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Preprint REVIEW | doi:10.20944/preprints202403.1641.v1

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Diego Fernandes Vilas-Boas, Eiji Kevin Nakasone Nakasone, Ana Alice Maia Gonçalves, Daniel Ferreira Lair, Diana Souza de Oliveira, Diogo Fonseca Soares Pereira, Geralda Gabriele Silva, Ingrid dos Santos Soares Conrado, Lucilene Aparecida Resende, Maykelin Fuentes Zaldívar, Reysla Maria da Silveira Mariano, Walderez Ornelas Dutra, Miguel Angel Chávez Fumagalli, Alexsandro Sobreira Galdino, Denise Silveira-Lemos, Rodolfo Cordeiro Giunchetti

Subject: Biology And Life Sciences, Parasitology Keywords: Leishmania infantum; Epidemiology; Canine Visceral Leishmaniasis

Online: 27 March 2024 (06:39:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1775.v1

Exploratory Study of Guanidine Derivatives as Novel Anti Trypanosoma cruzi Scaffolds

Eduardo Henrique Zampieri, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Predrag Kalaba, Alexandre Prado-Roller, Natalie Gajic, Martin Zehl, Ana Fabisikova, Luana Ribeiro dos Anjos, Luana Passianoto Gushiken, Gert Lubec, Eduardo Rene Perez Gonzalez

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Chagas disease; Trypanosoma cruzi; guanidines; in vitro trypanocidal activity; cytotoxic assays

Online: 23 July 2024 (10:00:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2054.v1

Structural Characterization and Antidepressant-Like Effects of Polygonum sibiricum Polysaccharides Associated with Regulating Microglial Polarization in Cums-Induced Zebrafish

Ying yu Zhang, Dan yang Wang, Jia meng Liu, Ya juan Bai, Bei Fan, Cong Lu, Feng zhong Wang

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: depression; Polygonati Rhizoma polysaccharides; microglia polarization

Online: 27 December 2023 (05:03:49 CET)

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: Background: The polysaccharides are one of the main active ingredients of Polygonum sibiricum (PSP), which is a traditional food and medicine homologues in China. The antidepressant-like effects of PSP and its underlying mechanisms remain to be studied in depth, especially the regulation of microglial polarization. Methods: The chemical composition and structural characteristics of PSP was determined firstly. The CUMS procedure was carried out to the zebrafish for 5 weeks and PSP were immersed administration for 9 days (1 h/d). The body weight of zebrafish was monitored and the behavioral tests, including the novel tank test and light and dark tank test, were performed to evaluate the antidepressant-like effects of PSP. Then the function of HPI axis, the levels of peripheral inflammation, neuronal and blood-brain barrier damage in mesencephalon and telencephalon and the mRNA expression of M1/M2 phenotype genes in brain were examined. Results: PSP samples had the typical structure characteristics of polysaccharide, consisting of glucose, mannose and galactose with the average Mw 20.48 kDa, which owned a porous and agglomerated morphology. Compared with untreated zebrafish, the depression-like behaviors of CUMS-induced zebrafish were significantly attenuated. PSP significantly decreased the levels of cortisol and the pro-inflammatory cytokines and increased the levels of the anti-inflammatory cytokines in the body of CUMS-induced depressive zebrafish. Furthermore, neuronal and blood-brain barrier damage in mesencephalon and telencephalon and the mRNA expression of M1/M2 phenotype genes in brain were remarkably reversed by PSP. Conclusion: These findings indicated that the antidepressant-like effects of PSP were related to alter the HPI axis hyperactivation, suppress peripheral inflammation, inhibit neuroinflammation induced by microglia hyperactivation, and modulate microglial M1/M2 polarization. The current study provides foundation to the future exploitation of PSP in the functional foods of emotional regulation.

Preprint ARTICLE | doi:10.20944/preprints202409.1855.v1

Antimicrobial Susceptibility of Uropathogenic Escherichia coli with Analysis of Impact of Socio-Economic Factors in Low, Medium and High-Income Countries

Meher Rizvi, Maria Khan, Amina AL Jardani, Ujjala Ghoshal, Zaaima AL Jabri, Mohammad Ahanjan, Azza AL Mamari, Nawal AL Shizawi, Hiba Sami, Abdullah Balkhair, Adila Shaukat, Alwarith Nasser Salem Alkharusi, Abdulrahman Almahrouqi, Afreenish Hassan, Ajay Kumar, Amal Malehi, Amina Gul, Ashima Singh, Asma Said Hamed AL Shidhani, Areena Hoda Siddiqui, Aruna Poojary, Azza AL Rashdi, Bradley Langford, Dmytro Stepanskyi, Abbas Dolatabadi, Aisha Al Mufraji AL Mufraji, Elham Said Ahmed AL Risi, Garima Kapoor, Isabella Princess, Hatim Ali Eltahir, Hilal Al Sidairi, Kaitlyn Dougherty, Katia Iskandar, Ken Masters, Ibrahim Khalaf Hamdan AL Busaidi, Laila AL Yazidi, Mahfuza Nasrin, Mahmood Salim AL Subhi, Mallika Sengupta Mallika Sengupta, Manisha Khandait, Nada Khalfan AL Tamtami, Nada Khafan Alsiyabi, Nawal AL Kindi, Nazla Musthafa Luthfee, Neha Shreshtha, Nihal Mohamed Amur AL Riyami, Noora Hilal Ali AL Busaidi, Nupur Goel, Oksana Ishchenko, Omnia Mohamed Elnabawy Ahmed Taher, Pragnya Paramita Jena, Rajni Ekadashi, Razan Zadjali, Reba Kanungo, Sara Abolghasemi, Salima Al-maqbali, Sanjay Jaju, Sayantan Banerjee, Shadma Yaqoob, Shahnaz Sali, Shafqat Husnain Khan, Shalini Malhotra, Stephen Hughes, Sundas Shaukat, Syed Mohammed Atif, Vrushali Vishwas Patwardhan, Victorien Dougnon, Wahid Khan, Walid Wali, Zakariya AL Muharrmi, Zeeshana Basit, Jasashree Choudhury, Rachita Pravalina, Sanjeev Singh, Sarman Singh, Neelam Taneja, Raman Sardana, Pawan Kapoor, Rajeev Soman, Rashid Al Abri

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: community acquired UTI; Escherichia coli; antimicrobial susceptibility; Indian subcontinent; MENA; GDP; temperature

Online: 24 September 2024 (12:32:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1100.v1

Identification of the Carboxylesterase, Nl-EST1 Gene Expression Regulation Possibly Involved in Carbamate Insecticide Resistance in Brown Planthopper Nilaparvata lugens

Murtaza Khan, Changhee Han, Nakjung Choi, Juil Kim

Subject: Biology And Life Sciences, Insect Science Keywords: Brown planthopper; carbamate resistance; RNA-seq analysis; Nl-EST1; metabolic resistance

Online: 16 August 2024 (03:33:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.1668.v1

The Emergence of New E. coli High-Risk Clones and Antibiotic Resistance: An Unstoppable Problem or Our Last Chance to Do Better?

