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Preprint REVIEW | doi:10.20944/preprints202402.0735.v1

Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury – State of the Art

Débora Gouveia, Ana Cardoso, Carla Carvalho, Ana Catarina Oliveira, António Almeida, Óscar Gamboa, B. Lopes, André Coelho, R.D. Alvites, Artur Severo P. Varejão, Ana Colette Maurício, António Ferreira, Ângela Martins

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: PNI; neurorehabilitation; nerve repair; electrical stimulation; exercises; locomotor training.

Online: 13 February 2024 (10:27:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0829.v1

Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy

Frédéric Gallardo, Pauline Brochet Brochet P, David Goudenège, João Paulo Silva Nunes, Pauline Andrieux, Barbara Maria Ianni, Amanda Farage Frade, Charles Mady, Ronaldo Honorato Barros Santos, Andreia Kuramoto, Samuel Steffen, Antonio Noedir Stolf, Pablo Pomerantzeff, Alfredo Inacio Fiorelli, Edimar Alcides Bocchi, Cristina Wide Pissetti, Bruno Saba, Fabrício Dias, Marcelo Ferraz Sampaio, Fabio Antônio Gaiotto, José Antonio Marin-Neto, Abílio Fragata, Ricardo Costa Fernandes Zaniratto, Sergio Siqueira, Giselle De Lima Peixoto, Fernando Bacal, Paula Buck, Rafael Ribeiro Almeida, Hui Tzu Lin-Wang, André Schmidt, Mario Hiroyuki Hirata, Eduardo Antonio Donadi, Alexandre Costa Pereira, Virmondes Rodrigues Junior, Martino Martinelli, Michel Naslavsky, Jorge Kalil, Vincent Procaccio, Edecio Cunha-Neto, Christophe Chevillard

Subject: Biology And Life Sciences, Parasitology Keywords: chagas; cardiomyopathy; mitochondria; haplgroups; variants; copy-number

Online: 13 October 2023 (03:03:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0714.v1

Towards a Biomanufactory on Mars

Aaron Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew McNulty, George Makrygiorgos, Nils J.H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Desiree Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Meraz, Vince Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert W. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Amor A. Menezes, Lance C. Seefeldt, Douglas S. Clark, Adam P. Arkin

Subject: Engineering, Automotive Engineering Keywords: space systems bioengineering; human exploration; mars; in situ resource utilization; life support systems; biomanufacturing

Online: 29 December 2020 (07:57:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2513.v1

Chrono-Nutrition, Chrono-Type, and the Prevalence of Type 2 Diabetes Mellitus in a Cross-Sectional Study from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Leila Luján-Barroso, Hernando J Margara-Escudero, Marta Crous-Bou, José María Huerta, Maria-Dolores Chirlaque, Esther Molina-Montes, María-José Sánchez, Marcela Guevara, Conchi Moreno-Iribas, Pilar Amiano, Olatz Mokoroa, Sonia González, Antonio Agudo, Jose Ramón Quirós, Paula Jakszyn

Subject: Public Health And Healthcare, Other Keywords: Chrono-nutrition; type 2 diabetes; meal timing; macronutrients; EPIC-Spain

Online: 31 July 2024 (11:14:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0612.v1

Mapping the Research Landscape of Conservation Agriculture as a Panacea for Achieving Soil Health and Sustainable Development Goals Using Scientometrics

Chukwudi Nwaogu, Bridget E. Diagi, Famous Ozabor, David Edokpa, Imuwahen P. Aigbedion, Obisesan Adekunle, Chineme C. Ifuwe, Justin N. Okorondu, Ushurhe Ochuko, Chudinma Acholonu, Chinonye Ekweogu, Vremudia Onyeayana Wekpe, Susan Ajiere, MeeluBari Barinua Tsaro Kpang, Osademe Chukwudi Dollah, Joshua Brown, Michael Ibiso Inko-Tariah, Lazarus Chikwendu, Ifeanyi Oduaro, Christopher C. Ejiogu, Patrick S.U. Eneche, Onyedikachi J. Okeke, Edwin Wallace, Chinedu Onugu, Enos Emereibeole, Dike Henry Ogbuagu, Martin C. Iwuji, Mauricio R. Cherubin

Subject: Environmental And Earth Sciences, Soil Science Keywords: Bibliometric analysis; no-till; cover cropping; thematic evolution; conservation agriculture

Online: 8 July 2024 (11:19:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0827.v1

Coprological Survey of Helminths in Reindeer (Rangifer tarandus) in 50 Selected Zoos and Menageries in Russia

Olga A. Loginova, Svetlana V. Akulova, Dmitry N. Egorov, Natalia S. Egorova, Sergei E. Spiridonov, Iuliia K. Plotnikova, Larisa M. Belova, Yuriy E. Kuznetsov, Daria I. Chuprak, Anna A. Krutikova, Iuliia V. Vasilkova, Diana A. Gelashvili, Yuri A. Shchepanovsky, Ivan A. Mizin, Danila V. Panchenko, Mikhail G. Bondar, Taras P. Sipko

Subject: Biology And Life Sciences, Parasitology Keywords: reindeer; Rangifer tarandus; helminth; trematode; cestode; nematode; mite; zoo

Online: 12 June 2024 (12:44:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1770.v1

Screening for Latent Tuberculosis Infection in People Living with HIV: TUBHIVIT Project, a Multicentre Italian Study

Luca Pipitò, Elena Delfina Ricci, Paolo Maggi, Giuseppe Vittorio De Socio, Giovanni Francesco Pellicano, Marcello Trizzino, Raffaella Rubino, Alessandra Lanzi, Lorenzo Crupi, Ilaria Capriglione, Nicola Squillace, Giuseppe Nunnari, Antonio Di Biagio, Paolo Bonfanti, Antonio Cascio

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Tuberculosis; HIV; latent tuberculosis; TB; LTBI

Online: 26 April 2024 (20:02:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1414.v1

Effects of Influenza Vaccine on the Immune Responses to SARS-CoV-2 Vaccination

A Riccomi, CM Trombetta, Maria Dorrucci, Daniela Di Placido, Nunzia Sanarico, Francesca Farchi, Roberto Giuseppetti, Umbertina Villano, C Marcantonio, Serena Marchi, Antonio Ciaramella, P Pezzotti, E Montomoli, C Valdarchi, AR Ciccaglione, S. Vendetti

Subject: Public Health And Healthcare, Other Keywords: Influenza vaccine; SARS-CoV-2 vaccine; immune response to vaccination

Online: 25 March 2024 (08:03:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0452.v1

Solar Neutrinos Spectroscopy with Borexino Phase-II

Lino Miramonti, M. Agostini, K. Altenmueller, S. Appel, V. Atroshchenko, Z. Bagdasarian, D. Basilico, G. Bellini, J. Benziger, D. Bick, I. Bolognino, G. Bonfini, D. Bravo, B. Caccianiga, F. Calaprice, A. Caminata, S. Caprioli, M. Carlini, P. Cavalcante, F. Cavanna, A. Chepurnov, K. Choi, L. Collica, S. Davini, A. Derbin, X.F. Ding, A. Di Ludovico, L. Di Noto, I. Drachnev, K. Fomenko, A. Formozov, D. Franco, F. Gabriele, C. Galbiati, M. Gschwender, C. Ghiano, M. Giammarchi, A. Goretti, M. Gromov, D. Guffanti, C. Hagner, T. Houdy, E. Hungerford, Aldo Ianni, Andrea Ianni, A. Jany, D. Jeschke, V. Kobychev, D. Korablev, G. Korga, T. Lachenmaier, M. Laubenstein, E. Litvinovich, F. Lombardi, P. Lombardi, L. Ludhova, G. Lukyanchenko, L. Lukyanchenko, I. Machulin, G. Manuzio, S. Marcocci, J. Maricic, J. Martyn, E. Meroni, M. Meyer, M. Misiaszek, L. Papp, O. Penek, L. Pietrofaccia, N. Pilipenko, A. Pocar, A. Porcelli, G. Raikov, G. Ranucci, A. Razeto, A. Re, M. Redchuk, A. Romani, N. Rossi, S. Rottenanger, S. Schönert, D. Semenov, M. Skorokhvatov, O. Smirnov, A. Sotnikov, L.F.F. Stokes, Y. Suvorov, R. Tartaglia, G. Testera, J. Thurn, M. Toropova, E. Unzhakov, A. Vishneva, R.B. Vogelaar, F. von Feilitzsch, S. Weinz, M. Wojcik, M. Wurm, Z. Yokley, O. Zaimidoroga, S. Zavatarelli, K. Zuber, G. Zuzel

Subject: Physical Sciences, Particle And Field Physics Keywords: solar neutrinos; neutrino oscillation; Borexino

Online: 19 October 2018 (11:49:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0915.v2

Trends in CO, CO₂, CH₄, BC, and NO_xduring the first 2020 COVID-19 lockdown: Source Insights from the WMO/GAW station of Lamezia Terme (Calabria, Southern Italy)

Francesco D’Amico, Ivano Ammoscato, Daniel Gullì, Elenio Avolio, Teresa Lo Feudo, Mariafrancesca De Pino, Paolo Cristofanelli, Luana Malacaria, Domenico Parise, Salvatore Sinopoli, Giorgia De Benedetto, Claudia Roberta Calidonna

