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Preprint ARTICLE | doi:10.20944/preprints202408.0950.v1

Insights into the Replication Kinetics Profiles of Malaysian SARS-CoV-2 Variant Alpha, Beta, Delta, and Omicron in Vero E6 cell line

Zarina Mohd Zawawi, Jeevanathan Kalyanasundram, Rozainanee Mohd Zain, Adiratna Mat Ripen, Dayang Fredalina Basri, Wei Boon Yap

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: SARS-CoV-2; variants; replication kinetics; infectivity; mutations; cell culture adaptation

Online: 13 August 2024 (13:02:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0608.v1

The Association Between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan, Kuwait, among Other Arab Countries

Malik Sallam, Kholoud Al-Mahzoum, Moudhi Ahmad Alenezi, Maryam Alsaeed, Fatmah Alsaeed, Noor Albayati, Sarah Alkhaldi, Rawan J. Obeidat, Muna Barakat

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; Long COVID; Post-COVID Condition; Long Haul COVID; PASC Post Acute Sequelae of COVID-19; COVID-19 Post-Acute Sequelae; COVID-19 Conspiracy Theories; Health Communication

Online: 8 August 2024 (17:30:36 CEST)

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Long COVID comprises persistent symptoms which extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long COVID and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries where high endorsement of these theories has been reported. This study aimed to explore the association between endorsing COVID-19 conspiracy theories and the prevalence of self-reported long COVID symptoms among adults in Jordan and Kuwait in addition to other Arab countries. The study employed a cross-sectional design using an electronic self-administered survey in Arabic language. Recruitment utilized snowball sampling via social media and the survey was distributed in July 2024. The survey instrument included sections on demographic information, the history of COVID-19 infection, and vaccination status. Long COVID manifestations were assessed using a score reflecting the frequency and intensity of ten recognized long COVID symptoms with subsequent categorization into three categories: low, middle, and high. The beliefs in COVID-19 conspiracy theories were measured via a 5-point Likert scale across five items. The final study sample comprised 756 respondents, the majority of whom self-reported a history of confirmed COVID-19 diagnosis at least once (n = 493, 65.2%). The results indicated a neutral average attitude towards COVID-19 conspiracy theories (mean score = 15.18±4.64 out of 30.00). Participants with high conspiracy theories scores were significantly more likely to report high (aOR = 6.85, 95% CI: 2.90–16.13, p < 0.001) and middle long COVID symptoms (aOR = 2.82, 95% CI: 1.32–6.06, p = 0.008) compared to those with lower scores. Additional predictors of higher long COVID reporting included female sex and lower self-reported household income. Frequent COVID-19 infections and hospitalizations were also associated with higher long COVID symptom reporting. The study results revealed a significant correlation between the endorsement of COVID-19 conspiracy theories and the higher frequency and magnitude of long COVID symptom reporting. The findings also highlighted the influence of sociodemographic factors and COVID-19 infection history on long COVID reporting, which suggests that public health strategies should address these factors to mitigate long COVID challenges effectively.

Preprint ARTICLE | doi:10.20944/preprints202408.0500.v1

Angiographic Correlation of Angina Topography in Patients Presenting with Acute Myocardial Infarction (AMI) -Can the Location of Angina Predict the Site of Coronary Artery Occlusion? – The ACOLYTE Study

Kamal Sharma, Ashwati Konat, Poojan Prajapati, Kavya Darji, Shalin Rawal, Vatsa Bhavsar, Prahar Darji, Yashrajsinh Gohil, Masum Patel, Shubham Patel, Parjanya Bhatt, Yashvi Pethani, Stuti Shah, Hardik Desai

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Chest Pain; Angina; Acute Coronary Syndrome; Angina Topography; STEMI; NSTEMI

Online: 7 August 2024 (10:34:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2206.v1

Study of the Features of Coating Deposition on a Carbide Substrate Using Preliminary Etching with Glow Discharge Plasma

Sergey Grigoriev, Marina Volosova, Yuri Bublikov, Catherine Sotova, Filipp Milovich, Ilya Shmakov, Alexey Vereschaka

Subject: Chemistry And Materials Science, Ceramics And Composites Keywords: glow discharge; coatings; surface preparation; ion bombardment; metal-cutting

Online: 29 July 2024 (07:09:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1976.v1

Sildenafil Citrate Oral Suspension: A Systematic Review and Expert Opinion

Carlos Miacola, Luca Boeri, Fabrizio Palumbo, Carlo Ceruti, Davide Arcaniolo, Marco Bitelli, Giorgio Piubello, Chiara Polito, Tommaso Cai, Alessandro Palmieri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: erectile dysfunction; phosphodiesterase-5 inhibitors; sildenafil

Online: 24 July 2024 (14:17:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1588.v2

The Interplay Between Multisystem Inflammatory Syndrome in Children, Interleukin 6, Microbiome, and Gut Barrier Integrity

Ali Zari, Elrashdy M. Redwan, Mikolaj Raszek, David Cowley, Altijana Hromić-Jahjefendić, Vladimir N. Uversky, Mark Fabrowski, Carlo Brogna, Marina Piscopo, Alberto Rubio-Casillas

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: MIS-C; IL-6; gut barrier dysfunction; zonulin levels; microbiome; SARS-CoV-2 bacteriophage behavior; Long COVID-19

Online: 28 June 2024 (08:07:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1678.v1

Ipsa Senectus Morbus Est? Approaching the Unmet Needs in Geriatric Depression: Results From a National Survey

Umberto Albert, Carmine Tomasetti, Raffaele Antonelli Incalzi, Alessandro Cicolin, Alessandro Padovani, Michela Zanetti, Giuseppe Maina

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: antidepressants; comorbidity; trazodone; psychiatry; neurology; geriatrics; elderly

Online: 25 June 2024 (09:29:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1725.v1

Ionosonde Measurements Comparison during an ICME- and a SIR/CIR-Driven Geomagnetic Storm over Europe

Kitti Alexandra Berényi, Loredana Perrone, Dario Sabbagh, Alessandro Ippolito, Carlo Scotto, Árpád Kis, Veronika Barta

Subject: Environmental And Earth Sciences, Space And Planetary Science Keywords: space weather; geomagnetic storms; ionosphere; ionospheric storm; ICME; SIR/CIR; ionosonde; Digisonde; rTEC; TIMED/GUVI

Online: 25 June 2024 (07:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1461.v1

Markers of Epithelial-Mesenchymal Transition and Mucinous Histology in Early-Onset Colorectal Cancer

Aleksandra Djikic Rom, Sandra Dragicevic, Radmila Jankovic, Sanja Radojevic Skodric, Predrag Sabljak, Velimir Markovic, Jovana Rosic, Goran Barisic, Aleksandra Nikolic

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: early-onset colorectal cancer; epithelial-mesenchymal transition; mucinous tumor

Online: 20 June 2024 (15:29:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0409.v1

Behavior of IL-6 and Its Soluble Receptor Complex during Different Waves of the COVID-19 Pandemic

Gaetano Di Spigna, Bianca Covelli, Maria Vargas, Roberta Di Caprio, Valentina Rubino, Carmine Iacovazzo, Filomena Napolitano, Giuseppe Servillo, Loredana Postiglione

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID 19 -; Severe Acute Respiratory Syndrome CoronaVirus 2; IL6 - IL6 receptor complex

Online: 6 June 2024 (12:47:11 CEST)

