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Preprint ARTICLE | doi:10.20944/preprints202404.0859.v1

Characterization of Grape Pomace Extract Microcapsules – the Influence of Carbohydrate Co-coating on the Stabilisation of Goat Whey Protein as Primary Coating

Gabriela Perković, Josipa Martinović, Gordana Šelo, Ana Bucić-Kojić, Mirela Planinić, Rita Ambrus

Subject: Biology And Life Sciences, Food Science And Technology Keywords: grape pomace; encapsulation; spray drying; goat whey protein; trehalose; sucrose; xylose; maltodextrin; microcapsule characterization; phenolic compounds

Online: 12 April 2024 (16:02:43 CEST)

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Working Paper ARTICLE

Assessment of Concentrations of Heavy Metals (Cu, Zn, Mn, Co, and Fe) in Postmyocardial Infarction Patients and Patients Free from Cardiovascular Event and Their Relationship with the Occurrence of Myocardial Infarction

Grzegorz Józef Nowicki, Barbara Ślusarska, Andrzej Prystupa, Eliza Blicharska, Agnieszka Adamczuk, Tomasz Czernecki, Krzysztof Jacek Jankowski

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiovascular disease; heavy metals; cooper; zinc; manganese; cobalt; iron; health risk assessment

Online: 9 June 2020 (03:25:06 CEST)

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Cardiovascular diseases (CVDs) constitute the first cause of death among the population of developing and developed countries. Atherosclerosis, which is a disorder with multifactorial etiopathogenesis, underlies most CVDs. The available literature includes ample research studies on the influence of classic cardiovascular (CV) risk factors. However, environmental exposure to heavy metals, among other substances, is still an unappreciated risk factor of CVDs. This study aimed to assess the concentration of some heavy metals (copper (Cu), zinc (Zn), manganese (Mn), cobalt (Co), and iron (Fe)) in the blood serum of postmyocardial infarction (post-MI) patients and patients free from myocardial infarction (MI) as well as estimate the relationship between the occurrence of MI and increased concentration of heavy metals. The concentration of heavy metals (Cu, Zn, Mn, Co, and Fe) was assessed using the inductively coupled plasma mass spectrometry technique in a group of 146 respondents divided into two groups: post-MI group (study group (SG), n = 74) and group without cardiovascular event (CVE) having a low CV risk (control group (CG), n = 72). The concentration of the analyzed heavy metals was higher in SG. All the heavy metals showed a significant diagnostic value (p < 0.001). The highest value of area under the curve (AUC) was observed for manganese (Mn) (0.955; 95% confidence interval (CI) = 0.922–0.988), while the lowest value was found for zinc (Zn) (0.691; 95% CI = 0.599–0.782). In one-dimensional models, high concentrations of each of the analyzed heavy metals significantly increased the chances of having MI from 7-fold (Cu) to 128-fold (Mn). All the models containing a particular metal showed a significant and high discrimination value for MI occurrence (AUC 0.72–0.92). Higher concentrations of Cu, Zn, Mn, Co, and Fe were found to considerably increase the chances of having MI. Considering the increasingly higher environmental exposure to heavy metals in recent times, their concentrations can be distinguished as a potential risk factor of CVDs.

Preprint ARTICLE | doi:10.20944/preprints202206.0248.v1

Relativistic Dilation and Contraction of the Probabilities of Quantum States of Light at Angular Incidence

Daniel Souza Cardoso, José Rafael Bordin

Subject: Physical Sciences, Optics And Photonics Keywords: Relativistic probability; relativistic synchronization; classical relativistic variability; quantized states of light; polarization inversion; light resonance curve; relativistic photon ignition; angular momentum; moment of inertia; relativistic constant; relativistic energy wave; photon-matter in-teraction

Online: 17 June 2022 (04:59:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1166.v1

Establishment of a System Dynamics Model for Sustainable Development of Ecotourism in Oceanic Island National Parks

Laurence Zsu-Hsin Chuang, Eric Li-Hau Chen

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: ecotourism; oceanic island national parks; sustainable development indicator framework; system dynamics; conservation fee

Online: 15 October 2024 (08:42:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0787.v1

Mitigating Acute Climate Change Threats to Reintroduced Migratory Northern Bald Ibises

Johannes Fritz, Markus Unsoeld, Bernhard Goenner, Regina Kramer, Lisbet Siebert-Lang, Helena Wehner

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: northern bald ibis; conservation; climate change; translocation; bird migration

Online: 10 October 2024 (11:58:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.0238.v1

Leveraging Chatbots for Effective Educational Administration: A Systematic Review

Kanaan Al-Jaf, Cemil Öz, Hoger Mahmud, Tarik A. Rashid

Subject: Computer Science And Mathematics, Computer Science Keywords: chatbots; educational administration; generative AI; ChatGPT; PRISMA; systematic review

Online: 7 October 2024 (03:27:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0105.v1

The Evolution of Dilatant Shear Bands in High Pressure Die Casting for Al-Si Alloy

JINGZHOU LU, ewan lordan, Kun Dou

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Shear bands; ; Segregation; ; Defects; ; Aluminium alloys; ; High pressure die casting

Online: 2 October 2024 (09:46:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0082.v1

Multi-Agent Reinforcement Learning for Smart Community Energy Management

Patrick Wilk, Ning Wang, Jie Li

Subject: Engineering, Electrical And Electronic Engineering Keywords: Reinforcement Learning; energy management; multi-agent; electric vehicle

Online: 1 October 2024 (16:09:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2452.v1

Urban Heritage Resilience 3.0 An Integrated and Operationable Definition from the SHELTER and ARCH Projects

Mathias Ripp, Aitziber Egusquiza, Daniel Lückerath

Subject: Arts And Humanities, Architecture Keywords: Urban Heritage; Resilience; Urban Planning; Climate change; Urban Development; Sustainable Urban Development

Online: 1 October 2024 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2349.v1

Effect of Different Marinades and Types of Grills on Polycyclic Aromatic Hydrocarbon Content in Grilled Chicken Breast Tenderloins

Marta Ciecierska, Urszula Komorowska

Subject: Biology And Life Sciences, Food Science And Technology Keywords: PAHs; chicken breast tenderloins; grill; marinades; QuEChERS; HPLC–FLD/DAD

Online: 30 September 2024 (04:28:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1520.v1

‘I Can’t Even Talk to My Parents About It’: South Sudanese Youth Advocates’ Perspectives on Suicide Through Reflexive Discussions and Collaborative Poetic Inquiry

Amani Kasherwa, Caroline Lenette, Achol Arop, Ajang Duot

Subject: Social Sciences, Area Studies Keywords: critical suicide studies; collective poetic inquiry; suicide; reflexive discussion; youth advocates; South Sudanese

Online: 20 September 2024 (10:50:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1538.v1

System, Life and Modernity: Study on the Design of the Collective Residential Buildings of the People’s Commune in the Early Stage of P.R.C

Fei Yu, Lu Ye, Yi Zhu

Subject: Arts And Humanities, Architecture Keywords: Rural construction; People’ s commune; collective housing; courtyard; sideline

Online: 19 September 2024 (16:47:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0086.v1

Enhancing Romanian Naval Resilience to Climate Change: Advanced Functional Materials for Green Defence Strategies

Maria Emanuela Mihailov, Alecsandru Vladimir Chirosca, Gianina Chirosca, Miruna Georgiana Ichim

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Climate change adaptation; Romanian Navy; Green Defence; Self-healing materials; Robust infrastructure; Sensor systems; Coastal security; Resilience

Online: 2 September 2024 (16:30:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0004.v1

Adverse Drug Reactions of Cardiovascular Classes of Medicines – Data for the Bulgarian Population

Zornitsa Mitkova, Anita Dimova, Guenka Petrova, Maria Dimitrova

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: drug-related side effects and adverse reactions; antihyperlipidemic medicines; angiotensin-converting enzyme (ACE) - inhibitors; sartans

