail, Yegor Y. Rumyantsev, Ilya A. Laskov

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mathematical modeling; non-small cell lung cancer; tumor microenvironment; patient-derived tumor organoids

Online: 12 October 2023 (05:05:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0480.v1

Ceramic-on-Metal Bearing in Total Hip Arthroplasty—Was It So Bad? A Narrative Review and a Critical Analysis of the Literature

Michela Saracco, Vincenzo Ciriello, Antonio Spinarelli, Giuseppe Solarino, Remo Goderecci, Giandomenico Logroscino

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: ceramic-on- metal; hip replacement; hard-on-hard bearings

Online: 9 October 2023 (07:40:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0460.v1

Artificial Pasture Grazing System Attenuates Lipopolysaccharide-Induced Gut Barrier Dysfunction, Liver Inflammation, and Metabolic Syndrome by Activating ALP-Dependent Keap1-Nrf2 Pathway

Qasim Ali, Sen Ma, Boshuai Liu, Ahsan Mustafa, Zhichang Wang, Hao Sun, Yalei Cui, Defeng Li, Yinghua Shi

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Geese; Pasture grazing; Intestinal alkaline phosphatase; Lipopolysaccharides; Systemic inflammation; Keap1-Nrf2

Online: 9 October 2023 (07:32:41 CEST)

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Reactive oxygen species (ROS) are a major risk factor for the development of oxidation and inflammation. Ryegrass (pasture), a natural dietary fiber source, acts as an antioxidant with well-known anti-inflammatory properties. The current study aimed to examine the alkaline phosphatase (ALP)-dependent Kelch-like-ECH-associated protein 1- Nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) signaling pathway that facilitates the anti-oxidative and anti-inflammatory properties of pasture and its protective effects on ileal permeability, systemic inflammation, nutrient absorption, liver dysfunction, growth performance, intestinal organ development, and metabolic syndrome in commercial diet-challenged geese. The lipopolysaccharides (LPS), ALP, ROS, and tight junction proteins were determined from the ileum tissues, and the antioxidant enzymes, immunoglobulins, and metabolic syndrome were determined from liver tissues via Enzyme-linked immunosorbent assay (ELISA) kits. While the Nrf2 and LPS/ROS/Keap1-induced inflammatory cytokines were determined by the quantitative reverse transcription polymerase chain reaction (RT-qPCR) method. The intestinal morphology was examined by Hematoxylin and Eosin (H&E) staining to determine nutrient absorption in ileal tissues. Pasture-dependent ALP activity significantly ameliorated commercial diet-induced LPS and ROS-facilitated ileal barrier dysfunction and systemic inflammation. The pasture supplementation induced nutrient absorption by influencing intestinal organ development. Our biochemical assays showed that the activation of Nrf2 significantly increased antioxidant enzymes and immunoglobulins, and decreased Keap1 and malondialdehyde (MDA) concentrations in the liver tissues after pasture supplementation. The correlation analysis of ALP, LPS, ROS, and Keap1-Nrf2 pathway-dependent antioxidant enzymes with other host markers showed that pasture supplementation induced intestinal barrier function via reducing LPS/ROS-induced intestinal permeability and systemic inflammation in the ileum and liver tissues. Pasture intake might attenuate LPS/ROS-induced gut permeability, systemic inflammation, and metabolic syndrome and augment gut barrier functions, nutrient absorption, immunity, and growth performance, possibly by its Keap1-Nrf2 pathway-dependent antioxidant properties.

Preprint ARTICLE | doi:10.20944/preprints202310.0307.v1

Modulation of Apoptosis by Bovine Herpesvirus Type 4 Infection in Bovine Endometrial Cells and the Possible Role of LPS in this Process

Florencia Romeo, Santiago Delgado, Marisol Yavorsky, Lucia Martinez Cuesta, Susana Pereyra, Erika Gonzalez Altamiranda, Enrique Louge Uriarte, Sandra Perez, Andrea Verna

Subject: Biology And Life Sciences, Virology Keywords: Bovine herpesvirus type 4; bovine endometrial primary culture cells; apoptosis

Online: 6 October 2023 (05:11:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0216.v1

Effect of L. crispatus M247 Administration on Pregnancy Out-comes in Women Undergoing IVF: a Controlled, Retrospective, Observational and Open-label Study

Francesco Di Pierro, Francesco Sinatra, Maddalena Cester, Lucia Da Ros, Mara Pistolato, Vania Da Parè, Laura Fabbro, Daniela Maccari, Silvia Dotto, Sara Sossai, Gemma Fabozzi, Alexander Bertuccioli, Massimiliano Cazzaniga, Martino Recchia, Nicola Zerbinati, Luigina Guasti, Andrea Baffoni

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: vaginal microbiota; D3-embryos; D5-blastocysts; ICSI; FIVET; ART

Online: 4 October 2023 (09:32:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0094.v1

Isolation and Molecular Characterization of a Novel Podo-virus BIS08P22 having a Unique Terminase Enzyme Representing a new Genus in Class Caudoviricetes

Sadia Sattar, Vincenzo Carbone, Zarrin Basharat, Nazish Bostan, Aamira Tariq, Sundus Javed, Inam Ullah, Sofia Khanum, Akasha Yaqoob, Ibrar Ahmed, Muhammad Athar Abbas, Syed Tahir Abbas Shah, Eric Altermann

Subject: Biology And Life Sciences, Virology Keywords: Podo virus; temperate phages; Short tail phages, novel phage terminase, Lederbergvirus

Online: 3 October 2023 (08:19:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2029.v1

From Health-in-all-policies to Climate-in-all-policies: using the synergies between Health Promotion and Climate Protection to Take Action

K. Viktoria Stein, Thomas Ernst Dorner

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: one health; health promotion; climate change; exercise; nutrition; health literacy; climate literacy; sustainability; social determinants

Online: 3 October 2023 (03:38:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0063.v1

Diagnostic Assessment in Wet and Dry Seasons of Simple Weirs Constructed by Small-scale Farmers in the Northern Region Provinces of Zambia

Alex Lushikanda KABWE, Masahiro HYODO, Hidehiro OGATA, Yoshihiro SAGAWA, Yoshinao ADACHI, Masayuki ISHII

Subject: Engineering, Other Keywords: ingle-line weir; small-scale irrigation; river diversion; rural areas; up-stream wa-ter level; emerging farmers

Online: 2 October 2023 (09:52:52 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202309.2067.v1

Local Storytelling for a Climate-Friendly Future: An Evidence-Based Approach and First Prototyping Results from the Region of Lake Constance, Germany

Maike Sippel

Subject: Social Sciences, Other Keywords: Climate communication; storytelling; public engagement; climate action; sustainability

Online: 30 September 2023 (10:19:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2068.v1

Demand-Oriented Review of Dynamic Energy Loss Monitoring System for Primary School Buildings through Micro-Environmental Data Monitoring and Occupant Behavior Analysis

Zhen Peng, Yanan Yu, Rui Guan

Subject: Engineering, Architecture, Building And Construction Keywords: school buildings; building dynamic energy loss; microenvironment; occupants’ behavior

Online: 30 September 2023 (10:16:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2017.v1

RC Electrical Modelling of Black Hole. New Method to Calculate the Amount of Dark Matter and the Rotation Speed Curves in Galaxies

Hector Gerardo Flores, Maria Isabel Gonçalves de Souza

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: RLC electrical model; RC electrical model; cosmology; background radiation; Hubble’s law; Boltzmann´s constant; dark energy; dark matter; black hole; Big Bang and cosmic inflation.