Ana da Cruz Campos, Nathalia Lucas da Silva Andrade

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: antibiotic resistance; E. coli high-risk clones; infections stewardship; Escherichia coli; ; multi-resistance bacteria; emergence

Online: 22 October 2024 (11:12:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1151.v1

Deciphering the Role of Waxy Gene Mutations in Enhancing Rice Grain Quality: From Molecular Insights to Breeding Soft Rice Varieties

Yong Yang, Lihui Zhou, Linhao Feng, Jianying Jiang, Lichun Huang, Qing Liu, Yadong Zhang, Changquan Zhang, Qiaoquan Liu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: soft rice; low amylose; grain transparency; Wx; eating and cooking quality

Online: 18 April 2024 (07:15:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0147.v1

Phytochemistry and biological activities of Cissus trifoliata against carcinomas

Luis Fernando Méndez-López

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cissus sp., Phytochemicals, Apoptosis, Proliferation, EMT, Anticancer

Online: 3 January 2024 (05:35:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1020.v1

Inhibitory Effects of Nicotinic Acid against Streptococcus pneumoniae Biofilm

Qaisara Fareesya Rosdi, Ahmad Asyraf Saiful Bahri

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Streptococcus pneumoniae; biofilm; nicotinic acid

Online: 16 April 2024 (08:58:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0482.v1

Antibiofilm Activity Of Benzoic Acid Against Salmonella Typhimurium

Muhammad Azinuddin Abdull Kamal, Khaniza Hasliza Abdul Khalil

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella typhimurium; biofilm; benzoic acid

Online: 16 April 2024 (04:20:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1688.v1

Title Impact of Exogenous Lactobacillus plantarum on the Gut Microbiome of Hematopoietic Stem Cell Transplantation Patients Colonized by Multi-Drug Resistant Bacteria

Bruna D.G.C. Moraes, Roberta CR Martins, Joyce Vanessa da Silva Fonseca, Lucas AM Franco, Gaspar CO Pereira, Thaisi F Bartelli, Marina F Cortes, Carolina F Santos, Priscila T Musqueira, Leonardo J Otuyama, Victor S. Pylro, Livia Mariano, Vanderson Rocha, Steven S Witkin, Ester C Sabino, Thais Guimaraes, Silvia F Costa

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: L. plantarum; Microbiome, MDRO colonization

Online: 27 November 2023 (11:32:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1000.v1

A New Strategy for Discovering Structurally Clear Plant Biostimulants

Peiwen Gao, Kui Wang, Chang Qi, Keming Chen, Wensheng Xiang, Yue Zhang, Jie Zhang, Changlong Shu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Biostimulant; Intestinal compound; Protaetia brevitarsis

Online: 15 November 2023 (12:01:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0570.v2

The Impact of Predation Risks on the Development and Fecundity of the Bactrocera dorsalis Hendel

Xin Liu, Jian Wen, Xingyu Geng, Lu Xiao, Zhe Shan, Yan zhou, Xianli Lu, Yu Fu, ying fu, Fengqin Cao

Subject: Biology And Life Sciences, Insect Science Keywords: Bactrocera dorsalis ; Hendel; non-lethal effects; phenotypic plasticity; predator-prey interaction; pest management

Online: 9 April 2024 (12:31:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0984.v1

Clinical Efficacy of Sitafloxacin-Colistin-Meropenem and Colistin-Meropenem among Carbapenem-Resistant and Multidrug-Resistant Acinetobacter baumannii Hospital-Acquired Pneumonia (Hap) / Ventilator-Associated Pneumonia (Vap) Patients in One Super-ter

Manasawee Wantanatavatod, Panuwat Wongkulab

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Acinetobacter baumannii HAP/VAP, carbapenem-resistant, sitafloxacin

Online: 12 January 2024 (09:21:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0297.v1

The Autophagy-Related Musa acuminata Protein MaATG8F Interacts with MaATG4B, Regulating Banana Disease Resistance to Fusarium oxysporum f. sp. cubense Tropical Race 4

Huoqing Huang, Yuzhen Tian, Yile Huo, Yushan Liu, Wenlong Yang, Yuqing Li, Mengxia Zhuo, Dandan Xiang, Chunyu Li, Ganjun Yi, Siwen Liu

Subject: Biology And Life Sciences, Horticulture Keywords: ATG8; ATG4; autophagy; Fusarium oxysporum f. sp. cubense tropical race 4; plant disease resistance

Online: 6 December 2023 (03:17:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1555.v1

Nutritional and Sensory Optimization of Functional Crackers with the Incorporation of Arthrospira platensis

Didem Gün, Abuzer Çelekli, Hüseyin Bozkurt

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Arthrospira platensis; cracker; functional food; food enrichment

Online: 19 July 2024 (09:35:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0478.v1

New Pyranone Derivatives and Sesquiterpenoid Isolated from the Endophytic Fungus Xylaria sp. Z184

Yan Zhang, Yang Jin, Wensi Yan, Peishan Gu, Ziqian Zeng, Ziying Li, Guangtao Zhang, Mi Wei, Yongbo Xue

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Xylaria sp.; pyranone derivative; sesquiterpenoid; antimicrobial activity

Online: 8 April 2024 (16:42:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1537.v1

Converting Candlenut Shell Waste into Graphene for Electrode Applications

Rikson Siburian, Kerista Tarigan, Yosia Gopas Oetama Manik, Fajar Hutagalung, Yatimah Alias, Yong Ching Chan, Boon Peng Chang, Jonathan Siow, Amanda Jiamin Ong, Jingfeng Huang, Suriati Paiman, Boon Tong Goh, Lisnawaty Simatupang, Ronn Goei, Alfred Iing Yoong Tok, Yahya Mohd Fakharul Zaman Raja, Fathan Bahfie

Subject: Engineering, Other Keywords: graphene; candlenut (Aleurites moluccanus) shell; Ce/graphene; carbon large scale production; energy storage electrodes

Online: 24 June 2024 (04:28:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0233.v1

Impact of Thinning on the Yield and Quality of Eucalyptus grandis Wood at Harvest Time

Fernando Resquin, Karen Yanet Baez, Sofía de Freitas, Diego Passarella, Ana Paula Coelho-Duarte, Cecilia Rachid-Casnati

Subject: Biology And Life Sciences, Forestry Keywords: Eucalyptus grandis; thinning; growth; wood quality; sawmill

Online: 3 April 2024 (13:16:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1387.v1

Epidemiological Data and Antimicrobial Resistance of Campylobacter spp in Portugal from 13 Years of Surveillance

Andreia Duarte, Luisa Pereira, Maria-Leonor Lemos, João Rodrigues, Rui Matias, Andrea Santos, Mónica Oleastro

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Campylobacter infection; epidemiology; surveillance; notification; antibiotic resistance

Online: 19 December 2023 (07:53:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0685.v1

Traffic Safety Analysis at Signalized Intersections during Work Zones Intervals by Using the LiDAR Sensor Technology

Alireza Ansariyar

Subject: Engineering, Civil Engineering Keywords: LiDAR Sensor, Signalized Intersections, Work Zone Safety, Traffic Analysis, Work Zone Management

Online: 10 April 2024 (09:23:10 CEST)

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The importance of conflict analysis and safety considerations during work zone intervals at signalized intersections cannot be overstated, as these periods pose unique challenges and safety risks for both motorists and pedestrians. Work zones introduce temporary changes to traffic patterns, lane configurations, and signal timings, which can disrupt the flow of traffic and increase the likelihood of conflicts between vehicles and pedestrians. By conducting comprehensive conflict analysis, it is possible to identify potential conflict points, such as merging areas, pedestrian crossings, and lane transitions, and implement targeted safety measures to mitigate risks. Additionally, considering safety considerations during work zone intervals is paramount to safeguarding the well-being of road users and minimizing the occurrence of conflicts or collisions. Measures such as enhanced signage, temporary traffic control devices, and increased enforcement efforts can help promote compliance with traffic regulations and ensure the safe passage of vehicles and pedestrians through work zones. This study investigates the dynamics of traffic behavior and safety implications within work zones at signalized intersections, aiming to address key challenges and enhance intersection management strategies. Through comprehensive analysis, varying frequencies of Vehicle-to-Vehicle (V2V) conflicts were observed across different movement directions, with significant occurrences identified in specific phases of the traffic signal cycle. Specifically, 69 V2V conflicts in phase #1, 181 in phase #2, 31 in phase #3, 207 in phase #4, 1 in phase #5, 274 in phase #6, 93 in phase #7, and 186 in phase #8 were recorded. Furthermore, the examination of Vehicle-to-Pedestrian (V2P) conflicts underscored the importance of prioritizing pedestrian safety, with notable occurrences observed in phases associated with pedestrian crossing movements. Meanwhile, despite the closure of left-turn movements, instances of red light running persisted, with 69 red light running events in phase #1, 181 in phase #2, 31 in phase #3, 207 in phase #4, 1 in phase #5, 274 in phase #6, 93 in phase #7, and 186 in phase #8.To mitigate these safety concerns during work zone intervals, proactive measures are essential. Strategies include improving communication through clear signage and advanced warning systems, enhancing enforcement efforts with red light cameras and increased police presence, and investing in infrastructure improvements such as temporary pedestrian facilities. Integration of real-time data from sensors, particularly LiDAR technology, offers significant advantages in detecting conflicts and red light runners during work zone intervals. LiDAR's precise, real-time data on vehicle and pedestrian movements, combined with its 360-degree coverage and high spatial resolution, facilitates accurate detection and tracking of potential conflict scenarios, contributing to enhanced intersection safety and traffic management efficiency. This study endeavored to conduct a traffic safety analysis during work zone intervals at a signalized intersection in Baltimore City, known for its high rate of traffic crashes, utilizing LiDAR sensor technology.