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Covid-19; 2020 lockdown; Lamezia Terme; Mediterranean Basin; GAW; carbon monoxide; carbon dioxide; methane; black carbon; nitrogen oxides

Online: 16 September 2024 (14:32:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1076.v1

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Yandra Cervelim Nunes, Nathalia. M. Mendes, Enzo Pereira de Lima, Amanda Chabrour Chehadi, Caroline Barbalho Lamas, Jesselina F. S. Haber, Manoela dos Santos Bueno, Adriano Cressoni Araújo, Vitor C. Strozze Catharin, Claudia Rucco. P. Detregiachi, Lucas Fornari Laurindo, Masaru Tanaka, Sandra Maria Barbalho, Maria José Sanches Marin

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Curcuma longa; curcumin; aging; inflammation; oxidative stress; frailty; neurodegeneration; sarcopenia; cardiovascular diseases; clinical trials

Online: 12 July 2024 (14:59:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0699.v1

Examining the Correlations between the Visceral Adiposity Index and Various Anthropometric, Biochemical, and Insulin Resistance Parameters in Brazilians: Findings from a Cross-Sectional Study

Lucas Fornari Laurindo, Francine Cruz Camargo, Alessandra Perfeito, Bruno Benedito Ciano, Clara Tainá Coelho, Gleice Assis Apolinário, Isabela Do Nascimento Vicentin, Jéssica Cambui Andreasi), Beatriz Leme Boaro, Ricardo José Tofano, Claudia Rucco P. Detregiachi, Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Lance Alan Sloan, Katia Portero Sloan, Antonelly Cassio Alves de Carvalho, Marie . Oshiiwa, Patrícia Cincotto dos Santos Bueno, Tereza Laís Menegucci Zutin, Marcelo Bechara, Karina Quesada

Subject: Public Health And Healthcare, Primary Health Care Keywords: Insulin Resistance; Visceral Adiposity Index; Cardiovascular Diseases; Cardiovascular Risk; Waist Circumference; Brazilian Population

Online: 10 May 2024 (16:56:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1954.v1

An Assessment of Semaglutide Safety Based on Real World Data: From Popularity to Spontaneous Reporting in EudraVigilance Database

Anca Butuca, Carmen Maximiliana Dobrea, Anca Maria Arseniu, Adina Frum, Adriana Aurelia Chis, Luca Liviu Rus, Steliana Ghibu, Anca Maria Juncan, Andrei Catalin Muntean, Antonina Evelina Lazăr, Felicia Gabriela Gligor, Claudiu Morgovan, Andreea Loredana Vonica-Tincu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: semaglutide; obesity; weight loss; overdose; underdose; off-label use; EudraVigilance; GLP-1

Online: 30 April 2024 (10:14:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1056.v1

Circulating miR-16 and miR-21 Levels in Multiple Myeloma: Prognostic Significance of Survival and Response to Lenalidomide Treatment.

Annita Ioanna Gkioka, Maria Tsota, Aspasia Koudouna, Alexandros Gkiokas, Christina Aggeliki Mitropoulou, Aikaterini Palaiokrassa, Alexandros Alexandropoulos, Mavra Papadatou-Gigante, Vasiliki Bartzi, Thomais Marina Tryfou, Petros P Sfikakis, George V. Dedoussis, Marie Christine Kyrtsonis

Subject: Biology And Life Sciences, Life Sciences Keywords: Multiple myeloma, miR-16, miR-21, prognosis, lenalidomide, serum expression level, downregulation.

Online: 16 April 2024 (12:01:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0469.v1

In Search for the Low-Molecular-Weight Ligands of Human Serum Albumin that Affect its Affinity for Monomeric Amyloid β Peptide

Evgenia I. Deryusheva, Marina P. Shevelyova, Victoria A. Rastrygina, Ekaterina L. Nemashkalova, Alisa A. Vologzhannikova, Andrey V. Machulin, Alija A. Nazipova, Maria E. Permyakova, Sergei E. Permyakov, Ekaterina A. Litus

Subject: Biology And Life Sciences, Biophysics Keywords: Alzheimer’ s disease; amyloid β peptide; human serum albumin; low-molecular-weight ligand; protein-ligand interaction; surface plasmon resonance spectroscopy

Online: 7 April 2024 (10:18:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1688.v1

Nature-Based Solutions for Optimizing the Water – Ecosystem – Food Nexus in Mediterranean Countries

Silvia Vanino, Valentina Baratella, Tiziana Pirelli, Donato Ferrari, Antonella Di Fonzo, Fabrizio Pucci, Nikolaos P. Nikolaidis, Maria A. Lilli, Zübeyde Albayram Doğan, Tuncay Topdemir, Sami Awabdeh, Luna Al-Hadidi, Nabeel Bani Hani, Andreas Panagopoulos, Vassilios Pisinaras, Anna Chatzi, Estrella López Moya, Christina Papadaskalopoulou, Dimitris Tassopoulos, Efstathia Chatzitheodorou, Alessandro Pagano, Raffaele Giordano, Ivan Portoghese, Esteban Henao, Anna Osann, Stefano Fabiani

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Nexus, sustainability; biodiversity; resilience; water distribution; food security; ecosystem services

Online: 29 February 2024 (07:05:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0307.v1

Bringing onco-innovation to Europe’s healthcare systems: the unexploited potential of biomarker testing, real world evidence and the potential of Tumour Agnostics. The lesson from BRCA1/2 genetic testing

Denis Horgan, Gennaro CILIBERTO, Pierfranco Conte, Giuseppe CURIGLIANO, Luis Seijo, Luis M. Montuenga, Luis Paz-Ares, Marina Chiara Garassino, Penault-Llorca Frederique, Fabrizia GALLI, Isabelle Ray-Coquard, Denis Querleu, David R. Baldwin, Susana Banerjee, Peter H.J. Riegman, Keith Kerr, Benjamin Horbach, Reinhard Büttner, Hendrik Van Poppel, Anders Bjartell, Giovanni Codacci-Pisanelli, Westphalen Christoph Benedikt, Fabien CALVO, Jasmina Koeva-Balabanova, Stephen Hall, Angelo Virgilio Paradiso, Dipak. Kalra, Christa M. Cobbaert, Rocio Varea Mendez, Zorana Maravic, Vassiliki Fotaki, Jaafar Bennouna, Estelle Cauchin, Núria Malats, Iñaki Gutiérrez-Ibarluzea, Benjamin Gannon, Ken Mastris, Chiara Benini, William M. Gallagher, Simonetta Buglioni, Alastair Kent, Elisabetta Munzone, Ivica Belina, Jan P. van Meerbeeck, Michael Joe Duffy, Elzbieta. Sarnowska, Beata Jagielska, Sarah Mee, Ettore Domenico Capoluongo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer biomarkers, BRCA1/2, genomics; European recommendation

Online: 14 August 2020 (04:27:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0202.v1

Nutritional Factors and Survival in a Cohort of Patients with Oral Cancer

Paolo Buscemi, Cristiana Randazzo, Carola Buscemi, Anna Maria Barile, Elena Finamore, Roberta Caruso, Piero Colombrita, Martina Lombardo, Serena Cangemi, Giulia Zucchi, Adriana Cordova, Antonio Lo Casto, Silvio Buscemi

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Oral cancer; malnutrition; artificial nutrition; bioimpedance analysis

Online: 6 May 2024 (08:46:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1709.v1

Low-Level Laser Can Increase Extracellular Matrix Signals Mediated by Cytokine Modulation during the Lung Recellularization Process

Leticia L. Guimarães, Auriléia A. Brito, Andressa D. Cereta, Ana Paula L. Oliveira, João Pedro R. Afonso, Diego A.C.P.G. Mello, Iransé Oliveira-Silva, Carlos H. M. Silva, Rodrigo F. Oliveira, Deise A. A. P. Oliveira, Rodolfo de Paula Vieira, Dante Brasil Santos, Giuseppe Insalaco, Luís V. F. Oliveira, Renata K. Palma

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: low-level laser; extracellular matrix; lung; decellularization

Online: 26 April 2024 (08:42:16 CEST)

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Several Lung diseases can result in lung damage structural changes, with lung transplantation as a only therapeutic option when the disease reaches an advanced progression, unfortunately, the success of lung transplantation is limited. In this context, lung bioengineering is considered a potential therapeutic alternative and the current approach is based on the use of the natural extracellular matrix (ECM) of the decellularized lung. The use of undifferentiated cells to seed an ECM can be a more practical strategy for lung bioengineering but the sterilization of the organ for this recellularization process is still a challenge. In this sense, Low-Level Laser Therapy (LLLT) can emerge as a potential treatment alternative. Therefore, the objective of this study was to verify if LLLT, can optimize lung recelularization with mesenchymal stem cells by cytokine modulation. For this, we decellularized lungs from C57BL/6 mice perfusing SDS 1% via pulmonary artery, sterilized with LLL (660nm, 100mW, 30s). Whole lung scaffolds were recellularized: (1) Recellularized Lung (2) Recellularized Lung + LLLT. Mesenchymal stem cells derived from human tooth pulp (DPSc) were seeded into lungs and incubated for 24 hours at 37ºC, 5% CO₂, in a bioreactor-like conditions, maintaining CPAP at 20cmH2O, 90% O2, and LLL at wavelength of 808nm, 100mW, 30s. Culture medium were analyzed at 24 hours. H&E, immunostaining, SEM and ELISA assay were performed. We produced viable biological scaffolds absent of DNA content, preserving glycosaminoglycans and collagen I, III and IV, fibronectin, laminin and elastin and lung structure (SEM). The levels of IL-6 and IL-8 were stable during the 24 hours of culture. IFN-γ levels showed significant difference in the DPSc and DPSc+LLLT group in the 24-hour evaluation. The levels of IL-10 decreased after LLLT. These findings highlight LLLT's role in cytokine regulation and contamination prevention during lung recellularization with mesenchymal stem cells. Overall, these results demonstrated that LLLT's modulated cytokine levels and could prevent contamination during the lung recellularization process with mesenchymal stem cells, offering promise for enhanced therapeutic strategies in lung bioengineering.