Online: 29 September 2023 (13:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2042.v1

An Analysis of the Impact of Religious Affiliation and Strength of Religiosity on Sexual Health Practices of Sexually Active Female College Students

Emily Glazer, Emma Valdez, Justin A. DeBlauw, Stephen Ives

Subject: Public Health And Healthcare, Primary Health Care Keywords: Sexual health; contraceptives; religion; social determinants

Online: 29 September 2023 (08:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2058.v1

Effects of Total Flavonoids from Taraxacum mongolicum Hand.-Mazz. on Fermentation Quality, Antioxidant Status and Microbial Community of Caragana korshinskii Kom. Silage

Shuai Huang, Can Wen Ke, Qiang Lu, Fei Long Gao, Dong Xiao Zhou, Yan Cheng Ma

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Caragana korshinskii Kom.; flavonoids; Taraxacum mongolicum Hand.-Mazz.; fermentation quality; antioxidant status; microbial community

Online: 29 September 2023 (04:26:21 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202309.1957.v1

SALIQ in Rhabdomyosarcoma: A Repurposed Multidrug Regimen to Augment Standard Treatments by Adding Simvastatin, All Trans Retinoic Acid, Lithium, Itraconazole, and Quercetin

Richard E. Kast, Mohamed S. Zaghloul, Iacopo Sardi, Marc-Eric Halatsch

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chemotherapy; repurposed drugs; rhabdomyosarcoma

Online: 28 September 2023 (07:39:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1376.v1

Circulation of Dengue Virus Serotype 1 genotype V and Dengue Virus Serotype 2 genotype III in Tocantins State, Northern Brazil, 2021-2022

Ueric José Borges de Souza, Ygor da Silva Miranda Macedo, Raíssa Nunes dos Santos, Franciano Dias Pereira Cardoso, Jucimária Dantas Galvão, Evgeni Evgeniev Gabev, Ana Cláudia Franco, Paulo Michel Roehe, Fernando Rosado Spilki, Fabrício Souza Campos

Subject: Biology And Life Sciences, Virology Keywords: DENV; Genomic surveillance; Epidemiology; molecular clock; SNPs; arboviruses

Online: 20 September 2023 (10:42:22 CEST)

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The dengue virus (DENV) is an arbovirus belonging to the Flaviviridae family; the species comprises four antigenically distinct serotypes (DENV–1, DENV–2, DENV–3, and DENV–4), which are further subdivided into genotypes. The virus is transmitted to humans through mosquito bites, primarily from the Aedes spp. genus. Dengue is endemic in various parts of the world, including tropical and subtropical regions of Asia, Latin America, Africa, and Oceania. In Brazil, the state of Tocantins, located in north-central Brazil, has experienced a significant number of arboviral disease cases, particularly dengue. This study aimed to monitor DENV circulation within the state by conducting full genome sequencing of viral genomes recovered from 61 patients between June 2021 and July 2022. During this period, both DENV-1 and DENV-2 serotypes were identified. Our findings confirm the circulation of DENV serotypes 1 and 2 in Tocantins, affecting males and females equally, with younger age groups (4 to 43 years old) being the most susceptible. Phylogenetic analysis revealed that the circulating viruses belong to DENV–1 genotype V American and DENV–2 genotype III Southeast Asian/American. The Bayesian analysis of DENV-1 Genotype V sequenced here is closely related to genomes previously sequenced in the state of São Paulo. Regarding DENV-2 genotype III genomes, these are clustered in a distinct, well-supported subclade, along with previously reported isolates from the states of Goiás and São Paulo. In both cases, our results suggest that multiple introductions of these genotypes occurred in the Tocantins state. This observation highlights the significant impact of major population centers in Brazil on virus dispersion, including other Latin-American countries and the USA. In the SNP analysis, DENV-1 displayed 122 distinct missense mutations, while DENV-2 had 44, with significant mutations predominantly occurring in the envelope and NS5 proteins. The analyses performed here reveal the concomitant circulation of distinct DENV-1 and -2 genotypes in some Brazilian states, underscoring the dynamic evolution of the DENV and the ongoing significance of surveillance efforts in supporting public health policies.

Preprint ARTICLE | doi:10.20944/preprints202309.1300.v1

Is There a Risk for Semaglutide Misuse? Focus on the Food and Drug Administration-FDA Adverse Events Reporting System (FAERS) Pharmacovigilance Dataset

Stefania Chiappini, Rachel Vickers-Smith, Daniel Harris, Duccio G. Petellier Papanti, John M. Corkery, Amira Guirguis, Giovanni Martinotti, Stefano L. Sensi, Fabrizio Schifano

Subject: Biology And Life Sciences, Toxicology Keywords: semaglutide; drug misuse; drug abuse; pharmacovigilance; image- and performance-enhancing (IPED) drugs; glucagon-like peptide-1 (GLP-1) agonists

Online: 20 September 2023 (05:05:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1037.v1

Evaluation of Standard M10 Assay for Rapid Molecular Diagnosis of SARS-CoV-2, Influenza A/B virus and Respiratory Syncytial Virus (RSV)

Azwani Abdullah, I-Ching Sam, Yin Jie Ong, Chun Hao Theo, Muhammad Harith Pukhari, Yoke Fun Chan

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: respiratory syncytial virus; influenza A virus; influenza B virus; SARS-CoV-2; rapid RT-PCR; diagnostic accuracy; point-of-care testing

Online: 15 September 2023 (05:38:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0982.v1

Cultivated Land Green Use Efficiency and Its Influencing Factors: A Case Study of 39 Cities in the Yangtze River Basin of China

Qiaowen Lin, Siran Bai, Rui Qi

Subject: Environmental And Earth Sciences, Geography Keywords: CLGUE; kernel density estimation; geographic detector method; Yangtze River Basin; regional differences

Online: 14 September 2023 (11:23:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0866.v1

Validation of the Histological Diagnosis of Hydatidiform Moles with p57KIP2 Immunophenotyping at the University Teaching Hospitals of Kigali and Butare (CHUK, CHUB)

Habanabakize Thomas, Ntirushwa David, Manirakiza Felix, Uwineza Annette, Rugwizangoga Belson

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: hydatidiform mole; histology; p57KIP2 immunohistochemistry; histomorphology; Rwanda

Online: 13 September 2023 (09:39:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0856.v1

A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant Staphylococcus aureus (MRSA)

Shraddha Ambade, Vivek Kumar Gupta, RItesh P Bhole, Pramod B Khedekar, Rupesh V Chikhale

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Penicillin-binding protein 2a (PBP2a); Mur enzymes; heterocycles; High-throughput screenings; transpeptidation

Online: 13 September 2023 (09:01:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0812.v1

Effect of Body Weight Gain During Cashmere Non-Growing Period on Cashmere Production Performance and Secondary Hair Follicle Activity of Cashmere Goats

Junxia Li, Wenhui Xing, Dong He, Xinming Duan, Yatu Ji, Tana Gegen, Chunxiang Zhang, Youshe Ren, Chunhe Yang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: cashmere goat; cashmere non-growing period; body weight gain; secondary hair follicle activity; cashmere production performance

Online: 13 September 2023 (03:08:00 CEST)

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The objective of this study was to investigate the effects of body weight gain during the cashmere non-growing period on cashmere production performance and secondary hair follicle activity, to provide a theoretical basis for appropriate supplementary feeding of cashmere goats. Fifty Inner Mongolian cashmere goats aged 2-4 years old were randomly selected and weighed in May and September 2019, respectively. Based on body weight gain between the two weights, the experi-mental ewe goats were divided into two groups: 0-5.0 kg group (n = 30) and 5.0-10.0 kg group (n = 20). Skin samples and cashmere samples were collected. Results of Pearson correlation analysis showed that body weight gain during the cashmere non-growing period had a moderate and strong positive correlation with cashmere yield (P = 0.021) and cashmere staple length (P = 0.002) respectively, but did not correlate with cashmere diameter (P = 0.254). Compared with cashmere goats with a body weight gain of 0-5.0 kg, cashmere goats with a body weight gain of 5.0-10.0 kg had a 17.10% increment in cashmere yield (P = 0.037), 8.09% increase in cashmere staple length (P=0.045) and had no significant difference in cashmere diameter (P = 0.324). Results of Pearson correlation analysis showed that there was a strong positive correlation between body weight gain and the population of active secondary hair follicles in the skin of cashmere goats (P < 0.01). Compared with cashmere goats with a body weight gain of 0-5.0 kg, cashmere goats with a body weight gain of 5.0-10.0 kg had an increase in the population of active secondary hair follicles (P < 0.05). In conclusion, the body weight gain during the cashmere non-growing period had a sig-nificant effect on secondary hair follicle activity and cashmere production performance in cash-mere goats. Since body weight gain reflects nutritional level to a certain extent, this study suggests that nutritional manipulations such as supplementary feeding during cashmere non-growing periods can increase cashmere production performance. However, specific nutritional manipula-tions during the cashmere non-growing period need further research to increase cashmere pro-duction performance.