Preprint ARTICLE | doi:10.20944/preprints202403.1652.v1

Unravelling the Function of the Sesquiterpene Cyclase STC3 in the Life Cycle of Botrytis cinerea

Víctor Coca-Ruiz, Ivonne Suárez, Josefina Aleu, Jesús M. Cantoral, Celedonio González, Carlos Garrido, Nélida Brito, and Isidro G. Collado

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Botrytis cinerea; sesquiterpene cyclase; secondary metabolism; metabolites and sesquiterpenes

Online: 27 March 2024 (08:20:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202409.2245.v1

Optimizing Fermentation Strategies for Enhanced Tryptophan Production in Escherichia coli: Integrating Genetic and Environmental Controls for Industrial Applications

Miguel Angel Ramos-Valdovinos, Agustino Martínez-Antonio

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Tryptophan; fermentation; metabolic engineering; biosynthesis; Escherichia coli

Online: 29 September 2024 (04:19:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0332.v1

An Entomopathogenic Nematode, Oscheius tipulae, Exhibiting a Wide Pathogenic Spectrum and Its Application to Control Dipteran Insect Pests

Eticha Abdisa, Mojtaba Esmaeily, Jiyoon Kwon, Gahyeon Jin, Yonggyun Kim

Subject: Biology And Life Sciences, Insect Science Keywords: Oscheius tipulae; Steinernema carpocapsae; metagenomics; virulence; immunity

Online: 4 April 2024 (05:55:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0736.v1

Discovery of Gibellula floridensis from Infected Spiders and Analysis of the Surrounding Fungal Entomopathogen Community

Ross A. Joseph, Abolfazl Masoudi, Mateo J Valdiviezo, Nemat O Keyhani

Subject: Biology And Life Sciences, Parasitology Keywords: spider; insect and spider fungal pathogens; Gibellula; habitat; amplicon sequencing

Online: 10 September 2024 (09:01:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0635.v1

Selenomethionine Mitigates Effects of Nocardia cyriacigeorgica-Induced Inflammation, Oxidative Stress and Apoptosis in Bovine Mammary Epithelial Cells

Talgat Assabayev, Jinge Han, Halihaxi Bahetijiang, Venera Abdrassilova, Muhammad Asfandyar Khan, Herman W. Barkema, Gang Liu, John P. Kastelic, Xueying Zhou, Bo Han

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: bovine mastitis; Nocardia cyriacigeorgica; selenomethionine; oxidative stress; apoptosis

Online: 9 September 2024 (09:21:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0715.v1

Dirofilaria sp. and Blood Meal Analysis in Mosquitoes Collected in Vojvodina and Mačva, and the First Report of Setaria tundra (Issaitshikoff &Amp; Rajewskaya, 1928) in Serbia

Sara Šiljegović, Theo Mouillaud, Davy Jiolle, Dušan Petrić, Aleksandra Ignjatović-Ćupina, Ana Vasić, Christophe Paupy, Mihaela Kavran

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Dirofilaria sp.; Setaria tundra; mosquito surveillance; Cox1 gene

Online: 11 April 2024 (04:07:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2019.v1

Agronomic and Functional Quality Traits in Various Underutilized Hot Pepper Landraces

Marwa Chouikhi, Imen Tlili, Imen Henane, Sándor Takács, Hussein Daood, Zoltàn Pék, Lajos Helyes, Anna Montefusco, Monica De Caroli, Gian Pietro Di Sansebastiano, Muhammad Azam, Mohammed Wasim Siddiqui, Riadh Ilahy, Thouraya R’him, Marcello Salvatore Lenucci

Subject: Biology And Life Sciences, Horticulture Keywords: agronomic characteristics; Capsicum annuum L., climate change; functional quality; pungent pep-per landraces

Online: 30 May 2024 (08:35:24 CEST)

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Landraces are considered a crucial component of biodiversity conservation, serving as a reservoir of genetic diversity. Consequently, the collection, cultivation and detailed characterization of such landraces constitute an inherent aspect of the world’s natural resource heritage. This effort holds promise for the development of elite varieties capable of thriving amidst continuous global climate fluctuations. In this context, we conducted a comprehensive assessment of the main agronomic attributes, physico-chemical properties, and functional quality traits of the major hot pepper landraces adapted to diverse climatic conditions in Tunisia. These landraces include ‘Dhirat’, ‘Semmane’, ‘Beldi’, ‘Nabeul’, ‘Jerid’, ‘Mahdia’, ‘Cayenne’, ‘Kairouan’ and ‘Baklouti’. Most of the pepper landraces exhibited satisfactory yields, ranging from 1163.25 to 1841.67 g plant-1 in ‘Jerid’ and ‘Kairouan’, respectively, indicating robust productivity, especially under prevailing climatic changes and high temperatures. Landraces such as ‘Baklouti’, ‘Beldi’, ‘Nabeul’, ‘Semmane’, ‘Kairouan’ and ‘Mahdia’ appear suitable for both fresh consumption and processing, owing to their favorable average fruit weight and soluble solids content. Functional quality and the levels of antioxidants, as well as radical scavenging activity, emerged as key discriminating factors among pepper landraces. Irrespective of genotype, capsaicin and dihydrocapsaicin constituted the major capsaicinoids, accounting for at least 87% of the total. Total capsaicinoids ranged from 1.81 µg g−1 to 193.71 µg g−1, with ‘Baklouti’ and ‘Jerid’ identified as the most pungent landraces. Total carotenoids ranged from 45.94 µg g−1 to 174.52 µg g−1 with ‘Semmane and ‘Jerid’ exhibiting the highest levels. Considerable variation was observed in β-carotene content, spanning from 3% to 24% of the total carotenoids. α-Tocopherol content ranged from 19.03 µg g-1 fw in ‘Kair-ouan’ to 30.93 µg g-1 fw in ‘Beldi’, exerting a notable influence on the overall tocopherol content. Conversely, the other isomers were detected at very low concentrations. The total vitamin C content ranged from 132 mg 100g-1 fw in ‘Mahdia’ to 200 mg 100 g-1 fw in ‘Nabeul’, indicating relatively low genetic variability. However, large variability was detected in total phenolics content, ranging from 168.58 mg GAE kg-1 fw in ‘Beldi ‘to 302.98 mg GAE kg-1 fw in ‘Cayenne’. Among the pepper landraces tested, ‘Cayenne’ achieved the highest value of radical scavenging activity in both hydrophilic and lipophilic fractions (RSAHF and RSALF), with variations rang-ing from 59% to 120% for RSAHF and from 4% to 64% for RSALF. This study aims to: 1) preserve and enhance the value of local genetic resources, 2) identify desiderable traits for incorporation into breeding programs, and 3) develop high-quality, high-yielding cultivars capable of with-standing climate variations.

Preprint ARTICLE | doi:10.20944/preprints202305.0941.v2

Six Years of Pasteurella spp. in the Pitiusas

Gemma Jiménez-Guerra

Subject: Medicine And Pharmacology, Other Keywords: Pasteurella spp; P. multocida; beta-lactams; skin and soft tissue infection; urinary tract infection; pets

Online: 22 January 2024 (04:26:22 CET)

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Abstract: Pasteurella spp. is a gram-negative bacterium that is part of the oral and upper respira-tory tract microbiota of many animals such as canids and felines. In humans it can produce pa-thology primarily associated with animal bites or scratches. In addition, members of this genus, and especially Pasteurella multocida, may also be involved in systemic infections, mainly in im-munocompromised patients in close contact with pets. The aim of this study is to analyse the prevalence and clinical characteristics of infections caused by Pasteurella spp. as well as the sensitivity profile of these isolates obtained in the Microbiology laboratory of the Hospital Can Misses (Ibiza, Ibiza and Formentera Health Area, ASEF) in the period from January 2013 to December 2018. The group of islands of Ibiza and Formentera is known as the Pitiusas Islands. Retrospective descriptive study in which all Pasteurella spp. isolates were analysed in the Microbiology Laboratory of Hospital Can Misses from 1 January 2013 to 31 De-cember 2018. Bacterial identification was performed by Vitek 2 automated biochemical test panel (bioMérieux, Spain) and antimicrobial susceptibility by E-test or antibiotic discs in Mueller-Hinton blood agar, interpreted based on European Committee on An-timicrobial Susceptibility Testing (EUCAST) standards, 2022 version. Medical records were systematically reviewed by collecting demographic data of infected patients, comorbidities, epidemiological data and clinical features of the infection. A total of 22 isolates of Pasterurella spp. were obtained from 22 different patients, 62.8% female, from three different species: 18 P. multocida, 2 P. canis and 2 P. pneumo-tropica. Most isolates came from soft tissue infection samples: 7 wound exudates and 5 abscess material. The antibiotics tested with the highest sensitivity profile were gen-tamicin and cefepime (100% sensitivity). The species most commonly isolated in our environment is P. multocida. Close contact with companion animals, especially cats and dogs, is the main risk factor for Pasteurella spp. infections, although in many cases such contact cannot be established. So Pasteurella spp. infection should be considered a zoonosis in possible emergency, especially in rural areas such as Pitiusas Islands.