Preprint ARTICLE | doi:10.20944/preprints201607.0044.v1

MWL Picture Of The Blazar S5 0716+714 During Its Brightest Outburst

Marina Manganaro, Giovanna Pedaletti, Marlene Doert, Denis Bastieri, Vandad Fallah Ramazani, Dario Gasparrini, Elina Lindfors, Benoit Lott, Mireia Nievas, Bindu Rani, Emmanouil Angelakis, George Borman, Mark Gurwell, Talvikki Hovatta, Ryosuke Itoh, Svetlana Jorstad, Alex Kraus, Thomas P Krichbaum, Paul Kuin, Anne Lahteenmaki, Valeri Larionov, Amy Yarleen Lien, Ioannis Myserlis, David J Thompson, Merja Tornikoski, J Anton Zensus

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: BL-Lacertae objects: individual: S5 0716+714; Galaxies:active; gamma-rays: galaxies

Online: 18 July 2016 (06:02:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0184.v1

Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (Euterpe oleracea, Mart.)

Iago Castro da Silva, Pamela Suelen da Silva Seabra, Kely Campos Navegantes Lima, Ricardo Barbosa Bezerra Filho, Alanna Lorena P. dos Santos, Amanda Caroline dos Santos Monteiro, Giovanna Quintero Pamplona, Alexandre Guilherme da Silva Dias, Rayane Caroline dos Santos Pereira, Leticia Araujo Costa, Thays Jhessica Mota Pinheiro, Lauro Henrique Hamoy Guerreiro, Nélio Teixeira Machado, Marta Chagas Monteiro

Subject: Medicine And Pharmacology, Pharmacy Keywords: Açaí; Bio-oil; Pyrolysis

Online: 2 August 2024 (16:44:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1156.v1

A High-Homology Region in Bacterial β-Barrel Pore-Forming Toxins

Alexey S. Nagel, Olesya Vetrova, Natalia V. Rudenko, Anna P. Karatovskaya, Anna Zamyatina, Zhanna I. Andreeva-Kovalevskaya, Vadim Salyamov, Nadezhda Egorova, Alexander V. Siunov, Tatiana D. Ivanova, Khanafi M. Boziev, Fedor A. Brovko, Alexander S. Solonin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus α -toxin; Bacillus cereus hemolysin II; cytotoxin K2; suppression of hemolytic activity; monoclonal antibodies; enzyme immunoassay

Online: 20 March 2024 (12:23:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.0760.v1

Rare-ID: The First Neonate Diagnostic Approach Using Genome Sequencing for Complex Pediatric Cases in a Greek Cohort

Yannis L. Loukas, Katherine Anagnostopoulou, Georgia Thodi, Maria Spanou, Christos Gavalas, Yannis Dotsikas, Maria Alvanou, Roser Pons, Konstantinos Tziouvas, Georgios Vartzelis, Eleni Skouteli, Eirini Loukatou, Antonia Charitou, Konstantinos Douros, Soultana Siahanidou, Melpomene Giorgi, Artemis Theodora Stephanede, Maria Angeli, Maria Nikolaidou, Eleftheria Kokkinou, Ioanna Kouri, Vasiliki Koute, Argirios Dinopoulos

Subject: Biology And Life Sciences, Life Sciences Keywords: newborn screening; neonates; WES; WGS; genome screening; genome sequencing

Online: 12 June 2024 (11:09:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1618.v1

Aflatoxin's Toll on Health: Insights into Human and Animal Impact

Jai P. Rai, Jeetu Narware, Ritesh Kumar, Randeep Kumar, Puja Pandey, Nishant Prakash, Somnath K. Holkar, Nadeem Akhtar, Sawant Shraddha Bhaskar, Santosh Kumar, Rekha Balodi, Vinod Upadhyay, Anirudh Chattopadhyay, Kaushik Banerjee, Mohammed Wasim Siddiqui, Akoijam Ratankumar Singh, S. Aravindan, Nisha Kumari, Udai B Singh, Abhijeet Ghatak

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: aflatoxin; human health; animal health; aflatoxicoses; fungi; Feed contamination; aflatoxin toxicity; aflatoxin detection; aflatoxin management

Online: 24 May 2024 (10:09:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0740.v1

Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets

Niklas Sandler, Farnaz Shokraneh, Mahsa Bahman, Julius Lahtinen, Niko Hassinen, Sari Airaksinen, Soumya Verma, Ludmila Hrizanovska, Jana Lass, Jyrki Heinämäki, Urve Paaver, Anssi Karlstedt, Janika Tähnas, Christoph Klaas, Catharina Kern, Adeline Bienfait, Frédéric Lagarce, Dominic Fenske, Katrin Muehlenfeld, Julia Malik, Holger Scherliess, Samuli Ojala, Sara P Cruz, Mattias Paulsson, Katja Kammonen, Maria Rautamo, Hendrik Lueck, Herwig Heindl, Laurent Carrez, Antoine Pierrot, Ralf Harnish, Stephanie Stareprawo, Marija Tubic-Grozdanii, Stefanie Zibolka, Uli Loesch, Martina Jeske, Ulrich Griesser, Karin Hummer, Andreas Thalmeier, Marianne Leitner, Susan Bischoff, Ralph Heimke-Brinck, Janine Paulus-Rohmer, Karim Khouckh, Fabien Bruno, Anna Harjans, Torsten Hoppe-Tichy

Subject: Medicine And Pharmacology, Pharmacy Keywords: automated compounding; hospital and community pharmcies; pharm inks; integrated quality control

Online: 13 March 2024 (12:02:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.2389.v1

Chromosome-Level Genome Assembly and Annotation of the Crested Gecko, Correlophus ciliatus, a Lizard Incapable of Tail Regeneration

Marc Angelo Gumangan, Zheyu Pan, Thomas Lozito

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Gekkota; crested gecko; Correlophus ciliatus; genome sequencing; assembly

Online: 30 September 2024 (11:04:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2279.v1

Using a First-Principles Molecular Dynamics Approach to Test the Total Attraction Forces with an Application to Hydrogen Storage on the 2D Material MoP2 at Different Temperatures

Alma Lorena Marcos Viquez, Osiris Salas Torres, Luis Fernando Magaña Solís

Subject: Condensed Matter Physics, Physical Sciences Keywords: 2D materials; 2D MoP2; Surface forces; Adsorption

Online: 30 September 2024 (11:03:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2254.v1

An Ultra-Selective and Sensitive Fluorescent Chemosensor based on Phage Display Derived Peptide with N-Terminal Cu(II)-Binding Motif

Marta Sosnowska, Tomasz Łęga, Dawid Nidzworski, Marcin Olszewski, Beata Gromadzka

Subject: Waste Management And Disposal, Environmental And Earth Sciences Keywords: phage display derived Cu(II)--Xxx-His complex; ultra-selective Cu2+ chemosensor; –N-teminal Xxx-His motif; fluorescent peptide based sensors; copper ions biosensor

Online: 30 September 2024 (11:01:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2275.v1

Sociodemographics and Lifestyle Cancer Risk Factors among a Population of Caribbean Immigrants

Angel Justiz-Vaillant, Darren Gopaul

Subject: Other, Public Health And Healthcare Keywords: Caribbean; West Indians; hypothesis; biostatistics; immigrants; cancer risk factors; Datasets

Online: 30 September 2024 (11:00:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2317.v1

Polyphenolic Compounds in the Stems of Raspberry (Rubus idaeus) Growing Wild and Cultivated

Ain Raal, Anni Vahtra, Oleh Koshovyi, Tetiana Ilina, Alla Kovalyova, Tõnu Püssa

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Rubus idaeus; stems; рolyphenolic compounds; HPLC/MS analysis

Online: 30 September 2024 (11:00:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2380.v1

Constructing an Early Risk Warning Model for Sequential Treatment Failure of High-Flow Nasal Cannula Oxygen Therapy Following Mechanical Ventilation Weaning Using Random Forest

Cong Liu, Hui-zhen Song, Wei Liu, Yong-ming Qin, Shuo Tian, Mu-lan Ni, Qian-wen Li

Subject: Nursing, Public Health And Healthcare Keywords: Acute Respiratory Failure; High-Flow Nasal Cannula oxygen therapy; Random Forest; Early Risk Warning

Online: 30 September 2024 (10:57:11 CEST)