Preprint ARTICLE | doi:10.20944/preprints202309.0745.v1

Debris Flow Prediction in Mountainous Terrain Using Remote Sensing and GIS: A Case Study of Al-Hada Road, Makkah Province, Saudi Arabia

Talal Alharbi, Abdelbaset S. El-Sorogy

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: debris flow; remote sensing; Geographic Information System; weighted overlay analysis; Saudi Arabia

Online: 12 September 2023 (09:00:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0739.v1

Short-Term Nitrous Oxide Emissions from Cattle Slurry for Silage Maize: Effects of Placement and the Nitrification Inhibitor 3,4-Dimethylpyrazole Phosphate (DMPP)

Arezoo Taghizadeh-Toosi, Khagendra Raj Baral, Peter Sørensen, Søren O. Petersen

Subject: Environmental And Earth Sciences, Soil Science Keywords: Slurry application method; silage maize; nitrous oxide emissions; mineral nitrogen; nitrification inhibitor

Online: 12 September 2023 (07:24:27 CEST)

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Cattle slurry is an important nitrogen source for maize on dairy farms. Slurry injection is an effective measure to reduce ammonia emissions after field application, but with higher risk of nitrous oxide emission than surface application. This study compared soil mineral nitrogen dynamics and nitrous oxide emissions with two ways of application. First, traditional injection at 25 cm spacing between rows followed by ploughing (called “non-placed slurry”), and second, injection using a new so-called goosefoot slurry injector that placed the slurry in ploughed soil as a c. 30 cm broad band at 10 cm depth below maize crop rows with 75 cm spacing (named “placed slurry”). Furthermore, the effect of treating slurry with the nitrification inhibitor 3,4-dimethylpyrazole phosphate (DMPP) in Vizura® was tested with both application methods. The field experiment was conducted on a sandy loam soil in a temperate climate. Both nitrous oxide emissions, and the dynamics of soil mineral nitrogen, were monitored for eight weeks after slurry application and seeding of maize using static chambers. The level of nitrous oxide emissions was higher with non-placed compared to placed slurry, mainly due to higher emissions during the first four weeks. That might be due to higher rates of nitrification rate and in turn stimulation of denitrification process. In both placed and non-placed slurry treatments, Vizura® caused higher soil ammonium concentrations and lower nitrate concentrations, particularly from 3 to 8 weeks after slurry application. The final level of soil nitrate was similar with and without the nitrification inhibitor, but higher with placed compared to non-placed slurry. Adding Vizura® to non-placed slurry reduced nitrous oxide emissions by 70 % when compared to placed slurry. Surprisingly, there was a non-significant trend towards higher cumulative emissions from placed slurry with the nitrification inhibitor compared to untreated slurry, which were due to higher emissions in the last part of the monitoring period (5-7 weeks after slurry application). Possibly degradation of the nitrification inhibitor, and nitrification activity inside the slurry band as the soil dried, promoted nitrous oxide emissions by this time. In summary, placement of untreated slurry in a broad band under maize seeds reduced nitrous oxide emissions compared to non-placed slurry with more soil contact. A comparable reduction was achieved by adding a nitrification inhibitor to non-placed slurry. The pattern of nitrous oxide emissions from placed slurry treated with the inhibitor was complex and requires more investigation.

Preprint ESSAY | doi:10.20944/preprints202309.0606.v1

Based on UHPLC-Q-Orbitrap HRMS, the Effect of Chemical Composition before and after Fermentation of Gastrodia Tuder Halimasch Powder Was Compared

Yaning Wu, Hongwei Zhang, Zhenling Zhang, Jianguang Zhu, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: gastrodia tuder halimasch powder; ultra high performance liquid chromatography tan- 34 dem quadrupole electrostatic field orbitrap high resolution mass spectrometry; stoichiometry; fer- 35 mentation processing

Online: 8 September 2023 (12:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0301.v1

Theory of the Generalization of the Boltzmann’s Constant in Curved Space-Time. Shannon-Boltzmann Gibbs Entropy Relation and the Effective Boltzmann’s Constant

Hector Gerardo Flores, Maria Isabel Gonçalvez de Souza

Subject: Physical Sciences, Theoretical Physics Keywords: RLC electrical model; RC electrical model; cosmology; background radiation; Hubble’s law; Boltzmann´s constant; dark energy; dark matter; black hole; Big Bang and cosmic inflation, statistical physics, astronomy, astrophysics and condensed matter physics.

Online: 6 September 2023 (03:24:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0338.v1

Understanding the Interactions of Climate and Land Use Changes with Runoff Components in Spatial-Temporal Dimensions in the Upper Chi Basin, Thailand

Rattana Hormwichian, Siwa Kaewplang, Anongrit Kangrang, Jirawat Supakosol, Kowit Boonrawd, Krit Sriworamat, Sompinit Muangthong, Songphol Songsaengrit, Haris Prasanchum

Subject: Engineering, Civil Engineering Keywords: climate change; land use change; QSWAT; runoff components; Upper Chi Basin

Online: 5 September 2023 (14:50:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0273.v1

Structure and High-Temperature Oxidation Properties of an Al-Co-Y diffusion Coating prepared on TiAl-Nb alloy at a Low Temperature

Xuan Li, Zekun Wei, Wei Lv, Lijing Zhang, Fuhua Liu, Xiaoqing Xie, Sheng Lai, Xuyi Zhang

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: TiAl alloy; Pack cementation; Coating structure; Coating formation process; High-temperature oxidation

Online: 5 September 2023 (08:17:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0110.v1

Plasmid-Mediated Genes Were Responsible for the Resistance and Spread of Metallo Beta-Lactamase (MBL)-Producing Pseudomonas Aeruginosa Isolates in Poultry Milieus

Chika Ejikeugwu, Carissa Duru, Euslar Onu, Emmanuel Nwakaeze, Cyril Adonu, Ndidiamaka Okorie, Nonye Ujam, Ijeoma Ebenebe, Theodora Mba, Anthonia Mba, Chika Ezeador, Chijioke Edeh, Malachy Ugwu, Michael Adikwu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Gram negative bacteria; multidrug resistance; plasmids; carbapenemase; carbapenems; mobile genetic elements (MGEs)

Online: 4 September 2023 (07:17:41 CEST)