Online: 2 September 2024 (03:31:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2152.v1

Adaptive Control of Retrieval-Augmented Generation for LLMs Through Reflective Tags

Chengyuan Yang, Satoshi Fujita

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Retrieval-Augmented Generation; Large Language Models; Chain of Thought; reflective tag

Online: 30 August 2024 (03:45:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1931.v1

An Android Based Internet Of Medical Things Adaptive User Authentication And Authorisation Model For The Elderly

Prudence M Mavhemwa, Marco Zennaro, Philibert Nsengiyumva, Frederic Nzanywayingoma

Subject: Computer Science And Mathematics, Security Systems Keywords: Elderly Patients; SSA; Chronic-ailments; Risk-Calculation; Adaptive-Authentication; Smartphone; Usable-Security

Online: 27 August 2024 (07:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1858.v1

A Dynamic Simulation of a Piezoelectric Energy Harvesting System Integrated with a Closed-Loop Voltage Source Converter for Sustainable Power Generation

Ahmed K Ali, Ali Abdulwahhab Abdulrazzaq, Ali H. Mohsin

Subject: Engineering, Electrical And Electronic Engineering Keywords: controlled PWM rectifier; P&; O MPPT; closed-loop converter; piezoelectric energy harvesting; sustainable renewable energy

Online: 26 August 2024 (17:08:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1359.v1

Preparing the Future Public Health Workforce: Integrating Relational Employability to Foster Critical Global Citizenship

Elizabeth J Cook, Sally-Anne Doherty, Ruth Wallace

Subject: Public Health And Healthcare, Other Keywords: Relational employability; global citizenship; public health education; research skills development; critical reflective practice; higher education curriculum; health workforce development; global competence; qualitative research

Online: 20 August 2024 (12:09:13 CEST)

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A well-prepared public health workforce is essential for reducing disease burdens and improving population health, requiring an education that addresses global and complex challenges. This paper examines the integration of the relational employability framework in public health education to cultivate critical global citizenship among students and graduates. Our research, conducted at Edith Cowan University in Perth, Western Australia, involved two case studies using qualitative interviews. Case Study 1, drawn from Cook’s doctoral research, explored student experiences with the relational employability framework within an undergraduate capstone unit. Case Study 2, a school-funded project, gathered graduate perspectives to inform ongoing curriculum development. The findings indicate that the relational employability framework enhances global competencies among students and graduates, through research skills development and critical reflective practice. Students reported improved awareness of their learning needs, self-confidence, and an increased ability to engage with diverse perspectives and societal challenges. Graduates highlighted the framework’s role in understanding ethical standards, conducting rigorous research and applying evidence-based practices in professional settings. Additionally, the framework supported the development of a reflective mindset, enabling graduates to make informed, value-based career decisions and advance their professional growth. The study suggests that adopting a relational employability approach can effectively prepare globally competent and reflective public health professionals. We advocate for the broader implementation of this framework in health education and higher education, offering practical recommendations for curriculum transformation. Such an approach will equip future professionals to contribute meaningfully to public health debates and embody the principles of global citizenship in their practice.

Preprint ARTICLE | doi:10.20944/preprints202408.1372.v1

Acute Stimulation of PBMCs Drives Switch from Dopamine-Induced Anti- to proinflammatory Phenotype of Monocytes Only in Women

Leonie Fleige, Silvia Capellino

Subject: Biology And Life Sciences, Other Keywords: dopamine; sex-specific differences; monocytes; B cells; cytokines; human

Online: 20 August 2024 (03:22:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1252.v1

An Analysis of General and Specific Deterrence Perception of Drivers Using Structural Equation Modeling

Mohammad Khojastehpour, Sina Sahebi, Mohammad SafariTaherkhani

Subject: Engineering, Transportation Science And Technology Keywords: General deterrence, Specific deterrence, Driving violations, Traffic enforcement, Private sector, Structural Equation Modeling

Online: 19 August 2024 (16:58:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1239.v1

Application of ALRW‐DDPG Algorithm on Offshore Oil‐Gas‐Water Separation Control

Xiaoyong He, Han Pang, Boying Liu, Yuqing Chen

Subject: Engineering, Energy And Fuel Technology Keywords: offshore oil‐gas production; ALRW‐DDPG algorithm; Three‐phase separator; liquid level control; slug flow

Online: 16 August 2024 (12:46:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0305.v1

Eight-Bar Elbow Joint Exoskeleton Mechanism

Giorgio Figliolini, Chiara Lanni, Luciano Tomassi, Jesús Ortiz

Subject: Engineering, Mechanical Engineering Keywords: ; upper-limb exoskeleton; elbow joint; multi-loop mechanisms; kinematic analysis; mechanical design ;

Online: 6 August 2024 (03:26:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0279.v1

New Clavelina (Ascidiacea) Species from the Bahamas

Xavier Turon, Susanna Lopez-Legentil

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Clavelina picta; Clavelina pawliki; Clavelina rochae; Clavelina erwinorum; Clavelinid; Tunicate; Ascidian; COI; Caribbean Sea; phylogenetic analyses

Online: 5 August 2024 (08:38:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0015.v1

Detection of Dengue Virus 1 and Mammalian Orthoreovirus 3, with Novel Reassortments, in a South African Family Returning from Thailand, 2017

Petrus Jansen van Vuren, Rhys H. Parry, Janusz T. Paweska

Subject: Biology And Life Sciences, Virology Keywords: dengue virus; mammalian orthoreovirus; MRV; imported infections; clinical metagenomics; metagenomics

Online: 1 August 2024 (11:13:04 CEST)

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In July 2017, a family of three members; a 46-year-old male, a 45-year-old female and their 8-year-old daughter, returned to South Africa from Thailand. They presented symptoms consistent with mosquito-borne diseases, including fever, headaches, severe body aches and nausea. Mosquito bites in all family members suggested recent exposure to arthropod-borne viruses. Dengue virus 1 (Genus Orthoflavivirus) was isolated (isolate no. SA397) from the serum of the 45-year-old female via intracerebral injection in neonatal mice and subsequent passage in VeroE6 cells. Phylogenetic analysis of this strain indicated close genetic identity with cosmopolitan genotype 1 DENV1 strains from Southeast Asia, assigned to major lineage K, minor lineage 1 (DENV1I_K.1), such as GZ8H (99.92%) collected in November 2018 from China and DV1I-TM19-74 isolate (99.72%) identified in Bangkok, Thailand, in 2019. Serum samples from the 46-year-old male yielded a virus isolate that could not be confirmed as DENV1, prompting unbiased metagenomic sequencing for virus identification and characterization. Illumina sequencing identified multiple segments of a Mammalian orthoreovirus (MRV), designated Human/SA395/SA/2017. Genomic and phylogenetic analysis classified Human/SA395/SA/2017 as MRV-3 and assigned a tentative genotype MRV-3d based on the S1 segment. Genomic analyses suggested Human/SA395/SA/2017 may have originated from reassortments of segments among swine, bat, and human MRVs. The closest identity of the viral attachment protein σ1 (S1) was related to a human isolate identified from Tahiti, French Polynesia, in 1960. This indicates ongoing circulation and cocirculation of Southeast Asian and Polynesian strains, but detailed knowledge is hampered by limited availability of genomic surveillance. This case represents a rare concurrent importation of two distinct viruses with different transmission routes in the same family with similar clinical presentations. It highlights the complexities of diagnosing diseases with similar sequelae in travellers returning from tropical areas.