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Objective: This study aims to construct an early risk warning model to predict the risk of treatment failure in patients undergoing sequential High-Flow Nasal Cannula (HFNC) oxygen therapy following mechanical ventilation weaning. Methods: A retrospective analysis was conducted on clinical data from 145 patients who received HFNC treatment in the Emergency Intensive Care Unit of the Third People's Hospital of Bengbu City from June 2018 to June 2023. A wide range of indicators including general information, comorbidities, laboratory test results, vital signs, disease-related scores, and oxygenation data were collected. Data analysis was performed using R software, starting with the Lasso regression to filter features related to treatment outcomes. Patients were divided into a training set (70%) and a validation set (30%) using random grouping software. The Random Forest algorithm was then employed to evaluate and rank the important features related to outcome indicators. The predictive efficiency and stability of the model were assessed through the Receiver Operating Characteristic (ROC) curve, calibration curve, and decision curve analysis, culminating in the construction of an early risk warning nomogram. Results: The study found that the Random Forest model exhibited high predictive accuracy in the training set (AUC=0.98) and good stability in the validation set (AUC=0.84). Key feature variables identified by the model, such as APACHE II score, BNP, NLR, mROX, and SOFA, were found to significantly impact the prediction of HFNC treatment failure. Based on these variables, an early warning nomogram was further developed, providing clinicians with a convenient and effective risk assessment tool. Conclusion: This study has constructed an early risk warning model based on the Random Forest algorithm, capable of effectively predicting the risk of HFNC treatment failure. The model's high predictive efficiency and stability offer strong support for clinical decision-making, contributing to personalized treatment and improved patient outcomes. Future research should aim to expand the sample size, perform multicenter validation, and explore the integration of the model into Clinical Decision Support Systems for real-time risk assessment and intervention.

Preprint ARTICLE | doi:10.20944/preprints202409.2273.v1

Cytotoxic Activity of Koninginins Isolated from the Mangrove-Derived Endophytic Fungus Trichoderma sp.

Gisele da Costa Ramos, Ingryd Nayara de Farias Ramos, Luciano Almeida Watanabe, Luciana Almeida Watanabe Castro, Alessandra Jackeline Guedes de Moraes, Gleiciane Rodrigues dos Santos, José Edson de Sousa Siqueira, André Salim Khayat, Andrey Moacir do Rosario Marinho, and Patrícia Santana Barbosa Marinho

Subject: Other, Chemistry And Materials Science Keywords: koninginins; cytotoxic activity; Thichoderma; Amazon

Online: 30 September 2024 (10:55:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2379.v1

Bacterial Agents for Biocontrol of American Foulbrood (AFB) of Larvae Honey Bee

Piotr Robert Nowotnik, Paweł Chorbiński, Paweł Migdał, Bogusław Górski

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: AFB; Paenibacillus larvae; bees; probiotics; biocontrol; biosecurity; beneficial microorganisms; bioasecuration; American foulbrood

Online: 30 September 2024 (10:55:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2398.v1

Customized Skincare Solutions for HIV-Positive People: A Comprehensive Analysis

Jemall Stuart

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Dermatological; Skincare; HIV; Healthcare; Mixed-Method Approach; Public Health

Online: 30 September 2024 (10:54:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2266.v1

Impact of Emotional Education Programs in the Development of Emotional Competence in Secondary Students: A Scoping Review

Susana Araya, Mabel Urrutia, Yasna Chávez-Castillo, Isidora Zañartu, Rafael Zapata-Lamana

Subject: Education, Social Sciences Keywords: emotional education; secondary education; scoping review

Online: 30 September 2024 (10:53:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2401.v1

Nouns as Essential Migration Signifiers for Improving Migrant Mental Health Through Social Services Supporting Problem-Focused or Emotion-Focused Coping

Carol Nash

Subject: Anthropology, Social Sciences Keywords: migrate; social services; migrants; mental health; nouns; self-direction; coping

Online: 30 September 2024 (10:52:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2383.v1

Biomass Refined: 99% of Organic Carbon in Soils

Robert J. Blakemore

Subject: Ecology, Environmental And Earth Sciences Keywords: Organic C; biogenic carbon; stocks; NPP; circular economy; CO₂ drawdown; climate

Online: 30 September 2024 (10:51:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2393.v1

Increasing Silicate Supply with Decreasing Npk Fertilization Can Mitigate the Stimulative Effect of Shading on Carbon Intensity in Paddy Field

Yunsheng Lou, Kun Wang, Yuyuan Xing, Jian Liu, Lixuan Ren

Subject: Atmospheric Science And Meteorology, Environmental And Earth Sciences Keywords: rice; shading; compound fertilization; silicate; GHGI

Online: 30 September 2024 (10:48:00 CEST)

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Decreased solar radiation is one of the main issues of climate change. Decreased solar radiation reduced rice yield, while compound fertilization with silicate enhanced the yield. However, it is not fully understood regarding the fertilization effects on the yield, the emissions of methane (CH4) and nitrous oxide in paddy fields under decreased solar radiation. Field simulation experiments with shading were conducted in two consecutive years (2019 to 2020) at the Agrometeorological Station, Nanjing, China. An orthogonal experimental design with three factors and three levels was adopted in this study. The shading was set at 3 levels, i.e. no shading (S0), shading from flowering to maturity period (S1), and shading from tillering to maturity period (S2), with 64% of shading rate. The compound fertilization (as NPK) was set at 3 rates, i.e. 100 kghm-2 (F1), 200 kghm-2 (F2), and 300 kghm-2 (F3). The silicate supply was set at 3 levels, i.e. no silicate supply (R0), adding steel slag at 200 kg SiO2hm-2 (R1), and adding steel slag at 400 kg SiO2hm-2 (R2). The results showed that, shading significantly reduced rice yield. Compared with S0, S1 and S2 significantly decreased rice yield by 43.31-43.32% and 48.51-48.52%, respectively. Shading extremely reduced the cumulative CH4 emission. Compared with S0, S1 and S2 decreased the cumulative CH4 emission by 7.47%-15.21 and 52.15-57.72, but increased the cumulative N2O emission by 8.56%-26.25% and 54.80-57.59%, respectively. The compound fertilization significantly increased the cumulative CH4 and N2O emissions. Compared with F1, F2 and F3 increased the cumulative CH4 emission by 42.01-48.29% and 9.59-57.00%; and enhanced the cumulative N2O emission by 5.67-85.81% and 21.32-192.98%, respectively. Compared with control (R0), silicate supply generally decreased the cumulative CH4 emission by 20.1%-29.57, while increased the cumulative N2O emission by 8.58%-39.57% and 9.12%-48.00%, respectively. Shading (S1 and S2) decreased the total global warming potential (GWP) by 6.88%-13.69% and 47.58%-55.73%, while compound fertilization increased the total GWP by 43.91-49.05% and 10.36-59.70%, respectively. In general, shading and compound fertilization increased the greenhouse gas emission intensity (GHGI) by 59.51%-60.62% and 33.13%-105.76%, while silicate application decreased the GHGI by 23.08%-50.50%, respectively. This study suggests that, controlling the fertilization amount was helpful in decreasing the GHGI, simultaneously ensuring rice yield under decreased solar radiation, with the optimal fertilization at 100 kg·hm-2 of compound fertilizer (as NPK) and 200 kg SiO2·hm-2 of steel slag in the lower reaches of Yangtze River, China.

Preprint ARTICLE | doi:10.20944/preprints202409.2378.v1

Impact of Different Foot and Mouth Disease Vaccine Schemes in the Cross-Neutralization against Heterologous Serotype O Strains in Cattle

María Cruz Miraglia, Melanie Barrios-Benito, Sabrina Galdo-Novo, Danilo Bucafusco, Ana Taffarel, Alejandra Victoria Capozzo, Manuel Victor Borca, Daniel Mariano Pérez-Filgueira

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: foot and mouth disease; cattle; heterologous protection

Online: 30 September 2024 (10:46:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2324.v1

Contributions of Medical Greenhouse Gases to Climate Change and Their Possible Alternatives

Joyce Wang, Shiladitya DasSarma

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: climate change; greenhouse gas emissions; volatile anesthesia; pressurized metered-dose inhaler; fluorinated gas; retinal detachment surgery; sustainability

Online: 30 September 2024 (10:45:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2396.v1

Microbiological Aspects and Enzymatic Characterization of Curvularia kusanoi L7: Ascomycete with Great Biomass Degradation Potentialities

Maryen Alberto Vazquez, Luis Rodrigo Saa, Elaine Valiño, Livio Torta, Vito Armando Laudicina

Subject: Other, Biology And Life Sciences Keywords: fungi; cell wall degrading enzymes; carbon mineralization; fiber modification

Online: 30 September 2024 (10:43:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2345.v1

In Situ Gel-Embedded Chitosan Nanoparticles for Nasal Delivery of Imipramine Hydrochloride: Optimization and Controlled Release Evaluation

Samer Adwan, Teiba Obeidi, Faisal Al-Akayleh

Subject: Pharmacy, Medicine And Pharmacology Keywords: Chitosan; Pluronic; Nanoparticles; In situ gel; Nasal drug delivery; Imipramine

Online: 30 September 2024 (10:43:28 CEST)