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Bacterial resistance to antibiotics is a public health menace that needs urgent efforts to mitigate and forestall their transmission in the general environment. Plasmid-mediated metallo beta-lactamase (MBL) gives bacteria an exceptional ability to transmit resistance genes. This study investigated plasmid-mediated resistance in MBL P. aeruginosa isolates from poultry food chain settings. Cloacal swab samples (n=120) were bacteriologically analyzed for the isolation of P. aeruginosa isolates. Susceptibility studies were performed by the CLSI guideline using selected antibiotics. MBL was phenotypically detected using modified Hodges test, and confirmed using PCR technique. Plasmid curing studies detected the presence of plasmids in the isolates. P. aeruginosa isolates (n=48) showed high levels of reduced susceptibility to cefoxitin (93.8%), imipenem (81.3%), gentamicin (85.4%), amikacin (85.4%), nitrofurantoin (83.3%), ofloxacin (72.9%) and cefotaxime (77.1%). MBL was phenotypically detected in 7 (14%) isolates of P. aeruginosa. The presence of blaIMP-1 and blaIMP-2 MBL genes in P. aeruginosa (n=5) isolates was confirmed by PCR. The PCR did not detect blaVIM-1 and blaVIM-2 MBL genes. The P. aeruginosa isolates were multidrug resistant, with about 50% of the isolates showing multidrug resistance (MDR) to the antibiotics. The genes for MDR in the P. aeruginosa isolates were borne on plasmids, indicating a high possibility of community transmission of MBL resistance genes. Finally, the P. aeruginosa isolates from poultry food chain milieus are multidrug resistant, produce MBL, and harbour their resistance genes on plasmids. Since many antibiotic resistance genes in bacteria are associated with mobile genetic elements (MGEs) like plasmids, it is important to step up actions to mitigate incessant use of antibiotics in poultry and other agricultural practices in Nigeria in order to diminish the evolution and spread of plasmid-mediated resistance which is capable of initiating community acquired infections that may prove difficult to treat in our hospitals with the available antibiotics.

Preprint ARTICLE | doi:10.20944/preprints202308.2142.v1

A Mouse Model of Low Adipocyte Transferrin Recapitulates the Phenotype of a Human Genetic Polymorphism Associated with Insulin Sensitivity and Transferrin Expression

Felipe R Lorenzo, Swapan K Das, Alexandra V Harrison, Sandy Sink, Donald A McClain

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Transferrin; Iron; Adipocyte; Insulin Resistance; Type 2 Diabetes Mellitus

Online: 31 August 2023 (07:14:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2012.v1

EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI) and Other Patient-Reported Outcomes in the Assessment of Glandular Dysfunction in Primary Sjögren’s Syndrome

Eon Jeong Nam, Hirut Yadeta Ture, Na Ri Kim

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Sjogren’s syndrome; ESSPRI; patient-reported outcomes; ClinTrialsESSDAI, glandular dysfunction

Online: 30 August 2023 (08:13:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1992.v1

University-Business Collaboration for the Design, Development and Delivery of Critical Thinking Blended Apprenticeships Curricula: Lessons Learned from a Three-Year Project

Hugo Rebelo, Panagiota Christodoulou, Rita Payan-Carreira, Daniela Dumitru, Elena Mäkiö, Juho Mäkiö, Dimitrios Pnevmatikos

Subject: Social Sciences, Education Keywords: university business collaboration; critical thinking; curriculum co-design, development and delivery; employability; research project; labour market; higher education; soft skills

Online: 30 August 2023 (04:07:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1977.v1

Ebola Virus Infection of Liver Cells: Effect of Interferon Gamma on Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line

José A. Aguilar-Briseño, Jonah M. Elliff, J. J. Patten, Lindsay R. Wilson, Robert A. Davey, Adam L. Bailey, Wendy J. Maury

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Macrophage; Kupffer cell; interferon gamma; Ebola virus; filovirus

Online: 29 August 2023 (14:17:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1650.v1

The Molecular Characterization of Lineage-IV Peste Des Petits Ruminants Virus and the Development of In-House IELISA for Its Rapid Detection

Tahira Kamal Rana, Saeed-ul-Hassan Khan, Fariha Hassan, Aamer Bin Zahur, Aman Ullah, S. Murtaza Hassan Andrabi, Ghulam Muhammad Ali

Subject: Biology And Life Sciences, Virology Keywords: IELISA; PPRV; RT-PCR; Cost-effective

Online: 23 August 2023 (10:08:12 CEST)

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Peste des Petits Ruminants (PPR), a highly contagious viral disease, causes significant economic losses in sheep and goats. Laboratory diagnosis is crucial to disease control and eradication. Since PPRVs have recently adopted new hosts, genetic diversity within isolates of the same lineage is more likely than if they were host-specific, sheep and goats most often. ELISA detects antibodies and antigens in serology. However, mishandling, environmental conditions (temperature and humidity), storage, and sensitivity issues of commercially available ELISA kits prevent rapid PPR virus detection in third-world countries like Pakistan. In the 2020-21 outbreaks in Pakistan, 325 blood samples, 19 swabs, and 6 virus tissue samples of sheep and goats were collected from Gilgit, Islamabad, and Fateh Jang. These virus isolates were submitted to NCBI for partial N gene sequencing. Antigen was prepared from indigenous virus Using semi-purified antigen from PPRV, an indirect ELISA for the detection of PPR antibodies in goat and sheep serum was developed using MW600922 grown in Vero cells. Dilutions of 1:200 serums and 1:32 antigens improve antibody detection. The N-gene-based analysis revealed a better understanding of PPRV genetic characterization. This study develops an RT-PCR assay to detect PPRV by targeting the N-protein gene. This assay offers an accurate and affordable diagnostic tool for PPRV and partial genome sequencing. Results described that PPRV isolates from the current study have 99.73% and 99.4% similarity to previously published Lahore and Faisalabad isolates from Pakistan, respectively. Compared to previous isolates from NCBI data, the virus showed high divergence rates with the Turkish strain. The comparative analysis between Commercial kit (c-ELISA) and I-ELISA revealed that the former had a high sensitivity of 90.60% and specificity of 85.23% compared with the cELISA kit. By comparing I-ELISA and VNT, we find that the current assay is 100% specific and 82.14 % sensitive. Based on these results, serological surveys for PPR antibodies, on a larger scale, in small ruminants can be conducted with indirect ELISA rather than competitive ELISA. Furthermore, the cost and storage efficiency was highly significant because the currently developed method has a low production cost, which is much lesser than the commercially available kit. Our findings demonstrated a significant breakthrough in terms of cost-effectiveness and storage efficiency, and they are highly recommended for developing countries.

Preprint REVIEW | doi:10.20944/preprints202308.1596.v1

Psychological and Social Aspects of Vaccination Hesitancy – Implications for Travel Medicine in the Aftermath of the COVID-19 Crisis. A Narrative Review

Charalampos Milionis, Ioannis Ilias, Athanasios Tselebis, Argyro Pachi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: vaccines; vaccination refusal; anti-vaccination movement; travel medicine; pandemics

Online: 23 August 2023 (07:45:31 CEST)

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Vaccines are an important tool of preventive medicine. Organized vaccination programs have saved numerous people from serious infectious diseases. Surprisingly, there is a considerable portion of the population who oppose vaccinations. In particular, the existence of anti-vaccination perceptions among travelers to countries with endemic diseases is a major public health concern. Although hesitancy towards vaccinations is not a novel phenomenon, it came back to the forefront during the fight against the COVID-19 pandemic. This review explored the etiology of anti-vaccination beliefs among travelers and drew conclusions about their impact on public health and society in general. For this purpose, a purposeful search for data on the causative factors of vaccine hesitancy and their impact on people’s health was conducted. A descriptive analysis of the findings and conclusions about possible implications in health policy and clinical practice are presented. Fear of side effects, lack of credence in the necessity of vaccines, and mistrust of medical authorities are important causative factors. Their interplay shapes hesitancy towards vaccines. However, anti-vaccination beliefs can also be an aspect of a more general unconventional stance of life. Health care professionals and organizations must be ready to tackle vaccine hesitancy by making the necessary interventions. Correcting misconceptions about vaccinations is a prerequisite for ensuring personal and public health, especially in the context of a pandemic or epidemic. Moreover, ensuring the efficacy and safety of vaccines, especially in cases of modern technology applications, is a fundamental factor in addressing people’s concerns about vaccines. For this purpose, medical authorities and organizations must provide accurate and clear information on vaccines so as to eliminate misinformation. Furthermore, clinicians should cultivate their communication skills in order to convey the appropriate messages to prospective recipients of vaccinations.