Preprint ARTICLE | doi:10.20944/preprints202402.1093.v1

Development and Characterization of a Value-Added Product Suitable for Food Applications from Agaricus bisporus and Pleurotus ostreatus Stems: Evaluation of Particle Size Influence and In Vitro Antioxidant Activity

Patricia Bermúdez-Gómez, Juana Fernández-López, Margarita Pérez-Clavijo, Manuel Viuda-Martos

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Agaricus bisporus; Pleurotus ostreatus; mushroom stem; mushroom co-products; particle size; antioxidant capacity; techno-functional properties; chemical characterization; bioactive compounds

Online: 20 February 2024 (09:06:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.0166.v1

Antimicrobial Susceptibility and Resistance Patterns of Staphylococcus aureus Isolated from Mastitic Cows in Hawassa City and Its Suburbs, South Ethiopia

Rahmeto Abebe, Hagere Hatiya

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: antimicrobial resistance; bovine; culture; Ethiopia; mastitis; S. aureus

Online: 2 October 2024 (12:17:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0675.v2

Green Synthesis of novel Rhododendron arboreum Based Zinc Nanocomposites for Enhanced Antimicrobial and Photocatalytic Degradation Activities

Sajid Ali, Sidra -, Tanveer Asghar, Muhammad Ishtiaq Jan, Muhammad Waqas, Tahir Ali, Riaz Ullah, Ahmed Bari

Subject: Chemistry And Materials Science, Nanotechnology Keywords: Rhododendron arboreum; Zinc nanoparticles; Antimicrobial activity; Photocatalyst; Methyl orange dye

Online: 11 April 2024 (11:15:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0510.v1

Lactic Acid Production by Lactiplantibacillus plantarum AC 11S – Kinetics, and Modeling

Petya Popova-Krumova, Svetla Danova, Dragomir Yankov, Nikoleta Atanasova

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: lactic acid; Lactiplantibacillus plantarum; lactose; growth; mathematical modeling

Online: 8 March 2024 (09:24:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1859.v1

Meta-Analysis of the Fisheries, and Life History for Trichiurus. Japonicas, T. brevis and T. nanhaiensis, in the Northwest of Pacific Ocean

Baochao LIAO, Can Zhou, Jianpeng Yu, Kui Zhang, Abdul Baset, Xiujuan Shan, Longchuan Zhuang

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Trichiurus spp.; spatiotemporal heterogeneity; population dynamics; meta-analysis; the northwest Pacific Ocean

Online: 24 September 2024 (11:58:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0074.v1

Characterization of Lithraea molleoides Gum Films

Federico Becerra, Maria Filomena Garro, Gisella Melo, Martin Alberto Masuelli

Subject: Chemistry And Materials Science, Biomaterials Keywords: Lithraea molleoides fruit gum; hydrolysis; films

Online: 2 October 2024 (07:54:53 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1602.v1

Rhodotorula mucilaginosa Fungaemia in an Infected Biloma Patient Following a Traumatic Liver Injury

Mohammad Nizam Mokhtar, Raha Abdul Rahman, Farah Hanim Abdullah, Izzuddin Azaharuddin, Azarinah Izaham, Chuan Hun Ding

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Biloma; Rhodotorula mucilaginosa; Fungaemia; Liver; Trauma

Online: 26 March 2024 (14:35:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0960.v1

A Preliminary Study of Antibiofilm Activity of Ethyl Acetate Extracts of Actinomycetes Isolated from Bris Soil, Terengganu against Salmonella typhimurium

Anis Amira Azhar, Amira Ahmad

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Salmonella typhimurium; biofilm; actinomycetes; BRIS soil

Online: 18 March 2024 (09:18:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0443.v1

Barcoding of Atropa Belladonna’s DNA: A Systemic Review

Mohammad Odah

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: DNA, Atropa belladonna, Barcoding, Adulteration, Sequencing.

Online: 7 March 2024 (10:47:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1135.v1

Adults of Sun-Coral Tubastraea coccinea Are Resistant to New Antifouling Biocides

Isabela Martins, Kátia Cristina Cruz Capel, Denis Moledo de Souza Abessa

Subject: Environmental And Earth Sciences, Pollution Keywords: Tubastraea coccinea; Antifouling; DCOIT; Nanomaterials; Ecotoxicology

Online: 15 December 2023 (07:23:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0378.v1

Tuluá in Pursuit of Bilingualism: Analysis of the Promotion of English in the Municipality (2013-2021)

Adela Macías Molina, Angie Yeliany Ruiz León, Carlos Mario Villada, Gonzalo Romero Martínez, Angelmiro Galindo Martínez

Subject: Social Sciences, Education Keywords: Bilingualism, language policy, education, English teaching.

Online: 6 December 2023 (10:34:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0093.v1

Speaking Skills: A Panacea for College Students in the Classroom and in the Workplace

Russel Jean Paris Perse

Subject: Social Sciences, Language And Linguistics Keywords: College Students, Education, Higher Education, Speaking Skills, Speech

Online: 1 July 2024 (13:00:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2039.v1

Chemical Composition of Healthy and Raspberry Leaf Blotch Emaravirus-Infected Red Raspberry ‘Willamette’ Fruits

Nemanja Miletić, Milan Mitić, Branko Popović, Marko Petković, Bojana Vasilijević, Vera Katanić, Darko Jevremović

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Raspberry(Rubus idaeus L.); Willamette; RLBV; phenolic profile

Online: 27 December 2023 (04:55:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1974.v1

Antimicrobial and Antibiofilm Effects of Enterocins Against Methicillin-Resistant Staphylococcus aureus Strains From Rabbits

Monika Pogány Simonová, Natália Zábolyová, Andrea Lauková

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: antibiofilm effect; enterocin; methicillin-resistance; rabbit; Staphylococcus aureus

Online: 30 November 2023 (10:16:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0104.v1

Pneumonia Detection from Chest X-rays Using the CheXNet Deep Learning Algorithm

Himanshu Bairwa, Rinku `Jangid

Subject: Computer Science And Mathematics, Computer Science Keywords: Pneumonia detection, chest X-ray, deep learning,CheXnet, neural networks, medical imaging, image
classification,convolution.

Online: 1 July 2024 (13:14:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1424.v1

Isolation and Characterization of Antimicrobial Constituent(s) from the Stem of Cissus populnea Guill. & Perr.