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Imipramine hydrochloride (IMP), a tricyclic antidepressant used for major depression, enuresis, and neuropathic pain, is limited by gastrointestinal complications, low oral bioavailability (44%), and complex dosing requirements. This study aimed to explore a novel non-invasive nasal delivery system using chitosan nanoparticles (Cs NPs) embedded in an in situ gel to address the limitations of oral IMP administration. Cs NPs loaded with IMP were synthesized via ionic gelation and assessed for precision in drug concentration using a validated HPLC method. The particles were integrated into a thermoresponsive polymer, Pluronic F127, to form an in situ gel suitable for nasal administration. The formulation was characterized for gelation temperature, duration, viscosity, mucoadhesive strength, and overall gel robustness. Drug release kinetics and the controlled release mechanism were studied using ex vivo permeation tests with Franz diffusion cells and nasal sheep mucosa. The optimized nanoparticle formulation (F4-50) exhibited a consistent PS of 141.7±2.2 nm, a ZP of 16.79±2.1 mV, and a high encapsulation efficiency of 67.71±1.9%. The selected in situ gel formulation, F4-50-P1, demonstrated a gelation temperature of 33.6±0.94°C and a rapid gelation time of 48.1±0.7 seconds. Transform-attenuated total reflectance infrared spectroscopy (ATR-IR) confirmed the compatibility and effective encapsulation of IMP within the formulation. The release profile of F4-50 included an initial burst release followed by a sustained release phase, with F4-50-P1 showing improved control over the burst release. The flux rates were 0.50±0.01 mg/cm²/h for F4-50 and 0.33±0.06 mg/cm²/h for F4-50-P1, indicating effective permeation. The developed chitosan nanoparticle-based in situ gel formulation provides a promising approach for the controlled release of IMP, enhancing therapeutic efficacy and patient compliance while mitigating the disadvantages associated with oral delivery.

Preprint ARTICLE | doi:10.20944/preprints202409.2399.v1

Identification and Analysis of Anticancer Therapeutic Targets from the Polysaccharides PSK and PSP Using Inverse Docking

Carlos Iván López-Gil, Alejandro Téllez-Jurado, Marco Antonio Velasco-Velázquez, Miguel Angel Anducho-Reyes

Subject: Mathematical And Computational Biology, Computer Science And Mathematics Keywords: PSK; PSP; inverse docking; carcinogenic proteins; Trametes versicolor; bioinformatics; immunostimulant

Online: 30 September 2024 (10:42:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2392.v1

CRISPR-Cas Systems Associated with Electrolyte-Gated Graphene-Based Transistors: How They Work and How to Combine Them

Pierre Guermonprez, Pierre Nioche, Louis Renaud, Nicolas Battaglini, Sebastien Sanaur, Eric Krejci, Benoît PIRO

Subject: Analytical Chemistry, Chemistry And Materials Science Keywords: CRISPR/Cas13a; electrolyte-gated transistor; Graphene; DNA; RNA; transduction; sensor

Online: 30 September 2024 (10:41:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2270.v1

Novel PCR-Based Technology for the Detection of Sunflower in Edible and Used Cooking Oils

Tamara Kutateladze, Kakha Karchkhadze, Kakha Bitskinashvili, Boris Vishnepolsky, Tata Ninidze, David Mikeladze, Nelly Datukishvili

Subject: Food Science And Technology, Biology And Life Sciences Keywords: sunflower detection; PCR technology; genomic DNA extraction; edible oil; used cooking oil

Online: 30 September 2024 (10:40:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2400.v1

Molecular Pathophysiology of Parathyroid Tumorigenesis—The Lesson from a Rare Disease: The “MEN1 Model”

Alessandro Brunetti, Roberta Cosso, Fabio Vescini, ALBERTO FALCHETTI

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: parathyroid tumorigenesis; primary hyperparathyrodism; genetics of primary hyperparathyrodism; MEN1 parathyroid tumors; loss of heterozygosity; clonality or parathyroid tumors; menin; epigenetics of parathyroid tumorigenesis; microRNAs; famillial parathyroid tumors

Online: 30 September 2024 (10:39:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2397.v1

COVID-19 Vaccinations, Infections and Outcomes among 784 People Living with HIV

Keren Mahlab-Guri, Irina Komarova, Laliv Kadar, Shay Nemet, Ramon Cohen, Sara Radian-Sade, Achiel Tova, Alex Guri, Shira Bezalel-Rosenberg, Daniel Elbirt

Subject: Internal Medicine, Medicine And Pharmacology Keywords: HIV; AIDS; COVID-19; COVID-19 mRNA Vaccine; Vaccination response

Online: 30 September 2024 (10:38:09 CEST)

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Introduction: Variants of COVID-19 are responsible for 700 million infections and 7 million deaths worldwide. Vaccinations have high efficiency in preventing infection and secondary benefits of reducing COVID-19 hospital admissions, attenuating disease severity and duration of illness. Conflicting reports were published regarding COVID-19 among PLWH. Objective: The aim of this study was to evaluate COVID-19 morbidity, hospitalization and the magnitude of immunological response to sequential BNT 162b2 mRNA vaccines in PLWH regarding demographic and clinical factors. Results: Our retrospective study included 784 PLWH who had at least one anti- SARS-CoV-2 antibody test between March 2021 and October 2021. Half of our patients (392) had CD4 cells count above 500 cells/µl, 40.2% (315) had 200<CD4<500 cells/µL and only 9.8% (77) had CD4 <200 cells/µL at their last laboratory workup. The mean age was 50.2±12.2 years. About 90% of our patients were given at least two doses of the BNT 1626b2 Pfizer vaccines, about 60% received three doses of the vaccine. About a quarter of our patients (27.3%) had COVID-19 infection. Only 6 patients required hospital admission. All six patients recovered from COVID-19 infection. Titers of COVID-19 antibodies were lower for patients with CD4 cells count of less than 200 cells/ µL in the first, second and third serological tests with statistical significance. In a multinomial logistic regression the influence of other factors such as age, sex, previous COVID-19 infection on first COVID-19 antibodies titers was not significant. Conclusions: PLWH are responsive to COVID-19 vaccines. As was expected, patients with higher CD4 cells count have higher titers of COVID-19 antibodies and less severe illness. Age, sex and previous COVID-19 infection did not significantly affect antibodies titers according to our study. Larger prospective studies with control groups are needed to further characterize immunologic response to COVID-19 vaccination among PLWH.

Preprint ARTICLE | doi:10.20944/preprints202409.2384.v1

Stability and Gas Diffusion: A Theoretical Approach to Evanescence and Permanence in Oxyhydrogen Nanobubbles

A. Hernowo

Subject: Nanotechnology, Chemistry And Materials Science Keywords: nanobubble; ultrafine bubble; gas diffusion; oxygen; hydrogen; oxyhydrogen; Chapman-Enskog theory; Arrhenius equation

Online: 30 September 2024 (10:36:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2391.v1

Design and Performance Analysis of a Platform-Based Multi-phase Interleaved Synchronous Buck Converter Using Si MOSFET

Mario Augusto Trape, Ali Hellany, Jamal Rizk, Mahmood Nagrial

Subject: Electrical And Electronic Engineering, Engineering Keywords: DC-DC Converter; Buck Converter; Si MOSFET; Power Electronics; Circuit Design

Online: 30 September 2024 (10:36:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0399.v9

New Concepts of Time and Matter Supported by Fifteen Proofs

Markolf H. Niemz, Siegfried W. Stein

Subject: Physical Sciences, Quantum Science And Technology Keywords: theory of everything; relativity; spacetime; cosmology; background radiation; Hubble’s law; Hubble constant; dark energy; wave–particle duality; quantum entanglement

Online: 6 September 2022 (03:44:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2394.v1

Thermal Deformation Behavior and Consitutive Equation of Uranium-50wt.%Zirconium Nuclear Fuel

Yanfeng Li, Guo Hong, Li Mingyang, Hu Bingkun, Liu Jiancheng

Subject: Metals, Alloys And Metallurgy, Chemistry And Materials Science Keywords: U-50wt.%Zr metallic fuel; hot compression deformation; constitutive equation; hot working diagram

Online: 30 September 2024 (10:32:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2386.v1

The Continuum of Filipino Cultural Identity: Balancing Tradition and Change in a Globalized and Post-Pandemic World

Edgar Eslit

Subject: Ethnic And Cultural Studies, Social Sciences Keywords: continuum of Filipino cultural identity; Globalized and Post-Pandemic World; Tradition and Change

Online: 30 September 2024 (10:24:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2284.v1

Synergizing Machine Learning and Remote Sensing for Urban Heat Island Dynamics: A Comprehensive Modelling Approach

Guglielmina Mutani, Alessandro Scalise, Xhoana Sufa, Stefania Grasso

Subject: Architecture, Building And Construction, Engineering Keywords: Urban Heat Islands (UHIs); Surface Urban Heat Island (SUHI); Remote Sensing; Satellite images; Geographic Information System (GIS); Data-driven modelling; Machine Learning (ML); Local Climate Zones (LCZ); Settlement morphologies, Mitigation measures; Urban Planning

Online: 30 September 2024 (10:20:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2281.v1

The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune Responses

Michel-Edwar Mickael, Marzena Łazarczyk, Norwin Kubick, Atanas G. Atanasov, Michał Ławiński, Justyna Paszkiewicz, Jarosław Olav Horbańczuk, Piotr Religa, Mariusz Sacharczuk

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: GFI1A; T cells; neutrophils

Online: 30 September 2024 (10:20:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2395.v1

A Review of Potential on Possible Greener Production of Slow-Release Nitrogen Fertilizer: From Fundamentals of Plasma and Nanotechnology Application

Stewart Kyebogola, Stella Kabiri, Richard Ndemo Onwonga, Onesimus Semalulu, Russell Yost, Godfrey Sseruwu

Subject: Sustainable Science And Technology, Environmental And Earth Sciences Keywords: Plasma nitrogen fixation; Slow-release fertilizer; Nano delivery; Climate change; Sustainable agriculture

Online: 30 September 2024 (10:14:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2344.v1

Natural Ginger Extract Versus Curcumin: Who Has Better Antioxidant and Anti-Inflammatory Properties for Wound Healing?