Preprint ARTICLE | doi:10.20944/preprints202408.0011.v1

Experimental Study of Sinkhole Propagation Induced by a Leaking Pipe Using Fibre Bragg Grating Sensors

Josué Yumba, Maria Ferentinou, Michael Grobler

Subject: Engineering, Civil Engineering Keywords: Sinkhole modelling; fibre Bragg grating; FBGs; optical fibre sensors

Online: 1 August 2024 (11:04:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2124.v1

Potential of a Low-iron Micronutrient Powder (MNP) for Prevention of Anemia in Children in a Low-iron Groundwater Setting: A Cross-sectional Study in Rural Bangladesh

Sabuktagin Rahman, Patricia Lee, Nezam Uddin Biswas, Moududur Rahman Khan, Faruk Ahmed

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Iron; Groundwater; Low-iron MNP; Anemia; Bangladesh

Online: 26 July 2024 (09:56:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1901.v1

Does Corporate Governance and Earning Quality Mitigate Idiosyncratic Risk? Evidence from an Emerging Economy

Habib Ur Rahman, Asif Ali, Adam Arian, John Sands

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Idiosyncratic risk; Accrual quality; Earning quality; Corporate governance; Board quality index

Online: 24 July 2024 (11:29:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1622.v1

Visual Cues, Liking, and Emotional Responses: What Combination of Factors Result in the Willingness to Eat Vegetables among Children with Food Neophobia?

Xiaoqin Tan, Shureen Faris Abdul Shukor, Soh Kim Geok

Subject: Social Sciences, Psychology Keywords: intrinsic cues; extrinsic cues; plate; color; shape

Online: 19 July 2024 (16:56:06 CEST)

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Childhood nutrition is a cornerstone of long-term health, yet many children exhibit reluctance to consume healthy foods such as vegetables. This aversion can be influenced by various factors, including food neophobia and the sensory and visual appeal of the foods presented. Understanding how visual cues affect children's willingness behaviors can provide insights into effective strategies to enhance their dietary habits. This study aims to investigate the liking and emotional responses on the relationships between intrinsic and extrinsic cues and children's willingness to eat and to ask parents to buy. To understand how these factors influence children with food neophobia food-related behaviors and to identify effective strategies to promote healthier eating habits. A sample size consisting of 420 children recruited was needed in this cross-sectional study. A validated and reliable self-administered questionnaire was employed. Independent t-test and ANOVA were used to test the differences between gender and food neophobia means. Spearman correlations were used for correlation analysis. Hierarchical regression analyses were conducted to explore the relationships among intrinsic cues, extrinsic cues, and the mediating effect of liking and emotional responses. Attributes such as plate color and shape significantly influence children's food-related behaviors and their emotions. Liking and emotional responses significantly mediates the relationship between intrinsic/extrinsic cues and willingness. Positive visual cues experiences are crucial for increasing children's inclination to purchase and consume. Positive emotional responses enhance acceptance and purchase. There are significant differences between boys and girls. Boys prefer blue and triangular plates, while girls prefer pink plates and generate more positive emotions. Children with food neophobia will initially experience a disorder, but its negative effects can be mitigated by increasing sensory appeal and emotional engagement. By employing strategies designed to enhance visual cues and liking and emotions, children’s willingness to choose healthy eating habits can be effectively increased.

Preprint ARTICLE | doi:10.20944/preprints202406.0082.v2

A Field-Theory Approach for Modeling Dissipative Relativistic Fluids

Nils Andersson, Thomas Celora, Gregory Comer, Ian Hawke

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: relativistic fluids; dissipation; field theory

Online: 16 July 2024 (05:26:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0702.v1

Attention Semantic Segmentation Network for Remote Sensing Images of Water Area

SEUNG JUN LEE, Hong Sik Yoon, Sang Woo Kwak

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: Remote sensing; semantic segmentation; deep convolutional neural networks

Online: 9 July 2024 (05:45:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0469.v1

The Role of HLA Class I Genes in Genital HPV Pathogenesis in African Women: A Review

Olwethu Majola, Eric Asempah, Yanga Mdleleni

Subject: Biology And Life Sciences, Virology Keywords: HPV; MHC; HLA Class 1 genes; cervical cancer; review.

Online: 5 July 2024 (06:57:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0332.v1

Interpolation of Nitrogen Fertilizer Use in Canada from Fertilizer Use Surveys

James Arthur Dyer, Angela Pearson, Raymond Louis Desjardins

Subject: Environmental And Earth Sciences, Soil Science Keywords: Nitrogen fertilizer rates; Fertiliizer use surveys; Survey histograms; Non-parametric deviation estimates; Crop area integrations; GHG emissions

Online: 3 July 2024 (10:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2011.v1

Comparative Analysis Of The Responses Of Various Bromodomain Inhibitors In Cancer Cell Lines Utilizing Various Machine Learning Models

Gizem Tutkun, Muharrem Okan Cakir, Ugur Bilge

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: machine learning; prediction methods; cancer; ic50; r programming

Online: 29 June 2024 (05:59:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.2002.v1

Experimental Study on the Suitability of Waste Plastics and Glass as Partial Replacement of Fine Aggregate in Concrete Production

Alemu Mosisa Legese, Degefe Mitiku, Fekadu Fufa Feyessa, Girum Urgessa, Yada Tesfaye Boru

Subject: Engineering, Civil Engineering Keywords: aggregate replacement, waste plastics, waste glass, workability, tensile strength, flexural strength, and compressive strength

Online: 28 June 2024 (10:52:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1911.v1

Progression of Coronary Artery Calcification According to Changes in Risk Factors in Asymptomatic Individuals

Jin Young Yoo, Se Ri Kang, Eun Ju Chun

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary artery calcium; computed tomography; clinical risk factors

Online: 27 June 2024 (04:26:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1350.v1

Advanced Scale-Propeller Design Using a MATLAB Optimization Code

Stephen D. Prior, Daniel Newman-Sanders

Subject: Engineering, Aerospace Engineering Keywords: Propeller; Small-Scale; Efficiency; Design; Optimization; MATLAB; Low Re Number.

Online: 20 June 2024 (03:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1322.v1

Self-Sustained Learning in English Learning and Its Predictors

Luxi Yang, Hui Wang, Hao Zhang, Haiying Long

Subject: Social Sciences, Education Keywords: learning English as a second language; self-sustained learning; intercultural communicative skills; language mindset; positive L2 self; Structural Equation Modeling; indirect effects ;

Online: 19 June 2024 (07:39:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1234.v1

Exposure to Sympathetic Stress during Gestation Modifies Cardiovascular and Metabolic Function in Female Progeny in Rats

Beatriz Piquer, Alfonso Paredes, Constanza Alanis, Sara Peña, Hernan E. Lara

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: gestational programming; cardiovascular; norepinephrine; beta receptors

Online: 19 June 2024 (02:45:39 CEST)

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Increased norepinephrine (NE) release from the sympathetic nerves during pregnancy in women or animal models, as occurs during stress, modifies the fetal environment and increases flow of NE to the fetus, programing the progeny and affecting its cardiovascular and metabolic function in adulthood. In the present work, gestating rats were exposed to stress during gestation and the female progeny was analyzed for heart and metabolic function. Pregnant Sprague–Dawley rats were exposed to cold stress (4 °C/3 h/day); rats’ female progeny were euthanized at 4, 20 and 60 days old and their hearts evaluated to determine the β-adrenergic receptor (βAR) mRNA, abundance and affinity to agonists and NE concentration. The in vivo response to glucose overload and the arterial pressure response to isoproterenol (ISO, 125 µg/kg weight/day/10 days) were monitored. Results: At 20 and 60 days old, stressed female progeny presented an increase in ventricular weight and no changes in the cardiac NE as compared with their age-matched controls. The β1AR mRNA in control rats decreased between 4 and 20 days of age, but stressed rats maintained 50% higher levels of mRNA as compared with their age-matched controls. This difference was also found in the protein abundance of β1AR. No differences were found at 60 days old. The β2AR mRNA levels were higher than in controls at both 4 and 20 days old, but not expressed in the amount of protein. An increase in the ratio of β1/β2 receptors was found at 20 days old but not at 60 days old. The displacement of 3H-dihydroalprenolol (DHA) from a membrane fraction with propranolol (β antagonist) showed decreased affinity (at 60 days old) but no changes in the βAR number. In vivo exposure to ISO induced a β-adrenergic overload and provoked death in 40% of stressed females by day 3 of ISO treatment. Regarding metabolic function, we found that stressed rats presented insulin resistance when adults. These data suggest permanent changes to the heart’s adrenergic response and metabolic function after rat progeny were stressed in the uterus.