Preprint ARTICLE | doi:10.20944/preprints202308.1559.v1

Unveiling the Potential of Weak Partial Discharges: Enhancing Defect Recognition through Extended Measurement Duration and CNN-Based Analysis from PDIV to PDEV

Chien-Hsun Chen, Chih-Ju Chou

Subject: Engineering, Electrical And Electronic Engineering Keywords: convolutional neural networks; defect recognition; partial discharge measurement durations; epoxy resin; PRPD.

Online: 23 August 2023 (07:33:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1217.v2

Cissus antractica -ZnO NPs Induce Apoptosis in A549 Cells through ROS-Mediated p53/Bcl-2/Bax Signaling Pathways and Inhibit Inflammatory Cytokines

Eshrat Jahan Rupa, Jinnatun Nahar, Md. Al-Amin, Jin-Kyu Park, Mohanapriya Murugesan, Muhammad Awais, Seung Jin Lee, Il Mun Kim, Li Ling, Deok Chun Yang, Dong Uk Yang, Seok-Kyu Jung

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Cissus antractica; ZnO NPs; anti-lung cancer; anti-inflammation; apoptosis

Online: 22 August 2023 (09:32:04 CEST)

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Green products have excellent potential for discovering and producing new medicinal products. In recent years, there is a growing interest towards the green synthesis of metal nanoparticles, particularly from plants sources. This eco-friendly approach was used in the recent research to biosynthesize zinc oxide nanoparticles (ZnO NPs) from Cissus antractica plant. The present study aims to examine the cell cytotoxicity, cell death, and pathways of apoptosis in lung cancer cells (A549) and inflammation properties treated with biosynthesized ZnO NPs. Additionally, synthe-sized ZnO nanoparticles were characterized using UV–vis spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), and Energy-dispersive X-ray spectroscopy (EDS). The XRD and TEM analyses exhibited 31 nm as the size of synthesized nanoparticles, the pure crystal form of ZnO NPs, and the shape of the NPs as nearly spherical and hexagonal quartzite. The MTT assay used for cytotoxicity evaluation de-picted the significant toxic effect of CA-ZnONPs against the A549 lung cancer cells at concentra-tions up to 20 µg/mL than non-cancerous cells. Furthermore, we observed an elevated ROS level in cancer cells. These NPs also demonstrated dose-dependent ability to suppress colony for-mation and cell migration, which increases their potential as a lung cancer treatment. Further-more, The NPs formulation's ability to induce apoptosis in cancer cells was further supported by Hoechst and propidium iodide dye. Further, CA ZnO NPs increased the gene expression of BAX, Cyto-c, Caspase 3 and 9, but decreased the expression of Bcl-2, indicating that the nanoformulation triggered mitochondrial-mediated apoptosis. Besides, this study showed that NPs suppressed in-flammatory responses by subsequently decreasing reactive oxygen species (ROS) generation, downregulating the expression of the pro-inflammatory cytokines TNF-α, iNOS, COX-2, IL-6, IL-8, and NO. Moreover, the study's findings imply that Cissus antractica are a potential source with biosynthesize nanoparticles that can might be further investigated for the progress of an-ti-inflammatory and anti-cancer drugs with further study.

Preprint ARTICLE | doi:10.20944/preprints202308.1446.v1

Genetic Association of UMOD Gene Variant (16:20353266A>G) and Bioinformatics Analyses of the Uromodulin Protein in CKD Patients of Pakistani Origin

Mehmoona Zahid, Rashid Saif, Amna Younus, Mehnaz Ghulam Hussain, Sadia Jabeen, Hooria Younas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: UMOD; CKD; Creatinine; Urea; eGFR; Uromodulin; Genotyping; ARMS-PCR

Online: 22 August 2023 (02:34:34 CEST)

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Chronic Kidney Disease (CKD) is one of the worldwide health threats, kidneys may be affected by internal pathologies and environmental factors as well as a number of genes are also involved in the kidney dysfunctioning, so UMOD is one of these genes which has significant effect in regulating urea and creatinine level in blood and decreased excretion of uric acid which causes interstitial damages in kidney and may result CKD. Hence, the present study is envisaged to observe the association of this gene locus (r.1264T>C) with CKD in Pakistani population using ARMS-PCR genotyping, for the purpose, a total of 75 samples were investigated, out of which 45 were found homozygous wild-type, 21 heterozygous and 09 homozygous mutants. PLINK data analysis toolset showed that our sampled population does not obeys Hardy-Weinberg Equilibrium by χ² (2, N = 75) = 18.87, p = and Chi-square statistics with p = 1.40×10^-005showing a significant genotypic association with the subject phenotype with an alternative allele frequency of 0.15 and 0.48 within cases & controls respectively. Furthermore, an odds-ratio of 0.2 predicts that the risk of wild-type allele (A) is 0.8 times higher in patient as compared to controls and mutant allele is 0.2 times preventive in patients. Additionally, a few bioinformatics tools e.g., ProtParam, PsiPred, TMHMM-2.0, Motif Scan, ScanProsite, NetPhos3.1, GPS PAIL2.0, NetOGlyc4.0, PRmePRed, PDB-RCSB and STRING were applied to predict different characteristics of Uromodulin protein including physicochemical properties, secondary/transmembrane structures, protein conserved domains and posttranslational modifications respectively. This pilot scale study provided a comprehensive insight of the association of aforementioned genetic variant with CKD to identify and evaluate the genetic risk factors along with functional effects of the subject variant which may be used as CKD prevention by adopting DNA screening and genetic counselling recommendations.

Preprint ARTICLE | doi:10.20944/preprints202308.1371.v1

Using Deep Neural Network Methods for Forecasting Energy Productivity Based on Comparison of Simulation and DNN Results for Central Poland – Swietokrzyskie Voivodeship

Michał Pikus, Jarosław Wąs

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: AI; Forecasting; RES

Online: 18 August 2023 (11:49:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1352.v1

Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial

Naohisa Tomosugi, Yoshitaka Koshino, Chie Ogawa, Kunimi Maeda, Noriaki Shimada, Kimio Tomita, Shoichiro Daimon, Tsutomu Shikano, Kazuyuki Ryu, Toru Takatani, Kazuya Sakamoto, Satonori Ueyama, Daisuke Nagasaku, Masato Nakamura, Shibun Ra, Masataka Nishimura, Chieko Takagi, Yoji Ishii, Noritoshi Kudo, Shinsuke Takechi, Takashi Ishizu, Takamoto Yanagawa, Masamichi Fukuda, Yutaka Nitta, Takayuki Yamaoka, Taku Saito, Suzuko Imayoshi, Momoyo Omata, Joji Oshima, Akira Onozaki, Hiroaki Ichihashi, Yasuhisa Matsushima, Hisahito Takae, Ryoichi Nakazawa, Koichi Ikeda, Masato Tsuboi, Keiko Konishi, Shouzaburo Kato, Maki Ooura, Masaki Koyama, Tsukasa Naganuma, Makoto Ogi, Shigeyuki Katayama, Toshiaki Okumura, Shigemi Kameda, Sayuri Shirai

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: oral iron absorption; ferric citrate hydrate; hemodialysis; hepcidin-25; iron shift