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In late December 2019 a novel RNA beta-coronavirus was recognized as the causative agent of previously pneumonia cases of unknown origin. The virus was successively named Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) as well as the respiratory illness that it causes Coronavirus disease 19 (COVID-19) (1, 2). The global spread of SARS-CoV-2 and the thousands of deaths caused by COVID-19 led the World Health Organization (WHO) to declare a pandemic on 11 March 2020. To date, the world has paid a high toll in this pandemic in terms of human lives lost, economic repercussions and increased poverty. Indeed, even if most patients with COVID-19 are asymptomatic or experience mild self-limiting disease, 14% of them progress to severe disease and 5% to critical illness with complications, such as interstitial pneumonia, respiratory failure with acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndromes (MODS) (3). It is accepted that SARS-CoV-2 primarily affects the respiratory system, although other organs are also involved (4). The virus enters host cells by attaching its Spike like surface projections to the angiotensin-converting enzyme-2 (ACE2) receptor which is mainly expressed on alveolar epithelial cells and in nearly all human organs in varying degrees. Thus, although the central target of SARS-CoV-2 infection is the lung, the wide distribution of ACE2 receptors in other organs may lead to cardiovascular, gastrointestinal, kidney, liver, central nervous system and ocular damages that have to be closely monitored during the disease (5, 6). The virus then activates the innate and adaptive immune system resulting in a large number of cytokines release, known as “cytokine storm”, that is directly correlated with tissue injury and unfavourable prognosis of severe lung disease (7). In particular, interleukin (IL)-6 seems to plays an important role in driving this cytokine release so that its increased levels have been recognized as a hallmark inflammatory signature in sera of COVID-19 patients (8). IL-6 is a polyfunctional cytokine with both anti-inflammatory and pro-inflammatory properties which exerts its several functions through two main signal transduction pathways (9). In the classical signal transduction pathway, IL-6 binds to IL-6-trans membrane receptor (IL-6R) to form a complex that, then, binds to the trans membrane glycoprotein gp130, inducing its homo-dimerization and initiating intracellular signal transduction. This kind of signaling is limited to cells (hepatocytes, macrophages, neutrophils, T cells, etc.) that express IL-6R on their cell surface (10). Nevertheless, cells do not express IL- 6R, as stromal and epithelial cells, are able to still respond to IL-6 because the soluble form of the receptor (sIL-6R) binds to IL-6 in circle and then anchors to membrane gp130 receptor, initiating the trans-signaling pathway. For this reason, sIL-6R is able to increase the function of IL-6 and is considered the agonist form of its receptor. When the level of IL-6 increases, its effects are widely expressed because gp130 molecules are ubiquitous and, therefore, also present in cells without IL-6R in the membrane form. On the contrary, a soluble form of the glycoprotein 130 (sgp130) can complex with sIL-6R to prevent the sIL-6R from binding to the membrane-bound gp130. In this case sgp130 is able to decrease the function of IL-6 and is considered the antagonist form of IL-6 receptor system (11). Based on the central role of IL-6 in the inflammatory pathology of COVID-19 and the consistent association between elevated levels of the cytokine and severe disease outcomes found in the first phase of infection, we sought to analysis IL-6 and its soluble receptor complex behavior during the different waves of COVID-19 pandemic, in order to evaluate the possible differences which occur among them and to hypothesize if they might be used as prognostic markers of disease severity.

Preprint ARTICLE | doi:10.20944/preprints202406.0032.v1

Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities

Alondra Vázquez Rivera, Heather Donald, Mounia Alaoui-El-Azher, John J. Skoko, John S. Lazo, Michael A. Parniak, Paul A. Johnston, Nicolas Sluis-Cremer

Subject: Biology And Life Sciences, Virology Keywords: HIV-1; reverse transcriptase; polymerase; ribonuclease H; inhibitor; benzisothiazolone

Online: 3 June 2024 (07:56:06 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.2094.v1

Detection of Mesothelial-to-Mesenchymal Transition-Derived Carcinoma-Associated Fibroblasts in Primary Ovarian Carcinomas

Henar Tomero-Sanz, José Antonio Jiménez-Heffernan, María Concepción Fernández-Chacón, Ignacio Cristóbal-García, Ricardo Sainz de la Cuesta, Lucía González-Cortijo, Manuel López-Cabrera, Pilar Sandoval

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Ovarian cancer; primary tumor; mesothelial cells; carcinoma-associated fibroblasts; mesothelial-to-mesenchymal transition

Online: 31 May 2024 (08:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1836.v1

Study on the Safety Characteristics of Different Types of Pepper (Capsicum L.)

László Kosár, Zuzana Szabová, Richard Kuracina, Stefan H Spitzer, Miroslav Mynarz, Bohdan Filipi

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: dust explosion; pepper samples; explosion characteristics; explosion protection

Online: 28 May 2024 (11:29:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0402.v2

Wheat Yield Estimation using Machine Learning Method Based on UAV Remote Sensing Data

Shurong Yang, Lei Li, Shuaipeng Fei, Mengjiao Yang, Zhiqiang Tao, Yaxiong Meng, Yonggui Xiao

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: machine learning; yield prediction; data fusion; wheat; phenotyping

Online: 23 May 2024 (12:31:37 CEST)

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Accurate forecasting of crop yields holds paramount importance in guiding decision-making processes related to breeding efforts. This study focused on the application of multi-sensor data fusion and machine learning algorithms based on unmanned aerial vehicles (UAVs) in wheat yield prediction. Five machine learning (ML) algorithms namely random forest (RF), partial least squares (PLS), ridge regression (RR), K-Nearest Neighbor (KNN) and eXtreme Gradient Boosting Decision Tree (XGboost) were utilized for multi-sensor data fusion, and three ensemble methods including the second-level ensemble methods (stacking and feature-weighted) and the third-level ensemble method (simple average) for wheat yield prediction. The 270 wheat hybrids were used as planting materials under full and limited irrigation treatments. A cost-effective multi-sensor UAV platform, equipped with red–green–blue (RGB), multispectral (MS), and thermal infrared (TIR) sensors, was utilized to gather remote sensing data. The results revealed that the XGboost algorithm exhibited outstanding performance in multi-sensor data fusion, with the RGB+MS+Texture+TIR combination demonstrating the highest fusion performance (R2=0.660, RMSE= 0.754). Compared with the single ML model, the employment of three ensemble methods significantly enhanced the prediction accuracy of wheat yield. Notably, the third-layer simple average ensemble method demonstrated superior performance (R2 = 0.733, RMSE= 0.668 t ha-1). It significantly outperformed both the second-layer ensemble methods of Stacking (R2= 0.668, RMSE= 0.673 t ha-1) and feature-weighted (R2= 0.667, RMSE= 0.674 t ha-1), thereby exhibiting superior predictive capabilities. This finding demonstrated that the third-layer ensemble method not only augments the predictive ability of the model but also fine-tuned the accuracy of wheat yield prediction through the employment of simple average ensemble learning. Consequently, it offers a novel perspective for crop yield prediction and breeding selection.

Preprint ARTICLE | doi:10.20944/preprints202405.1313.v1

Neutralization and Binding Capability of SARS-CoV-2 Variants by/of IgG Antibodies of Early COVID-19 Convalescent Inactivated Sera based on Indirect ELISA

Behzad Hussain, Peizhe Zhao, Bo Yang, Xiaoxiong Li, Zhichao Zhang, Guoqiang Feng, Demei Zhang, Defen Lu, Changxin Wu

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; neutralization; early COVID-19; convalescent sera; ELISA

Online: 21 May 2024 (08:47:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1073.v1

Zebrafish as a Model for Studying Age-Dependent Sarcopenia and Frailty

Paula Aranda-Martínez, Ramy K. A. Sayed, José Fernández-Martínez, Yolanda Ramírez-Casas, Yang Yang, Germaine Escames, Darío Acuña-Castroviejo

Subject: Biology And Life Sciences, Aging Keywords: zebrafish; aging; skeletal muscle; mitochondria; sarcopenia

Online: 16 May 2024 (11:55:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0647.v1

Emerging Mutations of SARS-COV-2 in Kenya

Elius Mbogori, Kelvin Thiongo, Harrison Yunyang Deng, Caroline Gikunyu, Winfrida Cheriro, Stanslaus Musyoki, Richard Biegon, Damaris Matoke-Muhia, Kirtika Patel, Binhua Liang, Elijah Songok

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; COVID-19; Spike protein; Epistasis; Reverse transcription; Pathogenesis; Vaccine efficacy; Complementary DNA; Reverse transcription-polymerase chain reaction

Online: 10 May 2024 (11:30:40 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202405.0291.v1

New Isomeric Dipyridothiazine Dimers — Synthesis, Structural Characterization and Cytotoxicity Screening

Emilia Martula, Beata Morak-Młodawska, Małgorzata Jeleń, Paulina Strzyga-Łach, Marta Struga, Katarzyna Żurawska, Anna Kasprzycka

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: phenothiazines; diazaphenothiazines; 2D NMR; structural analysis; Way2Drug; cytotoxicity

Online: 6 May 2024 (12:33:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1424.v1

Distinguishing Drivers via Wearable Sensor Data and Machine Learning

Natalia Piaseczna, Rafał Doniec, Konrad Duraj, Szymon Sieciński, Marek Jędrychowski, Ewaryst Tkacz, Marcin Grzegorzek