Preprint ARTICLE | doi:10.20944/preprints202406.1209.v1

Relationship between Family Factors, Food Consumption Behaviors, and Nutritional Status among Muslim School-Age Students in Nakhon Si Thammarat Province, Thailand

Pastraporn Kaewpawong, Kiatkamjorn Kusol

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: food consumption behaviors; nutritional status; Muslim school-age students

Online: 18 June 2024 (11:32:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1023.v1

Construction Quality Evaluation of Concrete Structures in Hydraulic Tunnels Based on CWM-UM Modeling

Liang Zhao, ChangHai He, Zhuangzhuang Luo, Qingfu Li

Subject: Engineering, Civil Engineering Keywords: combinatorial assignment; unconfirmed measure theory; hydraulic tunnels; concrete structures; construction quality evaluation

Online: 14 June 2024 (14:08:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0725.v1

A review on Machine Learning Deployment Patterns and Key Features in the Prediction of Preeclampsia

Louise Pedersen, Magdalena Mazur-Milecka, Jacek Ruminski, Stefan Wagner

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: deployment pattern; machine learning; prediction; preeclampsia; risk assessment; review

Online: 11 June 2024 (14:04:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0573.v1

Enhancing Metabolic Syndrome Detection through Blood Tests Using Advanced Machine Learning

Petros Paplomatas, Dimitris Rigas, Athanasia Sergounioti, Aristidis Vrahatis

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Metabolic Syndrome (MetS); Machine Learning (ML); Feature Importance; Borda Count Method; Predictive Modeling; Ensemble Models; Cross-Validation; Non-Invasive Diagnostics

Online: 10 June 2024 (12:50:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0449.v1

Interaction of Vasopressin with Hormones of the Hypothalamo-Pituitary-Adrenal Axis: Significance for Therapeutic Strategies in Cardiovascular and Metabolic Diseases

Ewa Krystyna Szczepańska-Sadowska, Katarzyna Czarzasta, Wiktor Bogacki-Rychlik, Michał Kowara

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: AVP; CRH; ACTH; glucocorticoids; mineralocorticoids; androgens; estrogens; hypertension; cardiac failure; stress

Online: 7 June 2024 (08:24:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0370.v1

Cardiovascular Aging in HIV Infection: Analysis of Involved Genes

Fabiola Boccuto, Salvatore De Rosa, Pierangelo Veltri, Daniele Torella, Pietro Hiram Guzzi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: HIV; aging; cardiovascular desease

Online: 6 June 2024 (11:34:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.2067.v1

Maternal Vaccination for the Prevention of Infantile RSV Disease: An Overview of the Authorized, In-Progress, and Unsuccessful Vaccine Candidates.

Georgios Papazisis, Xanthippi Topalidou

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: infant immunity; maternal antibody transfer; respiratory syncytial virus; maternal immunization; RSV vaccine; clinical trial; safety; immunogenicity

Online: 30 May 2024 (14:23:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.2016.v1

Tolerance Mechanisms of Olive Tree (Olea europaea) Under Saline Conditions

Mohamed El Yamani, María del Pilar Cordovilla

Subject: Biology And Life Sciences, Plant Sciences Keywords: ; salt stress; tolerance; morphological adaptation; photosynthesis; antioxidant defense; osmotic adjustment; proteins; molecular mechanisms

Online: 30 May 2024 (08:33:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1907.v1

Skin Health Benefits and Microbial Consortium of Stevia Fermented with Barley Nuruk

Hyun-Ju Han, Min Nyeong Ko, Chan Seong Shin, Chang-Gu Hyun

Subject: Biology And Life Sciences, Food Science And Technology Keywords: antioxidant; barley nuruk; α -glucosidase; microbiome; skin irritation; stevia; UPLC-Q-TOF-MS

Online: 29 May 2024 (08:33:51 CEST)

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In this study, the microbial community during the barley yeast fermentation of stevia leaves and its correlation with antioxidant, antiobesity, and anti-inflammatory properties, as well as metabolites, were investigated using UPLC-Q-TOF-MS. Stevia was fermented using commercial TSB media (TSB 1, TSB 2, and TSB 3) and sucrose (Sucrose 1, Sucrose 3, and Sucrose 3) for 1, 3, and 5 days, respectively. Stevia ferments showed higher DPPH and ABTS radical scavenging capacity compared to samples incubated with sucrose for 5 days, and all six ferments inhibited nitric oxide production in a concentration-dependent manner in LPS-induced mouse macrophages. Furthermore, UPLC-QTOF-MS analysis identified 23 related substances, including 10 terpenoids, including rubusoside, steviolbioside, and rebadioside derivatives; dulcoside A; and phlomisoside II, which are indicators of stevia, as well as five flavonoids, four phenolic acids, and four fatty acids. We also identified the microbial community during fermentation via the next-generation sequencing of the 16S rRNA gene for bacteria and the internal transcribed spacer (ITS) gene for fungi. The results showed that TSB 1 and Sucrose 1 ferments were dominated by the pathogens Enterococcus hirae (58.93%) and Cronobacter sakazakii (80.92%), while samples fermented for more than 3 days were pathogen-free and dominated by lactic acid bacteria such as Pediococcus stilesii (73.37%). Microbial community analysis using the ITS region showed that Saccharomycopsis fibuligera, classified as a yeast rather than a mold, dominated the stevia fermentation regardless of the fermentation duration. In particular, the microbial community of the fermentation with a sugar solution was dominated by S. fibuligera by more than 99% throughout the fermentation periods of 1, 3, and 5 days. Finally, to apply the stevia ferments topically to human skin, skin irritation tests were performed on 30 volunteers. The results showed that the highly concentrated extracts (1 mg/mL) of all six stevia ferments were hypoallergenic. Taken together, these findings suggest that brewer's yeast fermented from stevia leaves with a sugar solution offers promise as a natural ingredient for use in functional foods and cosmetics.

Preprint ARTICLE | doi:10.20944/preprints202405.1793.v1

A Secure Rubber Supply Chain Management System Based on Hyperledger Fabric Blockchain: A Use Case in Cambodia

Ratanak Keo, Muhammad Firdaus, Kyung-hyune Rhee

Subject: Computer Science And Mathematics, Information Systems Keywords: blockchain; rubber supply chain management; traceability; sustainability; security; privacy-preserving

Online: 28 May 2024 (08:10:44 CEST)

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Conventional traceability systems in Cambodian agriculture, such as Rubber Supply Chain Management (RSCM), often struggle to provide timely data and fair market prices, leading to mistrust among stakeholders, exploitation by intermediaries, and hindering progress towards ethical sourcing and sustainable practices. This research aims to showcase the potential of integrating blockchain technology, the Internet of Things (IoT), the InterPlanetary File System (IPFS), and Differential Privacy (DP) methods to empower Cambodian rubber farmers. By enhancing transparency, facilitating fair pricing, and promoting sustainable methods in the rubber industry, this integrated approach leverages Hyperledger Fabric (HLF) to create a decentralized and secure system for tracking rubber from its source to the end consumer. Integration with IPFS ensures secure and easily accessible data storage, further enhancing the system’s reliability. Additionally, the implementation of differential privacy techniques safeguards confidential data during information sharing among farmers and supply chain stakeholders, minimizing potential privacy concerns. This comprehensive system encourages consumers to make ethical and sustainable alternative options by providing accessible information on harvesting methods, processing procedures, labor conditions, and environmental impacts. The potential benefits extend beyond Cambodia, serving as a model for other developing countries aiming to modernize and enhance the agricultural distribution networks. Our results show that transaction send rates (TPS) and throughput in systems with and without differential privacy grow with increased transaction volumes. However, the system without differential privacy achieves greater scalability and efficiency above a certain threshold. However, it offers a slightly reduced latency, reflecting a trade-off between privacy and performance efficiency in blockchain-based agricultural traceability systems.