Online: 18 August 2023 (11:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1244.v1

Assessing the Impact of Data Sciences and Smart Technologies in Air Conditioning Project Management: A Delphi Method Analysis within the Construction Industry

Bashar Mahmood Ali, Mehmet Akkaş

Subject: Engineering, Mechanical Engineering Keywords: Intelligent Data Analyzing; energy consumption; thermal comfort; inclusion; exclusion criteria; Delphi method

Online: 18 August 2023 (10:45:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1332.v1

Human T-cell Leukemia Virus Type 1 Oncogenesis between Active Expression and Latency: A Possible Source for the Development of Therapeutic Targets

Francesca Marino-Merlo, Sandro Grelli, Antonio Mastino, Michele Lai, Paola Ferrari, Andrea Nicolini, Mauro Pistello, Beatrice Macchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HTLV-1; adult T-cell leukemia; viral oncogenesis; Tax; HBZ; apoptosis

Online: 18 August 2023 (09:41:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1276.v1

Monitoring Spatiotemporal Changes of Urban Surface Water Based on Satellite Imagery and Google Earth Engine Platform in Dhaka City From 1990-2021

Md. Jakir Hossain, Md. Munir Mahmud, Sheikh Tawhidul Islam

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Urban Surface Water; Spatiotemporal Changes; Satellite Imagery; Google Earth Engine (GEE)

Online: 17 August 2023 (08:46:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1246.v1

Identification of Damage in Planar Multi-Storey Reinforced Concrete Frames Developing a Beam-Sway Plastic Mechanism Using the “M and P” Technique

Triantafyllos K. Makarios, Athanasios P. Bakalis

Subject: Engineering, Civil Engineering Keywords: Damage identification; instantaneous eigen-frequencies diagram; pushover capacity curve; nonlinear analysis of reinforced concrete structures; seismic target-displacement; beam-sway plastic mechanism

Online: 17 August 2023 (05:25:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1002.v2

High Sensitivity for Detection of Primary Diagnostic Variants in Autism Spectrum Disorder, Including De Novo Variants, with Trio Whole Genome Sequencing and Data Reanalysis

Omri Bar, Elizabeth Vahey, Mark Mintz, Richard Eugene Frye, Richard Gregory Boles

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: autism; diagnostic yield; DNA sequencing; novel disorders

Online: 10 October 2023 (05:00:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0950.v1

Snow Cover Variability in Brunswick Peninsula, Patagonia, Derived from a Combination of Spectral Fusion, Mixture Analysis and Temporal Interpolation of MODIS Data

Francisco Aguirre, Deniz Bozkurt, Tobias Sauter, Jorge Carrasco, Christoph Schneider, Ricardo Jaña, Gino Casassa

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: snow cover; downscaling; Patagonia; spatio-temporal

Online: 14 August 2023 (08:53:11 CEST)

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Seasonal snow cover is a fundamental component of both the global energy budget and the water cycle. Its properties such as fractional snow cover or albedo are particularly affected by climate change. Several methods based on satellite data products are available to estimate these properties, each one with its pros and cons. This work presents a novel methodology that integrates three indexes applied to MODIS satellite data (Spectral Mixture Analysis (SMA), Normalized Difference Snow Index (NDSI) and Melt Area Detection Index (MADI)), to perform a spatio-temporal reconstruction of the fractional snow cover and albedo at 250 m spatial resolution in the Brunswick Peninsula, southwest Patagonia during the cold season (April-October) for the period 2000-2020. Three main steps are included: (1) the increase of the spatial resolution of MODIS (MOD09) data to 250 m using a spectral fusion technique; (2) the snow-cloud discrimination; (3) the daily spatio-temporal reconstruction of snow extent and its albedo signature with subpixel detection using the endmembers extraction and spectral mixture analysis. The results show a 98% agreement between MODIS snow detection and ground-based snow measurement at the automatic weather station Tres Morros (53.3174 °S, 71.2790 °W), with fractional snow cover values between 20% and 50%, showing a close relationship between snow and vegetation type. The number of snow days compiled from the MODIS data indicates a good performance (Pearson correlation of 0.9) compared with the number of skiing days at Cerro Mirador ski centre near Punta Arenas. Although the number of seasonal snow days show a significant increase trend of 0.54 days/year in Brunswick Peninsula during the 2000-2020 period a significant decreasing trend of -4.64 days/year was detected during 2010-2020, and also below the 400 m a.s.l. elevation, which is the most affected area. A reconstruction of the monthly mean temperature using the ERA5 Land reanalysis product shows a significant warming trend in May (0.068 ºC/year) and October (0.098 ºC/year) in the 2000-2020 period. Under the future emission scenario RCP8.5, the regional climate model RegCM4 predicts further warming during 2020-2050 of 0.059 ºC/year in July, 0.088 ºC/year in August, and 0.019 ºC/year in October, which will further reduce snow cover.

Preprint REVIEW | doi:10.20944/preprints202308.0916.v1

A Review of Isolation and Mechanism of the Crude Enzyme Chi-Tosanase for Chitosan Hydrolysis in the Production of Chitosan Oligosaccharide (COS)

Aris Munandar, Emma Rochima, Camellia Panatarani, Rida Oktarida Khastini

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: chitin; fishery waste; microorganism; oligomers; polysaccharides

Online: 11 August 2023 (10:11:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0811.v1

Therapeutic Effect of Nepenthes kampotiana Lecomte Ethanol Extract (Nk-EE) on Androgenic Alopecia through the Inhibition of Apoptosis and 5a-Reductase Activity

Dong Seon Kim, Won Young Jang, Sang Hee Park, Ji Hye Yoon, Chae Yun Shin, Lei Huang, Kry Masphal, Chhang Phourin, Hye-Woo Byun, Jino Son, Ga Ryun Kim, Byoung-Hee Lee, Jong-Hoon Kim, Jongsung Lee, Jae Youl Cho

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Alopecia areata; Nepenthes Kampotiana Lecomte; 5a-reductase; testosterone

Online: 10 August 2023 (10:48:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0661.v1

Cervical Pessary in Preterm Birth Prevention among Singleton Pregnant Women with a Short Cervix and Obtuse Uterocervical Angle: A Quasi-experimental Study

Thi Hoang Trang Nguyen, Van Tam Vu, Vu Quoc Huy Nguyen

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: uterocervical angle; cervical pessary; preterm birth; singleton pregnancy

Online: 8 August 2023 (11:21:49 CEST)

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(1) Background: This study aimed to evaluate the role of cervical pessary for preventing preterm birth in singleton pregnant women with a cervical length (CL) ≤25 mm and a uterocervical angle (UCA) ≥95o and ≥105o. (2) Methods: A quasi-experimental study was conducted on 225 singleton pregnant women with a gestational age of 16+o-23+6 weeks and transvaginal ultrasound CL measurements ≤25 mm, whose pregnancy was man-aged at the Haiphong Hospital of Obstetrics and Gynecology, Vietnam, from September 2020 to September 2022. Participants were allocated into two groups: prophylactic treatment with progesterone (123 pregnant women) and combined with a cervical pessary (102 pregnant women). The UCAs measured via transvaginal ultrasound by a single sonographer were divided into groups with UCA measurements ≥95o and ≥105o. The gestational age at birth was classified into full-term and preterm <37 weeks and <34 weeks. A binary regression model assessed the association between CL, UCA, and pre-term birth outcomes. The difference was statistically significant, with p<0.05. (3) Results: There was no statistically significant difference in the rate of preterm birth <37 weeks and <34 weeks between the two groups (16.3% vs. 11.8% and 6.5% vs. 4.9%, p>0.05). The probability of preterm birth <37 weeks in the group of pregnant women with a UCA ≥95o treated via cervical pessary plus progesterone decreased by 60.6%, OR (95% CI) of 0.394 (0.165-0.941), p<0.05. In the group of pregnant women with a UCA ≥105o, there was a significant association in the group of progesterone treatment combined with a cervical pessary, with the lower rate of PTB <37 weeks and <34 weeks, with OR (95% CI) of 0.028 (0.005-0.146), p<0.001, and 0.141 (0.030-0.664), p<0.05, respectively. (4) Conclusion: The results of this study suggest that cervical pessary is beneficial to the prevention of preterm birth in singleton pregnant women with an obtuse uterocervical angle. Further randomized studies among pregnant women with obtuse uterocervical angles will be needed to clarify the role of a cervical pessary in preventing preterm birth.