Subject: Engineering, Bioengineering Keywords: driving; wearable sensors; electrooculography; inertial sensors; machine learning

Online: 23 April 2024 (11:54:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1448.v1

Protein Bioengineering of a Crucial Biopharmaceutical for Acute Lymphoblastic Leukaemia: Improving Toxicogical, Immune and Inflammatory Responses to Asparaginase

Grace Verónica Ruiz Lara, Tales Alexandre Costa-Silva, Jorge Javier Muso Cachumba, Johanna Cevallos-Espinel, Marina Gabriel Fontes, Mitla Garcia-Maya, Khondaker Miraz Rahman, CARLOTA OLIVEIRA RANGEL-YAGUI, Gisele Monteiro

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: E. coli asparaginase; bioengineer; leukaemia; nonclinical assays

Online: 22 April 2024 (18:07:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1380.v1

Integration of Marine Spatial Planning and Terrestrial Spatial Planning and Its Implementation in Spain

F. Javier Córdoba-Donado, Vicente Negro-Valdecantos, Gregorio Gómez-Pina, Juan J. Muñoz-Pérez, Luis J. Moreno-Blasco

Subject: Environmental And Earth Sciences, Other Keywords: Marine Spatial Planning (MSP); Terrestrial Spatial Planning (TSP); Integrated Spatial Planning (ISP); integration; climate change; Land-sea interaction, extreme events; disastrous hazards

Online: 22 April 2024 (10:16:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1329.v1

Factors Associated with Communities’ Satisfaction of Receiving Curative Care Administered by Community Health Workers in the Health Districts of Boussé and Boussouma in Burkina Faso, 2024

Hamed Sidwaya Ouedraogo, Abdoul-Guaniyi Sawadogo, Ahmed Kabore, Badra Ali Traore, Mamadou Traore, Massoudou Harouna Maiga, Marcella Valerie Zombre Sanon, Maxime Koine Drabo

Subject: Public Health And Healthcare, Primary Health Care Keywords: community health workers; community health care; quality; perception; Burkina Faso Faso

Online: 19 April 2024 (10:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1152.v1

Synthesis, Activity, Toxicity, and In Silico Studies of New Antimycobacterial N-alkyl Nitrobenzamides as Potential DprE1 Inhibitors

João Pedro Pais, Olha Antoniuk, David Pires, Tiago Delgado, Andreia Fortuna, Paulo J Costa, Elsa Anes, Luis Constantino

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Tuberculosis; nitrobenzamides; DprE; mycobacteria

Online: 17 April 2024 (11:50:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0784.v1

Dramatic Suppression of Lipogenesis and No Increase in Beta- Oxidation Are the Main Effects of Bergamot Flavonoids on Gene Expression in Fatty Liver Disease

Maddalena Parafati, Daniele La Russa, Antonella Lascala, Francesco Crupi, Concetta Riillo, Bartosz Fotschki, Vincenzo Mollace, Elzbieta Janda

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: flavonoids; hepatic steatosis; lipogenesis; Citrus Bergamia; gene profiling

Online: 11 April 2024 (09:32:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1058.v1

Mesothelioma Associated Fibroblasts Modulate the Response of Mesothelioma Patient Derived Organoids to Chemotherapy through Interleukin-6.

Mario Cioce, Veronica Gatti, Fabiana Napolitano, Noemi Maria Giorgiano, Andrea Marra, Giuseppe Portella, Alfonso Fiorelli, Francesca Pentimalli, Vito Michele Fazio

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Mesothelioma patient-derived organoids, PDO, IL-6, mesothelioma-associated fibroblasts; cocultures, cisplatin; pemetrexed; chemoresistance

Online: 18 March 2024 (15:17:01 CET)

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Background. Malignant pleural mesothelioma (MPM) is still a rather incurable disease. Many classes of compounds with various mechanisms of action have been tested in vivo and ex-vivo, with rather disappointing results. This is partly due to preclinical studies mostly performed in models that fail to recapitulate MPM complexity and do not retain the intra-tumor heterogeneity, a propelling force for tumor progression. Additionally, we and others have shown that, under stress-induced chemotherapy, profound rearrangements take place in MPM cultures to fuel the emergence of chemoresistant cell subpopulations. Thus, finding clinically actionable modulators of MPM resistance is still a very urgent need. Methods. Setup and propagation of patient-derived organoid cultures from MPM pleural effusions; flow cytometry-based validation of organoid cultures, isola-tion and propagation of mesothelioma-associated fibroblasts; co-cultures, Lu-minex-based Cytokine array, ELISA assay to quantitate IL-6 in the conditioned media, qRT-PCR to assess mRNA expression of cancer stem cell markers and fibroblast markers. Results. Organoid cultures were obtained from eight MPM patients by using specific growth media and conditions to propagate pleural effusion-derived cells. We proved that primary MPM specimens and serially passaged (mesothelio-ma-Patient-Derived-Organoids) mPDOs were cytologically similar, with the obtained mPDOs expressing mesothelial markers similarly to the originating specimen. As expected from a clinically relevant model, the size and number of mPDOs were altered, in a patient-specific way, when pharmacologically relevant doses of chemotherapy drugs were added. We derived Mesothelio-ma-Associated-Fibroblasts (MAFs) and the addition of MAFs, to various ratios, altered the response of the mPDOs to pemetrexed + cisplatin, toward a reduced sensitivity to the latter anticancer agents. Additionally, organoid formation and size were altered by MAF-conditioned media, and this correlated with increased expression of cancer stem cell markers. We showed increased levels of IL-6 in the media of the treated cocultures and showed that this latter was derived from the MAFs. Conclusions. Increased secretion of IL-6 by mesothelioma-associated fibroblasts (MAFs) contributes to the resistance of the MPM to therapy.

Preprint ARTICLE | doi:10.20944/preprints202403.0507.v1

Parents’ Participation in Care during Neonatal Intensive Care Unit Stay in COVID-19 Era: A Quantitative Observational Study

Emanuele Buccione, Davide Scarponcini Fornaro, Damiana Pieragostino, Luca Natale, Adelaide D'Errico, Valentina Chiavaroli, Laura Rasero, Stefano Bambi, Carlo Della Pelle, Susanna Di Valerio

Subject: Public Health And Healthcare, Nursing Keywords: neonatal intensive care unit; parenthood; newborns; preterm; nurses

Online: 8 March 2024 (11:04:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0278.v1

External Hoof Measurements of Untrimmed and Unshod Mules in Northern Thailand

Thawijit Phannithi, Aree Laikul, Watcharapol Pathomsakulwong, Porrakote Rungsri, Tawanhathai Apichaimongkonkun, Krisana Watchrarat, Worakij Cherdchutham

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: mule; hoof conformation; forelimbs; hoof balanced; Equus caballus x Equus asinus; hoof measurement

Online: 6 March 2024 (05:14:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1670.v1

Understanding Microplastics Retention Efficiency and Sorption Dynamics in Porous Media

Hande Okutan, Çağdaş Sağır, Bedri Kurtuluş, Hasan Burak Özmen, Emrah Pekkan, Moumtaz Razack, Philippe Le Coustumer

Subject: Environmental And Earth Sciences, Environmental Science Keywords: microplastics; porous media; retention; transport; polyethylene; retention efficiency; numerical model; MT3DMS; MODFLOW

Online: 29 February 2024 (11:41:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1568.v1

The Town Crier: a Use Case Design and Implementation for a Socially Assistive Robot in Retirement Homes

Ana Iglesias, Raquel Viciana, Jose Manuel Perez-Lorenzo, Karine Lan Hing Ting, Alberto Tudela, Rebeca Marfil, Malak Al-Qbilat, Antonio Hurtado, Antonio Jerez, Juan Pedro Bandera

Subject: Computer Science And Mathematics, Robotics Keywords: social robot; wellbeing; human-centred design; participatory design; human-robot interfaces

Online: 28 February 2024 (03:12:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1159.v1

Effects of Gibberellic Acid on Soluble Sugar Content, Organic Acid Composition, Endogenous Hormone Levels, and Carbon Sink Strength in Shine Muscat Grapes during Berry Development Stage

Xiujie Li, Zhonghui Cai, Xueli Liu, Wu Yusen, Zhen Han, Guowei Yang, Shaoxuan Li, Zhaosen Xie, Li Liu, Bo Li