Preprint ARTICLE | doi:10.20944/preprints202403.0927.v2

Modeling Dynamics of Permafrost Degradation and their Impact on Ecosystems Across Entire Alaska: Arctic and Subarctic Engineering Design Tool (Part-1)

Sergey Marchenko, Kevin Bjella, Dmitry Nicolsky, Vladimir Romanovsky

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Permafrost; Active Layer; Permafrost Dynamics; Climate Change; Ecosystem; Numerical Modeling; Soil Thermal Properties.

Online: 1 May 2024 (10:08:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.2018.v1

Multiple Attack Detection Using SHAP and Heterogeneous Ensemble Model in the UAV’s Controller Area Network

Young-Woo Hong, Dong-Young Yoo

Subject: Computer Science And Mathematics, Security Systems Keywords: controller area network (CAN); shapley additive explanations (SHAP); machine learning(ML); deep learning(DL); unmanned aerial vehicles (UAVs)

Online: 30 April 2024 (15:36:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0971.v1

The New Horizon of Antipsychotics beyond the Classic Dopaminergic Hypothesis—The Case of the Xanomeline-Trospium Combination: A Systematic Review

Octavian Vasiliu, Beatrice Budeanu, Mihai Stefan Catanescu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: xanomeline; trospium; schizophrenia; Alzheimer’s disorder; psychoses; acetylcholine; muscarinic receptors; antipsychotics; dopaminergic hypothesis

Online: 15 April 2024 (14:36:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0850.v1

Green Synthesis of Cobalt-Doped CeFe2O5 Nanocomposites Using Waste Gossypium arboreum L. Stalk and Its Application in the Removal of Toxic Water Pollutants

Saloni Koul, Mamata Singhvi, Beom Soo Kim

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: green synthesis; co-precipitation; adsorption; dye removal; pollutant removal; cotton stalk; wastewater treatment; adsorption capacity

Online: 12 April 2024 (12:22:49 CEST)

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Currently, there is a tenacious need to find new ways to purify water by eliminating bacterial biofilms, textile dyes, and toxic water pollutants. These contaminants pose significant risks to both human health and the environment. To address this issue, in this study, we have developed an eco-friendly approach that involves synthesizing Cobalt-doped Cerium Iron Oxide (CCIO) nanocomposite (NC) using an aqueous extract of Gossypium arboreum L. stalks. The resulting nanoparticles can be used to effectively purify water and tackle the challenges associated with these harmful pollutants. Nanoparticles excel in water pollutant removal by providing high surface area for efficient adsorption, versatile design for simultaneous removal of multiple contaminants, catalytic properties for organic pollutant degradation, and magnetic features for easy separation, offering cost-effective and sustainable water treatment solutions. CCIO nanocomposite has been synthesized by green co-precipitation method due to biomolecules and co-enzymes present in the aqueous extract of Gossypium arboreum L. stalk; a single-step procedure completed in 5 h reaction time. Further, the synthesis of nanocomposites was confirmed by various characterization techniques such as Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), Thermogravimetric analysis (TGA), Dynamic light scattering (DLS), and Energy Dispersive X-Ray (EDX). CCIO NCs were discovered to have a spherical shape and an average size of 40 nm. Based on DLS zeta potential analysis, CCIO NCs were found to be anionic. Also, CCIO NCs showed significant antimicrobial and antioxidant activity. Overall, considering the physical and chemical properties, the application of CCIO NCs in the adsorption of various dyes (~91 %) and water pollutants (chromium = ~ 60 %) has been considered since they exhibit great adsorption capacity owing to their microporous structure which can be a step forward in water purification.

Preprint ARTICLE | doi:10.20944/preprints202403.1855.v1

Social Media Users' Visual and Emotional Preferences of internet-famous sites in Urban Riverfront Public Spaces: A Case Study on Changsha, China

Yuanyuan HUANG, Bohong Zheng, You Peng

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: riverfront public space; riverfront internet-famous sites (RIFS); visual elements; emotional preferences; social media; internet-celebrity city; Changsha; China

Online: 29 March 2024 (16:00:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1833.v1

ResECA-Unet: Enhancement of GI Tract Segmentation Using an Improved U-Net Framework

SM Nuruzzaman Nobel, Omar Faruque Sifat, MD Rajibul Islam, MD Shohel Sayeed, Md Amiruzzaman

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: U-Net; Deep learning; Transfer learning; ECA-Net; Computer vision; GI tract; Segmentation; Radiation therapy

Online: 29 March 2024 (13:51:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1403.v1

Botulinum Toxin in Chronic Lateral Epicondylitis, from Tendon to Muscle Approach

Daniela Poenaru, Miruna Ioana Sandulescu, Claudia-Gabriela Potcovaru, Delia Cinteza

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: botulinum toxin; lateral epicondylitis; intramuscular injection; intratendinous injection

Online: 25 March 2024 (07:57:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1099.v1

A Transient Voltage-based Approach for Mid-voltage Fault Detection through Low-voltage Sensors

Mingze ZHANG, Xinyu GUAN, Xin AI

Subject: Engineering, Electrical And Electronic Engineering Keywords: LV sensor measurement; non-effectively grounded system; single-phase-to-ground fault; transient aerial mode voltage

Online: 22 March 2024 (07:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1300.v1

Synthesis and Electrochemical Characterization of Nitrate-Doped Polypyrrole/Ag Nanowire Nanorods as Supercapacitors

Hyo-Kyung Kang, Ki-Hyun Pyo, Yoon Hee Jang, Yun-soo Kim, and Jin-Yeol Kim

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Supercapacitor; Silver nanowire-polypyrrole composite; Nanorods; Core-shell structure

Online: 21 March 2024 (11:21:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.1086.v1

Intention Recognition in Digital Forensics: Systematic Review

Yidnekachew Worku Kassa, Joshua Isaac James, Elefelious Getachew Belay

Subject: Computer Science And Mathematics, Security Systems Keywords: Digital Forensics; Intention Recognition; Goal Recognition; plan recognition; cyberattack; cybercrime; model

Online: 19 March 2024 (10:21:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1057.v1

Disruptive Factors in Product Portfolio Management: A Qualitative Exploratory Study in B2B Manufacturing

Till Gramberg, Thomas Bauernhansl, Andreas Eggert

Subject: Business, Economics And Management, Business And Management Keywords: product portfolio management; disruption; digitalization; sustainability; servitization; generative artificial intelligence; decision-making; value-oriented; business model; b2b; manufacturing

Online: 18 March 2024 (14:31:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0843.v1

Brain-inspired agents for Quantum Reinforcement Learning

E. Andrés, Manuel Pegalajar Cuellar, Gabriel Navarro

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Quantum Reinforcement Learning; Quantum Neural Networks; Quantum Spiking Neural Network; Quantum Long Short-Term Memory; Brain-inspired models.