Preprint ARTICLE | doi:10.20944/preprints202308.0489.v1

Hepato-Renal Protective Potential of Dimethyl Fumarate in Alloxan-Induced Diabetic Mice Model by Modulating of Sirt1, Nrf2 and Inflammatory Genes Expressions

Parisa Saberi Hasanabadi, Fatemeh Shaki, Mohammad Karami, Abouzar Bagheri, Mohammad Ranaee, Ramin Ataee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: diabetes; dimethyl fumarate; alloxan; anti-inflammatory responses; hepato-renal-protective effects

Online: 7 August 2023 (10:13:40 CEST)

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Background: Despite advances in diabetes-related treatments, the effects of the disease have not yet been adequately reversed or prevented in patients. Therefore, there is an urgent need to develop more effective medication-assisted treatments in this field. Methods: In this study, type 1 diabetes mice models was established using multiple low-dose alloxan, and the diabetic mice were treated with three doses of dimethyl fumarate (DMF) i.e low, medium, and high viz. 20, 40 and 80 mg/kg, respectively for a period of 21 days. Then, specific test were done to evaluate blood biochemical parameters, oxidative stress markers, inflammatory genes expression, and histopathological changes in the mice kidney and liver. Results: The obtained results showed remarkably improved anti-diabetic, hepato-renal-protective, and oxidative stress indexes of DMF in alloxan-induced diabetic mice (p< 0.001). Treated mice with DMF demonstrated a noteworthy decrease in blood glucose levels when compared with diabetic group (p< 0.001). Diabetic liver and kidney tissues showed marked dilation of bile ducts, tubules, infiltration, and inflammation. On the contrary, the histological features of the treated mice with DMF improve as shown by normal size of glomerular capillaries along with decrease in less dilatation of ducts in comparison with diabetic mice. The real-time quantitative PCR results indicated that DMF injection decreased the alloxan-induced increase of significant elevations in mRNA levels of pro-inflammatory cytokines and adhesion molecules such as TNF-α, IL-6, and NF-κB levels in both kidney and liver tissues. Meanwhile, mice treated with DMF showed an increase in Sirt1 and Nrf2 expression in comparison to diabetic group. Conclusion: In conclusion, it can be concluded that DMF treatment provides hepato-renal protective effects on alloxan-induced diabetic mice model by attenuating ROS inflammatory pathways. Keywords: Diabetes, Dimethyl fumarate, Alloxan, Anti-inflammatory responses, Hepato-renal-protective effects.

Preprint ARTICLE | doi:10.20944/preprints202308.0357.v1

Polyphenols Analysis by LC-MS-ESI and Potent Antioxidant, Anti-Inflammatory, Antimicrobial Activities of Jatropha multifida L. Extracts Used in Benin Pharmacopoeia

Durand Dah-Nouvlessounon, Michaelle Chokki, Essé A Agossou, Jean-Baptiste Houédanou, Martial Nounagnon, Haziz Sina, Romana Vulturar, Simona Codruta Heghes, Angela Cozma, Jacques François Mavoungou, Adriana Fodor, Farid Baba-Moussa, Ramona Suharoschi, Lamine Baba-Moussa

Subject: Biology And Life Sciences, Life Sciences Keywords: Plant extract; LC-MS-ESI; Bioactif compound; Biological activities; Benin

Online: 4 August 2023 (07:41:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0381.v1

[Bis(quinoline)palladium (II) Chloride] as an Anticancer Drug Demonstrates Promising Activity on Its Own and in the Presence of 6-Shogaol

Md Nur Alam, Muhammad Ali Abdullah Almoyad, Jun Qing Yu, Philip Beale, Nicholas Proschogo, Farjana Akter Rupon, Masum Shahriar, Fazlul Huq

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cancer; palladium; quinoline; curcumin; 6-shogaol; proteomics

Online: 4 August 2023 (07:24:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0248.v1

Effect of Alpha Lipoic Acid Supplementation on Oxidative Stress- And Lipid Parameters in Women Diagnosed With Low-Grade Squamous Intraepithelial Lesions (LSIL)

Anja Divković, Zinaida Karasalihović, Ivana Rumora Samarin, Damir Sabitović, Kristina Radić, Nikolina Golub, Lovorka Vujić, Marija Grdić Rajković, Dubravka Vitali Čepo

Subject: Medicine And Pharmacology, Pharmacy Keywords: alpha lipoic acid; lipid status parameters; oxidative stress parameters; LSIL, diet quality index

Online: 3 August 2023 (10:16:22 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202308.0285.v1

Impact of Treatment with Ustekinumab in Severe Infections in a Patient with Uncontrolled Psoriasis and Late-Onset Combined Primary Immunodeficiency: Case Report

Luiz Euribel Prestes-Carneiro, Marilda Aparecida Milanez Morgado de Abreu, Eduardo Vinicius Mendes Roncada, Diego Garcia Muchon, Fernanda Miranda Caliani, Dewton Moraes Vasconcelos

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: late-onset combined immunodeficiency; psoriasis; ustekinumab; infections

Online: 3 August 2023 (07:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0176.v1

Effect of the Polymer Composition on the Optical Properties of a New Aggregation-Induced Emission Fluorophore: A Combined Experimental and Computational Approach

Alberto Picchi, Qinfan Wang, Francesco Ventura, Cosimo Micheletti, Jesse Heijkoop, Francesco Picchioni, Ilaria Ciofini, Carlo Adamo, Andrea Pucci

Subject: Chemistry And Materials Science, Electronic, Optical And Magnetic Materials Keywords: Poly(methyl methacrylate); Poly(cyclohexyl methacrylate); Tetraphenylethylene (TPE); Aggregation-induced emission; Density functional theory investigations; Luminescent solar concentrator

Online: 2 August 2023 (10:49:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0201.v1

Comparing System of Rice Intensification Methods With Alternatives, considering Labor-Saving, Water-Saving, Economic, Energy, Soil Biology, and Climate Effects in India

Mahender Kumar Rapolu, Padmavathi Chintalapati, Santhosha Rathod, Vidhan Singh Tapeshwar, Surekha Kuchi, Prasad Babu MBB, Latha PC, Somasekhar Nethi, Nirmala B, Srinivas Prasad M, Jasti Prasad V.N.S, Vijay Kumar S, Srinivas D, Sreedevi B, Mangaldeep Tuti, Arun MN, Sailaja B, Sundaram RM

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Rice-rice system; crop establishment methods; System of Rice Intensification; modified System of Rice Intensification; greenhouse gases; climate-resilience

Online: 2 August 2023 (10:10:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0112.v1

Seasonal Changes of Sea Ice Thickness in the Eastern Arctic Ocean Evident from Remotely Sensed and In-Situ Observations in 2013–2015

Andrey V. Pnyushkov

Subject: Environmental And Earth Sciences, Oceanography Keywords: sea ice thickness; Arctic Ocean; Eurasian Basin; ice profiling sonars

Online: 2 August 2023 (08:36:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0060.v1