Subject: Biology And Life Sciences, Horticulture Keywords: Gibberellin; Grape; Soluble sugar; Organic acid; Sugar unloading; Sink strength

Online: 20 February 2024 (14:39:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0587.v1

Novel Dry Powder of Hyaluronic Acid-Vancomycin Complex for Inhalation Useful on Pulmonary Infections Associated to Cystic Fibrosis

María Sol Magi, Yanina De Lafuente, Eride Quarta, María Celeste Palena, Perla Ardiles, Paulina Laura Páez, Fabio Sonvico, Francesca Buttini, Alvaro Jimenez-Kairuz

Subject: Chemistry And Materials Science, Other Keywords: Vancomycin inhalable; cystic fibrosis; polyelectrolyte-drug complex; hyaluronic acid; pulmonary infection

Online: 12 February 2024 (04:53:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0125.v1

Peptidylarginine Deiminases as Mediators of Microvesicular Release - Novel Therapeutic Interventions

Sigrun Lange, Sharad Kholia, Uchini Kosgodage, Mariya Hristova, John Hardy, Jameel M Inal

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Extracellular vesicles (EVs); Peptidylarginine deiminases (PADs); Chlor-amidine (Cl-Am); cancer; neurodegeneration; deimination; cytoskeleton; induced pluripotent stem cells (iPSCs); histone H3; epigenetics

Online: 16 March 2017 (17:54:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0060.v1

Biomass-Derived, Interconnected and Reticular Carbon Microtubes Electrodes for Symmetric Capacitors

Nannan Wang, Ning Zhang, Wutao Wei, Shizhong Cui, Hongwei Hou, Guangshan Zhu, Weihua Chen, Liwei Mi

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: elasticbiomass; tubular structure; interconnected porous carbon; electric double layer capacitance

Online: 13 March 2017 (08:01:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0085.v1

Economic Driven Patterns of the Urban Environment

Anibal Gusso, Conrad Philipp, André Silva, John Boland, Leticia Lenz

Subject: Environmental And Earth Sciences, Environmental Science Keywords: thermal remote sensing; EKC theory; urban development

Online: 16 December 2016 (08:00:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202410.0208.v1

The Efficacy of Food Bioactive Compounds in The Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Damilola Ibirogba, Oluwagbemisola Olukogbe, Ebsitu Haile, Moses Asori, Stephen Engmann, Abdullahi Abdulraheem, Gabriel Edeh, Thomas Mergerssa, Fortune Effiong, Babatunde Olowu, Prettyossa Kusemwa, Ukamaka Okafor, Isaac Omulepu, Stanley Eneh, Taiwo Aderinola, Renuka Thami, Nduka Okwose

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Silymarin; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); Meta-analysis; Food Bioactive Substances; Nutraceuticals; Polyphenols

Online: 2 October 2024 (16:34:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0421.v1

Novel Drug-like HsrA Inhibitors Exhibit Potent Narrow-Spectrum Antimicrobial Activities against Helicobacter pylori

Javier Casado, Irene Olivan-Muro, Sonia Algarate, Eduardo Chueca, Sandra Salillas, Adrián Velázquez-Campoy, Elena Piazuelo, María F. Fillat, Javier Sancho, Ángel Lanas, Andrés González

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Helicobacter pylori; antimicrobial resistance; narrow-spectrum antibiotic; antibacterial target; response regulator; HsrA; Campylobacter jejuni

Online: 5 September 2024 (10:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2401.v1

Staphylococcus aureus Stress Response to Bicarbonate Depletion

Elisa Liberini, Sook-Ha Fan, Arnold S. Bayer, Christian Beck, Jacob Biboy, Patrice François, Joe Gray, Katharina Hipp, Iris Koch, Andreas Peschel, Brigitte Sailer, Daniela Vollmer, Waldemar Vollmer, Friedrich Götz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; bicarbonate transporter; MpsABC; cell wall; peptidoglycan; transcriptome

Online: 30 July 2024 (11:03:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0599.v1

Effects of ACE Mutations Associated with Alzheimer’s Disease on Blood ACE Phenotype

Olga V. Kryukova, Igor O. Islanov, Elena V. Zaklyazminskaya, Dmitriy O Korostin, Vera A. Belova, Valery V. Cheranev, Zhanna A. Repinskaia, Svetlana A. Tonevitskaya, Alexander G. Tonevitsky, Pavel A. Petukhov, Steven M. Dudek, Olga A. Kost, Denis V. Rebrikov, Sergei M. Danilov

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Angiotensin I-converting enzyme; mutations; conformational changes; blood ACE; screening; Alzheimer’s disease

Online: 11 June 2024 (08:02:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0451.v1

Hypertriglyceridemia- from Innocent Bystander to Independent Cardiovascular Risk Factor in Younger Prehypertensives

Josipa Josipovic, Ana Jelakovic, Bernardica Valent Moric, Vladimir Prelevic, Gorana Mirosevic, Hana Matijaca, Iva Ivanko, Nikola Bulj, Ivo Darko Gabric, Bojan Jelakovic

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: prehypertension; hypertriglyceridemia; uromodulin; cardiovascular risk

Online: 7 June 2024 (08:24:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v3

IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; glioblastoma multiforme (GBM); scaffold protein; podosome/invadosome

Online: 16 January 2017 (10:30:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1748.v1

Application of the Sponge Model Implants in the Study of Vaccine Memory in Mice Previously Immunized with LBSap

Mariana Ferreira Lanna, Lucilene Aparecida Resende, Paula Mello De Luca, Wanessa Moreira Goes, Maykelin Fuentes Zaldívar, André Tetzl Costa, Walderez Ornelas Dutra, Alexandre Barbosa Reis, Olindo Assis Martins-Filho, Kenneth Jhon Gollob, Sandra Aparecida Lima De Moura, Edelberto Santos Dias, Érika Michalsky Monteiro, Denise Silveira-Lemos, Rodolfo Cordeiro Giunchetti

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: sponge implant model; vaccine; immune response; mice

Online: 24 October 2024 (12:08:35 CEST)

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Considering the large number of candidates in vaccine testing studies against different pathogens and the amount of time spent in the pre- and clinical trials, there is a pressing need to develop an improved in vivo system to quickly screen vaccine candidates. The model of a polyester-polyurethane sponge implant provides a rapid analysis of the specific stimulus-response, allowing the study of a compartmentalized microenvironment. The sponge implant’s defined measurements were standardized as a compartment to assess the immune response triggered by vaccinal antigen. The LBSap vaccine (composed by Leishmania braziliensis antigens associated with saponin adjuvant) was used in the sponge model to assess the antigen-specific immunological biomarker, including memory generation after initial contact with the antigen. Mice strains (Swiss, BALB/c, and C57BL/6) were previously immunized using LBSap vaccine followed by an antigenic booster performed inside the sponge implant. The sponge implants were assessed after 72 hours, and the immune response pattern was analyzed according to leukocyte immunophenotyping and cytokine production. After LBSap vaccination, the innate immune response of the antigenic booster in the sponge implants demonstrated higher levels in the Ly+ neutrophils and CD11c+ dendritic cells with reduced numbers of F4/80+ macrophages. Moreover, the adaptive immune response in Swiss mice demonstrated a high CD3+CD4+ T-cells frequency consisting of an effector memory component in addition to a cytoxicity response (CD3+CD8+ T-cells), displaying the central memory biomarker. The major cell surface biomarker in the BALB/c mice strain was related to CD3+CD4+ effector memory while the increased CD3+CD8+ effector memory was highlighted in C57/BL6. The cytokine profile was more inflammatory in Swiss mice, with the highest levels of IL-6, TNF, IFN-g, and IL-17, while the same cytokine was observed in in C57BL/6 yet modulated by enhanced IL-10 levels. Similar to Swiss mice, BALB/c mice triggered an inflammatory environment after the antigenic booster in the sponge implant with the increased levels in the ILL-6, TNF, and IFN-g. The results highlighted how genetic background can influence populations involved in the immune response and indicated that it is possible to use this model to optimize and monitor the innate and adaptive immune responses of vaccine candidates. In this sense, these results could guide the choice of the most appropriate experimental model in biomolecule tests, considering that the particularities of each mouse strain influenced the dynamics of the immune response.