Li Sun, Long Chen, Jun Huang, Peikun Xin, Qiming Yang, Conglai Zhou, XiaoLi You

Subject: Plant Sciences, Biology And Life Sciences Keywords: ginger extract; curcumin; antioxidant; anti-inflammatory; wound healing

Online: 30 September 2024 (09:58:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2388.v1

Real-World Clinical Outcomes of Neoadjuvant Platinum-Based Chemotherapy with Nivolumab in Non-Small Cell Lung Cancer

Walid Shalata, Sameh Daher, Natali Maimon Rabinovitch, Sivan Shami, Waleed Kian, Ilit Turgeman, Yulia Dudnik, Olga Kazareen, Yulia Robetski, Edmond Sabo, Dan Levy Faber, Ronen Galili, Ory Wiesel, Konstantin Baranovsky, Abed Agbarya

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: Neoadjuvant; Chemotherapy; Immunotherapy; Non-Small Cell Lung Cancer; Resection surgery; Real-world clinical outcomes

Online: 30 September 2024 (09:51:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2329.v1

Analysis of Hierarchical Task Analysis (HTA) Impact on cognitive workload using NASA TLX: A Study on the Assembly of a Three Jaw Chuck

KarthiK Patel, Hanumakeerthy E, Shailaja V.N, Ravishankar B, Mayur Appaiah

Subject: Industrial And Manufacturing Engineering, Engineering Keywords: Cognitive Workload; Hierarchical Task Analysis; NASA Task Load Index; Assembly; Workload Reduction

Online: 30 September 2024 (09:45:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2390.v1

Direct Interaction Between CD34+ Hematopoietic Stem Cells and Mesenchymal Stem Cells Reciprocally Preserves Stemness

Rémi Safi, Tala Mohsen-Kanson, Farah Kouzi, Jamal El-Saghir, Vera Dermesrobian, Inés Zugasti, Kazem Zibara, Pablo Menéndez, Hiba El Hajj, Marwan El-Sabban

Subject: Other, Biology And Life Sciences Keywords: Bone marrow, microenvironment; CD34+ hematopoietic stem cells; mesenchymal stem cells; connexin 43; N-cadherin; gap junction; acute myeloid leukemia; direct contact.

Online: 30 September 2024 (09:44:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2387.v1

Evaluation of the Presence, Frequency, and Distribution Range of Vegetal Invasive Alien Species in an Urban Area of Southern Spain

Herminia García-Mozo

Subject: Plant Sciences, Biology And Life Sciences Keywords: Plant alien species, invasive species, biodiversity conservation, plant ecology

Online: 30 September 2024 (09:43:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2338.v1

The Effects of Service Quality on an Online Shopping Mall on Consumption Behavior of Sporting Goods Consumers: Moderating Effects of Positive Emotion

Feng Yang, Yuanyan Tong, Jie Wu

Subject: Business And Management, Business, Economics And Management Keywords: Online Shopping Mall; Service Quality; Sporting Goods; Positive Emotion; Shopping Value; Consumer Behavior

Online: 30 September 2024 (09:41:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2267.v1

Investigating the Riemann Hypothesis with HQF ASA and Modular Surfaces - a Detailed Description

Hime Oliveira

Subject: Mathematics, Computer Science And Mathematics Keywords: Riemann Hypothesis; Riemann Zeta Function; Artificial Inference; HQF ASA; Global Optimization.

Online: 30 September 2024 (09:28:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2272.v1

A Machine Learning Classification Model for Gastrointestinal Health in Cancer Survivors: Roles of Telomere Length and Social Determinants of Health

Claire J Han, Xia Ning, Christin E Burd, Fode Tounkara, Matthew F Kalady, Anne M Noonan, Diane Von Ah

Subject: Primary Health Care, Public Health And Healthcare Keywords: cancer survivors, gastrointestinal health, telomere, social determinants of health, machine learning.

Online: 30 September 2024 (09:22:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2322.v1

Evaluating Fitness in Older Acute Myeloid Leukemia Patients: Balancing Therapy and Treatment Risks

Matteo Molica, Martina Canichella, Elias Jabbour, Felicetto Ferrara

Subject: Hematology, Medicine And Pharmacology Keywords: fitness, acute myeloid leukemia, dynamic fitness

Online: 30 September 2024 (09:19:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2337.v1

Telehandler Dynamics Analysis using Bond Graph Methodology

Beatriz Puras, Gustavo Raush, Javier Freire, Germán Filippini, Pedro Roquet, Manel Tirado, Oriol Casadesús, Esteve Codina

Subject: Mechanical Engineering, Engineering Keywords: Telehandler; Experimentation; Simulation; Dynamic Model; Multi-solid; Multi-domain; Bond Graph; Coupled Model, Mechanics and Hydraulics.

Online: 30 September 2024 (09:14:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2336.v1

Esports Training, Periodization, and Software – a Scoping Review

Andrzej Białecki, Bartłomiej Michalak, Jan Gajewski

Subject: Other, Computer Science And Mathematics Keywords: esports; sport science; periodization; training; gaming; competitive gaming; review; human-computer interaction

Online: 30 September 2024 (09:12:09 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202409.1598.v2

Quantum Relativity (Quantum World)

Ahmed Mohamed Ismail, Samira Ezzat E. Mohamed

Subject: Theoretical Physics, Physical Sciences Keywords: special relativity; general relativity; Bohr atomic model; the fine-structure constant; photon energy; energy of the total photon; electron wave by de Broglie; gravity constant; quantum jump and cosmic constants of nature

Online: 30 September 2024 (09:09:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2300.v1

Adeno-Associated Viral Vectors in the Treatment of Epilepsy

Aysilu Mullagulova, Elena Timechko, Valeriya Solovyeva, Alexey Yakimov, Ahmad Ibrahim, Diana V. Dmitrenko, Albert Sufianov, Galina Sufianova, Albert Rizvanov

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: adeno-associated virus, epilepsy, gene therapy, neuropeptides, ion channels, receptors, transcription factors, neurotrophic factors, antisense oligonucleotides.

Online: 30 September 2024 (09:08:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2261.v1

Impact of Non-Antibiotic Antibacterial Substances against Multidrug Resistant Staphylococcus aureus, E. coli and Klebsiella

Zarreen Sajjad, Muhammad Fayaz Khan, Shumaila Manzoor, Eid Nawaz, Fatima Sajjad, Muhammad Abubakar

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: acetic acid,; minimum inhibitory concentration,; multidrug resistance,; lactic acid,; zone of inhibition

Online: 30 September 2024 (09:06:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2367.v1

BOANN: Bayesian-Optimized Attentive Neural Network for Classification

Luoyao He, Xingqi Wang, Yuzhen Lin, Xinjin Li, Yu Ma, Zhenglin Li

Subject: Computer Science, Computer Science And Mathematics Keywords: ; deep learning; Image classification; Convolutional neural network; Bayesian optimization ;

Online: 30 September 2024 (08:57:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2368.v1

Peripheral Eosinophil Count May Be the Prognostic Factor for Overall Survival in PDAC Patients Undergoing Surgical Resection

Wojciech Ciesielski, Izabela Kupryś-Lipińska, Anna Kumor-Kisielewska, Oliwia Grząsiak, Julia Borodacz, Sebastian Niedźwiecki, Piotr Hogendorf, Adam Durczyński, Janusz Strzelczyk, Alicja Majos

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: cancer biology; clinical observations; immunology; pancreatic ductal adenocarcinoma; pancreatic cancer

Online: 30 September 2024 (08:55:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2215.v1

Probabilities on a Heyting Algebra

Jean-Pascal Laedermann

Subject: Logic, Computer Science And Mathematics Keywords: probability; Heyting algebra; projector; quantum physics

Online: 30 September 2024 (08:53:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2369.v1

The Impact of Foreign Bank Entry on the Efficiency and Sustainability of Domestic Banks in Developing Countries: A Meta-Frontier Approach

Fathi Bouzidi, Aida Nefzi

Subject: Finance, Business, Economics And Management Keywords: foreign banks; bank efficiency; sustainability; financial sustainability; social sustainability; environmental sustainability; meta-frontier analysis; developing countries; green lending; sme lending; macroeconomic factors; banking competition ;

Online: 30 September 2024 (08:53:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2346.v1