Anita Alex-Asaolu, Ahmad Uba, Umar Abubakar Birnin-Yauri, Amina Jega Yusuf

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Cissus populnea; steroids; phthalates; antimicrobial; stigmasterol; β -sitosterol

Online: 22 November 2023 (12:28:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1498.v1

Exploring the In Vitro Effects of Zingerone on Differentiation and Signalling Pathways in Bone Cell Lines

Brunhilde de Vos, Annie Joubert, Abe Kasinga, Trevor Nyakudya

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Bone metabolism; in vitro physiology; osteoblast; osteoclast; zingerone

Online: 18 October 2024 (12:59:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1689.v2

No Association between Antimicrobial Consumption and Antimicrobial Resistance in a PrEP Population: A Cross Sectional Study

Thibaut Vanbaelen, Jolein Laument, Tessa De Block, Christophe Van Dijck, Sheeba Santhini Manoharan-Basil, Chris Kenyon

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Antimicrobial resistance; PrEP; saturation; Neisseria gonorrhoeae; gonorrhoea; stewardship

Online: 16 January 2024 (14:32:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.2100.v1

Beneficial Effects of Phosphite in Arabidopsis thaliana Are Mediated by Activation of ABA, SA, and JA Biosynthesis and Signaling Pathways

Francisco Gabriel Perez-Zavala, Jonathan Odilón Ojeda-Rivera, Luis Herrera-Estrella, Damar López-Arredondo

Subject: Biology And Life Sciences, Plant Sciences Keywords: Arabidopsis thaliana; phosphite; abscisic acid; jasmonic acid; salicylic acid; phosphorus sensing; defense responses; stress conditions

Online: 31 May 2024 (09:08:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2055.v1

Maximum Ismail’s Second Entropy Formalism of Heavy-Tailed Queues with Hurst Exponent Heuristic Mean Queue Length Combined with Potential Applications of Hurst Exponent to Social Computing and Connected Health

Dr Ismail A Mageed

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Queue, Noros Mean Queue Length, stable M/G/1 queue, Ismail&rsquo; s second entropy.

Online: 30 January 2024 (08:45:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202410.1349.v1

Lactiplantibacillus plantarum Promotes Reproductive Function and Cognitive Activity in Aged Male Mice with High-Fat Diet-Induced Obesity

Chin-Yu Liu, Tsung-Yu Tsai, Te-Hua Liu, Ting-Chia Chang, Yi-Wen Chen, Chih-Wei Tsao

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Lactiplantibacillus plantarum 1008; aged; obesity; hypogonadism; memory; spermatogenesis

Online: 17 October 2024 (10:48:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1426.v1

Canopy Characteristics of Gamba Grass Cultivars and Their Effects on the Weight Gain of Beef Cattle under Grazing

Gustavo José Braga, Allan Kardec Braga Ramos, Marcelo Ayres Carvalho, Carlos Eduardo Lazarini Fonseca, Claudio Takao Karia

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Andropogon gayanus; Cerrado; leaf; stem; Planaltina; BRS Sarandi

Online: 25 March 2024 (07:52:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.0606.v1

Novel TRIM Proteins Involved in Rainbow Trout Innate Immune Response

Francisco Donoso, Felipe Ramírez-Cepeda, Nicolás Salinas-Parra, Claudio A. Álvarez, Paula Santana, Rubén Avendaño-Herrera, Rafael Diego Rosa, Byron Morales-Lange, Luis Mercado

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Tripartite motif-containing proteins; Oncorhynchus mykiss; fish innate immunology; PAMP’ s signalling in fish; MAMP-triggered immunity in fish; LPS; poly(I:C); Flavobacterium psychrophilum

Online: 10 May 2024 (09:27:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2008.v1

Genetic Diversity of Listeria monocytogenes in Fruits and Vegetables: Environmental Persistence and Antimicrobial Resistance

María Guadalupe Avila-Novoa, Oscar Alberto Solis-Velazquez, Pedro Javier Guerrero-Medina, Liliana Martínez-Chávez, Nanci Edid Matínez-Gonzáles, Melesio Gutiérrez-Lomelí

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Listeria monocytogenes; virulence factors; antimicrobial resistance; benzalkonium chloride; biofilms

Online: 25 September 2024 (11:55:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0037.v1

Distribution and Dendrometry Evolution of Gall Oak (Quercus faginea Lam.) Forest Stands in the Region of Murcia (Southeastern Spain)

Miguel Ángel Sánchez-Sánchez, Alfonso Albacete

Subject: Biology And Life Sciences, Forestry Keywords: dendrometry; desertification; barrennes; region of murcia; Quercus faginea

Online: 1 February 2024 (12:49:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202405.1915.v1

Sublethal and Transgenerational Effects of Nitenpyram on Acyrthosiphon gossypii and Its Impacts on Symbiotic Bacteria

Yindi Wei, Wenjie Li, Ting Chen, Yue Su, Xu Han, Yongsheng Yao

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: nitenpyram; Acyrthosiphon gossypii; symbiotic bacteria; sublethal effects; transgenerational effects

Online: 29 May 2024 (07:40:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0764.v1

Comparison of Trapping Efficacy of Locally Modified Gravid Aedes Trap and Autocidal Gravid Ovitrap for the Monitoring and Surveillance of Aedes aegypti Mosquitoes in Tanzania

Jane Johnson Machange, Masudi Suleiman Maasayi, John Mungi, Jason Moore, Joseph Barnabas Muganga, Olukayode G. Odufuwa, Sarah J. Moore, Frank Chelestino Tenywa

Subject: Biology And Life Sciences, Insect Science Keywords: Aedes aegypti; mosquito traps; vector control; Bio-Gents Sentinel trap; Gravid Aedes Trap; Autocidal Gravid Ovitrap; Tanzania

Online: 11 April 2024 (14:11:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0776.v1

Neutral Red Film Augments Direct and Mediated Extracellular Electron Transfer Performed by Clostridium pasteurianum DSM 525

Ana Clara Bonizol Zani, João Carlos de Souza, Adalgisa Rodrigues de Andrade, Valeria Reginatto

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Clostridium pasteurianum DSM 525; glycerol; mediated electron transfer (MET); neutral red (NR); methyl viologen (MV)

Online: 10 September 2024 (15:18:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0533.v1

Exploring the Dual Benefits of Fermented and Non-fermented Garlic on Growth, Antioxidative Capacity, Immune Responses, and Histology in Grey Mullet (Liza ramada)

Mohammed F. El Basuini, Mahasen M. E. A. Shaban, Abdelaziz M. El-Hais, Ali A. Soliman, Nermeen M. Abu-Elala, Islam I. Teiba, Mayada Alhoshy, Ghada R. Sallam, Ronick S. Shadrack, Kumbukani Mzengereza, Akram Ismael Shehata

Subject: Biology And Life Sciences, Aquatic Science Keywords: Allium sativum; Antioxidant status; Digestive enzymes; Feed additives; Fermented garlic; Growth performance; Liza ramada

Online: 6 September 2024 (11:11:47 CEST)

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This study investigated the effects of dietary garlic powder and fermented garlic powder supplementation at 1% and 2% levels on growth performance, digestive tract efficacy, blood biochemistry, immunity, and antioxidant status of Liza ramada (n=225 fish; 86.00±0.42 g) over a 60-day period. Fish fed diets supplemented with both forms of garlic at both levels exhibited significantly improved final body weight, weight gain, specific growth rate, and feed conversion ratio compared to the control group. Digestive enzyme activities (amylase, lipase, and protease) were significantly enhanced in all supplemented groups. Blood biochemical analysis revealed reduced glucose levels and increased total protein in garlic-supplemented groups, with no adverse effects on liver or kidney function markers. Immune parameters, including lysozyme activity, bactericidal activity against Streptococcus agalactiae, alternative complement pathway (ACP), and, respiratory burst (NBT) were significantly enhanced in garlic-supplemented groups, with fermented garlic showing more pronounced effects. Antioxidant enzyme activities (SOD, CAT, and GPx) were also significantly increased in all supplemented groups, particularly in those fed fermented garlic. No significant differences in survival rates were observed among treatments. The results suggest that both garlic powder and fermented garlic powder supplementation, especially at the 2% level, can effectively improve growth, feed utilization, immune function, and antioxidant status in L. ramada. Fermented garlic generally demonstrated superior effects, indicating its potential as a beneficial feed additive in aquaculture. Based on these findings, it is recommended to incorporate fermented garlic powder at a 2% level in L. ramada diets to optimize growth performance and health status. Further research is warranted to investigate the long-term effects and cost-effectiveness of this supplementation strategy in commercial aquaculture settings.