Preprint ARTICLE | doi:10.20944/preprints202409.0917.v1

Real Life Comparative Analysis of Robotic Assisted versus Laparoscopic Radical Prostatectomy in a Single Centre and Single Surgeon Experience

Stefano Salciccia, Valerio Santarelli, Giovanni Battista Di PIerro, Francesco Del Giudice, Giulio Bevilacqua, Giovanni Di Lascio, Alessandro Gentilucci, Roberta Corvino, Valentina Brunelli, Greta Basile, Carlo Maria Scornajenghi, Lorenzo Santodirocco, Luca Gobbi, Davide Rosati, Martina Moriconi, Valeria Panebianco, Fabio Massimo Magliocca, Daniele Santini, Mattia Alberto Di Civita, Flavio Forte, Marco Frisenda, Giorgio Franco, Alessandro Sciarra

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: prostatic neoplasm; radical prostatectomy; robotic surgery; laparoscopic surgery

Online: 12 September 2024 (11:01:00 CEST)

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Background: The advantage of a robotic assisted (RARP) over a laparoscopic (LRP) approach in radical prostatectomy (RP) remains to be demonstrated. Aim of the study is to use a homogeneous population in real life and single surgeon surgery, to analyze the oncological and functional results based on the type of the surgical approach. Methods: This is a prospective trial on non-metastatic prostate cancers (PC) patients considered after multidisciplinary decision to RP, using RARP or LRP. A real-life setting was analyzed at our Urological Departments, using homogeneous criteria for the management of PC cases and a one surgeon experience on 444 cases (284 LRP and 160 RARP) .Results: Mean operative time was significantly lower in RARP (173.33±44.3 min) than in LRP (153.21±25.1 min) (p<0.001). In cases submitted to an extended lymph node dissection (eLND), the mean number of lymph nodes removed was 15.16±7.83 and 19.83±4.78 respectively in LRP and RARP procedures (p<0.001), but positive lymph nodes (pN1) were similarly found in 15.8% of LRP patients and 13.6% of RARP patients (p=0.430). Surgical margins (SM) positivity was not significantly higher in RARP group (20.0%) when compared to LRP group (15.9%) (p=0.145). During the postoperative follow-up, a biochemical recurrence (BCR) was detected in 14.4% and 7.5% of cases in the LRP and RARP group respectively (p=0.014). Better results of PAD test at 3-month interval using RARP approach (mean pad weight 75.57±122 grams and 14±42 grams respectively in LRP and RARP (p<0.01)) were described. Conclusions: In the comparison between RARP and LRP approach, a clear advantage of the robotic approach is a significant reduction in operating times, days of hospitalization and postoperative catheterization compared to laparoscopic surgery. It is not possible to describe any certain oncological advantage both in terms of surgical margins and pathological lymph nodes removed. In RARP cases a reduction to the limit of significance is described in terms of biochemical recurrence. RARP produces a more rapid recovery of urinary continence at 3 months postoperatively without significant advantages in terms of erective potency recovery.

Preprint ARTICLE | doi:10.20944/preprints202404.1992.v1

N-Terminal Sequences of Signal Peptides Assuming Critical Roles in Expression of Heterologous Proteins in Bacillus subtilis

Meijuan Zhang, Jie Zhen, Jia Teng, Xingya Zhao, Xiaoping Fu, Hui Song, Yeni Zhang, Hongchen Zheng, Wenqin Bai

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: signal peptide; secretion; transcription; extracellular expression; N-terminal amino acids sequence; alkaline pectinase

Online: 30 April 2024 (10:18:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.2455.v1

Tennis Game Dynamic Prediction Model Based on Players’ Momentum

Lechuan Wang, Puning Chen

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: tennis; momentum; quantification; match prediction; XGBoost

Online: 30 October 2024 (14:10:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1483.v1

Quantitative Modeling in Systems Biology: How to Develop Relevant Models

Gülbahar Akgün, Rza Bashirov

Subject: Medicine And Pharmacology, Other Keywords: systems biology; quantitative modeling; Petri nets; descriptive statistics; spinal muscular atrophy

Online: 18 October 2024 (14:02:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2131.v1

Numerical Approach to Determine the Resistance of Threaded Anchors in UHPFRC

Antonina Hochuli, Eugen Brühwiler

Subject: Engineering, Architecture, Building And Construction Keywords: short anchorage; threaded anchor; numerical simulation; structural behavior; pull-out force

Online: 27 September 2024 (00:15:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1990.v1

Deep Learning Models for White Blood Cell Image Classification

Noureldin Said Youssef, Omar Sameh Emam, Adel Said Elmaghraby

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: white blood cells; image classification; deep learning; machine learning; health informatics

Online: 25 September 2024 (12:09:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.1853.v1

Comprehensive Understanding of Recent Molecular and Physio-Biochemical Mechanisms in the Response of Tomatoes to Low Temperature Stress

Kwanuk Lee, Hunseung Kang

Subject: Biology And Life Sciences, Plant Sciences Keywords: low temperature (LT) response; cold stress; morphological and physiological traits; biochemical changes; C-repeat binding factor (CBF); RNA and DNA methylation; epigenetic regulations; climate change

Online: 27 August 2024 (11:54:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1143.v1

Effect of the Localized Insecticides Spray Technique to Control Halyomorpha halys in Actinidia chinensis Orchards

Matteo Landi, Michele Preti, Antonio Masetti, and Francesco Spinelli

Subject: Biology And Life Sciences, Insect Science Keywords: brown marmorated stink bug; kiwifruit; integrated pest management; fruit damage; chemical control; atomizer; insecticide application

Online: 15 August 2024 (14:33:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0443.v1

A Novel Hashcode-based Duplication Reduction via Thresholding Approach for Large-scale Web Documents

Sana Ejaz, Asma Naseer, asma Ahmad, maria Tamoor, Samina Naz

Subject: Computer Science And Mathematics, Computer Science Keywords: Duplicate detection; Hash keys; Information Retrieval; Threshold; Web documents; and Web pages

Online: 6 August 2024 (15:56:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2006.v1

Study of the Feasibility of Multi-channel WDM Transmission Using RGB LEDs in Visible Light Communication

Véronique Georlette, Théo Deffrennes, Veronique Moeyaert

Subject: Engineering, Telecommunications Keywords: VLC; WDM; RGB; OOK; Raspberry Pi; OFDM

Online: 25 July 2024 (09:45:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1300.v1

Parallel PSO for the Efficient Training of Neural Networks Using the GPGPU and Apache Spark in an Edge Computing Environment

Manuel I. Capel, Alberto Salguero-Hidalgo, Juan Antonio Holgado-Terriza

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Apache Spark; Classification recall; Deep Neural Networks; GPU Parallelism; Optimization research; Particle Swarm Optimization (PSO); Predictive Accuracy

Online: 16 July 2024 (08:29:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0882.v1

Recent Advances in Phthalocyanine-Based Hybrid Composites for Electrochemical Biosensors

Keshavananda Prabhu Channabasavana Hundi Puttaningaiah, Jaehyun Hur, Shivalingayya Gaddimath

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Biosensors; Phthalocyanine; Nanoparticles (NPs); Carbon nanomaterials; Hybrid Materials; Biomolecule Detection

Online: 10 July 2024 (14:09:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1722.v1

Economic Efficiency versus Energy Efficiency of Selected Crops in EU Farms

Paweł Boczar, Lucyna Błażejczyk-Majka

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: agricultural resources; economic security of farmers; Europe’ s energy security; agricultural production efficiency; economics of land use

Online: 25 June 2024 (10:09:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1363.v1

Application of the Transmutation Operator Method to the Solution of an Initial Boundary Value Problem for the Equation of Multidimensional Free Transverse Vibration of a Thin Elastic Plate Containing the Bessel Operator

Shakhobiddin Karimov, Yorkinoy Tulasheva

Subject: Computer Science And Mathematics, Mathematics Keywords: fourth-order equation; plate vibration equation; Bessel operator; transmutation operator; Erdélyi–Kober operator

Online: 19 June 2024 (15:02:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0825.v1

Development of Artificial Intelligence/Machine Learning (AI/ML) Models for Methane Emissions Forecasting in Seaweed

Clifford Jaylen Louime, Tariq Asleem Raza

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Methane Emission; Sargassum; Convolutional Neural Network (CNN); Environmental Impact Assessment; Artificial Intelligence; Machine Learning

Online: 12 June 2024 (17:41:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0074.v1