Online: 18 March 2024 (10:24:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0768.v1

Towards Cognition-Aligned Visual Language Models via Zero-Shot Instance Retrieval

Teng Ma, Daniel Organisciak, Wenbao Ma, Yang Long

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Large Visual Language Models; Zero-Shot Instance Retrieval; Cognition-Alignment

Online: 13 March 2024 (07:29:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0498.v1

Investigation of Deposition Parameters for Near-Beta Alloy Ti-55511 Fabricated by Directed Energy Deposition

Addison Rayner, Greg Sweet, Owen Craig, Mahdi Habibnejad-Korayem, Paul Bishop

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Directed energy deposition; Near-beta titanium alloys; Ti-55511; Plasma Atomized Powder

Online: 8 March 2024 (09:24:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1596.v1

Advances in Target Therapy Research in Osteosarcoma

Caterina Chiappetta, Carlo Della Rocca, Claudio Di Cristofano

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Osteosarcoma; Next Generation Sequencing; Tumor targeted therapy; Immunotherapy

Online: 28 February 2024 (08:01:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1581.v1

Identification and Characterization of the Gene responsible for 2 the O3 Mating Type Substance in Paramecium caudatum

Yuta Chiba, Yasuhiro Takenaka, Nobuyuki Haga

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: mating-type substance; kinase-C domain; EF hand motif; Phylogenic tree; RNAi; silent mutations; microinjection; Paramecium caudatum

Online: 28 February 2024 (00:09:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1252.v1

Regulatory and Sensing Iron-Sulfur Clusters: New Insights and Unanswered Questions

Anna M. SantaMaria, Tracey A. Rouault

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Iron-sulfur clusters; iron metabolism; iron sensing; IRE; PAIR; Aft1/2; IRP1/2; RirA; Yap5; ACO1; IREB2; HSCB

Online: 22 February 2024 (09:23:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1082.v1

Development of a Landslide Hazard Index to Land Use by Using Logistic Regression and Geographic Information System: A Case Study in Pingtung County in Southern Taiwan

Chih-Ming Tseng, Yie-Ruey Chen, Ching-Ya Tsai, Shun-Chieh Hsieh

Subject: Environmental And Earth Sciences, Environmental Science Keywords: land use; mountainous area; rainfall; landslide hazard; random tree classifier; logistic regression; geographic information system; Taiwan

Online: 20 February 2024 (11:27:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0916.v1

Floating Zone Growth of Pure and Pb-Doped Bi-2201 Crystals

Maria Roslova, Bernd Büchner, Andrey Maljuk

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Bi-2201; floating zone crystal growth; crystal structure; cuprates; superconductivity

Online: 17 February 2024 (09:10:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0768.v1

Validation of the Gaming Skills Questionnaire: Gaming Skills Effects on Cognitive and Affective Functioning in Adolescence

Triantafyllia Zioga, Chrysanthi Nega, Petros Roussos, Panagiotis Kourtesis

Subject: Social Sciences, Psychology Keywords: Videogames; Adolescence; Cognition; Memory; Executive Functions; Attention; Language; Verbal Fluency; Emotion Recognition; Empathy

Online: 14 February 2024 (09:34:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0067.v1

Influences of Multiscale Land Cover Characteristics and Specific Conductivity on Fish Assemblages in the Nolichucky River Watershed, Tennessee

Hayley S. Gotwald, J. Brian Alford

Subject: Environmental And Earth Sciences, Environmental Science Keywords: spatial scale; CCA; indicator species analysis; land use; SWAT; bioassessment

Online: 17 February 2017 (07:33:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0058.v1

Effects of Domain Boundaries on the Diffraction Patterns of One Dimensional Structures

Frederic Timmer, Joachim Wollschläger

Subject: Physical Sciences, Condensed Matter Physics Keywords: spot-profile analysis; one dimensional physics; low energy electron diffraction; binary surface technique; supercell model; domain boundary

Online: 10 November 2016 (15:50:29 CET)

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Motivated by diffraction experiments on the

(2 \sqrt{3} \times \sqrt{3}) R 30^{\circ}

reconstructed Si(111) due to deposition of rare earth elements (Dy, Tb) and silicide formation we analyse the splitting and non-splitting of superstructure spots. For this purpose, we model diffraction patterns for one dimensional structures generated by the binary surface technique and use supercell models to keep the analysis simple. Diffraction pattern are calculated in the framework of the kinematical diffraction theory and they are analyzed as a function of the domains and domain boundaries. Basic properties of the diffraction pattern are analyzed for model systems of a two-fold and a three-fold periodicity. The rules derived from these calculations are applied to the "real-world" system of Si(111)-(

(2 \sqrt{3} \times \sqrt{3}) R 30^{\circ}

)-RESi

2

(RE = Dy or Tb). Depending on the combination of domains and domain boundaries of different types a plethora of different features are observed in the diffraction patterns. These are analyzed to determine the sizes of both domain boundaries and domains from experimentally observed splitting of specific superstructure spots.

Preprint ARTICLE | doi:10.20944/preprints201610.0102.v1

Isolation and Characterisation of Probiotics for Antagonising Cariogenic Bacterium Streptococcus mutans and Preventing Biofilm Formation

Pei-Pei Lin, You-Miin Hsieh, Cheng-Chih Tsai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: dental caries; Streptococcus mutans; lactic acid bacteria; biofilm; glucosyltransferases

Online: 24 October 2016 (09:37:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0114.v1

Marginal Generation Technology in the Chinese Power Market towards 2030 Based on Consequential Life Cycle Assessment

Guangling Zhao, Josep M. Guerrero, Yingying Pei

Subject: Environmental And Earth Sciences, Environmental Science Keywords: marginal technology; power grid; consequential LCA; China

Online: 28 September 2016 (11:49:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0235.v1

American’s Energy Future: An Analysis of the Proposed Energy Policy Plans in Presidential Election

Ming-Hsun Cheng, Minliang Yang, Yu Wang

Subject: Social Sciences, Political Science Keywords: president election; renewable energy; energy future; public opinion; polarization

Online: 31 August 2016 (08:34:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0184.v1

Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (Euterpe oleracea, Mart.)

Iago Castro da Silva, Pamela Suelen da Silva Seabra, Kely Campos Navegantes Lima, Ricardo Barbosa Bezerra Filho, Alanna Lorena P. dos Santos, Amanda Caroline dos Santos Monteiro, Giovanna Quintero Pamplona, Alexandre Guilherme da Silva Dias, Rayane Caroline dos Santos Pereira, Leticia Araujo Costa, Thays Jhessica Mota Pinheiro, Lauro Henrique Hamoy Guerreiro, Nélio Teixeira Machado, Marta Chagas Monteiro

Subject: Medicine And Pharmacology, Pharmacy Keywords: Açaí; Bio-oil; Pyrolysis

Online: 2 August 2024 (16:44:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1833.v1

Co-expression Networks in Sunflower: Harnessing the Power of Multi-Study Transcriptomic Public Data to Identify and Categorize Candidate Genes for Fungal Resistance

Andres Ribone, Mónica Fass, Sergio Gonzalez, Veronica Lia, Norma Paniego, Máximo Rivarola

Subject: Biology And Life Sciences, Plant Sciences Keywords: transcriptomics; co-expression networks; fungal pathogens; WRKY; plant pathology; meta-analysis; multi-study analysis; sunflower; candidate genes

Online: 26 June 2023 (15:48:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2129.v1

Moderation of Clean Energy Innovation in the Relationship between the Carbon Footprint and Profits in CO₂e-Intensive Firms: A Quantitative Longitudinal Study

Francisco Porles Ochoa, Ruben Guevara

Subject: Social Sciences, Other Keywords: clean energy innovation; corporate carbon footprint; corporate profits; high CO₂e emissions; longitudinal model panel; latent growth curve (LGC)

Online: 30 May 2023 (11:33:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0165.v1

Prevalence, Risk Factors and Residential Variation among HIV/TB co-infected Mortality in Amhara Region, Fenote Selam Hospital: Application of Multilevel Logistic Regression

Berhanu Bekele Debelu

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: HIV/TB co-infected Mortality; Residential Variations; Multilevel Logistic Regression