Influence of the heat treatment duration on the cycling performance and electrochemical mechanism of Na2Ti3O7 as anode material for Na-ion batteries

Caroline Piffet, Nicolas Eshraghi, Gregory Mottet, Frédéric Hatert, Jolanta Swiatowska, Rudi Cloots, Frederic Boschini, Abdelfattah Mahmoud

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Na-ion batteries; Na2Ti3O7; Operando XRD; Insertion mechanism; Electreochemical impedance spectroscopy

Online: 2 August 2023 (05:42:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0103.v1

Long Range Transport Analysis Based on Eastern Atmospheric Circulation and Its Impact to the Dust Event over Moldavia, Romania in August 2022

Diana Corina Bostan, Ingrid Mihaela Miclăuș, Cosmina Apetroaie, Mirela Voiculescu, Adrian Timofte, Marius Mihai Cazacu

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: dust transport; air pollution; eastern atmospheric circulation; aerosols

Online: 2 August 2023 (02:31:18 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202307.2162.v1

Long-Term L-Glutamine Treatment Reduces Hemolysis Without Ameliorating Hepatic Vasoocclusion and Liver Fibrosis in a Mouse Model of Sickle Cell Disease

Omika Katoch, Ramakrishna UV, Tomasz Kaminski, Ziming Li, Rikesh K Dubey, Isabella Burholt, Shweta Gudapati, Tirthadipa Pradhan-Sundd

Subject: Medicine And Pharmacology, Hematology Keywords: Sickle cell disease; hemolysis; vasoocclusion; l-glutamine; Liver injury; Kupffer cells

Online: 1 August 2023 (14:24:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2069.v1

Involvement of the Soluble Guanylate Cyclase, Nitric Oxide Synthase and Cytokines Pathway in the Anti-inflammatory Profile of N-acylhydrazone Derivatives (JR19)

Pablo Rayff Da Silva, Nadjaele de Melo Apolinário, Simone Ângela Soares Da Silva, Maria Elaine Cristina Araruna, Thássia Borges Costa, Yvnni M. S. de Medeiros e Silva, Teresinha Gonçalves Da Silva, Vanda Lucia Lucia Dos Santos, Ricardo Olímpio De Moura

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: cytokines; leukocyte migration; N-acylhydrazones; nitric oxide

Online: 31 July 2023 (10:51:13 CEST)

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The N-acylhydrazone function has been reported as a pharmacophore group of molecules with diverse pharmacological activities, including anti-inflammatory effects. Thus, this study evaluated the anti-inflammatory potential of the compound N'-(3-(1H-indol-3-yl)benzylidene)-2-cyanoacetohydrazide (JR19) in vivo. The study started with the carrageenan-induced peritonitis model, followed by an investigation of leukocyte migration using the subcutaneous air pouch test and an assessment of the antinociceptive profile using formalin-induced pain. To find out the likely mechanism of action, a preliminary molecular docking study was performed focusing on the crystallographic structures of NFκB, iNOS, and sGCs. The computational study revealed satisfactory interaction energies with the selected targets, and the same peritonitis model was used to validate the involvement of the nitric oxide pathway and cytokine expression in the peritoneal exudate of mice pretreated with L-NAME or methylene blue. In the peritonitis assay, JR19 (10 and 20 mg/kg) reduced leukocyte migration by 59% and 52%, respectively, compared to the control group, with the 10 mg/kg dose used in subsequent assays. In the subcutaneous air pouch assay, the reduction in cell migration was 66%, and the response to intraplantar formalin was reduced by 39%, particularly during the inflammatory phase, suggesting that the compound lacks central analgesic activity. In addition, a reversal of the anti-inflammatory effect was observed in mice pretreated with L-NAME or methylene blue, indicating the involvement of iNOS and sGC in the anti-inflammatory response of JR19. The compound effectively and significantly decreased the levels of IL-6, TNF-α, IL-17, and IFN-γ, and this effect was reversed in animals pretreated with L-NAME, supporting a NO-dependent anti-inflammatory effect. In contrast, pretreatment with methylene blue only reversed the reduction in TNF-α levels. Therefore, these results demonstrate the pharmacological potential of the novel N-acylhydrazone derivative, which acts through the nitric oxide pathway and cytokine signaling, making it a strong candidate as an anti-inflammatory and immunomodulatory agent.

Preprint ARTICLE | doi:10.20944/preprints202307.1987.v1

Urban Governance and Sanitation in the Peri-Urban Commune of Agoè-Nyvé 6 in Togo: Diagnosis of the Sanitation System in Adétikopé

Efui Holaly GBEKLEY, Koko Zébéto HOUEDAKOR, Kossi KOMI, Sossawè POLI, Koffi ADJALO, Ablam NYAKPO, Ayayivi Mensah AYIVIGAN, Abdourahamane Aissa Ghanny Vanessa ALI, Kossiwa ZINSOU-KLASSOU, Pèssiezoum ADJOUSSI

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: urban governance; sustainable development; wastewater management; Adétikopé; Togo

Online: 28 July 2023 (10:08:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.1739.v1

The Genetic Puzzle of a SOD1-Patient with Ocular Ptosis and a Motor Neuron Disease: How Many Variants Contribute to the Phenotype?

Veria Vacchiano, Flavia Palombo, Danara Ormanbekova, Claudio Fiorini, Alessia Fiorentino, Leonardo Caporali, Andrea Mastrangelo, Maria Lucia Valentino, Sabina Capellari, Rocco Liguori, Valerio Carelli

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: SOD1; amyotrophic lateral sclerosis; TBK1; mitochondrial DNA; oligogenic inheritance.

Online: 26 July 2023 (11:25:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1721.v1

Application of the Simplified Landscape Irrigation Design Estimation (Slide) Rule for Outdoor Water Conservation for the Industrial, Commercial, and Institutional (Ici) Sector

Denise Blanchard

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: Water scarcity; water conservation-ICI sector; Pittenger SLIDE formula; landscape irrigation; outdoor water savings technologies; scenario analysis water and climate types

Online: 25 July 2023 (13:11:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1699.v1

The Effects of Transplantation of the Spaceflight Intestinal Microbiome on Short Chain Fatty Acid Production, Lymphoid organ Immune Composition and Transport Kinetics

Reid Powell, Mark Endsley, Walter Emerson Cromer

Subject: Biology And Life Sciences, Life Sciences Keywords: microbiome; spaceflight; lymphatic; short chain fatty acid; trascriptome

Online: 25 July 2023 (10:46:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1641.v1

Robust Tracking as Constrained Optimization by Uncertain Dynamic Plant: Mirror Descent and Average Sub-Gradient Methods -- Version of Integral Sliding Mode Control

Alexander Nazin, Alexander Poznyak

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: robust control; trajectory tracking; convex constrained optimization; subgradient descent method; sliding mode

Online: 25 July 2023 (09:30:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1647.v1

Association Between Non-Steroidal Anti-Inflammatory Drug Use and Major Cardiovascular Outcomes in Patients with Acute Coronary Syndrome in the Arabian Gulf

Ibrahim Al-Zakwani, Juhaina Salim Al-Maqbali, Wael Almahmeed, Najib AlRawahi, Abdullah Al-Asmi, Mohammad Zubaid

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: non-steroidal anti-inflammatory drug; stroke; acute coronary syndrome; myocardial infarction; mortality; readmission; Arabian Gulf

Online: 25 July 2023 (08:26:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1543.v1

Recruitment of the Histone Variant macroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation

Ludmila Recoules, Nicolas Tanguy Le Gac, Fatima Moutahir, Kerstin Bystricky, Anne-Claire Lavigne

Subject: Biology And Life Sciences, Life Sciences Keywords: chromatin; macroH2A1; pericentromere

Online: 24 July 2023 (09:28:32 CEST)

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