Preprint ARTICLE | doi:10.20944/preprints202403.0905.v1

Phosphoric Acid Pre-treatment Improves Enzymatic Hydrolysis of Weedy Biomass (Thysanolaena latifolia) for Bioethanol Production

Suwanan Wongleang, Duangporn Premjet, Siripong Premjet

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: weed biomass; Thysanolaena latifolia; renewable resource; glucose recovery; bioethanol; phosphoric acid pretreatment

Online: 15 March 2024 (07:26:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0812.v1

Genetic Markers of Helicobacter pylori Antibiotic Resistance in Moscow

Natalia Bodunova, Larisa Tsapkova, Vera Polyakova, Irina Baratova, Konstantin Rumyantsev, Natalia Dekhnich, Karina Nikolskaya, Margarita Chebotareva, Irina Voynovan, Elena Parfenchikova, Galina Pronina, Ekaterina Chernikova, Dmitry Bordin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Helicobacter pylori; antibiotic resistance; methods for determining H. pylori resistance; molecular genetic diagnostics; phenotypic methods for determining antibiotic resistance; geographical distribution of H. ; pylori antibiotic resistance

Online: 12 April 2024 (03:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0829.v1

Exploring Phytochemical Therapies for Long COVID: A Computational Docking Study of Phytochemicals with GPCR Targets

Pavithren Aaron, Suresh Kumar

Subject: Biology And Life Sciences, Virology Keywords: long covid; GPCR; receptor; drugs; chemokine receptors; serotonin receptors; adrenergic receptors; and histamine receptors docking; phytochemical

Online: 12 August 2024 (14:13:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0265.v1

A Joint Limit Theorem for Epstein and Hurwitz Zeta-Functions

Hany Gerges, Antanas Laurinčikas, Renata Macaitienė

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: dirichlet L-function; epstein zeta-function; hurwitz zeta-function; limit theorem; probability haar measure; weak convergence

Online: 6 June 2024 (02:54:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1289.v1

Optimization of the Conditions for the Transformation of a Bacillus subtilis Strain L11 to Prepare Nano Selenium and Its Preliminary Application in Sheep Feed

Wenxin Guo, Xinyu Shi, Lu Wang, Xin Cong, Shuiyuan Cheng, Linling Li, Hua Cheng

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Bacillus subtilis; SeNPs; subcellular localization; biological activity; immunity

Online: 17 January 2024 (14:03:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.2452.v1

Heterozygous Smad4 Knock out Effect on Pancreatic and Body Weight Variation in F1 Population Using Mutant and Wild Type Collaborative Cross Mice

Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Aysar Nashef, Imad Abu-Elnaaj, Fuad A. Iraqi

Subject: Biology And Life Sciences, Other Keywords: Smad4; pancreatic weight; genetic background; sex differences; Collaborative Cross; F1 mice; genetic modifiers; tumor suppressor gene

Online: 30 July 2024 (10:53:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2225.v1

The Extract of Larrea tridentata Promotes the Synthesis of Silver Nanoparticles and Stimulates Immune Responses in Penaeus vannamei against Vibrio spp, Causing Acute Hepatopancreatic Necrosis Disease

Germán León-Valdez, Wenceslao Valenzuela-Quiñonez, Píndaro Álvarez-Ruiz, C. A. Soto-Robles, Eusebio Nava-Perez, Gabriela López-Cervantes, Magnolia Montoya-Mejía

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Pacific white shrimp; Vibrio; green synthesis; AHPND; MIC

Online: 27 September 2024 (13:44:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1483.v1

Isolation and Characterization of a Bacteriophage with Potential for the Control of Multidrug-Resistant Salmonella Strains Encoding Virulence Factors Associated with the Promotion of Precancerous Lesions

Luis Amarillas, Fedra Padilla, Rubén León-Chan, Jorge Padilla, Yadira Lugo-Melchor, Erique López-Avendaño, Luis Lightbourn, Mitzi Estrada-Acosta

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Antibiotic resistance; Wastewater epidemiology; Oncogenic Salmonella; Lytic phage

Online: 19 September 2024 (10:41:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0834.v2

Elevating Natural Gas Liquid(ngl) Extraction and Fractionation Train Performance: A Synertistic Approach of Simulation Analysis, Advanced Modification, and Vertical Advancement

NNADIKWE JOHNSON, AKUJURU KELVIN, UNYIME ENOBONG OKURE, SAMUEL .H. KWELLE

Subject: Engineering, Energy And Fuel Technology Keywords: ; HYSYS ; Simulation; Heat; Pump; NGL; Extraction; Distillation

Online: 22 April 2024 (10:29:06 CEST)

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Enhancing the Efficiency of Natural Gas Liquid (NGL) Extraction and Fractionation Trains: An Integrated Approach of Simulation Analysis, Advanced Modifications, and Technological Advancements. Through comprehensive research, innovative solutions such as the heat pump aided distillation (HPAD) system and self-heat recuperation technology (SHRT) have been developed to significantly reduce the energy consumption associated with conventional distillation systems. To identify a practical system for NGL fractionation trains, this study extensively examined and compared various HPAD and SHRT options to retrofit a single column. The objective was to find the most suitable and efficient solution for the fractionation process of natural gas liquids (NGLs). The retrofit options analyzed in this study encompassed a range of techniques, including vapor compression (VC), mechanical vapor re-compression (MVR), thermal vapor re-compression (TVR), bottom flashing (BF), side heat exchanger (SHE), intermediate heating and cooling (IHC), self-heat recuperative (SHR), and modified self-heat recuperative (MSHR) distillation. These methods were carefully examined to determine their suitability and effectiveness in improving the performance of NGL fractionation trains.In this study, a depropanizer column, typically employed in conventional NGL plants, was selected as a case study. The simulation software Aspen HYSYS V7.3 was employed to model and analyze eight retrofit designs based on predefined criteria. The simulation data was carefully evaluated to identify the most efficient design for minimizing energy consumption. Among the retrofit options, the mechanical vapor re-compression (MVR) technique demonstrated the most significant energy cost reduction, with a remarkable 68.11 percent improvement compared to the base case conventional column. These findings highlight the potential of MVR as an effective solution for lowering energy costs in NGL fractionation trains.Following the MVR retrofit option, the study found that vapor compression (VC) achieved a considerable energy cost reduction of 66.65 percent, closely followed by modified self-heat recuperative (MSHR) at 64.02 percent, bottom flashing (BF) at 62.88 percent, self-heat recuperative (SHR) at 55.85 percent, side heat exchanger (SHE) at 54.23 percent, intermediate heating and cooling (IHC) at 39.54 percent, and thermal vapor re-compression (TVR) also at 39.54 percent. These findings highlight the significant potential for energy savings offered by these retrofit options, with VC being the most popular choice, closely followed by MSHR, BF, SHR, SHE, IHC, and TVR.

Preprint ARTICLE | doi:10.20944/preprints202311.1185.v1

Isoprenylated Flavonoids and 2-Arylbenzofurans from the Root Bark of Morus alba L. and Their Cytotoxic Activity of against HGC27 Cancer Cells

Hang Yi Pu, Dong Yi Cao, Xue Zhou, Fu Li, Lun Wang, Ming Kui Wang

Subject: Medicine And Pharmacology, Other Keywords: Morus alba L.; gastric cancer; HGC27 cells; cytotoxic activities

Online: 21 November 2023 (10:26:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0018.v1

Metabolic Response to Cropping Pattern in Saffron (Crocus sativus L.)

Qianqian Jiang, Kai Liu, Yan Zhang, Junjie Zhai, Yang Yang, Wenli Gao, Xiang Cheng, Liang Zhou, Huimei Cai

Subject: Biology And Life Sciences, Horticulture Keywords: Crocus sativus L.; cropping pattern; metabolomics; UPLC-MS/MS

Online: 2 September 2024 (13:28:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1917.v1

Exploring the Phytochemical Composition and the Bioactive Properties of Malbec and Torrontés Wine Pomace from the Calchaquíes Valleys (Argentina) for their Sustainable Exploitation

Pablo Ezequiel Tapia, Ana Margarida Silva, Cristina Delerue-Matos, Manuela Moreira, Francisca Rodrigues, Romina Torres Carro, María Daniela Santi, María Gabriela Ortega, María Amparo Blázquez, Mario Eduardo Arena, María Rosa Alberto

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Vitis vinifera; antioxidant; cancer cell cytotoxicity; tyrosinase; lipoxygenase; xanthine oxidase

Online: 29 May 2024 (07:34:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1668.v2

Comparison of the Proteome of Staphylococcus aureus Planktonic Culture and 3-Day Biofilm Reveals Potential Role of Key Proteins in Biofilm

Md Arifur Rahman, Ardeshir Amirkhani, Durdana Chowdhury, Karen Vickery, Honghua Hu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Staphylococcus aureus; biofilms; proteomics; TMT-MS; virulence factors; biosynthetic processes; stress responses.