Evolving HPC Data Centers with Kubernetes, Performance Analysis, and Dynamic Workload Placement Based on ML Scheduling

Vedran Dakić, Mario Kovač, Jurica Slovinac

Subject: Computer Science And Mathematics, Computer Science Keywords: high-performance computing; data center architecture; hardware and software integration; Kubernetes; dynamic performance evaluation ;

Online: 6 June 2024 (03:20:32 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.2167.v1

Adult-Onset Systemic Chronic Active Epstein - Barr virus Disease: A Case Report Highlighting Unique Immunophenotype and Novel Molecular Insights in the Context of Chronic HBV Hepatitis

Tulasi Geevar, Peter JB Sabatini, Tong Zhang, Ali Sakhdari

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic EBV infection; T cell lymphoproliferative disorder; mutational profile

Online: 3 June 2024 (07:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2091.v1

Occupational Accidents, Injuries, and Associated Factors among Migrant and Domestic Construction Workers in Saudi Arabia

Musaad Alruwaili, Patricia Carrillo, Robby Soetanto, Fehmidah Munir

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: construction industry; migrants; occupational accidents; occupational injuries; Saudi Arabia

Online: 31 May 2024 (08:49:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1941.v1

An Innovative n-Shifted Sigmoid Channel and Spatial Attention Module for Efficient 3D Scene Object Detection

Shengzhi Du, Desire Mulindwa Burume, Qingxue Liu

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: attention mechanism; Hough voting; point clouds; activation function

Online: 29 May 2024 (13:50:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1148.v1

Method for Revealing the Violation of Synchronization in the Operation of Geomagnetic Observatories of Intermagnet Network

Ivan Veniaminovich Vassilyev, Zhassulan Korabayevich Mendakulov, Inna Nikolaevna Fedulina, Beibit Tenelovich Zhumabayev

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: Intermagnet; SuperMAG; ecliptic coordinate system; magnetic storms; violation of synchronization in operation of magnetic observatories; correlation; signal-to-noise ratio; SSC – storm sudden commence

Online: 17 May 2024 (11:36:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0423.v1

Predictive Analytics Performance on Oil and Gas: A Significant Review

Putri Azmira R Azmi, Marina Yusoff, Mohamad Taufik Mohd Salledud-din

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: classification; clustering; machine learning; oil and gas; predictive analytics

Online: 8 May 2024 (09:05:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1881.v1

The Status of Food Insecurity at the Household Level in the North-Eastern Highlands of Ethiopia

Umar Demisse Mohammed, Arega Bazezew Berlie, Simachew Bantigegen Wassie

Subject: Social Sciences, Geography, Planning And Development Keywords: Livelihood zone; Households; Food insecurity status; South wollo

Online: 29 April 2024 (05:06:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1583.v1

Some Results on Coefﬁcient Estimate Problems for Four-Leaf-Type Bounded Turning Functions

Chuanjun Wen, Zongtao LI, Dong Guo

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Hankel determinant; Schwarz functions; bounded turning functions; four-leaf-type domain

Online: 24 April 2024 (04:43:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1422.v1

A City Shared Bike Dispatch Approach Based on Temporal Graph Convolutional Network and Genetic Algorithm

Ji Ma, Shenggen Zheng, Shangjing Lin, Yonghong Cheng

Subject: Engineering, Transportation Science And Technology Keywords: Spatio-temporal demand forecasting; Bike sharing; T-GCN; Scheduling optimization

Online: 23 April 2024 (11:49:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0381.v2

Knowledge and Beliefs of Clinical Trials Among Adults in Poland

Natalia Daria Cięszczyk, Marcin Czech, Łukasz Pronicki, Mariusz Gujski

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: clinical trials; awareness; knowledge

Online: 23 April 2024 (11:18:21 CEST)

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Clinical trials, by contributing to the development of diagnostics and to the search for modern, more effective, and safer therapies, have become one of the most important elements of the healthcare system. The aim of this study was to assess Poles' knowledge and beliefs about clinical trials. Methods: The survey was conducted among Poles aged 18 and over with the help of external company, Ariadna, which is an independent research panel. The questionnaire contained 22 questions, of which 13 questions concerned beliefs and attitudes towards clinical trials. Results: One thousand and seventy-nine participants took part in the study (N = 1079). The mean age of respondents was 44.96 years (SD = 16.30). Slightly more women (N = 568, 52.6%) than men (N = 511, 47.4%) took part in the study. Among the respondents, 86.5% (N = 933) were aware of clinical trials. The main sources of information about clinical trials were the media (53.8%) including the Internet (N= 355, 32.9%), TV (N = 175, 16.2%), press (N = 30, 2.8%) and radio (N = 21, 1.9%). 43.2% (N = 466) of respondents reported little knowledge of clinical trials, while more than three quarters (N = 805, 75.2%) said they would like to learn more about clinical trials. Most respondents (N = 879, 81.4%) agreed with the statement that participation in a clinical trial is completely voluntary, and more than half (N = 580, 53.7%) agreed with the statement that hospitals participating in clinical trials provide better healthcare. The statement that the results of clinical trials are made available to the public was disagreed with by 37.2% (N = 402) of participants. Only 30.3% (N = 327) of participants agreed that clinical trials should be conducted with children. Conclusions: Poles rate their knowledge of clinical trials as low and would like to learn more. To reach the largest possible group of Polish patients, parallel educational activities on multiple levels may have the best effect. Poles' knowledge of clinical trials is mainly based on commercial sources. Further studies in different groups, i.e., clinical trial patients and investigators, are needed.

Preprint ARTICLE | doi:10.20944/preprints202404.1247.v1

Beta-Cyclodextrin Molecules (β‐CD) Modified PVDF Membranes to Remove Multi-Ionic Dye Solutions using Steric, Inclusion, and Dielectric Exclusion

Wadha Alrashedi, Hafedh Ben KOCHKAR, Ismail Ercan

Subject: Chemistry And Materials Science, Biomaterials Keywords: β ‐cyclodextrin; hydrophilicity; PVDF membrane; Dye separation; dielectric exclusion

Online: 18 April 2024 (14:07:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1060.v1

The Platform Technology Approach to mRNA Product Development and Regulation

John Howard SKERRITT, Carolyn Tucek-Szabo, Brett Sutton, Terry Nolan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: mRNA, vaccine development, drug development, regulation

Online: 16 April 2024 (13:56:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0663.v1

Creep Characteristics of Reconstituted Silty Clay Under Different Pre-loading Path Histories

Bin Xiao, Peijiao Zhou, Shuchong Wu

Subject: Engineering, Civil Engineering Keywords: Reconstituted silty clay; Isotropic compression; Triaxial shear; Loading steps; Creep model.

Online: 10 April 2024 (06:49:26 CEST)

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Due to the long-term deformation settlement of foundations, issues such as damage and functional failure of buildings and structures have long been of concern in the engineering field. The creep of soil is one of the primary causes leading to long-term deformation of foundations. In this paper, the consolidation deformation, creep characteristics, and creep model of reconstituted saturated silty clay were studied by isotropic compression test and triaxial shear creep test. The results show that for the isotropic compression test, although the applied load adopts different stages of loading, as long as the final applied confining pressure is the same, the number of stages applied by the confining pressure has little effect on the final isotropic consolidation deformation of the sample and the triaxial undrained shear strength after creep. However, for the triaxial shear creep test, it is found that under the same final deviatoric stress, the final deviatoric strain of the sample is closely related to the number of loading stages of deviatoric stress. It shows that the more loading stages of the sample loaded with the same deviatoric stress, the smaller the final deviatoric strain, and the triaxial undrained shear strength of the sample after creep will increase. In addition, it is reasonable to determine the pore pressure dissipation of the sample to 95%((u0-u0)/u0=95%) as the main consolidation end time (tEOP) of the sample. The isotropic consolidation creep curves and the triaxial shear creep curves show certain nonlinearity. Then the logarithmic model and the hyperbolic model were used to fit the creep curves of the samples. It is found that the hyperbolic model has a better fitting effect than the logarithmic model, but for the triaxial shear creep test, the creep parameters of the sample change greatly. Therefore, studying the creep characteristics of soil under different pre-loading steps is of significant engineering importance for evaluating the long-term deformation of underground structures.