Online: 12 January 2022 (13:34:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0076.v1

Co-toxicity of Endotoxin and Indoxyl Sulfate, Gut-Derived Bacterial Metabolites, to Vascular Endothelial Cells in Coronary Arterial Disease Accompanied by Gut Dysbiosis

Marcin Choroszy, Beata Sobieszczanska, Kamil Litwinowicz, Lukasz Laczmanski, Mateusz Chmielarz, Urszula Walczuk, Tomasz Roleder, Jadwiga Radziejewska, Magdalena Wawrzyńska

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary artery disease; gut microbiome; dysbiosis; obesity; Bacteroidetes; LPS; indoxyl sulfate

Online: 5 October 2021 (10:33:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0430.v2

To Serum or Not to Serum: Reduced-serum Based Approaches for Contact-based Co-culture of Fibroblasts and Keratinocytes for Wound Bed Studies

Snehal Kadam, Madhusoodhanan Vandana, Karishma Kaushik

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Co-culture; Reduced-serum; Wound bed; Fibroblasts; Keratinocytes

Online: 12 March 2020 (13:24:46 CET)

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Working Paper ARTICLE

Understanding the Synergy of NKP46 and Co-Activating Signals in Various NK Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy

Loris Zamai, Genny Del Zotto, Flavia Buccella, Sara Gabrielli, Barbara Canonico, Marco Artico, Claudio Ortolani, Stefano Papa

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: NK cell biology; NK cell subsets; NK activating receptors; cell adhesion molecules; granule polarization; cytotoxicity assay; cis interactions; trogocytosis; NK cell degranulation; NK-Based Immunotherapies

Online: 14 February 2020 (03:13:05 CET)

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NK population is characterized by distinct NK cell subsets which respond differently to the various activating stimuli. For this reason, the determination of the optimal cytotoxic activation of the different NK subsets can be a crucial aspect to be exploited to counter cancer cells in oncologic patients. To evaluate how the triggering of different combination of activating receptors can affect the cytotoxic responses of different NK cell subsets, we developed a microbead-based degranulation assay. By using this new assay, we were able to detect CD107a+ degranulating NK cells even within the less cytotoxic subsets (i.e. resting CD56bright and unlicensed CD56dim NK cells), thus demonstrating its high sensitivity. Interestingly, signals delivered by the co-engagement of NKp46 with 2B4, but not with CD2 or DNAM-1, strongly cooperate to enhance degranulation on both licensed and unlicensed CD56dim NK cells. Of note, 2B4 is known to bind CD48 hematopoietic antigen, therefore this observation may provide the rationale why CD56dim subset expansion correlates with successful hematopoietic stem cell transplantation mediated by alloreactive NK cells against host T, DC and leukemic cells, while sparing host non-hematopoietic tissues and graft versus host disease. The assay further confirms that activation of LFA-1 on NK cells leads to their granule polarization, even if, in some cases, this also takes to an inhibition of NK degranulation, suggesting that LFA-1 engagement by ICAMs on target cells may differently affect NK cell response. Finally, we observed that NK cells undergo a time-dependent spontaneous (cytokine-independent) activation after blood withdrawal, an aspect that may strongly bias the evaluation of the resting NK cell response. Altogether our data may pave the way to develop new NK activation and expansion strategies that target the highly cytotoxic CD56dim NK cells and can be feasible and useful for cancer and viral infection treatment.

Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.1821.v1

Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients

Marton Papp, Can Ince, Jan Bakker, Zsolt Molnar

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sepsis; septic shock; hemoadsorption; cytokines; endothelium; capillary leakage

Online: 24 October 2024 (08:28:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1732.v1

A Qualitative Study on Understanding Family Experiences: Mental Health Literacy in Adolescent Eating Disorder Diagnoses

Eva García Carpintero-Blas, Esperanza Vélez-Vélez, Esther Martínez-Miguel, Alberto Tovar-Reinoso, Pablo DelPozo-Herce, Carlos González-Navajas, Cristina Gómez-Moreno

Subject: Public Health And Healthcare, Nursing Keywords: Family Therapy; Nursing; Eating Disorders; Qualitative Research; Mental Health Literacy

Online: 22 October 2024 (16:37:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0764.v1

Drowsiness Detection of Construction Workers: A Proactive Approach to Accident Prevention Leveraging Yolov8 Deep Learning And Computer Vision Techniques

Adetayo Olugbenga Onososen, Innocent Musonda, Damilola Onatayo, Abdullahi Babatunde Saka, Samuel Adeniyi Adekunle, Eniola Onatayo

Subject: Engineering, Architecture, Building And Construction Keywords: Construction; Deep Learning; Drowsiness; Construction safety; Computer vision; Accident; Yolo

Online: 10 October 2024 (06:22:56 CEST)

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Construction projects' unsatisfactory performance has been linked to factors influencing individuals' well-being and mental alertness on projects. Drowsiness is a significant indicator of sleep deprivation and fatigue, being able to identify the cognitive and physical preparedness of workers on site to engage in construction tasks. As a consequence of the strenuous nature of the work involved in construction, long work hours, and environmental conditions, drowsiness is commonplace and has received less attention despite being a leading cause of accidents occurring on-site. Detecting drowsiness is essential for determining the safety and well-being of site workers. This study presents a vision-based approach using an improved version of the You Only Look Once (YOLOv8) algorithm for real-time drowsiness exposure among construction workers. The proposed method leverages computer vision techniques to analyse facial and eye features, enabling early detection of drowsiness signs, effectively preventing accidents, and enhancing on-site safety. The model showed significant precision and efficiency in detecting drowsiness from the given dataset, accomplishing a drowsiness class with a mean average precision (mAP) of 92%. However, it also exhibited difficulties handling imbalanced classes, particularly the underrepresented 'Awake with PPE' class, which was detected with high precision but comparatively lower recall and mAP. This highlighted the necessity of balanced datasets for optimal deep learning performance. The YOLOv8 model's average mAP of 78% in drowsiness detection compared favourably with other studies employing different methodologies. The vision-based drowsiness detection system has broad applications in the construction industry. It can be integrated into existing safety protocols, enabling real-time alerts to supervisors or workers when drowsiness is detected. The system improves productivity and reduces costs by preventing accidents and enhancing worker safety. However, limitations, such as sensitivity to lighting conditions and occlusions, must be addressed in future iterations.

Preprint ARTICLE | doi:10.20944/preprints202410.0229.v1

Efficient Access to New Structures with Incorporated 1,2,3-Triazolium Salts as Preferred Dual Cholinesterase Inhibitors

Milena Mlakić, Maja Ratajec, Ana Ratković, Anamarija Raspudić, Danijela Baric, Ivana Šagud, Zlata Lasić, Ilijana Odak, Irena Škorić

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: cholinesterase inhibition; docking; genotoxicity; 1,2,3-triazolium salts

Online: 3 October 2024 (10:55:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1980.v1

Enhanced Outer Membrane Vesicle Production in Escherichia coli: from Metabolic Network Model to Designed Strain Lipidomic Profile

Héctor Alejandro Ruiz-Moreno, Juan Daniel Valderrama-Rincon, Monica Patricia Cala, Miguel Fernández-Niño, Andrés Fernando Gonzalez Barrios

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Outer Membrane Vesicles; Lipidomics; CRISPR; Metabolic Network Models; E. coli JC8031

Online: 25 September 2024 (12:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1918.v1

Stable Microclimates and Autonomic Modulation in Horses Sin-Gle-Stall Housed in Different Stable Architectures During Mon-Soon in a Tropical Savannah Environment

Chanoknun Poochipakorn, Kanokpan Sanigavatee, Kansuda Leelehapongsathon, Thita Wonghanchao, Metha Chanda

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Air velocity; Humidity; Interior environment; Monsoon; Noxious gases; Single-stall housing; Stress responses; Temperature; Tropical savannah climate; Welfare