Online: 29 May 2024 (09:12:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0893.v1

Dynamic and Floristic Structure of Kouampante Community Forest (Savannahs’ Region, Togo)

Kossi Senyo EHLUI

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Community forest; Landscape restoration; biodiversity; Koampante; Savannah Region; Togo

Online: 16 February 2024 (07:05:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202406.1037.v1

Vitamin Solutions Effects on Reproduction of Broodstock, Growth Performance and Survival Rate of Pangasius Catfish Fingerling

Chau Thi Da, Bui Thi Kim Xuyen, Thi Kieu Oanh Nguyen, Van Tai Tang, Pham Thi Thu Ha, Minh Tan Pham, Håkan Berg

Subject: Biology And Life Sciences, Aquatic Science Keywords: Pangasius catfish; broodstock nutrition; reproduction; growth performances; fingerling; survival rates

Online: 19 June 2024 (10:57:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0174.v1

Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract

Ionuț Mădălin Ivan, Octavian Tudorel Olaru, Violeta Popovici, Carmen Lidia Chițescu, Liliana Popescu, Emanuela Alice Luță, Elena Iuliana Ilie, Lorelei Irina Brașoveanu, Camelia Mia Hotnog, George Mihai Nițulescu, Rica Boscencu, Cerasela Elena Gîrd

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Berberis volgaris (L.) stem bark; dry hydro-ethanolic extract; phenolic secondary metabolites; berberine; antioxidant activity; cytotoxicity

Online: 2 April 2024 (10:27:54 CEST)

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Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigates B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 ± 3.9320 mg Eq Tannic acid / 100 g extract, phenolic acids amount of 3.3886 ± 0.3481 mg Eq Chlorogenic acid / 100 g extract and 78.95 µg/g berberine. The dried hydro-ethanolic extract (BVE) was thoroughly analyzed using Ultra-High Performance Liquid Chromatography coupled with High-Resolution Mass Spectrometry (UHPLC–HRMS/MS) and HPLC and 40 bioactive phenolic constituents were identified. Then, the antioxidant potential of BVE was evaluated using three methods; our results could explain the protective effects of Berberidis cortex EC50FRAP = 0.1398 mg/mL, IC50ABTS = 0.0442 mg/mL, IC50DPPH = 0.2610 mg/mL compared to ascorbic acid (IC50 = 0.0165 mg/mL). Next, the acute toxicity and teratogenicity of BVE and Berberine - Berberine sulfate hydrate (BS) - investigated on Daphnia sp reported significant BS toxicity after 24 h; BVE revealed considerable toxicity after 48 hours and induced embryonic developmental delays. Finally, the anticancer effects of BVE and BS were evaluated on different tumor cell lines after 24 and 48 hours of treatments. The MTS assay evidenced a dose- and time-dependent antiproliferative activity, higher on BS than BVE. The strongest diminution of tumor cell viability was recorded on breast (MDA-MB-231), colon (LoVo) cancer, and OSCC (PE/CA-PJ49) cell lines after 48 h of exposure (IC50 < 100 µg/mL). However, no cytotoxicity was reported on normal epithelial cells (HUVEC) and hepatocellular carcinoma (HT-29) cell lines. Extensive data analysis supports our results, showing a significant correlation between the BVE's concentration, phenolic compounds content, antioxidant activity, exposure time, and the viability rate of various normal cells and cancer cell lines.

Preprint ARTICLE | doi:10.20944/preprints202401.1088.v1

Numerical Simulation Approaches for Vertical-Axis Wind Turbines: Investigating Airfoil Design and Predictive Techniques

Ayomide Adesiyan, Olumide Akinnawo

Subject: Engineering, Energy And Fuel Technology Keywords: Lift-Drag coefficient, Airfoil, numerical simulation, NACA 4412, CFD

Online: 15 January 2024 (10:43:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1051.v1

Proteomics Applications in Toxoplasma gondii: Unveiling the Host-Parasite Interactions and Therapeutic Target Discovery

Bin Deng, Laura Vanagas, Sergio O. Angel

Subject: Biology And Life Sciences, Parasitology Keywords: Toxoplasma gondii; proteomics; host-parasite interactions; PTMs; drug discovery

Online: 16 November 2023 (07:46:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0074.v1

The Language Development in the Digital Age: A Review

Leo Marcos

Subject: Social Sciences, Language And Linguistics Keywords: Digital Age, Education, Language, Language Development, Review

Online: 1 July 2024 (13:10:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2045.v1

New records of sharpshooters (Hemiptera, Cicadellidae, Cicadellinae) in citrus orchards in the Amazonas State, Brazil

Paola Victoria Moreno Franco, Agno Nonato Serrão Acioli, Joyce Adriana Froza, Nathalia Hiluy Pecly, Jânia Lilia da Silva Bentes, João Roberto Spotti Lopes

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Amazonia; citrus variegated chlorosis; vector; Xylella fastidiosa

Online: 30 May 2024 (13:30:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1944.v1

An Efficient Plant DNA Extraction Protocol of Inga feuilleei (Pacae)

Jossimar Vicente

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Inga feuilleei; pacae; DNA; nucleic acids; plant

Online: 29 May 2024 (14:07:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0226.v1

Quorum Quenchers as an Emerging New Strategy against Pseudomonas aeruginosa Infections

Alejandra Leonor Valdez, Torres Mariela Analía, Rodolfo García Contreras, Carlos Nieto Peñalver

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: quorum quenching; Pseudomonas aeruginosa

Online: 6 May 2024 (09:53:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0463.v1

Graphene Oxide 2D Films for Integrated Thermo-Optic Devices

David Moss

Subject: Physical Sciences, Optics And Photonics Keywords: Integrated photonics; 2D material; thermo-optics

Online: 8 April 2024 (06:02:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0018.v1

First Report of the Emerging Pathogen Kodamaea ohmeri in Honduras

Bryan Ortiz, Roque López, Carlos Muñóz, Kateryn Aguilar, Fernando Pérez, Isis Laínez-Arteaga, Fernando Chávez, Celeste Galindo, Luis Rivera, Manuel G Ballesteros-Monrreal, Pablo Mendez-Pfeiffer, Dora Valencia, Gustavo Fontecha

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Kodamaea ohmeri; Honduras; virulence; diagnosis; adhesion; macrophages

Online: 1 February 2024 (08:35:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1881.v1

Enhancing Structural Diversity of Lathyrane Derivatives through Biotransformation by the Marine-Derived Actinomycete Streptomyces puniceus BC-5GB.11

Felipe Escobar-Montaño, Victoria E. González-Rodríguez, Antonio J. Macías-Sánchez, José M. Botubol-Ares, Rosa Durán-Patrón, Rosario Hernández-Galán

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: marine-derived actynomicete; Streptomyces; diterpenoids; lathyranes; biotransformation

Online: 26 January 2024 (07:51:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1358.v1

Larvicidal Potency of Some Selected Nigerian Plants against Aedes aegypti

Eze Elijah Ajaegbu, Gloria Tochukwu Onah, Adeniran John Ikuesan, Abdulrsheed Momoh Bello

Subject: Biology And Life Sciences, Insect Science Keywords: Aedes aegypti; dengue; diseases; arboviruses; toxicity; phytochemical

Online: 18 January 2024 (03:31:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1510.v1

Molecular Responses of The Eukaryotic Cell Line INT407 on the Internalised C. jejuni - the other Side of the Coin

Anita Steinbach, Kun József, Peter Urban, Tamás Palkovics, Schneider György

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Campylobacter jejuni; INT407 cell line infection; WTA

Online: 23 November 2023 (10:51:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0942.v1

Population Genetic Structure of a Viviparous Sand Lizard, the Phrynocephalus forsythii in the Tarim Basin, Xinjiang of China

Jiabao Duan, Luoxue Jiang, Tianying Chen, Wen Zhong, Wei Zhao, Yue Qi, Penghui Guo, You Li

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Phrynocephalus forsythii; microsatellite; genetic diversity; population structure

Online: 14 November 2023 (15:25:45 CET)

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Preprint ESSAY | doi:10.20944/preprints201802.0131.v9