On the Roles of Protein Intrinsic Disorder in the Origin of Life and Evolution

Vladimir N. Uversky

Subject: Life Sciences, Biology And Life Sciences Keywords: intrinsically disordered proteins; protein-protein interactions; posttranslational modifications; alternative splicing; structural heterogeneity; multifunctionality; membrane-less organelles; liquid-liquid phase separation; origin of life; evolution

Online: 30 September 2024 (08:49:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2334.v1

Microstructure Refinement of Bulk Inconel 718 Parts during Fabrication with EB-PBF Using Scanning Strategies: Transition from Bidirectional-Raster to Stochastic Point-Based Melting

Shadman Tahsin Nabil, Cristian Banuelos, Michael Edward Madigan, Sammy Tin, Jacob I Rodriguez, Lawrence E Murr, Ryan B Wicker, Francisco Medina

Subject: Mechanical Engineering, Engineering Keywords: microstructure control; electron beam melting; scanning strategy; Inconel 718; spot melting

Online: 30 September 2024 (08:39:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2342.v1

Paul A Peters, Morgan Klym, Michel Lopez Barrios, Tomoko McGaughey

Subject: Demography, Social Sciences Keywords: multiple causes of death; comorbidity; mortality; mortality determinants; COVID-19; chronic diseases; population health; demography

Online: 30 September 2024 (08:37:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2343.v1

Ornamental Traits and Sensory Analysis of ‘Biquinho Vermelha’ Pepper Treated with Paclobutrazol

Beatriz Romanini Morales, Lucas Cavalcante da Costa, Marta Regina Verruma-Bernardi, Josiane Rodrigues, Fernando Cesar Sala, Fernando Luiz Finger, Christiane de Fátima Martins França

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: paclobutrazol; Capsicum chinense; ornamental plants; growth regulator; canopy

Online: 30 September 2024 (08:06:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2364.v1

The Industrialization of Brazil: An Economical Historical Analysis until Modern Times

Richard Murdoch Montgomery

Subject: Political Science, Social Sciences Keywords: Brazil; Industrialization; Economic development; Inequality; Structural racism; Social inclusion; Lula da Silva; Dilma Rousseff; Jair Bolsonaro; Operation Lava Jato; Environmental sustainability; Regional development; Import Substitution Industrialization; Neoliberal reforms; Sustainable development; Social justice

Online: 30 September 2024 (07:48:19 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202409.2354.v1

Person-to-Person Bacterial Transmission Can Change the Sleep Pattern in Newly Married Couples

Reza Rastmanesh, Francesco Marotta

Subject: Internal Medicine, Medicine And Pharmacology Keywords: Gut microbiota; bacterial transmission; person-to-person contact; sleep disturbances; newly married couples

Online: 30 September 2024 (07:48:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2359.v1

Multi-Criteria Calibration of a Thermo-Mechanical Model of Steel Plate Welding in Vacuum

Ivo Draganov, Venko Vitliemov, Yuliyan Angelov Angelov, Stiliyana Mileva Mileva, Nikolay Ferdinandov, Danail Gospodinov, Rossen Hristov Radev

Subject: Mechanical Engineering, Engineering Keywords: welding in vacuum; thermo-mechanical model; multicriteria identification; inverse identification problem; adequacy criteria; parameter space investigation method; selection; Salukvadze optimum

Online: 30 September 2024 (07:47:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2363.v1

Modafinil for Narcolepsy: A Systematic Review and Meta-Analysis of Its Effectiveness in Combating Daytime Sleepiness

Govind Singh Mann, Manju Ramakrishnan, Madona L. Pakkam, Nimra Sufiyan, Romil Kukadiya, Khushal B. Girigosavi

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Modafinil; Narcolepsy; Daytime sleepiness; CNS stimulant

Online: 30 September 2024 (07:47:46 CEST)

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Background: Narcolepsy is characterized by excessive daytime sleepiness (EDS) and episodes of cataplexy, frequently triggered by psychological stress, significant disturbances in sleep-wake cycles, pregnancy, or trauma. Modafinil is widely used as the preferred treatment due to its effectiveness in alleviating EDS, improving disease outcomes, and enhancing overall quality of life. Nonetheless, long-term safety and efficacy data are still lacking, underscoring the importance of future research to advance treatment options for narcolepsy. Aim: In our systematic review and meta-analysis, we aim to assess the effectiveness of Modafinil in the treatment of Narcolepsy. Methods: We searched in electronic databases (PubMed, Embase, Google Scholar, Scopus, Science Direct, Web of Science) was performed to identify cohort studies and randomized controlled trials (RCTs) up to 8th July 2024. Data extraction focused on baseline characteristics of the included studies and efficacy outcomes, including scores on the Maintenance of Wakefulness Test (MWT) and Epworth Sleepiness Scale (ESS) . We performed the meta-analysis utilizing the Review Manager software, version 5.4. To assess the outcomes, we compared the Modafinil-treated group with the placebo group, employing the mean difference (MD) and a 95% confidence interval (CI) for statistical analysis. Result: In total, 3833 articles were identified for screening, with nine studies included in the systematic review and five in the meta-analysis. These studies involved 997 adult patients with Narcolepsy treated with Modafinil. MWT revealed a significant increase in total scores (MD= 3.56, 95% CI [2.25 to 4.86], p < 0.00001) and ESS revealed a significant decrease in scores (MD= -3.34, 95% CI [-4.13 to -2.56], p < 0.00001). Conclusion: The research emphasizes the potential of Modafinil in alleviating EDS associated with Narcolepsy. While the results are promising, they are based on short term scale studies. It is crucial to undertake larger-scale, extended-duration, placebo-controlled studies that include a broad range of demographic populations. These trials are essential to confirm the efficacy, verify the safety profile, and fine-tune dosing strategies to maximize the long-term therapeutic benefits.

Preprint ARTICLE | doi:10.20944/preprints202409.2358.v1

Feasibility of GPT-3.5 Versus Machine Learning for Automated Surgical Decision-Making Determination: A Multicenter Study in Suspected Appendicitis

Sebastian Sanduleanu, Koray Ersahin, Johannes Bremm, Narmin Talibova, Tim Damer, Merve Erdogan, Jonathan Kottlors, Lukas Goertz, Christiane Bruns, David Maintz, Nuran Abdullayev

Subject: Other, Public Health And Healthcare Keywords: appendectomy; surgical decision making; artificial intelligence

Online: 30 September 2024 (07:47:37 CEST)

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Background: Nonsurgical treatment in uncomplicated appendicitis is in many cases a reasonable option, despite the sparsity of robust, easy access, externally validated and multimodally informed clinical decision support systems (CDSS). Developed by OpenAI, the Generative Pre trained Transformer 3.5 model (GPT 3), may provide enhanced decision support for surgeons in less certain appendicitis cases or those posing a higher risk for (relative) operative contra indications. Our objective was to determine whether GPT 3.5, when provided high throughput clinical, laboratory and radiological text based information will come to similar clinical decisions as a machine learning model and a board certified surgeon (reference standard) in decision making for appendectomy versus conservative treatment. Methods: In this cohort study we randomly collected patients presenting at the Emergency Department (ED) of two German hospitals (GFO, Troisdorf and University Hospital Cologne) with right abdominal pain between October 2022 and October 2023. Statistical analysis was performed using R, version 3.6.2, on RStudio, version 2023.03.0+386. Overall agreement between GPT 3.5 output and the reference standard was assessed by means of inter observer kappa values as well as accuracy, sensitivity, specificity, positive and negative predictive value with the “Caret” and “irr” package. Statistical significance was defined as p < 0.05. Results: There was agreement between surgeon decision and GPT 3.5 in 102 of 113 cases and all cases where the surgeon decided upon conservative treatment were correctly classified by GPT 3.5. The estimated model training accuracy was 83.3 % (95% CI: 74.0, 90.4), while the validation accuracy for the model was 87.0 % (95% CI: 66.4, 97.2). This in comparison to the GPT 3.5 accuracy of 90.3% (95% CI: 83.2, 95.0), which did not perform significantly better in comparison to the machine learning model (P = 0.21). Conclusions: This to our knowledge first “intended use” for surgical treatment GPT 3.5 study comparing surgical decision making versus algorithm found a high degree of agreement between board certified surgeons and GPT 3.5 for surgical decision making in patients presenting to the emergency department with lower abdominal pain.