Preprint ARTICLE | doi:10.20944/preprints202403.1821.v1

Oxygen Defects Containing TiN Films for the Hydrogen Evolution Reaction: A Robust Thin Film Electrocatalyst With Outstanding Performance

Ayoub Laghrissi, Mohammed Es-Souni

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Hydrogen evolution reaction; Titanium nitride; Oxygen defects; TiNO; linear sweep voltammertry; DFT

Online: 29 March 2024 (10:01:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1472.v1

Perceptions of Adulthood and Mental Health

Mediss Tavakkoli, Erick Valarezo, Luis F. García

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Perceptions of Adulthood; Subjective adult status; Mental health; Well-being; pathological personality

Online: 25 March 2024 (09:59:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0963.v1

The Generalized Eta Transformation Formulas as the Hecke Modular Relation

Nianliang Wang, Takato kuzumaki, Shigeru Kanemitsu

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: RHB correspondence; transformation formula for Lambert series; Hurwitz zeta-function; Lerch zeta-function; vector space structure

Online: 18 March 2024 (08:12:55 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.0899.v1

A Study on the Factors for the Occurrence of Vacant Homes in Medium Cities and Characteristics of Each Types – Focusing on Asan City, Chungcheongnam-Do

Jeonghyeon Choi, Seung-Seok Han, Myung-je Woo

Subject: Social Sciences, Urban Studies And Planning Keywords: vacant home; poisson; negative binomial regression; spatial regression

Online: 15 March 2024 (07:48:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0683.v1

Optimizing Well Placement in Carbon Capture and Storage (CCS): A Bayesian Optimization Framework under Permutation Invariance

Sofianos Panagiotis Fotias, Ismail Ismail, Vassilis Gaganis

Subject: Engineering, Control And Systems Engineering Keywords: CCS; machine learning; Bayesian optimization; Gaussian Process; applied sciences; regression; predictive modelling; well placement optimization

Online: 12 March 2024 (10:26:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0395.v1

The Sensitivity of Structure to Ionic Radius and Reaction Stoichiometry. A Crystallographic Study of Metal Coordination and Hydrogen Bonding in Barbiturate Complexes of All Five Alkali Metals Li–Cs

William Clegg, Gary S. Nichol

Subject: Chemistry And Materials Science, Other Keywords: crystal structure; alkali metals; barbituric acid; coordination; stoichiometry; bridging ligands; hydrogen bonding

Online: 8 March 2024 (01:53:36 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.0283.v1

Compost-Derived Bacterial Communities Offer Promise as Organic Biocontrol Agents against Meloidogyne javanica and Promote Plant Growth in Tomato

Eirini Karanastasi, Vassileios Kotsantonis, Iakovos S. Pantelides

Subject: Environmental And Earth Sciences, Other Keywords: Meloidogyne javanica; synthetic bacterial communities; sustainable agriculture

Online: 5 March 2024 (16:14:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0260.v1

Research Review of GBRS under the Background of Carbon Neutralization

Jin Mao, Hao Yuan, Lun Xiong, Bo Huang

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: green building; rating system; weight setting; indicators setting; automation

Online: 5 March 2024 (12:24:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1088.v1

Retarded Gravity in Disk Galaxies

Yuval Glas, Tomer Zimmerman, Asher Yahalom

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Dark Matter; MOND; Retardation; General Relativity

Online: 20 February 2024 (11:28:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0675.v1

The Predictors of Perceived Barriers and Facilitators of Applying Sepsis Six Guidelines Among Critical Care Nurses

Dania *Bani Hamad, Mohammad Rababa, Mu’ath Tanash, Raeda Abu Ali

Subject: Public Health And Healthcare, Nursing Keywords: barriers; facilitators; sepsis; sepsis six guidelines; nurses

Online: 12 February 2024 (10:35:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0424.v1

Forest Supply Chains during Digitalization: Current Implementations and Prospects in Near Future

Teijo Palander, Stelian Alexandru Borz, Timo Tokola, Peter Rauch

Subject: Computer Science And Mathematics, Information Systems Keywords: Data-driven optimization; Dynamics; ERP; Logistics; Simulation; Technology

Online: 7 February 2024 (07:55:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1571.v1

Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport

Vasily A. Aleshin, Thilo Kaehne, Olga N. Solovjeva, Maria V. Maslova, Anastasia V. Graf, And Victoria I. Bunik

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Transketolase; malonylation; acetylation; sirtuin 5; oxythiamine; metformin; amprolium; thiamine; posttranslational modifications.

Online: 25 October 2023 (05:30:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0875.v1

On-site evaluation of constituent content and functionality of Perilla frutescens var. crispa using fluorescence spectra

Hidemichi Sano, Satoru Kawaguchi, Toshifumi Iimori, Masahiro Kuragano, Kiyotaka Tokuraku, And Koji Uwai

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: nondestructive analysis, ratio spectral index (RSI); normalized difference spectral index (NDSI); difference spectral index (DSI); polyphenols; antioxidation; Aβ aggregation inhibitory activity

Online: 13 September 2023 (10:57:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2052.v1

Deep Learning-Based Link Quality Estimation for RIS-Assisted UAV-Enabled Wireless Communications System

Belayneh Abebe Tesfaw, Rong-Terng Juang, Li-Chia Ta, Hsin-Piao Lin, Getaneh Berie Tarekegn, And Kabore Wendenda Nathanael

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Link quality estimation; reconfigurable intelligent surfaces (RIS); gated recurrent unit (GRU); unmanned aerial vehicle (UAV).

Online: 30 August 2023 (11:39:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1116.v1

Impact of Environmental Sub-Inhibitory Concentrations of Antibiotics, Heavy Metals, and Biocides on the Emergence of Tolerance and Effects on the Mutant Selection Window in E. coli

Kelechi B. Chukwu, Ovokeroye A. Abafe, Daniel G. Amoako, Arshad Ismail, Sabiha Y. Essack, And Akebe L. K. Abia

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: environmental stressors; pharmaceuticals; antibiotic resistance; selection pressure; public health; tolerant bacteria; environmental pollution; mutation; whole genome sequencing; single nucleotide polymorphisms

Online: 18 July 2023 (05:36:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1241.v1

Decomposition and Modeling of the Situational Awareness of Unmanned Aerial Vehicle for Advanced Air Mobility

Sorelle Audrey Kamkuimo, Felipe Magalhaes, Rim Zrelli, Henrique Amaral Misson, And Gabriela Nicolescu, Gabriela Nicolescu

Subject: Computer Science And Mathematics, Software Keywords: unmanned aerial vehicle (UAV); drone; situational awareness (SA); advanced air mobility (AAM); beyond visual line-of-sight (BVLOS)

Online: 16 June 2023 (12:38:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0506.v1

Influencing Factors and Symbiotic Mechanism of the Integration of Medical and Disease Prevention during the COVID-19 Pandemic: A Cross-Sectional Survey of Public Hospital Employees

Zhen Wu, Huiyi Tian, Dongjian Xu, Jiaying Chen, Yaqi Hu, Xiaohe Wang, And Siyu Zhou

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Integration; Medical and disease prevention; Mediating effect; Public health; Symbiotic

Online: 28 November 2022 (08:56:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0060.v1

Visualization of Renewable Energy Powered Automatic Railway Crossing Systems in Bangladesh

Iftekharuzzaman Rifat, Susmita Ghosh, Mohammad Khairul Basher, Mohammad Aminul Islam, Narottam Das, and Mohammad Nur-E-Alam

Subject: Engineering, Energy And Fuel Technology Keywords: Railway crossing; obstacle detection; renewable energy; hybrid system; sustainable development.