Tutorial on EM Algorithm

Loc Nguyen

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: expectation maximum; EM; generalized expectation maximum; GEM; EM convergence

Online: 23 November 2020 (14:25:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1386.v2

Enterococci from Food-producing Animals at a Slaughterhouse: Antibiotic Resistance and Genetic Diversity in Turkey

Tugba Cebeci

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Antibiotic resistance; carcass; Enterococcus spp.; MALDI-TOF MS; slaughterhouse

Online: 30 January 2024 (04:03:53 CET)

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Enterococci are widely acknowledged as prominent pathogens in hospitals, with the potential to transfer resistance genes, virulence factors, or other characteristics that increase their ability to survive in humans. Healthy cattle, sheep, and goats can be reservoirs for gastrointestinal pathogenic fecal enterococci, some of which could be multidrug-resistant to antimicrobials. The objective of this study was to determine the prevalence and diversity of Enterococcus species in healthy sheep, goat, and cattle carcasses, as well as to analyze the antimicrobial resistance phenotype/genotype and the virulence gene content. During 2019–2020, carcass surface samples of 150 ruminants were collected in a slaughterhouse. A total of 90 enterococci, comprising 5 species, were obtained. The overall prevalence of enterococci was found to be 60%, out of which 37.7% were identified as E. hirae, 33.3% as E. casseliflavus, 15.5% as E. faecium, 12.2% as E. faecalis, and 1.1% as E. gallinarum. Virulence-associated genes of efaA (12.2%) were commonly observed in the Enterococcus isolates, followed by gelE (3.3%), asaI (3.3%), and ace (2.2%). Characteristic resistance genes were identified by PCR with an incidence of 6.6%, 2.2%, 1.1%, 1.1%, 1.1%, and 1.1% for the tetM, ermB, ermA, aac(6’)Ie-aph(2")-la VanC1, and VanC2 genes, respectively. The high resistance to quinupristin-dalfopristin (28.8%), tetracycline (21.1%), ampisilin (20%), and rifampin (15.5%) was distributed among two, four, four, and five of the five species, respectively. The resistance of Enterococcus isolates to 11 antibiotic groups was determined and multidrug-resistant (MDR) strains occupied 18.8% of the Enterococcus isolates. Efflux pump genes causing multidrug resistance were detected in Enterococcus isolates (34.4%). The study's results showed that there were enterococci in the slaughterhouse that were multidrug resistant (MDR) and had a number of genes linked to virulence that could be harmful to human health.

Preprint REVIEW | doi:10.20944/preprints202407.1788.v1

Aggregatibacter actinomycetemcomitans Dispersin B: The Quintessential Antibiofilm Enzyme

Jeffrey B. Kaplan, Svetlana A. Sukhishvili, Milosalv Sailer, Khalaf Kridin, Narayanan Ramasubbu

Subject: Biology And Life Sciences, Other Keywords: biofilm matrix; biomaterial coating; DspB; EPS; exopolysaccharide; extracellular DNA; eDNA; matrix-degrading enzyme; PIA; PNAG; Staphylococcus aureus; Staphylococcus

Online: 23 July 2024 (13:56:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1437.v1

Differential Selection for Translation Efficiency Shapes Translation Machineries in Bacterial Species

Heba Farookhi, Xuhua Xia

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Mycobacterium leprae; Mycobacterium tuberculosis; translation efficiency; translation initiation; translation elongation; translation termination; RNA secondary structure; rrn operons; tRNA

Online: 25 March 2024 (08:53:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.1149.v1

Aquibium pacificus sp. nov., a Novel Mixotrophic Bacterium from Bathypelagic Seawater in the Western Pacific Ocean

Fan Jiang, Xun Hao, Ding Li, Xuying Zhu, Jiamei Huang, Qiliang Lai, Jianning Wang, Liping Wang, Zongze Shao

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Aquibium pacificus LZ166^T; taxonomy; mixotrophy; carbon fixation; sulfur oxidation

Online: 15 July 2024 (10:47:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1745.v1

Transcription Factor OsbZIP60-Like Regulating OsP5CS1 Gene and 2-Acetyl-1-Pyrroline (2-AP) Biosynthesis in Aromatic Rice

Gegen Bao, Umair Ashraf, Lin Li, Jingxuan Qiao, Chunling Wang, Yixiog Zheng

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fragrant rice; 2-acetyl-1-pyrroline; OsP5CS1; OsbZIP60-like

Online: 28 November 2023 (03:45:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2144.v1

Physical and Chemical Properties of Convective and Microwave Dried Blackberries Fruits Grown by Organic Procedure

Marko Petković, Nemanja Miletić, Valerija Pantelić, Vladimir Filipović, Biljana Lončar, Olga Mitrović

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Blackberry (Rubus fruticosus); convective drying; microwave drying; polyphenols; antioxidant capacity

Online: 31 January 2024 (02:58:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202408.1208.v1

Gabapentin-Induced Adrenal Insufficiency: The HPA Axis—Stress Misresponse and Risk of Infection

Evmorfia Pechlivanidou, Alexandros Chatzikyriakos, Maria Anna Zisi, Nikolaos Paraskevopoulos, Semeli Kaltsa, Orestis Constantas, Panteleimon Zogakis, Aikaterini Catsouli, Nick Sekouris, Rodanthi Margariti

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: gabapentin; adrenal insufficiency; infections; HPA axis; stress responses; Staphylococcus xylosus

Online: 16 August 2024 (07:23:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0735.v1

Preparation and Evaluation of Niosomal Formulation for Solubility Enhancement of Anti-fungal Agent for the Treatment of Oral Candidiasis

Yogesh Chaudhari, Manisha Chaudhari, Shikha Prasad

Subject: Medicine And Pharmacology, Pharmacy Keywords: Candida albicans; Oral thrush; Anti-fungal; Subgingival film; Niosomes

Online: 11 April 2024 (04:02:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.2399.v1

Identification and Analysis of Anticancer Therapeutic Targets from the Polysaccharides PSK and PSP Using Inverse Docking

Carlos Iván López-Gil, Alejandro Téllez-Jurado, Marco Antonio Velasco-Velázquez, Miguel Angel Anducho-Reyes

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: PSK; PSP; inverse docking; carcinogenic proteins; Trametes versicolor; bioinformatics; immunostimulant

Online: 30 September 2024 (10:42:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1860.v1

Nutritional, Biochemical and Functional Properties of Pearl Millet and Moringa oleifera Leaf Powder Composite Meal Powders

Faith Sibanda, Anthony Olusegun Obilana, Victoria Jideani

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Pearl millet, Moringa oleifera; fermentation; malting; compositing; optimization; mixture design

Online: 26 January 2024 (07:23:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0470.v1

Identification and Characterization of AREB/ABF Gene Family in Three Orchid Species and Functional Analysis of DcaABI5 in Arabidopsis

Xi Xie, Miaoyan Lin, Gengsheng Xiao, Qin Wang, Zhiyong Li

Subject: Biology And Life Sciences, Plant Sciences Keywords: Orchid; gene family; AREB/ABF genes; cis-regulatory elements (CREs) analysis; gene expression; abscisic acid (ABA); ABA INSENSITIVE 5 (ABI5)

Online: 8 February 2024 (07:32:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.0500.v1

Commiphora myrrha Resin Extract-Modulated Cytochrome P-450 2C9 Enzyme Expression Is Associated with Resin Extract-Derived Metabolites Binding to Pregnane X Receptor

Amani Alsharidah, Zeyad Alehaideb, Sahar Alghamdi, Rasha Suliman, Saleh Althenayyan, Feras Almourfi, Bader Hazzazi, Aljawhara Almogren, Abeer Altuwaijri, Mohamed Boudjelal, Afrah AlKhuraiji, Sabine Matou-Nasri

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Commiphora myrrha; Cytochrome P-450 2C9; Diayangambin; Herb-Drug Interactions

Online: 9 September 2024 (02:58:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0614.v1

Population Structure and Genetic Diversity of Ajuga Arabica in Saudi Arabia: A Comparative Analysis of DNA and Gene Sequences

Mohammad Odah

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Ajuga arabica, Genetic Diversity, Population Structure, DNA Sequence, Gene Sequence.

Online: 11 March 2024 (11:02:33 CET)

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