Online: 24 September 2024 (14:06:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1224.v1

Translation, Cultural Adaptation of the Portuguese Provider Attitudes toward Cardiac Rehabilitation and Referral (PACRR-P) Scale and Assessment of its’ Measurement Properties

Mayara Moura Alves da Cruz, Luiz Carlos Marques Vanderlei, Carolina Takarashi, Maria Julia Lopez Laurino, Murilo Reis Alves da Cruz, Sherry L Grace, Gabriela L M Ghisi

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Attitudes; Cardiac rehabilitation; Health knowledge; Physician’ s practice patterns; Practice; Questionnaires

Online: 16 September 2024 (12:29:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0349.v1

Evaluation of a Point of Care Gem Premier ChemSTAT Analyzer in Emergency Department: Prevention of Contrast-Induced Nephropathy and Optimization of Patient Flow

Marina Brailova, Marie Audin, Julien Raconnat, Jean-Baptiste Bouillon-Minois, Jeannot Schmidt, Bruno Pereira, Damien Bouvier, Vincent Sapin

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: contrast media; creatinine; contrast-induced nephropathy; point-of-care; ChemSTAT; emergency

Online: 4 September 2024 (11:24:04 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.0141.v1

Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report

Serena Xodo, Bassma Benchick, Ginevra Battello, Giovanni Baccarini, Marta Angelini, Maria Orsaria, Lorenza Driul

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cervical insufficiency; triple antibiotic therapy; cerclage; intra-amniotic infection; case report

Online: 3 September 2024 (11:21:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1609.v1

Expression Profiling of Coding and Noncoding RNAs in the Endometrium of Patients with Endometriosis

Mi Ran Choi, Hye Jin Chang, Jeong-Hyeon Heo, Sun Hyung Yum, Eunae Jo, Miran Kim, Sang-Rae Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Endometriosis; endometrium; menstrual cycle; long noncoding RNA; neighboring gene

Online: 23 August 2024 (10:12:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1305.v1

Comorbidity Burden among Adults with Symptomatic COVID-19 Illness: A Cross-Sectional Study

Mini M. Jose, Juan Feng, Bushra Manakkat, Hoang Nguyen, Josie Tombrella, Patricia Savard, Hanaa S. Sallam, Hani Serag

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19 positive adults; Charlson Comorbidity Index; Comorbidity burden and COVID-19; Depression and COVID-19; Comorbidities and COVID-19; Social determinants of COVID-19

Online: 19 August 2024 (10:05:29 CEST)

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Preprint ESSAY | doi:10.20944/preprints202408.1079.v1

Overexpression of EuSIP5 Gene to Improve Drought Resistance in Tobacco

Yue-Ling Lin, Xi Chen, De-Gang Zhao, Chao Li

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: E. ulmoides; EuSIP5; transgenic; tobacco; drought resistance

Online: 15 August 2024 (12:19:08 CEST)

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Soluble inorganic pyrophosphatase (sPPase), a pyrophosphate hydrolase, has been shown to play an important role in several physiological processes such as plant growth and development, metabolic activities, and response to abiotic stresses, but sPPase has been less studied in woody plants. In order to preliminarily verify whether the soluble inorganic pyrophosphatase in Eucommia ulmoides Oliver (E. ulmoides) has a role in resistance to drought stress, we amplified the EuSIP5 (E. ulmoides soluble inorganic pyrophosphatase 5) cDNA sequence from E. ulmoides by RT-PCR. In order to study the drought resistance of the Eucommia ulmoides soluble inorganic pyrophosphatase 5 (EuSIP5) gene, the cDNA sequence of the EuSIP5 gene was amplified from Eucommia ulmoides Oliver by RT-PCR. Bioinformatic analysis indicated that EuSIP5 might be an unstable amphipathic protein, mainly located in the cytoplasm. E. ulmoides, the highest expression of the EuSIP5 gene was found in male leaves and pericarp from April to October, and in leaves of E. ulmoides in July and September. During drought, the expression of EuSIP5 in seedling E. ulmoides leaves was significantly higher than that of the control. An overexpression vector harboring the EuSIP5 was constructed and introduced into the tobacco (Nicotiana tabacum cv. Xanthi). We found that during drought stress, the appearance of wilting was delayed by 4 days in transgenic tobacco plants (OE) compared with wild type plants (WT), and the expression of drought-related genes DET2, CYP85A1, P5CS, ERF1 and F-box was found to be increased in transgenic tobacco leaves, as well as the enzyme activities of the protective enzymes: peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) were significantly higher than those of the WT, and the malondialdehyde (MDA) content was lower than the WT. These results indicated that the introduction of EuSIP5 gene into tobacco increased the expression of drought-related genes, enhanced the anti-membrane oxidation ability of tobacco, and reduced the oxidative stress damage, thus improving the drought resistance of tobacco.

Preprint ARTICLE | doi:10.20944/preprints202408.1040.v1

Creation of an Experimental Animal Model for the Study of Postmortal Dark Scleral Spots

Matteo Nioi, Pietro Emanuele Napoli, Domenico Nieddu, Alberto Chighine, Maurizio Fossarello, Ernesto D'Aloja

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: postmortal scleral spots; postmortem tache noire; forensic ophthalmology; eye postmortem; ocular surface; sclera; animal models; postmortem interval; postmortem optical coherence tomography

Online: 14 August 2024 (18:04:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0580.v1

Optical Properties of Yttrium Orthoferrite Films Prepared by Plasma Laser Deposition

Dinara Sobola, Saleh H. Fawaeer, Pavla Kočková, Richard Schubert, Rashid Dallaev, Tomáš Trčka

Subject: Engineering, Electrical And Electronic Engineering Keywords: yttrium orthoferrite; plasma laser deposition; optical properties; thin films; bandgap; optoelectronics

Online: 8 August 2024 (12:03:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0303.v1

Characterisation of the Mitochondrial Genome of Capulus danieli: Insights into Evolutionary History and Ecological Adaptations

Yaoyu Xie, Yida Han, Junxia Mao, Xubo Wang, Zhenlin Hao, Ying Tian

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Capulus danieli; mitochondrial genome; protein-coding genes; divergence time estimation

Online: 6 August 2024 (03:19:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0237.v1

Emotional Intelligence Increases Nurses’ Work Performance: Evidence from Greece

Petros Galanis, Aglaia Katsiroumpa, Ioannis Moisoglou, Konstantina Derizioti, Parisis Gallos, Maria Kalogeropoulou, Vasiliki Papanikolaou

Subject: Public Health And Healthcare, Nursing Keywords: emotional intelligence; work performance; job performance; nurses; emotions

Online: 5 August 2024 (08:18:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2276.v1

Understanding the Mellowing Effect of Bottle Aging on the Sensory and Aesthetic Perceptions of Varietal Dry White Wines

Giovanni Marasà, Joana Ferreira, Mariana Mota, Manuel Malfeito-Ferreira

Subject: Biology And Life Sciences, Food Science And Technology Keywords: fine wines; aging bouquet; vertical tasting; maturation; quality; complexity; sensory space; aroma; mouthfeel

Online: 29 July 2024 (10:07:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1835.v1

Population-Based Incidence and Mortality Rates of Hematologic Malignancies regarding the Adult Population of Crete, Greece, and Analyses of Their Time Trends and Their Geographical Dis-Tribution: A First Approach from the Cancer Registry of Crete (CRC) for a 22-Year Time Period (1992–2013)

Stelios Lionakis, Dimitra Sifaki-Pistolla, Helen A. Papadaki, Dimitrios Mavroudis, Christos Lionis

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hematologic neoplasms; incidence; mortality; cancer epidemiology; kaplan meier estimate; registries; spatio-temporal analysis

Online: 24 July 2024 (07:10:57 CEST)

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