Preprint ARTICLE | doi:10.20944/preprints202409.2362.v1

Survey for Exploring Blockchain with Graph Neural Network

Amanda Hasebe

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Graph Neural Network; Graph Convolutional Networks; Graph Attention Networks; blockchain; cryptocurrency

Online: 30 September 2024 (07:47:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2323.v1

Phylogenetic In Silico Analysis Indicates that the Moonlighting 14-3-3 Protein of Ajellomycetaceae Family and Homo sapiens Share Conserved and Distinct Features in Their Peptide Binding Site

Samanta de Matos Silva, Oscar Mauricio Gómez, Marco Antonio Rodrigues, Henrique Gomes Martins, Orville Hernandez Ruiz, Maria José Soares Mendes-Giannini, Ana Marisa Fusco-Almeida, Ángel González

Subject: Other, Medicine And Pharmacology Keywords: 4-3-3 protein; dimorphic fungi; Ajellomycetaceae family; phylogenetic analysis; OrthoFinder; Swiss-model

Online: 30 September 2024 (07:47:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2361.v1

C-Reactive Protein Levels Can Predict Post-Operative Pancreatic Fistula (POPF) Formation After Pancreatic Resections

Forat Swaid, Muhammad Masalha, Rajaa Elias, Ibrahim Matter, Ahmad Asadi, Osama Kanaana, Viktor Sebek, Dejan Radonjic, Rola Shehadeh, Salem Billan, Abed Agbarya

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: C-reactive protein; early marker; pancreatic fistula; post-operative complication; surgery

Online: 30 September 2024 (07:47:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2382.v1

Optimization of Production Parameters for Impact Strength of 3D-Printed Carbon/Glass Fiber Reinforced Nylon Composite in Critical ZX Printing Orientation

Selim HARTOMACIOĞLU

Subject: Mechanical Engineering, Engineering Keywords: additive manufacturing; polymer composite; short carbon/glass fiber; nylon

Online: 30 September 2024 (07:39:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2248.v1

A Cox Proportional Hazards Model with Latent Covariates Reflecting Student’s Preparation, Motives, and Expectations for the Analysis of Time to Degree

Dimitrios Kalamaras, Laura Maska, Fani Nasika

Subject: Education, Social Sciences Keywords: time to degree; late graduation; duration of university studies; cox proportional hazards model; latent covariates; academic success; graduation rate

Online: 30 September 2024 (07:38:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.2241.v1

Lignin: An Adaptable Molecule

Andreea Creteanu, Claudiu N. Lungu, Mirela Lungu

Subject: Pharmacy, Medicine And Pharmacology Keywords: lignin; polymers; drug molecules; biomolecules

Online: 30 September 2024 (07:35:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2257.v1

Translational Research on Azacitidine Post- Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2)

Esther Natalie Oliva, Maria Cuzzola, Matteo Della Porta, Anna Candoni, Prassede Salutari, Giuseppe A Palumbo, Gianluigi Reda, Giuseppe Iannì, Matteo Zampini, Saverio D’Amico, Giovanni Tripepi, Debora Capelli, Caterina Alati, Maria Concetta Cannatà, Pasquale Niscola, Bianca Serio, Santina Barillà, Pellegrino Musto, Ernesto Vigna, Lorella Maria Antonia Melillo, Rocco Tripepi, Maria Elena Zannier, Yasuhito Nannya, Seishi Ogawa, Corrado Mammì

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: acute myeloid leukemia; azacitidine; disease-free survival; malignancy-related genes

Online: 30 September 2024 (07:33:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2240.v1

Genome-Wide Identification and Characterization of bHLH Gene Family in Hevea brasiliensis

Zheng Wang, Yuan Yuan, Fazal Rehman, Xin Wang, Tingkai Wu, Zhi Deng, Han Cheng

Subject: Plant Sciences, Biology And Life Sciences Keywords: bHLH transcription factor; Rubber tree; Cis-element; Expression analysis; Transcriptome; Abiotic stress; RT-qPCR; Gene structure; Subcellular localization

Online: 30 September 2024 (07:31:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2285.v1

A Dual-Module System for Copyright-Free Image Recommendation and Infringement Detection in Educational Materials

Yeongha Kim, Soyeon Kim, Seonghyun Min, Youngung Han, Ohyoung Lee, Wongyum Kim

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Copyright protection; Copyright-free; Image retrieval; Infringement detection

Online: 30 September 2024 (07:29:11 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.2249.v1

Post-Operative Tearing of Zygomatic Implant

Valthierre Nunes de Lima, Giovanni de Almeida, Luana Ferreira Oliveira, Osvaldo Magro-Filho

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: Dental Implant; Zygoma; Postoperative Complications

Online: 30 September 2024 (07:27:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2247.v1

Generalisation Increases the Adaptive Value of Mate-Choice Copying when Immediate Copying is Costly

Geoff Kushnick

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Mate-choice copying; generalisation; trait-based copying; reproductive strategies; human evolution; cultural evolution; human behavioural ecology

Online: 30 September 2024 (07:24:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2231.v1

Early PCR Confirmation and Fewer Visit as the Key to Improving HCV Treatment Rates in a Predominantly African American GI Clinic

Crisshy Auguste, Rana Khamis, Paul H Naylor, Milton G Mutchnick

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: hepatitis C; African American; direct acting antivirals

Online: 30 September 2024 (07:22:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2376.v1

Graph Neural Network for Daily Supply Chain Problems

Fabian Raul Gonzalez

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: supply chain; graph neural network; machine learning

Online: 30 September 2024 (06:07:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2372.v1

Thurstonian Scaling for Sensory Discrimination Methods

Jian Bi, Carla Kuesten

Subject: Behavior Sciences, Social Sciences Keywords: sensory discrimination methods; Thurstonian discriminal distance d'; statistical inference for d'; difference testing; equivalence/similarity testing

Online: 30 September 2024 (05:39:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2357.v1

Predicting the Open Porosity of Industrial Mortar Applied on Different Substrates: A Machine Learning Approach

Rafael Travincas, Maria Paula Mendes, Isabel Torres, Inês Flores-Colen

Subject: Civil Engineering, Engineering Keywords: random forest; support vector machine; industrial mortar; substrate; prediction

Online: 30 September 2024 (04:45:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2349.v1

Effect of Different Marinades and Types of Grills on Polycyclic Aromatic Hydrocarbon Content in Grilled Chicken Breast Tenderloins

Marta Ciecierska, Urszula Komorowska

Subject: Food Science And Technology, Biology And Life Sciences Keywords: PAHs; chicken breast tenderloins; grill; marinades; QuEChERS; HPLC–FLD/DAD

Online: 30 September 2024 (04:28:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0284.v2

Sympathetic Innervation of Interscapular Brown Adipose Tissue is not a Predominant Mediator of Oxytocin-Induced Brown Adipose Tissue Thermogenesis in Female High Fat Diet-Fed Rats

Andrew D. Dodson, Adam J. Herbertson, Mackenzie K. Honeycutt, Ron Vered, Jared D. Slattery, Matvey Goldberg, Edison Tsui, Tami Wolden-Hanson, James L. Graham, Tomasz A. Wietecha, Kevin D. O'Brien, Peter J. Havel, Carl L. Sikkema, Elaine R. Peskind, Thomas O. Mundinger, Gerald J. Taborsky, Jr., James E. Blevins

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Obesity; brown adipose tissue; oxytocin; female rodents

Online: 30 September 2024 (04:15:01 CEST)

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Previous studies in our lab show that that administration of oxytocin (OT) into the fourth ventricle (4V; hindbrain) elicits weight loss and stimulates interscapular brown adipose tissue temperature (T_IBAT) in male diet-induced obese (DIO) rats. What remains unclear is whether chronic hindbrain (4V) OT can impact body weight in female high fat diet-fed (HFD) rodents and whether this involves activation of brown adipose tissue (BAT). We hypothesized that OT-elicited stimulation of sympathetic nervous system (SNS) activation of interscapular brown adipose tissue (IBAT) contributes to its ability to activate BAT and reduce body weight in female high HFD-fed rats. To test this hypothesis, we determined the effect of disrupting SNS activation of IBAT on OT-elicited stimulation of T_IBAT and reduction of body weight in DIO rats. We first measured the impact of bilateral surgical SNS denervation to IBAT on the ability of acute 4V OT (0.5, 1, and 5 µg ≈ 0.5, 0.99, and 4.96 nmol) to stimulate T_IBAT in female HFD-fed rats. We found that the high dose of 4V OT (5 µg ≈ 4.96 nmol) stimulated T_IBAT similarly between sham rats and denervated rats (P=NS). We subsequently measured the effect of bilateral surgical denervation of IBAT on the effect of chronic 4V OT (16 nmol/day ≈ 16.1 mg/day) or vehicle infusion to reduce body weight, adiposity and energy intake in female HFD-fed rats (N=7-8/group). Chronic 4V OT reduced body weight gain (sham: -18.0±4.9 g; denervation: -15.9±3.7 g) and adiposity (sham: -13.9±3.7 g; denervation: -13.6±2.4 g) relative to vehicle treatment (P<0.05) and these effects were similar between groups (P=NS). These effects were attributed, in part, to reduced energy intake evident during weeks 2 (P<0.05) and 3 (P<0.05). To test whether these results translate to other female rodent species, we also examined the effect of chronic 4V infusion of OT on body weight and adiposity in two strains of female HFD-fed mice. Similar to what we found in the HFD-fed rat model, we also found that chronic 4V OT (16 nmol/day) infusion resulted in reduced body weight gain, adiposity and energy intake in female DIO C57BL/6J and DBA/2J mice (P<0.05 vs vehicle). Together, these findings suggest that 1) sympathetic innervation of IBAT is not necessary for OT-elicited increases in BAT thermogenesis and weight loss in female HFD-fed rats and 2) the effects of OT to elicit weight loss translate to other mouse models of diet-induced obesity (DIO).

Preprint ARTICLE | doi:10.20944/preprints202409.2331.v1

Advancing Subgroup Discovery in Classification: A Novel Random PRIM-Based Classifier Compared with well-established Algorithms

Rym Nassih, Abdelaziz Berrado

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Classification; Subgroup Discovery; Patient Rule Induction Method; Metarules; Interpretability

Online: 30 September 2024 (04:10:40 CEST)

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