Online: 3 February 2022 (15:36:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0707.v1

Towards Distributed Recycling with Additive Manufacturing of PET Flake Feedstocks

Helen A. Little, Nagendra G. Tanikella, Matthew Reich, Matthew J. Fiedler, Samantha L. Snabes, and Joshua M. Pearce

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymers; recycling; waste plastic; upcycle; circular economy; PET; additive manufacturing; distributed recycling; distributed manufacturing; 3D printing

Online: 30 July 2020 (07:49:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0051.v1

Search for QPOs in the Light Curve of the Blazar OJ287: Preliminary Results from 2015/16 Observing Campaign

S. Zola, M. Valtonen, G. Bhatta, A. Goyal, B. Debski, A. Baran, J. Krzesinski, M. Siwak, S. Ciprini, A. Gopakumar, H. Jermak, K. Nilsson, D. Reichart, K. Matsumoto, K. Sadakane, K. Gazeas, M. Kidger, V. Piirola, F. Alicavus, K.S. Baliyan, A. Berdyugin, D. Boyd, M. Campas Torrent, F. Campos, J. Carrillo Gomez, D.B. Caton, V. Chavushyan, J. Dalessio, D. Dimitrov, M. Drozdz, A. Erdem, A. Escartin Perez, V. Fallah Ramazani, A.V. Filippenko, F. Garcia, F. Gomez Pinilla, M. Gopinathan, J.B. Haislip, J. Harmanen, G. Hurst, K.M. Ivarsen, M. Jelinek, A. Joshi, M. Kagitani, N. Kaur, N. Karaman, W.C. Keel, A.P. LaCluyze, B.C. Lee, E. Lindfors, J. Lozano De Haro, J.P. Moore, R. Naves Nogues, A.W. Neely, R.H. Nelson, W. Ogloza, S. Okano, J.C. Pandey, M. Perri, P. Pihajoki, G. Poyner, J. Provencal, T. Pursimo, A. Raj, R. Reinthal, S. Sadegi, T. Sakanoi, J.-L. Salto Gonzales, T. Schweyer, F.C. Soldan Alfaro, E. Sonbas, I. Steele, J.T. Stocke, J. Strobl, L.O. Takalo, T. Tomov, L. Tremosa Espasa, J.R. Valdes, J. Valero Perez, F. Verrecchia, J.R. Webb, M. Yoneda, M. Zejmo, W. Zheng, J. Telting, J. Saario, T. Reynolds, A. Kvammen, E. Gafton, R. Karjalainen, P. Blay

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: galaxies: active; BL Lacertae objects: individual (OJ 287); super massive black holes

Online: 18 July 2016 (10:46:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2150.v1

Adaptation of the Taiwan version of the Supportive and Palliative Care Indicators Tool (SPICT-TW) and Its Association with Six-Month Mortality: A Multi-Center Validation Study in Older People

Jung-Yu Liao, Hsiao-Ting Chang, Jen-Kuei Peng, Scott A Murray, Chien-Yi Wu, Hsien-Cheng Chang, Chia-Ming Li, Shao-Yi Cheng, Wei-Zhe Tseng, Chao A. Hsiung, Hung-Yi Chiou, Sang–Ju Yu, Kirsty Boyd, Ping-Jen Chen

Subject: Public Health And Healthcare, Primary Health Care Keywords: Home-based medical care (HBMC); older people; palliative care; Taiwan version of the Supportive and Palliative Care Indicators Tool (SPICT-TW); validation study

Online: 27 September 2024 (12:16:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1552.v1

Polysaccharide-Based Bioplastics: Eco-Friendly and Sustainable Solutions for Packaging

Ashoka Gamage, Punniamoorthy Thiviya, Anuradhi Liyanapathiranage, M.L. Dilini Wasana, Yasasvi Jayakodi, Amith Bamdara, Asanga Manamperi, Rohan S. Dassanayake, Philippe Evon, Othmane Merah, Terrence Madhujith

Subject: Chemistry And Materials Science, Surfaces, Coatings And Films Keywords: Active packaging; Alginates; Bioplastics; Carrageenan; Cellulose; Chitin; Chitosan; Gellan gum; Intelligent packaging; Polysaccharides; Starch

Online: 20 September 2024 (05:46:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1544.v1

Extreme Tolerance of Extraocular Muscles to Diseases and Aging: Why and How?

Angelina Titova, Sergey Nikolaev, Airat Bilyalov, Nikita Filatov, Sergei Brovkin, Dmitrii Shestakov, Igor Khatkov, Ekaterina Pismennaya, Vyacheslav Bondarev, Margarita Antyuxina, Elena Shagimardanova, Natalia Bodunova, Oleg Gusev

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: extraocular muscles; muscular dystrophies; muscular aging

Online: 23 April 2024 (18:02:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0190.v1

Na and K Intake from Lunches Served in a Japanese Company Cafeteria and the Estimated Improvement in the Dietary Na/K Ratio Using Low-Na/K Seasonings and Dairy to Prevent Hypertension

Nagako Okuda, Aya Higashiyama, Kozo Tanno, Yuki Yonekura, Makoto Miura, Hiroshi Kuno, Toru Nakajima, Tomomi Nagahata, Hirokazu Taniguchi, Koki Kosami, Kyoko Kojima, Akira Okayama

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: hypertension; nutrition; sodium; potassium; Japanese; company cafeteria; seasoning; dairy

Online: 2 April 2024 (10:37:24 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0136.v1

From Investigating a Case of Cellulitis to Exploring Nosocomial Infection Control of ST1 Legionella pneumophila Using Genomic Approaches

Charlotte Michel, Fedoua Echahidi, Sammy Place, Lorenzo Filippin, Vincent Colombie, Nicolas Yin, Delphine Martiny, Olivier Vandenberg, Denis Piérard, Marie Hallin

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Legionella pneumophila; Legionella pneumophila ST1; WGS; genomic typing; wgMLST; cgMLST; wgSNP; nosocomial; hygiene investigation

Online: 2 April 2024 (07:26:36 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.0031.v1

Rationale and Design of the KOSovan Acute Coronary Syndrome (KOS-ACS) Registry

Gani Bajraktari, Shpend Elezi, Ibadete Bytyci, Pranvera Ibrahimi, Genc Abdyli, Edita Pllana-Pruthi, Rona Karahoda, Arlind Batalli, Afrim Poniku, Mentor Shatri, Drilon Gashi, Artan Bajraktari, Faik Shatri, Michael Y. Henein

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Acute myocardial infarction; mortalit; ; primary PCI

Online: 1 April 2024 (10:59:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1605.v1

Autoprobiotics in the treatment of patients with colorectal cancer in the early postoperative period

Elena I Ermolenko, Natalia V Baryshnikova, Galina Alekhina, Alexander Zakharenko, Oleg Ten, Victor A Kashchenko, Nadezhda Lavrenova, Olga Gushchina, Timofey Ovchinnikov, Anastasia Morozova, Anastasia Ilina, Alena B. Karaseva, Anna Tsapieva, Nikita Gladyshev, Alexander V. Dmitriev, Alexander Suvorov

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: microbiome, autoprobiotics, Enterococcus spp., Parvomonas micra, alpha diversity, gut dysbiosis, interleukins

Online: 28 February 2024 (08:05:17 CET)

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Introduction: Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics remains relevant. The aim of the study: to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and Enterococcus hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. Materials and methods: A total of 36 patients diagnosed with CRC were enrolled in the study. The study group (Group A) comprised 24 CRC patients who received autoprobiotic therapy in the early postoperative period, while the control group (Group C) included 12 CRC patients without autoprobiotic therapy.Prior to surgery and between days 14-16 post-surgery, comprehensive evaluations were conducted on all patients, encompassing the following: stool and gastroenterological complains analysis. examination of the gut microbiota (bacteriological study, quantitative polymerase chain reaction, metagenome analysis), analysis of interleukins in serum. Results: The use of autoprobiotics led to decrease dyspeptic complaints after surgery, was associated with absence of postoperative complications, did not cause side effects, led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The use of autoprobiotics led to positive changes in the structure of escherichia and enterococci populations, the elimination of Parvomonas micra, Fusobacterium nucleatum, decrease in the quantitative content of Clostridium perfringens, Akkermansia muciniphila. Metagenomic analysis (16S rRNA) revealed an increase in alpha diversity. Conclusion: The administration of autoprobiotics in the postoperative period is highly effective and safe in the comprehensive treatment of colorectal cancer patients. Future studies will allow the discovery of additional fine mechanisms of autoprobiotic therapy and its impact on the digestive, immune, endocrine and neural systems.

Preprint ARTICLE | doi:10.20944/preprints201608.0111.v1

Biological Activities of the Essential Oil from Erigeron floribundus

Riccardo Petrelli, Giuseppe Orsomando, Leonardo Sorci, Filippo Maggi, Farahnaz Ranjbarian, Prosper C. Biapa Nya, Dezemona Petrelli, Luca A. Vitali, Giulio Lupidi, Luana Quassinti, Massimo Bramucci, Anders Hofer, Loredana Cappel

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Erigeron floribundus; essential oil; antimicrobial; NadD; Trypanosoma brucei; cytotoxicity; antioxidant; limonene; caryophyllene oxide

Online: 10 August 2016 (12:36:57 CEST)

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